Solid Lipid Nanoparticles for Ocular Delivery of Posaconazole: Design, Optimization and Evaluation Assay

Abstract

Extended Abstract Ocular drug delivery continues challenging due to the unique anatomic and physiological properties of the eye. Although the drugs are easily applied topically to the eye, different barriers such as the cornea, conjunctiva, blood-aqueous barrier, and blood-retinal barrier limit the reaching of the drugs to the target area [1]. In addition, due to some effective mechanisms such as blinking, tear turnover and drainage, the duration of the applied formulation in the eye area is very limited. For these reasons, drugs administered by the ocular route cannot reach the target area at the desired concentration and cannot remain in the ocular area for a sufficient period of time [2]. Conventional dosage forms cannot indicate enough efficacy since they are quickly removed from the eye surface by eyelid movements and tears [3]. Therefore, it is significant to design a suitable ocular drug delivery system to increase the bioavailability of drugs. To overcome the problem of bioavailability in ocular drug delivery, it was planned to prepare solid lipid nanoparticles (SLN) systems that are using for their penetration enhancer effect in different barriers of the eye SLN are nanometer-sized particles prepared with solid lipids at room and body temperature and stabilized with emulsifiers. The use of SLN in ocular drug delivery has been increasing in recent years thanks to its advantages such as not showing toxicity problems, having high penetration ability in different barriers of the eye, increasing the ocular bioavailability and being suitable for large-scale production In addition, SLN enables autoclave sterilization,