中华口腔医学杂志最新文献

{"title":"[Numerical considerations for defining a rare disease in China].","authors":"S Yu, H Qiao, X Zhang","doi":"10.3760/cma.j.cn112144-20250717-00272","DOIUrl":"10.3760/cma.j.cn112144-20250717-00272","url":null,"abstract":"<p><p>Rare diseases have become an issue of public health concern globally. In China, two rare diseases lists have been released officially in 2018 and 2023, respectively. However, due to its importance in research, clinical management , therapeutic drug development and health security, we still need a clear definition of rare diseases in China. Considering the current actual condition of our country and our population size, we would suggest a prevalence of less than 1/10 000 to define a rare disease in China.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"939-942"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Periodontal health status and associated factors in community-managed patients with type 2 diabetes mellitus in Nanjing].","authors":"H Xu, N Zhou, C C Wang, Y J Chen, Y Zhang, X Hong","doi":"10.3760/cma.j.cn112144-20250318-00091","DOIUrl":"10.3760/cma.j.cn112144-20250318-00091","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the prevalence, severity, and influencing factors of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM) in Nanjing. &lt;b&gt;Methods:&lt;/b&gt; From June to August 2022, by using a multi-stage stratified cluster random sampling method, a total of 1 477 community-dwelling T2DM patients aged 35 years and older were selected and included from the National Essential Public Health Services Program for T2DM health management. Physical examinations, laboratory tests, and questionnaire surveys were conducted. Study participants were divided into chronic periodontitis group and non-chronic periodontitis group. The chronic periodontitis group was defined as having interproximal clinical attachment loss (CAL) detected at least at two non-adjacent sites, or having buccal/lingual CAL≥3 mm at least at two sites with probing depth (PD)≥3 mm, while excluding CAL caused by non-periodontal reasons. The remaining participants were classified as the non-chronic periodontitis group. In the chronic periodontitis group, patients who had PD≥6 mm at least at two sites with CAL≥5 mm were defined as severe periodontitis, with remaining cases classified as mild-to-moderate periodontitis. &lt;b&gt;Results:&lt;/b&gt; The prevalence of chronic periodontitis among T2DM patients was 70.1% (962/1 373), with mild to moderate and severe periodontitis prevalence rates of 62.4% (857/1 373) and 7.6% (105/1 373), respectively. After complex weighted processing, the prevalence of chronic periodontitis in T2DM patients was 67.9%, with mild to moderate and severe periodontitis prevalence rates of 61.2% and 6.7%, respectively. Multivariate logistic regression analysis showed that after adjusting all covariates, compared with mental workers, the risk of chronic periodontitis was significantly higher in retired people (&lt;i&gt;OR=&lt;/i&gt;1.78, 95&lt;i&gt;%CI&lt;/i&gt;: 1.75-1.81, &lt;i&gt;P&lt;&lt;/i&gt;0.001), unemployed/others (&lt;i&gt;OR=&lt;/i&gt;2.18, 95&lt;i&gt;%CI&lt;/i&gt;: 2.14-2.22, &lt;i&gt;P&lt;&lt;/i&gt;0.001), and physical workers (&lt;i&gt;OR=&lt;/i&gt;3.80, 95&lt;i&gt;%CI&lt;/i&gt;: 3.73-3.87, &lt;i&gt;P&lt;&lt;/i&gt;0.001). In terms of blood glucose control status, compared with the group that met both control targets, the risk of chronic periodontitis was significantly higher in the group that met only one target (&lt;i&gt;OR=&lt;/i&gt;1.28, 95&lt;i&gt;%CI&lt;/i&gt;: 1.27-1.30, &lt;i&gt;P&lt;&lt;/i&gt;0.001) and the group that met neither target (&lt;i&gt;OR=&lt;/i&gt;3.29, 95&lt;i&gt;%CI&lt;/i&gt;: 3.25-3.34) (&lt;i&gt;P&lt;&lt;/i&gt;0.001). The results of ordered Logistic regression showed that after adjusting for all covariates, compared with male patients, female patients had a significantly lower risk of progression to severe periodontitis (&lt;i&gt;OR=&lt;/i&gt;0.77, 95&lt;i&gt;%CI&lt;/i&gt;: 0.76-0.78, &lt;i&gt;P&lt;&lt;/i&gt;0.001). In terms of the score of healthy lifestyle, compared with those with a score of 0-2, the risk of progression to severe periodontitis was significantly lower in those with a score of 3 (&lt;i&gt;OR=&lt;/i&gt;0.85, 95&lt;i&gt;%CI&lt;/i&gt;: 0.84-0.86, &lt;i&gt;P&lt;&lt;/i&gt;0.001) and 4 (&lt;i&gt;OR=&lt;/i&gt;0.51, 95&lt;i&gt;%CI&lt;/i&gt;: 0.50-0.52, &lt;i&gt;P&lt;&lt;/i&gt;0.001). In terms of blood gluco","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"997-1007"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Single-cell sequencing reveals the temporal expression characteristics of key molecules related to tooth agenesis and dental hard tissues in mouse molars].","authors":"W Guo, X P Wang, T Y Su, S Q Wei, X Y Pan, X H Duan","doi":"10.3769/cma.j.cn112144-20250605-00206","DOIUrl":"10.3769/cma.j.cn112144-20250605-00206","url":null,"abstract":"<p><p><b>Objective:</b> To utilize single-cell RNA sequencing (scRNA-seq) to untangle the temporal expression profiles of molecules associated with congenital tooth agenesis and dental hard tissue formation during mouse molar development, and to construct a comprehensive cell atlas spanning the entire developmental period from E13.5 to P7.5, thereby providing new insights into the molecular mechanisms underlying abnormal tooth development. <b>Methods:</b> scRNA-seq data of murine mandibular molar tooth germs at five developmental stages (E13.5, E14.5, E16.5, P3.5, P7.5) were obtained from the GEO database (accession: GSE189381). The Seurat pipeline was employed for quality control, data normalization, dimensionality reduction, and Harmony-based batch effect correction. Cellular subpopulations were identified through uniform manifold approximation and projection dimensionality reduction, while developmental trajectories were reconstructed using Monocle for pseudotime analysis. <b>Results:</b> scRNA-seq analysis profiling identified 27 distinct cellular clusters, which were annotated into twelve major cell types including epithelial cells, mesenchymal cells, and endothelial cells. Msx1 exhibited a bimodal expression pattern. Pax9 reached its peak at E14.5 and then gradually decreased. Eda had a low expression level with a diffuse distribution. In contrast, Amelx and Enam were barely expressed during the embryonic stage and were activated at P3.5. Dspp was ectopically highly expressed in epithelial cells from P3.5 to P7.5, while Dmp1 was specifically upregulated in mesenchymal cells at P7.5. <b>Conclusions:</b> The temporal expression patterns of key regulatory genes for tooth agenesis (Msx1, Pax9, Eda), ameloblast differentiation (Amelx, Enam), and odontoblast development (Dspp, Dmp1) during mouse molar development. These findings provide a theoretical foundation and potential therapeutic targets for deciphering the molecular mechanisms underlying tooth agenesis and other developmental dental anomalies, paving the way for targeted clinical interventions.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"987-996"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Phenome-wide mendelian randomization identifies causal exposures for nonsyndromic cleft lip with or without cleft palate].","authors":"S Lou, C Y Xing, Y C Pan","doi":"10.3760/cma.j.cn112144-20250430-00165","DOIUrl":"10.3760/cma.j.cn112144-20250430-00165","url":null,"abstract":"<p><p><b>Objective:</b> To systematically investigate the causal effects of exposure factors on nonsyndromic cleft lip with or without cleft palate (NSCL/P) using a phenome-wide mendelian randomization (MR-PheWAS) framework and identify pleiotropic loci. <b>Methods:</b> This study integrated genome-wide association study (GWAS) data for NSCL/P, including 1 069 cases and 1 724 controls, and systematically evaluated causal associations between exposures and NSCL/P using the MR-PheWAS framework. GWAS summary data for 2 106 Asian population-exposure phenotypes were obtained from the IEU OpenGWAS database. The inverse-variance weighted (IVW) method served as the core causal inference model, supplemented by weighted median and MR-Egger regression to verify the robustness of causal associations. Additionally, multivariable MR analysis was conducted to adjust for confounding effects, alongside sensitivity tests (Cochran's Q and MR-PRESSO). Genetic correlations were analyzed using LD Score regression, and cross-phenotype pleiotropy analysis (PLACO/CPASSOC) was employed to identify shared genetic loci. Pathway enrichment and gene annotation data were integrated to explore potential biological mechanisms. <b>Results:</b> MR analysis identified serum calcium (<i>OR</i>=0.12, <i>P</i>=0.019), high-density lipoprotein (HDL, <i>OR</i>=0.61, <i>P</i>=0.039), and mean corpuscular hemoglobin concentration (MCHC, <i>OR</i>=0.39, <i>P</i>=0.032) as protective factors, whereas serum sodium (<i>OR</i>=21.41, <i>P</i>=0.013) was a risk factor. Furthermore, in subsequent analyses of genetic correlation and genetic overlap, a strong association was observed between serum calcium and NSCL/P. Cross-trait analysis localized pleiotropic loci to 16q24.2 and 3q21.1, involving CASR and CSTA, with significant enrichment in vitamin D response pathways. <b>Conclusions:</b> Numerous environmental exposure factors may have a causal impact on the outcomes of NSCL/P, and metabolic homeostasis (especially calcium signaling) plays a significant role in the pathogenesis of NSCL/P. Further genetic analyses identified potential pleiotropic loci primarily located at 16q24.2 and 3q21.1, involving key genes such as CASR and CSTA, and enriched in vitamin D response pathways. This study highlights the crucial position of genetic-environmental factors in the development of cleft lip and palate.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"971-979"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Personalized milled primary denture restoration for a pediatric patient with severe congenital tooth agenesis: a case report].","authors":"C X Geng, T T Pu, M Li, H Q Ye, D Tong, D Han","doi":"10.3760/cma.j.cn112144-20250506-00169","DOIUrl":"10.3760/cma.j.cn112144-20250506-00169","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"1044-1048"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Investigation of the role and mechanism of <i>Porphyromonas gingivalis</i> in inducing ferroptosis in vascular endothelial cells].","authors":"Q Li, C Lu, J Lin","doi":"10.3760/cma.j.cn112144-20250420-00145","DOIUrl":"10.3760/cma.j.cn112144-20250420-00145","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate whether &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; (Pg) induces ferroptosis in vascular endothelial cells and predict the Hub genes. &lt;b&gt;Methods:&lt;/b&gt; Firstly, human umbilical vein endothelial cells (HUVEC) were stimulated with Pg (W83) for 4 h, and transmission electron microscopy was used to observe ferroptosis-related morphological characteristics. Subsequently, RNA was extracted from HUVEC before and after Pg stimulation for transcriptome sequencing (RNA-seq). Enrichment analysis was performed to determine if differentially expressed genes (DEG) associated with ferroptosis. Ferroptosis-related DEG (Fer-DEG) were identified and then underwent gene ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, protein-protein interaction (PPI) network construction, and Hub gene prediction. Next, based on RNA-seq results, HUVEC were stimulated with lipopolysaccharide (LPS) for 24 h. Established ferroptosis markers were detected. The indices and detection methods were as follows: cell viability via cell counting kit-8; reactive oxygen species (ROS) by the DCFH-DA probe; Fe²⁺, lipid peroxides (LPO), malondialdehyde (MDA), and reduced/oxidized glutathione ratio (GSH/GSSG) with commercial kits; mitochondrial membrane potential (MMP) using the JC-1 probe; solute carrier family 7 member 11 (SLC7A11), solute carrier family 3 member 2 (SLC3A2), and glutathione peroxidase 4 (GPX4) expressions by Western blotting (WB) and real-time fluorescence quantitative PCR (RT-qPCR). Finally, RT-qPCR was used to validate the expression of predicted Hub genes in HUVEC after 24 h LPS stimulation, including tumor necrosis factor (TNF) or TNF-α, interleukin (IL)-6, and prostaglandin-endoperoxide synthase 2 (PTGS2). &lt;b&gt;Results:&lt;/b&gt; The mitochondria exhibited size reduction and cristae loss in Pg-stimulated HUVEC. DEG of HUVEC between the Pg-infected and control groups were enriched in the pathway of ferroptosis, and from which 56 Fer-DEG were identified. GO analysis showed enrichment in in responses to TNF, LPS, biotic stimulus, etc. and KEGG analysis revealed enrichment in TNF, C-type lectin receptor, and IL-17 signaling pathways, etc. In the 56-gene PPI network, TNF, IL-6, and PTGS2 were predicted as Hub genes, which were significantly associated with ferroptosis-related pathways, including unsaturated fatty acid biosynthesis and ROS metabolic process regulation. Compared to the control group [(100.00±1.44)%], LPS significantly reduced HUVEC viability [(66.77±1.80)%], which could be ameliorated by Fer-1 [(84.50±1.47)%] (&lt;i&gt;P&lt;&lt;/i&gt;0.05). The ROS fluorescence intensity in the LPS group (1 523.00±250.70) was significantly higher than in the control (328.20±38.68) or LPS+Fer-1 (753.30±67.11) group (all &lt;i&gt;P&lt;&lt;/i&gt;0.05). The Fe²⁺, LPO, and MDA levels in the LPS group [(29.83±4.25) μmol/10&lt;sup&gt;6&lt;/sup&gt; cells, (3.58±0.24) μmol/gprot, (5.54±0.33) μmol/gprot, respectively] were significantly higher than both","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"1008-1018"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Review of oral genetic diseases in China].","authors":"J Liang, Z Bian","doi":"10.3760/cma.j.cn112144-20250701-00240","DOIUrl":"10.3760/cma.j.cn112144-20250701-00240","url":null,"abstract":"<p><p>This study provides a comprehensive review of the development and achievements in the field of oral genetic disorders research in China. Since the 1950s, Chinese scholars have progressed from epidemiological surveys to the elucidation of molecular mechanisms and functional genomics, marking a transition from macro-level observations to micro-level analyses. The research focuses on three major categories: cleft lip and palate, dental developmental anomalies, and rare hereditary oral diseases. Several critical pathogenic genes have been identified, and their molecular mechanisms and phenotypic characteristics elucidated. This paper summarizes representative findings, analyzes current challenges, and outlines future research directions, aiming to provide theoretical support for advancing both basic research and clinical translation in the field of oral genetics in China.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 9","pages":"951-958"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of galectin-3 on lipopolysaccharide-induced proliferation, migration, apoptosis, reactive oxygen species and inflammatory cytokine production in human gingival fibroblasts].","authors":"W J Song, W Y Kang, S H Ge","doi":"10.3760/cma.j.cn112144-20241115-00431","DOIUrl":"10.3760/cma.j.cn112144-20241115-00431","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effects of galectin-3 (Gal-3) expression on lipopolysaccharide (LPS)-induced proliferation, migration, apoptosis, reactive oxygen species (ROS) and inflammatory cytokine production in human gingival fibroblasts (GF) as well as its mechanism, thus laying the foundation for an in-depth discussion of the regulatory role of Gal-3 in periodontitis and its mechanisms. &lt;b&gt;Methods:&lt;/b&gt; Gingival tissues from 6 periodontally healthy subjects undergoing crown lengthening were collected at the Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University from December 2022 to December 2023. GFs were extracted and cultured by collagenase digestion. Lentivirals with multiplicity of infection (MOI) of 15, 20, 30, 40, 50, 60, 70, 80 were used to achieve knockdown and overexpression of Gal-3 gene in GFs, whose efficiencies of Gal-3 gene were detected by using immunofluorescence, real-time fluorescence quantitative PCR (RT-qPCR) and Western blotting. Negative control of knockdown (shNC)+LPS group, Gal-3 knockdown (shGal-3)+LPS group, negative control of overexpression (oeNC)+LPS group, and Gal-3 overexpression (oeGal-3)+LPS group were established, respectively. 5-Ethynyl-2'-deoxyuridine (EdU), Ki67 staining, scratch migration assay, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) technology, immunofluorescence assay and RT-qPCR were used to investigate the effects of Gal-3 on LPS-induced proliferation, migration, apoptosis, ROS, interleukin (IL)-6, IL-8 expression. The effects of Gal-3 knockdown on the expression of differential genes and the enrichment of signaling pathways in LPS-induced GFs were investigated by RNA sequencing (RNA-seq). &lt;b&gt;Results:&lt;/b&gt; More than 80% of GFs were successfully transfected by shGal-3 MOI 40 and oeGal-3 MOI 70. Immunofluorescence results showed that the morphologies of GFs were normal after lentiviral transfection, and green fluorescence could be distributed in the cytoplasm, nucleus, and cell membrane. The results of RT-qPCR and Western blotting assay showed that the expressions of Gal-3 at the gene and protein levels in shGal-3 group (0.26±0.01, 0.26±0.03, respectively) were significantly lower than those in the shNC group (1.00±0.03, 1.00±0.09, respectively) (&lt;i&gt;P&lt;/i&gt;&lt;0.001); the expressions of Gal-3 at the gene and protein levels in the oeGal-3 group (4.26±0.05, 3.94±0.34) were significantly higher than those in the oeNC group (1.00±0.00, 1.00±0.24, respectively) (&lt;i&gt;P&lt;/i&gt;&lt;0.001). EdU, Ki67 experiments showed that the percentage of GFs proliferation was significantly lower in the shGal-3+LPS group [(16.99±1.79)%, (13.48±0.95)%, respectively] than in the shNC+LPS group [(33.86±3.84)%, (35.63±1.62)%, respectively] (&lt;i&gt;P&lt;/i&gt;&lt;0.05), and the proliferation ratio of GFs was significantly increased in the oeGal-3+LPS group [(45.36±1.56)%, (45.83±1.50)%, respectively] compared to the oeNC+LPS group [(34.47±","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 8","pages":"886-896"},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevention and supportive treatment of peri-implant diseases].","authors":"J Han, H X Meng","doi":"10.3760/cma.j.cn112144-20250101-00001","DOIUrl":"10.3760/cma.j.cn112144-20250101-00001","url":null,"abstract":"<p><p>Peri-implant disease is an oral disease that occurs with dental implant treatment. It is an inflammatory disease of peri-implant tissues caused by plaque biofilm, which can be divided into peri-implant mucositis and peri-implantitis. Peri-implant mucositis is limited in the soft tissues surrounding the implant and can be relieved through effective treatment. However if untreated, the inflammation can affect the bone around the implant and develop into peri-implantitis. Progressive resorption of supporting bone can ultimately lead to loss of osseointegration, which is the main cause of implant failure. There is a high incidence of peri-implant disease worldwide, which has become an increasingly serious public health problem. Prevention and supportive treatment of peri-implant disease is an important aspect of promoting oral health and deserves the attention of all dental professionals. This article combines literature review and relevant researches conducted by our research group in the past 15 years to introduce the control of risk factors, prevention, and supportive treatment of peri-implant disease. The aim is to raise the great attention of dentists, who engaged in oral implantation and restoration, to peri-implant and periodontal health, and master the prevention and supportive treatment methods of peri-implant disease.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 8","pages":"838-845"},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the effect of root canal therapy on vertical root fracture].","authors":"D Wan, R T Shi","doi":"10.3760/cma.j.cn112144-20241218-00498","DOIUrl":"10.3760/cma.j.cn112144-20241218-00498","url":null,"abstract":"<p><p>Vertical root fracture (VRF) often occurs in endodontically treated teeth. Root canal therapy (RCT) requires removal of part of the dentin, which affects the microhardness and elastic modulus of dentine, induces dentin microcracks, and increases the risk of VRF. The early diagnosis of VRF is challenging and the prognosis is poor, due to the absence of specific clinical manifestations. This narrative review analyzes the incidence and related factors of VRF after RCT from the perspective of etiology, discusses the effect and mechanism of each step during RCT on the occurrence of VRF, and briefly summarizes the diagnosis, prevention and treatment strategies of VRF, so as to reduce the occurrence of VRF and improve the prognosis of endodontically treated teeth.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 8","pages":"921-927"},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}