Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences最新文献

{"title":"Research progress of metalloporphyrin against neurodegen-erative diseases.","authors":"Jie Chen, Jing Lu, Qingyi Wang, Chu Chu, Linghui Zeng, Jie Zhao","doi":"10.3724/zdxbyxb-2024-0208","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2024-0208","url":null,"abstract":"<p><p>Neurodegenerative disorders are a group of diseases caused by the degeneration and apoptosis of neurons in the brain and spinal cord, which seriously affect human ability of motion perception, memory and cognition. Peroxynitrite can cause oxidative damage in the brain exhibiting neurotoxicity, and its excussive accumulation is closely related to neurodegenerative diseases. Therefore, effectively scavenging peroxynitrite may become a therapeutic strategy for neurodegenerative diseases. Due to their high peroxynitrite scavenging ability, some water-soluble metalloporphyrins have recently attracted much attention. Metalloporphyrins such as iron porphyrins and manganese porphyrins have certain neuroprotective effects, including inhibiting amyloid plaque accumulation, alleviating oxidative stress and neuroinflammatory damage, improving mitochondrial function and reducing neuronal apoptosis. However, there are certain limitations for metalloporphyrins as neuroprotective drugs, and some metal porphyrins have poor blood-brain barrier penetration. To overcome the obstacle, in addition to traditional synthesis processes, metalloporphyrins can also be prepared into nanoparticles to improve bioavailability <i>in vivo</i>. Here, we will review the mechanisms underlying the neuroprotective effects of metalloporphyrin and explore its therapeutic potential for neurodegenerative disorders.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The best evidence for the management of ovarian hyper-stimulation syndrome in patients undergoing assisted reproductive therapy].","authors":"Yu He, Zilian Wang, Yongmei Zhang, Xuechun Jiang, Xuling Shen, Meiling Xu, Qun Wei","doi":"10.3724/zdxbyxb-2024-0349","DOIUrl":"10.3724/zdxbyxb-2024-0349","url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the best evidence for the management of ovarian hyperstimulation syndrome in patients undergoing assisted reproductive therapy.</p><p><strong>Methods: </strong>Evidence related to the management of ovarian hyperstimulation syndrome in patients undergoing assisted reproductive therapy, including guidelines, clinical decision, best clinical practice, systematic evaluation, expert consensus and evidence summary and related original research were systematically searched in UpToDate, BMJ Best Practice, World Health Organization (WHO) website, Guidelines International Network (GIN), National Institute for Health and Clinical Excellence (NICE) website, National Guidelines website, American Society for Reproductive Medicine (ASRM) website, New York Academy of Sciences (NYAS) website, Joanna Briggs Institute (JBI) database, Cochrane Library, CINAHL, PubMed, Wanfang database, CNKI, and China Biomedical Literature Database from inception to May 31, 2024. Two researchers independently evaluated the quality of the literature, and a senior researcher made the final decision for literature inclusion.</p><p><strong>Results: </strong>A total of 15 articles were included in the study. Following quality assessment, one article was excluded. The remaining 14 articles included 5 practice guidelines, 3 systematic reviews, 2 expert consensuses, 1 evidence summary, and 3 from UpToDate. Ultimately, 27 pieces of evidence were identified across five key aspects: risk assessment, disease monitoring, early prevention, institutional management and health education.</p><p><strong>Conclusions: </strong>The updated evidence indicates that the monitoring and prevention of ovarian hyperstimulation syndrome should start early, personalized treatment plans should be provided for patients, and the rational allocation of treatment resources needs to be promoted to enhance effective management of ovarian hyper-stimulation syndrome.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"632-640"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the regulatory cell death of osteoblasts in periodontitis].","authors":"Jiaqi Bao, Yingming Wei, Lili Chen","doi":"10.3724/zdxbyxb-2024-0038","DOIUrl":"10.3724/zdxbyxb-2024-0038","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease characterized by progressive destruction of alveolar bone. The most critical mechanism underlying alveolar bone destruction is the imbalance of bone homeostasis, where osteoblast-mediated bone matrix synthesis plays an important role in regulating bone homeostasis. Regulated cell death is instrumental in both the inflammatory microenvironment and the regulation of bone homeostasis. Chronic inflammation, oxidative stress, and other factors can be directly involved in mitochondrial and death receptor-mediated signaling pathways, modulating B-cell lymphoma 2 family proteins and cysteine aspartic acid specific protease (caspase) activity, thereby affecting osteoblast apoptosis and alveolar bone homeostasis. Chronic inflammation and cellular damage induce osteoblast necroptosis via the RIPK1/RIPK3/MLKL signaling pathway, exacerbating the inflammatory response and accelerating alveolar bone destruction. Stimuli such as pathogenic microorganisms and cellular injury may also activate caspase-1-dependent or independent signaling pathways and gasdermin D family proteins, promoting osteoblast pyroptosis and releasing pro-inflammatory cytokines to mediate alveolar bone damage. Iron overload and lipid peroxidation in periodontitis can trigger ferroptosis in osteoblasts, impacting their survival and function, ultimately leading to bone homeostasis imbalance. This article focuses on the mechanism of periodontal disease affecting bone homeostasis through regulatory cell death, aiming to provide research evidence for the treatment of periodontitis and alveolar bone homeostasis imbalance.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"533-540"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of drug delivery microspheres in cancer therapy].","authors":"Weipan Xu, Xingzhi Zhou","doi":"10.3724/zdxbyxb-2024-0024","DOIUrl":"10.3724/zdxbyxb-2024-0024","url":null,"abstract":"<p><p>Microspheres are a novel drug delivery system, which provides a new approach for cancer therapy. Anti-cancer agents loaded in microspheres can be released in a controlled and sustained pattern, thereby enhancing the therapeutic efficacy and reducing the side effects and toxicity. The preparation methods for drug delivery microspheres include solvent evaporation, phase separation, spray drying, and microfluidic technology, each of these have advantages and limitations. Based on the preparation materials, drug delivery microspheres can be categorized into natural polymer microspheres, synthetic polymer microspheres and bioceramic microspheres. Natural polymer micro-spheres have good biocompatibility and degradability; synthetic polymer microspheres exhibit superior mechanical properties; bioceramic microspheres have good biocompatibility and specific biological functions, which are widely used in bone tissue engineering. Drug delivery microspheres are used for cancer treatment in various modalities, including photothermal therapy, photodynamic therapy, radioembolization, and immunotherapy, as well as chemotherapy. This article reviews the recent progress of microspheres as nano drug delivery system in cancer treatment to provide a reference for further clinical and translation research.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"641-649"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Strategies for prevention and treatment of vascular and nerve injuries in mandibular anterior implant surgery].","authors":"Haiying Ma, Yiting Lou, Zheyuan Sun, Baixiang Wang, Mengfei Yu, Huiming Wang","doi":"10.3724/zdxbyxb-2024-0256","DOIUrl":"10.3724/zdxbyxb-2024-0256","url":null,"abstract":"<p><p>Important anatomical structures such as mandibular incisive canal, tongue foramen, and mouth floor vessels may be damaged during implant surgery in the mandibular anterior region, which may lead to mouth floor hematoma, asphyxia, pain, paresthesia and other symptoms. In severe cases, this can be life-threatening. The insufficient alveolar bone space and the anatomical variation of blood vessels and nerves in the mandibular anterior region increase the risk of blood vessel and nerve injury during implant surgery. In case of vascular injury, airway control and hemostasis should be performed, and in case of nerve injury, implant removal and early medical treatment should be performed. To avoid vascular and nerve injury during implant surgery in the mandibular anterior region, it is necessary to be familiar with the anatomical structure, take cone-beam computed tomography, design properly before surgery, and use digital technology during surgery to achieve accurate implant placement. This article summarizes the anatomical structure of the mandibular anterior region, discusses the prevention strategies of vascular and nerve injuries in this region, and discusses the treatment methods after the occurrence of vascular and nerve injuries, to provide clinical reference.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"550-560"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on accuracy of intraoral digital impressions for implant-supported prostheses in edentulous jaw].","authors":"Jieying Zhu, Ke Zhao, Xinhua Gu","doi":"10.3724/zdxbyxb-2024-0079","DOIUrl":"10.3724/zdxbyxb-2024-0079","url":null,"abstract":"<p><p>With the rapid development of implant techniques and digital technology, intraoral digital impressions have become a commonly used impression method in implant restoration. At present, the accuracy of intraoral digital impressions directly applied to implant-supported prostheses in edentulous jaw remains inadequate. This is due to the high accuracy requirement of full-arch implant impressions, while there are still technical challenges in intraoral digital impressions about recognition and stitching. In this regard, scholars have proposed a variety of scanning strategies to improve the accuracy of intraoral scans, including mucosal modifications, auxiliary devices and novel scan bodies. At the same time, as a new digital impression technique, stereo photogrammetry has been developing steadily and exhibits promising accuracy. This article reviews the research progress on the accuracy of edentulous full-arch implant impressions and techniques which can improve the accuracy of intraoral digital impressions thus providing a reference for clinical application.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"569-577"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].","authors":"Ping Yang, Dandan Dai, Qingyu Li, Haichao Zhan, Xumei Li, Xiaoyan Lu, Min He, Na Chen, Saiping Jiang, Xiaoyang Lu","doi":"10.3724/zdxbyxb-2024-0100","DOIUrl":"10.3724/zdxbyxb-2024-0100","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the incidence and influencing factors of allergic reactions to cephalosporins.</p><p><strong>Methods: </strong>A cross-sectional study of 29 medical institutions in Zhejiang Province was conducted from April 2021 to June 2021. The incidence of allergic reactions to cephalosporins was investigated, and the influencing factors of cephalosporin-induced allergic reactions were analyzed by Poisson regression.</p><p><strong>Results: </strong>A total of 56 155 patients were included in this study. The total incidence of allergic reactions to cephalosporin was 1.67‰, the highest incidence of anaphylaxis occurred for ceftizoxime (4.27‰), followed by ceftriaxone (3.49‰) and cefotaxime (2.40‰). There was no significant difference in the incidence of allergic reactions between patients with negative skin tests and those without skin tests (1.75‰ <i>vs</i>. 1.63‰, <i>RR</i>=1.07, 95%<i>CI</i>: 0.70-1.63, <i>P</i>>0.05). Poisson regression showed that body mass index (BMI) <18.5 kg/m² (<i>RR</i>=2.43, 95%<i>CI</i>: 1.23-4.82, <i>P</i><0.05) and history of β-lactam antibiotics allergy (<i>RR</i>=33.88, 95%<i>CI</i>: 1.47-781.12, <i>P</i><0.05) increased cephalosporin-induced anaphylaxis. Compared with cefuroxime, the risk of allergic reactions was increased for ceftriaxone (<i>RR</i>=3.08, 95%<i>CI</i>: 1.70-5.59, <i>P</i><0.01), ceftazidime (<i>RR</i>=1.89, 95%<i>CI</i>: 1.03-3.47, <i>P</i><0.05), and ceftizoxime (<i>RR</i>=3.74, 95%<i>CI</i>: 1.64-8.50, <i>P</i><0.01).</p><p><strong>Conclusions: </strong>Lower BMI and history of β-lactam antibiotics allergy increase the risk of cephalosporin allergic reactions. The routine skin test may not reduce the occurrence of allergic reactions to cephalosporins.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"615-622"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of probiotics regulating intestinal micro-ecological environment in obese patients after bariatric surgery].","authors":"Xiaoxiao Zhang, Mizhi Wu, Jianan Wang, Jionghuang Chen, Weihua Yu, Hongying Pan","doi":"10.3724/zdxbyxb-2024-0060","DOIUrl":"10.3724/zdxbyxb-2024-0060","url":null,"abstract":"<p><p>Bariatric surgery may cause intestinal microecological environment imbalance due to changes in gastrointestinal anatomy. Some patients may have compli-cations, even regain weight. Probiotics can act on intestinal mucosa, epithelium and gut-associated lymphoid tissue to improve the intestinal microecological environment of obese patients after bariatric surgery. Probiotics can promote the production of short-chain fatty acids, stimulate intestinal cells to release glucagon-like peptide-1, peptide tyrosine-tyrosine, insulin and other endocrine hormones, affect the function of the central nervous system through the gut-brain axis, make patients after bariatric surgery feel full, and reduce blood sugar at the same time. Probiotics can produce lactic acid, acetic acid and lactase, to inhibit the growth of harmful bacteria and to improve gastrointestinal symptoms of patients after bariatric surgery. Probiotics can activate the AMP-activated protein kinase signaling pathway, improve lipid metabolism, and promote the recovery of symptom indicators of nonalcoholic fatty liver disease after bariatric surgery. Probiotics can regulate the release of neurotransmitters or metabolites by the microbiota through the gut-brain axis to affect brain activity and behavior, thus helping patients improve negative emotions after bariatric surgery. This article describes the intestinal microecological environment of obese patients and mechanism of the change after bariatric surgery and summarizes the effects and possible mechanisms of probiotics in improving the intestinal microecological environment of obese patients after bariatric surgery, to provide references for promoting the clinical application of probiotics.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"659-666"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress and clinical application of veneer materials for implant-fixed restoration in edentulous jaws].","authors":"Yan Chen, Xinhua Gu","doi":"10.3724/zdxbyxb-2024-0137","DOIUrl":"10.3724/zdxbyxb-2024-0137","url":null,"abstract":"<p><p>Commonly used materials for fixed restorations in edentulous jaws include acrylic resins, polymerized ceramics, ceramics and zirconia, which have distinct physicochemical properties and clinical application features. The selection of these materials in clinical practice is related to the prosthodontic space, oral soft and hard tissue conditions, occlusal force, lifestyle habits, oral parafunctions, opposing dentition materials, and expectations of patients. Common mechanical complications associated with fixed restorations in edentulous jaws are cracking/chipping and abrasion of the facing materials, which can be avoided through occlusal adjustment, restoration design and processing, and the selection of appropriate restorative materials. This article reviews the characteristics, selection, and design considerations of commonly used materials for fixed restorations in edentulous jaws, as well as the causes and management of common clinical complications related to restorative materials, aiming to provide references for the selection of appropriate materials in fixed restorations for edentulous jaws in clinical practice.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"578-585"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenesis and potential diagnostic biomarkers of atrial fibrillation in Chinese population: a study based on bioinfor-matics].","authors":"Xize Wu, Yue Li, Jiaxiang Pan, Jian Kang, Xue Pan, Chentian Xue, Lihong Gong","doi":"10.3724/zdxbyxb-2024-0027","DOIUrl":"10.3724/zdxbyxb-2024-0027","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To explore the pathogenesis and potential biomarkers of atrial fibrillation based on bioinformatics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Differentially expressed genes and module genes related to atrial fibrillation were obtained from GSE41177 and GSE79768 datasets (Chinese-origin tissue samples) through differential expression analysis and weighted gene co-expression network analysis. Candidate hub genes were obtained by taking intersections, and hub genes were obtained after gender stratification. Subsequently, functional enrichment analysis and immune infiltration analysis were performed. Four machine learning models were constructed based on the hub genes, and the optimal model was selected to construct a prediction nomogram. The prediction ability of the nomogram was verified using calibration curves and decision curves. Finally, potential therapeutic drugs for atrial fibrillation were screened from the DGIdb database.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 67 differentially expressed genes and 65 module genes related to atrial fibrillation were identified. Functional enrichment analysis indicated that the pathogenesis of atrial fibrillation was closely related to inflammatory response, immune response, and immune and infectious diseases. Four common hub genes (&lt;i&gt;TYROBP&lt;/i&gt;, &lt;i&gt;FCER1G&lt;/i&gt;, &lt;i&gt;EVI2B&lt;/i&gt; and &lt;i&gt;SOD2&lt;/i&gt;), and two genes specifically expressed in male (&lt;i&gt;PILRA&lt;/i&gt; and &lt;i&gt;SLC35G3&lt;/i&gt;) and female (&lt;i&gt;HLA&lt;/i&gt;-&lt;i&gt;DRA&lt;/i&gt; and &lt;i&gt;GATP&lt;/i&gt;) patients with atrial fibrillation were obtained after gender-segregated screening. The extreme gradient boosting model had satisfactory diagnostic efficiency, and the nomogram constructed based on the hub genes, male significant variables (&lt;i&gt;PILRA&lt;/i&gt;, &lt;i&gt;SLC35G3&lt;/i&gt; and &lt;i&gt;SOD2&lt;/i&gt;), and female significant variables (&lt;i&gt;FCER1G&lt;/i&gt;, &lt;i&gt;SOD2&lt;/i&gt; and &lt;i&gt;TYROBP&lt;/i&gt;) had satisfactory predictive ability. Immune infiltration analysis demonstrated a disturbed immune infiltration microenvironment in atrial fibrillation with a higher abundance of plasma cells, neutrophils, and γδT cells, with a higher abundance of neutrophils in males and resting mast cells in females. Two potential drugs for the treatment of atrial fibrillation, valproic acid and methotrexate, were obtained by database and literature screening.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The pathogenesis of atrial fibrillation is closely related to inflammation and immune response, and the microenvironment of immune cell infiltration of cardiomyocytes in the atrial tissue of patients with atrial fibrillation is disordered. &lt;i&gt;TYROBP&lt;/i&gt;, &lt;i&gt;FCER1G&lt;/i&gt;, &lt;i&gt;EVI2B&lt;/i&gt; and &lt;i&gt;SOD2&lt;/i&gt; serve as potential diagnostic biomarkers of atrial fibrillation; &lt;i&gt;PILRA&lt;/i&gt; and &lt;i&gt;SLC35G3&lt;/i&gt; serve as potential specific diagnostic biomarkers of atrial fibrillation in the male population, which can effectively predict the risk of atrial fibrillation development and are also potential targets for the treatment of atrial fibrillation","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"593-603"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}