Surface Plasmon Resonance Imaging For the Characterization of Dual-Targeting-Peptides Liposomes

Abstract

Extended Abstract The blood-brain barrier (BBB) plays a key role for brain homeostasis, but at the same time it represents a major obstacle to the development of efficacious treatment for brain diseases. The application of nanomedicine to neurological disorders is one of the most promising strategies to improve the current therapies [1]. Liposomes (LPs) have been widely studied as therapeutic tools for the delivery of drugs to the central nervous system, demonstrating their ability to cross the BBB and to target specific brain sites. Some approaches for BBB crossing involve the surface modification of LPs with biologically active ligands and, among them, Apolipoprotein E-modified peptide (mApoE)