Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences最新文献

{"title":"A neural circuit from hypothalamic paraventricular oxytocin neurons to trigeminal nucleus caudalis GABAergic neurons modulates pain sensitization in a mouse model of chronic migraine.","authors":"Houda Chen, Wanyun Zou, Xufeng Xu, Jiang Bian","doi":"10.3724/zdxbyxb-2025-0211","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0211","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role of a neural pathway from oxytocin (OXT) neurons in the hypothalamic paraventricular nucleus (PVN) to γ-aminobutyric acid (GABA) neurons in the trigeminal nucleus caudalis (TNC) in regulating pain sensitization in a mouse model of chronic migraine and to explore the underlying mechanisms.</p><p><strong>Methods: </strong>A chronic migraine model was established by intraperitoneal injection of nitroglycerin (NTG, 10 mg/kg) on days 1, 3, 5, 7, and 9. The study consisted of four parts: PartⅠ: Wild-type C57BL/6J mice were divided into 4 groups (<i>n</i>=6 in each), receiving single or repeated injection of NTG or saline, respectively. Immunofluorescence was used to detect c-Fos and OXT expression in the PVN. Part II: OXT-Cre transgenic mice (n=6) were used for anterograde monosynaptic tracing combined with RNAscope and immunofluorescence to identify neural projections from PVN OXT neurons to TNC GABA neurons. Part III: 30 male OXT-Cre transgenic mice were bilaterally injected Cre-dependent chemogenetic activation virus into the PVN. These mice were randomly divided into five groups, with six mice in each group. Mice in CNO group and control group were intraperitoneally injected with 0.1 mg/mL of clozapine <i>N</i>-oxide (CNO) solution (1 mg/kg) and the same volume of isotonic normal saline, respectively. 3 hours after the injection, the brain tissues were harvest and c-Fos immunofluorescence staining was performed to verify the efficiency of chemogenetic activation virus. Mice in model control group and CNO activate model group were subjected to chronic migraine modeling, with bilateral TNC injection of isotonic normal saline and CNO, respectively, on day 10. The mice in Negative control group were bilaterally intraTNC injected with isotonic normal saline. After 30 minutes, the von Frey filament and acetone tests were used to assess the mechanical pain threshold and cold pain response time in the periorbital region of mice in these three groups. Part IV: 24 male OXT-Cre transgenic mice were bilaterally injected the Cre-dependent chemogenetic activation virus into the PVN. These mice were randomly divided into the four groups, with six mice in each group. Mice in model control group, CNO activate model group and Atosiban group were subjected to chronic migraine modeling. On day 10, mice in Negative control group and Model control group were intraperitoneally injected with isotonic normal saline, while mice in CNO activate model group and Atosiban group were intraperitoneally injected with CNO. After 15 minutes, mice in the Atosiban group were bilaterally intraTNC injected with atosiban, while mice in other three groups were bilaterally intraTNC injected with isotonic normal saline containing 1% dimethyl sulfoxide. After 15 minutes, the von Frey filament and acetone tests were used to assess the mechanical pain threshold and cold pain response time in the periorbital region of the mice. The GABA con","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive management of tophaceous wounds.","authors":"Guoyu He, Shuliang Lu, Xinyi Lu, Yingkai Liu","doi":"10.3724/zdxbyxb-2025-0159","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0159","url":null,"abstract":"<p><p>Tophaceous wounds represent a severe complication of end-stage gout, characterized by the deposition of monosodium urate (MSU) crystals leading to localized tissue ischemia, chronic inflammation, and non-healing ulcers. The pathological mechanism involves the formation of MSU crystals under persistent hyperuricemia, inflammatory encapsulation, and mechanical compression of the vascular system due to tophus enlarge-ment, ultimately resulting in chronic non-healing ulcers. This article consolidates current evidence to outline an integrated management strategy for such wounds, combining systemic metabolic control with localized interventions. Effective treatment hinges on maintaining serum uric acid levels below 300 μmol/L through urate-lowering agents, including conventional drugs and novel urate transporter 1 inhibitors such as AR882, complemented by anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs and glucocorticoid alleviate pain and reduce inflammation. Topical agents and advanced dressings are utilized to support healing and manage exudate. Debridement-encompassing sharp, ultrasonic, and micro-techniques-is essential for removing necrotic tissue and MSU deposits, with efficacy assessed via local uric acid monitoring. Surgical interventions, including flap transfers and tendon or ligament reconstruction, are indicated for significant tissue loss or functional impairment. Long-term management emphasizes continuous metabolic control, personalized rehabilitation, and lifestyle modification. The comprehensive treatment of tophaceous wounds requires multidisciplinary collaboration to balance local repair and systemic regulation for improved prognosis. Future research directions include gene therapy to regulate purine metabolism and artificial intelligence-assisted personalized treatment plans, aiming to achieve precision medicine for tophaceous wounds.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hepatic neuroendocrine neoplasms: a case series of 10 patients and literature review.","authors":"Yin Jiang, Yudi Meng, Shiwei Zhang, Yongtao Wang, Chunnian Wang, Caide Lu","doi":"10.3724/zdxbyxb-2025-0488","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0488","url":null,"abstract":"<p><p>The clinical data of 10 patients with pathologically confirmed primary hepatic neuroendocrine neoplasms from Ningbo medical institutions between 2012 and 2024 were retrospectively analyzed. The cohort included 8 males and 2 females, with a median age of 63 years. None presented with carcinoid syndrome. Three cases were detected incidentally during health check-ups, 2 presented with painless jaundice, and 5 reported abdominal distension or pain (1 with concurrent jaundice). Elevated tumor markers included CA199 in 4 cases, AFP in 2, and NSE in 1. All patients underwent surgical resection, including hepatectomy and hepatopancreatoduodenectomy. Preoperative imaging failed to diagnose neuroendocrine neoplasms in all cases. Final pathological diagnoses were neuroendocrine tumor (NET) G2 in 5 cases, NET G3 in 1, and neuroendocrine carcinoma (NEC) in 4. During follow-up (median 27.5 months), 4 patients died and 6 survived. The study demonstrates that primary hepatic neuroendocrine neoplasms are rare and lack specific clinical or imaging features. Diagnosis relies on pathological examination after excluding metastatic disease. Radical resection remains the primary treatment, with prognosis varying significantly by tumor grade.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the role of peripheral nerves in wound healing.","authors":"Ziwei Zhang, Danyang Ren, Jingwen Tang, Songxue Guo","doi":"10.3724/zdxbyxb-2025-0032","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0032","url":null,"abstract":"<p><p>Skin wound repair is critically regulated by peripheral nerves, whose injury or dysfunction represents a key factor impairing the healing of pathological wounds such as diabetic ulcers and deep burns. The mechanisms through which peripheral nerves participate in cutaneous wound healing primarily involve the modulation of immune responses, the regulation of stem cell niches, and the promotion of angiogenesis. Sensory neurons initiate and mediate essential local immune responses, contribute to the epidermal stem cell microenvironment, and support regenerative potential. Sympathetic nerves bidirectionally regulate immune homeostasis through the release of various neuromodulators and finely control the activation of hair follicle stem cells and the homeostasis of melanocyte stem cells. Schwann cells also play pivotal roles in immune modulation, balancing repair processes and mitigating scar formation. During revascularization, sensory and autonomic nerve terminals release neurotransmitters that precisely regulate vasomotor activity and angiogenesis, while Schwann cells facilitate the reconstruction of functional vascular networks through potent paracrine signaling. This review systematically summarizes the crucial roles of peripheral nerves in skin wound repair, with emphasis on their regulatory mechanisms in immune responses, stem cell activation and homeostasis, and vascular dynamics, thereby providing insights for developing novel therapeutic strategies targeting neuroregulation.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter valve-in-valve mitral valve replacement with SAPIEN 3 valve for bioprosthetic mitral valve failure: one-year outcomes in 26 patients.","authors":"Zechao Ran, Lulu Liu, Jun Shi, Yuqiang Wang, Tingqian Cao, Siyu He, Xiaoting Li, Yingqiang Guo","doi":"10.3724/zdxbyxb-2024-0454","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2024-0454","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the one-year outcomes of valve-in-valve transcatheter mitral valve replacement (ViV-TMVR) using the SAPIEN 3 valve for treating mitral bioprosthetic valve failure.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 26 patients with mitral bioprosthetic valve failure who underwent ViV-TMVR at West China Hospital, Sichuan University, between November 2022 and July 2024. The age of patients was 71.5 (64.5-74.5) years, and 69.2% were female. Bioprosthetic valve failure occurred at a mean of (9.7±3.7) years after initial surgical implantation, with the most common failure mode being mixed stenosis and regurgitation (53.8%). The SAPIEN 3 valve was implanted via either a transseptal or transapical approach. Follow-up assessments, including clinical evaluation and echocardiography, were performed preoperatively, immediately post-procedure, and at 1 month, 6 months, and 1 year. Outcomes included all-cause mortality, quality of life, and postoperative complications.</p><p><strong>Results: </strong>The procedure was performed via the transseptal approach in 21 patients (80.8%) and the transapical approach in 5 patients (19.2%) after failed transseptal puncture. All procedures were technically successful. No paravalvular leakage was observed immediately post-procedure, and mitral valve hemodynamics improved significantly. At the 1-year follow-up, 2 patients had died. Two patients (8.3% of survivors) were in New York Heart Association (NYHA) functional class Ⅲ, and the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 score improved significantly to (88.4±14.6) points (both <i>P</i><0.01). Echocardiography at 1 year showed significant reductions in peak mitral valve velocity [to (2.29±0.32) m/s] and mean transvalvular pressure gradient [to (9.5±3.5) mmHg, 1 mmHg=0.133 kPa] compared to baseline (both <i>P</i><0.05). No moderate or severe mitral regurgitation or paravalvular leakage was observed. The proportion of patients with moderate-to-severe pulmonary hypertension decreased significantly from 65.4% preoperatively to 13.0% at 1 year (<i>P</i><0.01).</p><p><strong>Conclusions: </strong>ViV-TMVR with the SAPIEN 3 valve for mitral bioprosthetic valve failure is associated with high procedural success, significantly improved valve hemodynamics, alleviation of pulmonary hypertension, enhanced patient QoL, and a low rate of complications at 1 year.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in antibody-drug conjugates for metastatic castration-resistant prostate cancer.","authors":"Jiacheng Xu, Yutao Ma, Pengcheng Hu, Jiatao Yao, Haichao Chen, Qi Ma","doi":"10.3724/zdxbyxb-2025-0391","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0391","url":null,"abstract":"<p><p>Patients with metastatic castration-resistant prostate cancer (mCRPC) face poor prognoses due to tumor heterogeneity and drug resistance. Antibody-drug conjugates (ADCs) have been under development for over two decades for mCRPC treatment. Several clinical trials have demonstrated promising antitumor activity and acceptable safety profiles for ADCs in this setting. Among prostate-specific membrane antigen (PSMA)-targeted ADCs, ARX517 demonstrates superior safety and more significant prostate-specific antigen (PSA) reductions compared to earlier agents such as MLN2704, PSMA-ADC, and MEDI3726. ADCs targeting B7-H3, such as MGC018 and DB-1311, have also shown antitumor activity. ADCs targeting other antigens, including six-transmembrane epithelial antigen of the prostate (STEAP)1 (DSTP3086S), trophoblast cell surface antigen (TROP)2 (sacituzumab govitecan), and solute carrier (SLC) 44A4 (ASG-5ME), have shown preliminary antitumor activity in early trials but face challenges with insufficient efficacy or toxicity. Tisotumab vedotin (targeting tissue factor) has shown no significant therapeutic response in mCRPC. Meanwhile, disitamab vedotin (HER2-targeted), ABBV-969 (dual PSMA/STEAP1-targeted), and DXC008 (dual PSMA/STEAP1-targeted) are currently under evaluation. Notably, the B7-H3-targeted ADC ifinatamab deruxtecan has initiated an international multicenter phase Ⅲ clinical trial (NCT06925737) for mCRPC in May 2025. This review summarizes recent advances in ADCs targeting key antigens in mCRPC (including PSMA, B7-H3, STEAP1, TROP2, SLC44A4, and others) and explores combination strategies, offering insights to inform the clinical management of this highly lethal disease.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of human biological dressing transplantation for refractory wounds in middle-aged and elderly patients.","authors":"Xiangwei Ling, Peng Zhang, Tingting Zhang, Su Li","doi":"10.3724/zdxbyxb-2025-0204","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0204","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the clinical efficacy of human biological dressing (human acellular dermal matrix) transplantation in the management of refractory wounds among middle-aged and elderly patients.</p><p><strong>Methods: </strong>A retrospective observational study was conducted involving 104 middle-aged and elderly patients (74 males, 30 females; aged 56-95 years) with refractory wounds treated at the First Affiliated Hospital of Wenzhou Medical University from January 2023 to December 2024. Following debridement, wound areas ranged from 1.0 to 48.0 cm². All patients received vacuum sealing drainage for 7 days, followed by human biological dressing transplantation. Subsequent wound management was determined based on wound status and patient preference: patients with wounds ≥2 cm² who consented underwent autologous skin grafting (ASG); those who declined ASG or had wounds <2 cm² received regular dressing changes. Outcome measures included: post-human biological dressing coverage of exposed tendons/bones and occurrence of tendon infection/osteomyelitis; survival rate of ASG at postoperative day 7; healing time in patients managed with dressing changes alone; patient satisfaction; and changes in pain intensity, sleep disturbance, and anxiety scores assessed before and 1 month after human biological dressing transplantation using the Edmonton Symptom Assessment Scale.</p><p><strong>Results: </strong>After human biological dressing transplantation, 103 patients exhibited robust granulation tissue formation achieving complete coverage of exposed tendons/bones, with no instances of tendon/bone necrosis, infection, or osteomyelitis. Among these, 51 patients underwent successful ASG at (44.4±13.0) days post-human biological dressing (success rate 100.0%). The remaining 52 patients achieved primary wound healing through dressing changes alone within (62.6 ±13.4) days post-human biological dressing. One patient experienced human biological dressing dissolution and detachment due to gluteal wound infection, resulting in non-healing. The overall cure rate was 99.04% (103/104). Patient satisfaction was high: 95 very satisfied, 8 satisfied, and 1 dissatisfied (satisfaction rate 99.04%). Pain, sleep disturbance, and anxiety scores at 1 month post-human biological dressing were significantly reduced compared to pre-transplantation scores (all <i>P</i><0.05).</p><p><strong>Conclusions: </strong>Human biological dressing transplantation is an effective therapeutic strategy for managing refractory wounds in middle-aged and elderly patients, demonstrating excellent outcomes in promoting granulation tissue growth, facilitating subsequent wound closure, and improving patient-reported symptoms.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restorative strategies for complex crown-root fractures in the esthetic zone: a risk assessment based on the restoration-tooth-periodontium interface.","authors":"Ao Sun, Baiping Fu, Huiyong Zhu","doi":"10.3724/zdxbyxb-2025-0174","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0174","url":null,"abstract":"<p><p>Complex crown-root fractures in the esthetic zone refer to a type of dental trauma occurring in the anterior region, characterized by concurrent fractures involving both the crown and root, with associated pulp exposure and periodontal tissue injury. These injuries consistently exhibit critical anatomical features, including a fixed palatal fracture location below the alveolar crest, compromised residual tooth structure, and frequent violation of the biological width. To predict treatment outcomes, a risk assessment framework based on the restoration-tooth-periodontium (RTP) interface was developed. Resistance risk was evaluated by assessing the type of residual dentin ferrule and the length of the root within the alveolar bone, while periodontal risk was assessed according to gingival phenotype and alveolar bone morphology. Based on these risk dimensions and the principles of aesthetics, stability, and minimally invasive treatment, a diagnostic classification system was established, categorizing fractures into three types: favorable, intervention and high-risk. Type-specific management strategies were proposed: for favorable cases, crown lengthening combined with deep margin elevation to reduce periodontal risk is recommended; for intervention cases, orthodontic extrusion or surgical extrusion is applied to simultaneously address ferrule deficiency and biological width violation; for high-risk cases, extraction followed by implant restoration is advised due to limited root preservation value. This classification system translates subjective clinical experience into objective risk stratification, providing a standardized yet individualized framework for multidisciplinary management of complex crown-root fractures in the esthetic zone.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of superficial ultrasonography in diagnosing and guiding management of a refractory scalp wound complicated by epidural abscess.","authors":"Yu Ling, Hongyang Hu, Gang Xiang, Panpan Lyu","doi":"10.3724/zdxbyxb-2025-0162","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2025-0162","url":null,"abstract":"<p><p>A middle-aged patient presented with persistent purulent discharge from a scalp incision five years after undergoing craniotomy with artificial dura mater implantation. The wound showed no significant improvement despite a month of standardized treatment, including systemic antibiotic therapy and local debridement. Subsequent superficial ultrasonographic examination revealed complete separation of the artificial dura mater implant area from the surrounding flap tissue, with local blood supply loss. Guided by these findings, the artificial dura mater was surgically removed, and a free flap transplantation was performed to successfully cover the wound. The wound healed well at 10 months post-surgery.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress on ultrasound-responsive piezoelectric drug delivery system for treatment of neurodegenerative diseases].","authors":"Rongjie Ma, Yingxin Chen","doi":"10.3724/zdxbyxb-2025-0155","DOIUrl":"10.3724/zdxbyxb-2025-0155","url":null,"abstract":"<p><p>Ultrasound has emerged as a non-invasive neural modulation technique. Its mechanisms of action in the brain involve mechanical, cavitation, and thermal effects, which modulate neural activity by activating mechanosensitive ion channels, enhancing cell permeability, and improving blood circulation. The ultrasound-piezo-electric systems, based on the coupling between ultrasound and piezoelectric materials, can generate wireless electrical stimulation to promote neural repair, significantly improving therapeutic outcomes for neurodegenerative diseases and showing potential as a replacement for traditional invasive deep brain stimulation techniques. The ultrasound-responsive piezoelectric drug delivery system combines mechano-electrical conversion capability of piezoelectric materials with the non-invasive penetration advantage of ultrasound. This system achieves synergistic therapeutic effects for neurodegenerative diseases through on-demand drug release and wireless electrical stimulation in deep brain regions. It can effectively overcome the blood-brain barrier limitation, enabling precisely targeted drug delivery to specific brain regions. Simultaneously, it generates electrical stimulation in deep brain areas to exert synergistic neuroreparative effects. Together, these capabilities provide a more precise, efficient, and safe solution for treating neurodegenerative diseases. This review summarizes the neural regulatory mechanisms, technical advantages, and research progress of the ultrasound-responsive piezoelectric drug delivery systems for neurodegenerative disease therapy, aiming to offer novel insights for the field.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"522-528"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}