不同大小的生物材料增强实体瘤过继细胞转移治疗。

Q2 Medicine
Jiaxin Chen, Rui Liu, Yingqi Tang, Chenggen Qian
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引用次数: 0

摘要

过继细胞疗法(ACT)对血液学恶性肿瘤显示出显著的疗效,但在实体肿瘤中由于t细胞浸润不良、免疫无抑制性微环境和全身毒性而受到限制。跨越纳米到宏观尺度的生物材料——包括纳米颗粒(NPs)、微球/微针和水凝胶——为体外细胞工程、体内递送和肿瘤微环境调节提供了独特的优势。具体来说,NPs能够实现基因传递、人工抗原呈递细胞(aAPC)工程和免疫微环境重塑。微球/微针改善免疫细胞扩增、靶向激活和局部保留。水凝胶通过原位基因工程、3D培养支持和细胞因子共递送来增强ACT。本文综述了生物材料增强ACT的研究进展,强调了它们在提高递送效率、增强抗肿瘤反应和降低毒性方面的潜力。这些发现可能会加速ACT治疗实体瘤的临床转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors.

Adoptive cell therapy (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors by poor T-cell infiltration, immu-nosuppressive microenvironments, and systemic toxicity. Biomaterials spanning nano- to macroscales-including nanoparticles (NPs), microspheres/microneedles, and hydrogels-offer unique advantages for ex vivo cell engineering, in vivo delivery, and tumor micro-environment modulation. Specifically, NPs enable gene delivery, artificial antigen-pre-senting cell (aAPC) engineering, and immune microenvironment remodeling. Microspheres/microneedles improve immune cell expansion, targeted activation, and localized retention. Hydrogels enhance ACT via in situ genetic engineering, 3D culture support, and cytokine co-delivery. This review summarizes advances in biomaterial-enhanced ACT, highlighting their potential to improve delivery efficiency, amplify antitumor responses, and reduce toxicity. These insights may accelerate the clinical translation of ACT for solid tumors.

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CiteScore
3.80
自引率
0.00%
发文量
67
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