中华口腔医学杂志最新文献

{"title":"[Analysis of oral health status in Chinese children with Williams syndrome].","authors":"L H Lyu, X W Ye, F Zhang, C Ji, J M Su","doi":"10.3760/cma.j.cn112144-20251218-00521","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251218-00521","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the oral health status of Chinese children with Williams syndrome (WS), providing a basis for the comprehensive prevention, treatment, and early intervention of oral diseases associated with this syndrome. <b>Methods:</b> This was a cross-sectional descriptive study. A total of 137 children with WS aged 3 to 12 years who visited the Department of Stomatology at the Children's Hospital, Zhejiang University School of Medicine from January 2023 to May 2025 were enrolled and divided into two groups: 81 children aged 3 to 5 years and 56 children aged 6 to 12 years. All participants underwent routine oral examinations. Oral health status was assessed from three aspects: dental caries indicators, dental developmental anomalies, and malocclusion. The distribution of oral phenotypes was compared across age groups and between the sexes. Caries indicators were also compared with those of same-aged children from the Fourth National Oral Health Epidemiological Survey of China (2018). Univariate and multivariate logistic regression analyses were used to explore factors independently associated with malocclusion. <b>Results:</b> Children with WS exhibited prominent oral health problems. Regarding dental caries, in the 3 to 5 years group, the prevalence of caries in primary teeth was 64.2% (52/81), with dmft (decayed, missing, and filled teeth) of 4.48±2.39 and a caries filling ratio of 6.8%(17/249). In the 6 to 12 years group, the prevalence of caries in primary teeth was 76.8% (43/56), with dmft of 4.89±3.12 and a caries filling ratio of 23.7% (65/274); the prevalence of caries in permanent teeth in the same group was 23.2% (13/56), with a mean DMFT (Decayed, Missing, and Filled Teeth) of 0.46±1.05 and a caries filling ratio of 19.2% (5/26). Regarding dental developmental anomalies, congenital tooth agenesis and incisor morphological anomalies were the most common findings. The prevalence of congenital tooth agenesis was 35.8% (29/81) in the 3 to 5 years group and 66.1% (37/56) in the 6 to 12 years group. The prevalence of incisor morphological anomalies was 64.2% (52/81) and 60.7% (34/56) in two groups, respectively. The overall prevalence of malocclusion was 66.7% (54/81) in the 3 to 5 years group, with the top three types being diastema [43.2% (35/81)], crossbite [23.5% (19/81)], and deep overbite [19.8% (16/81)]. In the 6 to 12 years group, the prevalence was 32.1% (18/56), with the top three being increased overjet [35.7% (20/56)], deep overbite [33.9% (19/56)], and diastema [33.9% (19/56)]. Multivariate Logistic regression analysis showed that high caries status [adjusted odds ratio (aOR)=2.26, 95% confidence interval (CI): 1.01-5.05, P=0.046] and congenital tooth agenesis (aOR=2.86, 95%CI: 1.26-6.52, P=0.012) were independently associated with malocclusion. <b>Conclusions:</b> Children with WS exhibit high prevalences of dental caries, developmental anomalies, and malocclusion, along with poorer oral health than ty","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1456-1465"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Re-evaluation of the etiology and diagnosis of persistent periapical periodontitis].","authors":"H Li, B X Hou","doi":"10.3760/cma.j.cn112144-20260129-00059","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260129-00059","url":null,"abstract":"<p><p>The professional terms \"persistent apical periodontitis\" and \"refractory apical periodontitis\" are both used to describe clinical cases that periapical lesions fail to heal after root canal therapy. Both share similarities and differences in terms of their connotations, pathogenesis, treatment methods, and prognosis. Using suitable term to describe this type of disease has always been a dilemma in clinical practice, scientific research, or academic exchanges. Based on extensive literature searches, clinical research findings and experience, this paper systematically analyzes the reasons for the formation of these two terms and their clinical significance, providing guidance for clinicians to understand and manage this type of disease, and to use the medical terminology accurately.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1419-1426"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of clinical characteristics and treatment strategies for elderly patients in oral emergency].","authors":"Z Wang, J Bai, M K Ding","doi":"10.3760/cma.j.cn112144-20260131-00074","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260131-00074","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical characteristics and treatment status in elderly patients with oral emergencies, and to provide a reference for improving emergency care level for this population. <b>Methods:</b> A retrospective study was performed on the patients aged 80 years and above in the Department of Oral Emergency in Peking University School and Hospital of Stomatology from January 2022 to December 2024. Gender, age, systemic conditions, disease types and treatment strategies were statistically analyzed. <b>Results:</b> A total of 3 470 patients were enrolled, including 1 403 males (1 403/3 470) and 2, 067 females (2 067/3 470), with a male-to-female ratio of 0.68∶1. The age range was 80 to 101 years, with median age of 84 years. Elderly patients had a wide variety of diseases involving multiple disciplines, in which acute toothache [38.3%(1 330/3 470)], maxillofacial trauma [10.14%(352/3 470)], infectious diseases [10.06%(349/3 470)], hemorrhage [9.00%(312/3 470)], and temporomandibular joint emergencies [6.43%(223/3 470)] were the most prevalent. Comorbid systemic diseases were present in 63% of patients, showing an increasing trend with advancing age. Hypertension [43.8%(1 519/3 470)], cardiovascular and cerebrovascular diseases [27.6%(958/3 470)], and diabetes mellitus [16.9%(588/3 470)] were the most common comorbidities. Emergencies were effectively managed in 69.6% (2 414/3 470) patients. 30.4% (1 056/3 470) patients had no effective resolution, mostly due to the need for scheduled treatment under electrocardiographic monitoring or surgical tooth extraction. Whether electrocardiographic monitoring was needed varied between the two groups with different age characteristics. <b>Conclusions:</b> Elderly patients with oral emergencies have a diverse range of diseases involving multiple disciplines, and the risk of treatment complications is relatively high due to their complex comorbid systemic conditions. Clinicians should formulate individualized treatment plans based on patients' systemic status in clinical treatment.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1478-1482"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Adipose tissue-derived extracellular vesicles ameliorate zoledronic acid-induced functional impairment of bone marrow mesenchymal stem cells: an <i>in vitro</i> study].","authors":"X Y Sun, Z J Pan, Z W Cao, X X Zhou, L Wang, P Y Hong, J Pan","doi":"10.3760/cma.j.cn112144-20260506-00279","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260506-00279","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effects of adipose tissue-derived extracellular vesicles (AT-EVs) on zoledronic acid (ZA)-induced impairment of proliferation, migration, osteogenic differentiation and apoptosis of bone marrow mesenchymal stem cells (BMSCs), and to preliminarily explore the underlying molecular mechanisms. &lt;b&gt;Methods:&lt;/b&gt; AT-EVs were isolated from subcutaneous adipose tissue of 4-week-old male SPF SD rats, and characterized by transmission electron microscopy, nanoparticle tracking analysis and Western blotting; the uptake of AT-EVs by BMSCs was observed. BMSCs derived from the femurs and tibias of rats of the same batch were isolated and cultured, and identified by flow cytometry and tri-lineage differentiation. The working concentration of ZA was screened by cell counting kit-8 (CCK-8). BMSCs were divided into control, ZA (5 μmol/L), and ZA+AT-EVs (5 μmol/L ZA+50 μg/ml AT-EVs) groups; proliferation was evaluated by CCK-8 combined with 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay, and migration was evaluated by wound healing and Transwell assays; for the apoptosis assay, 10 μmol/L ZA was applied and detected by flow cytometry after Annexin V/PI staining. The osteogenic differentiation experiment included five groups (Control, Osteogenic induction, Osteogenic induction+AT-EVs, ZA, and ZA+AT-EVs), in which alkaline phosphatase (ALP) staining and Alizarin red S staining were performed, mineralized nodule formation was quantified by the cetylpyridinium chloride decolorization method, and the mRNA expression of Runx2, ALP and OCN was detected by real-time quantitative PCR. Cells from the ZA and ZA+AT-EVs groups after 7 days of osteogenic induction were subjected to liquid chromatography-tandem mass spectrometry-based proteomic analysis, followed by principal component analysis, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. &lt;b&gt;Results:&lt;/b&gt; AT-EVs exhibited a cup-shaped bilayer membrane structure with a peak diameter of 116.8 nm, were positive for CD9, CD63 and CD81 and negative for Calnexin, and were efficiently taken up by BMSCs. CCK-8 results showed that 5 μmol/L ZA significantly inhibited BMSCs proliferation (&lt;i&gt;P&lt;/i&gt;&lt;0.001), and AT-EVs partially restored the proliferation capacity. The EdU incorporation assay further showed that, compared with the Control group, the EdU-positive rate of the ZA group was significantly decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.001), while that of the ZA+AT-EVs group was significantly increased compared with the ZA group (&lt;i&gt;P&lt;/i&gt;&lt;0.01), consistent with the CCK-8 results. Compared with the ZA group, the ZA+AT-EVs group showed enhanced BMSCs migration (all &lt;i&gt;P&lt;/i&gt;&lt;0.05) and a significantly reduced total apoptosis rate (&lt;i&gt;P&lt;/i&gt;&lt;0.001). Western blotting further showed that AT-EVs down-regulated the ZA-induced elevation of cleaved caspase-3 (&lt;i&gt;P&lt;/i&gt;&lt;0.001) and BAX (&lt;i&gt;P&lt;/i&gt;&lt;0.01) and up-regulated Bcl-2 expression. AT-EVs significantly ameliorated the ZA-induced suppressio","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1507-1518"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the rule of guiding inclinations of maxillary posterior teeth and their correlation with mandibular movement trajectory angles].","authors":"J Y Zhu, J Li, J W Yang, Z N Liu, T Jiang","doi":"10.3760/cma.j.cn112144-20260130-00070","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260130-00070","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the angle of maxillary posterior guiding inclination (referred to as maxillary guiding inclination) during mandibular protrusive and lateral movements, as well as its relationship with the trajectory angle of the corresponding mandibular posterior buccal cusp apex (referred to as mandibular trajectory angle), providing the feasibility of directly using mandibular movement trajectory for occlusal design and pre-adjustment of digital prostheses. <b>Methods:</b> Eighteen medical student volunteers with individual normal occlusion aged 23-27 years were recruited from Peking University School and Hospital of Stomatology. Their maxillary and mandibular dentition models and occlusal relationship data were obtained via intraoral scanning. Mandibular movement trajectories were recorded using a mandibular motion analyzer. Geomagic Studio software aligned coordinate systems between dental models and kinematic data. Using the occlusal plane as a reference, the angles of the guiding inclinations (the distal surfaces and lingual surfaces of the buccal cusps) of each maxillary posterior tooth during protrusive and lateral movements (hereinafter referred to as the guiding inclinations), as well as the trajectory angles of the corresponding mandibular buccal cusp apices during mandibular lateral and protrusive movements (hereinafter referred to as the trajectory angles), were measured respectively. The variation regularity of each angle and the correlation between the angles were analyzed. <b>Results:</b> The guiding inclination varied among different tooth positions and differed from the trajectory angles. The protrusive guiding inclination (16.31°-27.40°) was smaller than the protrusive trajectory angles (34.29°-35.99°). The maxillary guiding inclination decreased first and then increased, while the latter remained relatively stable, with no statistically significant correlation between them (<i>r</i>=0.23, 0.31, 0.30, 0.05, all <i>P</i>>0.05). The lateral guiding inclination gradually decreased from the first premolar to the second molar (31.48°-13.06°), whereas the lateral trajectory angles remained relatively stable (22.32°-17.10°). A positive correlation existed between them (<i>r</i>=0.74, 0.65, 0.61, 0.62, all <i>P</i><0.05). <b>Conclusions:</b> During mandibular protrusion, the guiding inclination varies significantly while the trajectory angles remain relatively stable, with no correlation observed between them. In contrast, during lateral mandibular movement, the guiding inclination and trajectory angles show a positive correlation.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1491-1496"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Design and transmission of the emergence profile of implant-supported prosthesis in aesthetic area].","authors":"Q Q Yao, E H Zhu, L N Guo, R Li, Y Z Feng","doi":"10.3760/cma.j.cn112144-20260509-00295","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260509-00295","url":null,"abstract":"<p><p>The emergence profile of an implant prosthesis is very important to maintain the health and aesthetic shape of soft tissue around prostheses. The reasonable design of the emergence profile of an implant-supported interim prosthesis not only preserves the soft tissue around the implant but is also very important for long-term stability and an ideal aesthetic outcome. This article summarizes the concepts, tissue composition, design, and transfer method of the ideal emergence profile of an implant prosthesis in the aesthetic area, and the application of digital technology to transfer the emergence profile, to provide a reference for clinical practice.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1443-1449"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The expanded concept of orthognathic surgery as a \"five-in-one\" mode involving appearance, occlusion, joints, airway and psychology].","authors":"Y F Li, E Luo","doi":"10.3760/cma.j.cn112144-20251210-00501","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251210-00501","url":null,"abstract":"<p><p>The orthognathic surgery aims to treat dentofacial deformities, with the fundamental principle of addressing both appearance and function, and combining surgical and orthodontic treatments. This approach integrates orthodontics and orthognathic surgery to resolve issues related to facial appearance and occlusal relationships. With the development of socio-economic conditions and the widespread dissemination of scientific knowledge, patients' awareness and acceptance of orthognathic surgery have continuously increased. The accumulation of clinical experience has led scholars to realize that orthognathic surgery not only affects appearance and occlusion but also has a significant impact on joint health and upper airway width. These two factors-joint and airway-have become essential considerations in the planning of orthognathic surgery. In addition, psychological factors are gaining increasing prominence in the preoperative evaluation of orthognathic surgery, and the importance of patients' psychological assessment has also been gradually recognized by scholars. Through long-term clinical practice, scholars have continuously summarized experiences and lessons, and the new concept of orthognathic surgery as a 'five-in-one' approach involving appearance, occlusion, joints,airway and psychology has gradually become clear. In this article, the authors summarized the latest domestic and international literature and clinical experience from their own institution to emphasize the importance and necessity of considering joint, airway and psychology in orthognathic surgery, based on the emphasis of appearance and occlusion.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1436-1442"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of RNA therapy in oral squamous cell carcinoma].","authors":"S Q Long, J H Wang, R Sun","doi":"10.3760/cma.j.cn112144-20260601-00335","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260601-00335","url":null,"abstract":"<p><p>Accounting for more than 90% of oral malignancies, oral squamous cell carcinoma (OSCC) is recognized as the predominant histological subtype of oral cancer. The overall five-year survival rate of patients with advanced OSCC remains unsatisfactory.With the rapid advancement of transcriptomics, molecular biology, and nucleic acid delivery technologies, increasing attention has been directed toward RNA-based therapeutics as a promising approach for OSCC treatment, owing to their capacity for precise regulation of oncogenes, signaling pathways, and the tumor microenvironment. Included among the major forms of RNA therapeutics are small interfering RNA, micro RNA, messenger RNA, long non-coding RNA, and circular RNA. By modulating oncogenes, tumor microenvironment-related factors, and signaling pathways associated with therapeutic resistance, suppression of tumor proliferation, invasion, and metastasis can be achieved, while apoptosis induction and the enhancement of chemo-radiotherapeutic sensitivity may also be promoted.Considerable potential has therefore been demonstrated by RNA therapeutics in the treatment of OSCC. Nevertheless, multiple obstacles continue to hinder their clinical translation, among which insufficient in vivo stability, limited delivery efficiency, off-target effects, and the specific oral environment are particularly prominent. In this review, the theoretical basis of RNA therapy, recent advances in its application to OSCC, RNA delivery systems, and the current challenges faced are comprehensively summarized, with the aim of providing references for future research on precision therapy for OSCC.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1542-1547"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychological factors and comprehensive intervention in factitious oral ulcer among children and adolescents: a real-world study].","authors":"L Lin, T Lin, C H Lu, L Shuai, J Wei, M Y Jiang, Y N Wang, C L Yang, G Y Tang","doi":"10.3760/cma.j.cn112144-20251201-00477","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251201-00477","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of psychological factors in the development and progression of factitious oral ulcer (FOU) among children and adolescents, and to evaluate the clinical efficacy of a comprehensive intervention strategy based on standardized psychological assessment. <b>Methods:</b> In a prospective real-world study, 35 patients aged 3-16 years with FOU who visited the Department of Stomatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine were enrolled from April 23, 2024, to August 30, 2025. Stratified by age, systematic psychological assessment was performed using the parent symptom questionnaire (PSQ), strengths and difficulties questionnaire (SDQ), screen for child anxiety related emotional disorders, and depression self-pating scale for children. All patients received topical recombinant bovine basic fibroblast growth factor and oral health education. Those with abnormal psychological scores received individualized psychological education and clinical psychology referral. Patients with low serum zinc concentration received zinc supplementation. The overall clinical effectiveness rate, ulcer area, pain visual analog scale (VAS) score, cessation of self-injurious behavior, psychological scores, and recurrence were assessed at baseline, 2, 4, and 12 weeks post-treatment. <b>Results:</b> All 35 patients completed the study, with a mean age of (8.34 ± 2.79) years and a male proportion of 65.7% (23/35). Abnormal psychological scores were present in 82.9% (29/35) of patients. At 12 weeks post-treatment, the clinical effectiveness rate was 91.4% (32/35), with a cure rate of 88.6% (31/35); significant reductions in ulcer area and pain VAS score were observed compared to baseline (both P<0.001). The entire cohort showed significant improvements in the PSQ total score (conduct problems) at 4 and 12 weeks (both <i>P</i><0.05), and the SDQ total difficulties score at 12 weeks compared to baseline (<i>P</i><0.05). By week 12, 37.1% (13/35) of patients had successfully ceased self-injurious behavior. Multivariate logistic regression identified cessation of self-injurious behavior as an independent protective factor against ulcer recurrence (<i>OR</i>=0.080, 95%<i>CI</i>: 0.007-0.918, <i>P</i>=0.042). <b>Conclusions:</b> Psychological factors play a central role in FOU, with a high prevalence of anxiety, emotional, and behavioral problems among affected children. A comprehensive intervention strategy, guided by precise psychological assessment and integrating topical treatment, psychological-behavioral intervention, and nutritional supplementation, effectively promotes ulcer healing, improves psychological and behavioral status, and reduces recurrence.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1466-1477"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the relationship between <i>Porphyromonas gingivalis</i> and the pathogenesis of Parkinson disease].","authors":"Y Z Chen, L L Chen, L H Lei","doi":"10.3760/cma.j.cn112144-20251201-00479","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251201-00479","url":null,"abstract":"<p><p><i>Porphyromonas gingivalis</i>, a keystone pathogen in periodontitis, has been confirmed to be associated with various systemic diseases. In recent years, increasing attention has been paid to the link between <i>Porphyromonas gingivalis</i> and neurodegenerative disorders. However, researches on its association with Parkinson disease still lack a systematic review. Starting from the epidemiological evidence connecting <i>Porphyromonas gingivalis</i> and Parkinson disease, this research reviews their clinical and pathological correlations, along with potential underlying mechanisms, aiming to provide insights for further exploration of its pathogenesis and future prevention or treatment strategies.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 10","pages":"1536-1541"},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}