{"title":"不同大小的生物材料增强实体瘤过继细胞转移治疗。","authors":"Jiaxin Chen, Rui Liu, Yingqi Tang, Chenggen Qian","doi":"10.3724/zdxbyxb-2024-0651","DOIUrl":null,"url":null,"abstract":"<p><p>Adoptive cell therapy (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors by poor T-cell infiltration, immu-nosuppressive microenvironments, and systemic toxicity. Biomaterials spanning nano- to macroscales-including nanoparticles (NPs), microspheres/microneedles, and hydrogels-offer unique advantages for <i>ex vivo</i> cell engineering, <i>in vivo</i> delivery, and tumor micro-environment modulation. Specifically, NPs enable gene delivery, artificial antigen-pre-senting cell (aAPC) engineering, and immune microenvironment remodeling. Microspheres/microneedles improve immune cell expansion, targeted activation, and localized retention. Hydrogels enhance ACT via in situ genetic engineering, 3D culture support, and cytokine co-delivery. This review summarizes advances in biomaterial-enhanced ACT, highlighting their potential to improve delivery efficiency, amplify antitumor responses, and reduce toxicity. These insights may accelerate the clinical translation of ACT for solid tumors.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"1-10"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors.\",\"authors\":\"Jiaxin Chen, Rui Liu, Yingqi Tang, Chenggen Qian\",\"doi\":\"10.3724/zdxbyxb-2024-0651\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Adoptive cell therapy (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors by poor T-cell infiltration, immu-nosuppressive microenvironments, and systemic toxicity. Biomaterials spanning nano- to macroscales-including nanoparticles (NPs), microspheres/microneedles, and hydrogels-offer unique advantages for <i>ex vivo</i> cell engineering, <i>in vivo</i> delivery, and tumor micro-environment modulation. Specifically, NPs enable gene delivery, artificial antigen-pre-senting cell (aAPC) engineering, and immune microenvironment remodeling. Microspheres/microneedles improve immune cell expansion, targeted activation, and localized retention. Hydrogels enhance ACT via in situ genetic engineering, 3D culture support, and cytokine co-delivery. This review summarizes advances in biomaterial-enhanced ACT, highlighting their potential to improve delivery efficiency, amplify antitumor responses, and reduce toxicity. These insights may accelerate the clinical translation of ACT for solid tumors.</p>\",\"PeriodicalId\":24007,\"journal\":{\"name\":\"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences\",\"volume\":\" \",\"pages\":\"1-10\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3724/zdxbyxb-2024-0651\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3724/zdxbyxb-2024-0651","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors.
Adoptive cell therapy (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors by poor T-cell infiltration, immu-nosuppressive microenvironments, and systemic toxicity. Biomaterials spanning nano- to macroscales-including nanoparticles (NPs), microspheres/microneedles, and hydrogels-offer unique advantages for ex vivo cell engineering, in vivo delivery, and tumor micro-environment modulation. Specifically, NPs enable gene delivery, artificial antigen-pre-senting cell (aAPC) engineering, and immune microenvironment remodeling. Microspheres/microneedles improve immune cell expansion, targeted activation, and localized retention. Hydrogels enhance ACT via in situ genetic engineering, 3D culture support, and cytokine co-delivery. This review summarizes advances in biomaterial-enhanced ACT, highlighting their potential to improve delivery efficiency, amplify antitumor responses, and reduce toxicity. These insights may accelerate the clinical translation of ACT for solid tumors.