中华口腔医学杂志最新文献

{"title":"[Identification of diagnostic biomarkers for metastatic lymph nodes in oral squamous cell carcinoma using spatial metabolomics].","authors":"G F Luo, W Lu, H Y Yang, Y Q Yang, H T Zhao, W Han, X H Yang","doi":"10.3760/cma.j.cn112144-20250227-00057","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250227-00057","url":null,"abstract":"<p><p><b>Objective:</b> To uncover alterations in the metabolic microenvironment of lymph node metasasis, LNM in oral squamous cell carcinoma (OSCC) and identify potential metabolic biomarkers for the early diagnosis of LNM using desorption electrospray ionization mass spectrometry imaging (DESI-MSI) spatial metabolomics. <b>Methods:</b> Six OSCC patients with LNM, who underwent neck dissection surgery at the Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University between October 2020 and October 2022, were enrolled. Matched metastatically involved (positive) and benign (negative) lymph node tissue samples were collected and analyzed using DESI-MSI. Univariate and multivariate statistical analyses were employed to identify differentially abundant metabolites. The diagnostic efficacy of these metabolites was evaluated using receiver operating characteristic (ROC) curve analysis. Finally, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to determine the implicated metabolic pathways. <b>Results:</b> A total of 62 and 29 differentially abundant metabolites were identified in the metastatically involved lymph nodes compared to benign lymph nodes under positive-ion mode and negative-ion mode, respectively. These metabolites were predominantly amino acids and lipids. Four metabolites common to both ionization modes were selected for ROC curve analysis: phenylalanine, phosphoethanolamine, histidine, and taurine. The area under the curve values were 0.861, 0.802, 0.729, and 0.722, respectively, indicating promising diagnostic performance. Metabolic pathway analysis revealed significantly heightened activity in Amino acid metabolism (<i>P</i>=0.469) and Glycerophospholipid metabolism (<i>P</i>=0.006) within the LNM microenvironment. <b>Conclusions:</b> This DESI-MSI-based study identified disruptions in amino acid and glycerophospholipid metabolism within OSCC metastatic lymph node tissues. The associated differentially abundant metabolites represent potential candidate molecules for diagnosing OSCC LNM.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1137-1143"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Transient apical breakdown after dental trauma: clinical features and therapeutic decisions].","authors":"G Y Lai, J Wang","doi":"10.3760/cma.j.cn112144-20250720-00276","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250720-00276","url":null,"abstract":"<p><p>Transient apical breakdown (TAB) may occur after dental trauma, which is manifested by obvious radiolucent shadows at the root apex of the affected tooth on X-ray examination within a certain period after trauma, or persistent widening of the periodontal ligament space for a long time after trauma. However, it can resolve spontaneously without intervention. At present, research on TAB is relatively limited, and clinicians have insufficient understanding of it, which may easily lead to misdiagnosis as apical periodontitis and thus unnecessary endodontic treatment. In view of this, this article intends to discuss the occurrence of TAB, related influencing factors, characteristic imaging findings, diagnostic methods and possible mechanisms, aiming to provide reference for clinical diagnosis and treatment and reduce misdiagnosis and mistreatment.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1091-1095"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Alkali-etched curved microgrooves on modified polycaprolactone guided bone regeneration membranes promote <i>in vitro</i> osteogenic performance of MC3T3-E1 cells].","authors":"W X Wang, Y X Lei, Y Z Lai, H T Ye, M L Cao, Y Q He","doi":"10.3760/cma.j.cn112144-20250410-00131","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250410-00131","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To construct curved microgrooves with gradient surface roughness on polycaprolactone (PCL) members by regulating alkali etching time and to investigate the synergistic effect of surface roughness and curved microgrooves on the &lt;i&gt;in vitro&lt;/i&gt; osteogenic differentiation of mouse pre-osteoblasts (MC3T3-E1), aiming to determine the optimal PCL surface modification strategy. &lt;b&gt;Methods:&lt;/b&gt; Soft lithography and melt-casting techniques were used to fabricate PCL membranes with regularly arranged curved microgrooves (CMP). Alkali etching was performed for 24, 48, and 72 h. Groups: smooth PCL (control), CMP (curved microgrooves only), CMP-24 h, CMP-48 h, CMP-72 h (CMP etched for 24, 48, 72 h, respectively). Surface physicochemical properties were characterized: surface morphology was observed by scanning electron microscopy (SEM), surface roughness was measured by atomic force microscopy (AFM), and surface hydrophilicity was evaluated by contact angle measurement. MC3T3-E1 cells were cultured &lt;i&gt;in vitro&lt;/i&gt;. Cell adhesion,poproliferation, and osteogenic differentiation were assessed using cell counting (CCK-8), immunofluorescence staining, alkaline phosphatase (ALP) and Alizarin red staining with quantification. The mRNA expression levels of osteogenesis-related genes [ALP, collagen type Ⅰ (COL-1), Runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN), osteopontin (OPN)] were detected by quantitative real-time PCR (RT-qPCR). &lt;b&gt;Results:&lt;/b&gt; Curved microgrooves were successfully fabricated on PCL membranes. Alkali treatment improved surface hydrophilicity and increased roughness. The CMP-72 h group exhibited the best hydrophilicity (contact angle: 33.2°±5.5°), with significant differences compared to all other groups (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The CMP-72 h group showed the highest roughness [(59.966±4.729) nm], which was significantly different from all other groups (&lt;i&gt;P&lt;/i&gt;&lt;0.05). CCK-8 results on day 5 showed that both curved microgrooves and roughness promoted cell proliferation: CMP-24 h (0.292±0.003) and CMP-72 h (0.383±0.004) were significantly higher than those in the smooth group (0.270±0.005) (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Immunofluorescence staining revealed that curved microgrooves induced significant contact guidance of cells; this effect weakened with increasing etching time. ALP and Alizarin red staining indicated the deepest osteogenic staining in the CMP-48 h group. Both ALP activity (0.013 021±0.000 032) and Alizarin red quantification (0.290±0.003) were highest in the CMP-48 h group, significantly different from all other groups (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). RUNX-2 expression in CMP-24 h and CMP-48 h groups (1.845±0.087 and 1.837±0.027, respectively) was significantly higher than in other groups, with no significant difference between these two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05). CMP-48 h group exhibited the highest mRNA expression of all osteogenic genes tested, specifically ALP (2.194±0.028), COL-1 (1.983±0.024), OCN (7.644±0.156), and OPN (2.","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1152-1161"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the application of multimodal image fusion technique in stomatology].","authors":"T Y Ma, N Zhu, Y Zhang","doi":"10.3760/cma.j.cn112144-20250423-00154","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250423-00154","url":null,"abstract":"<p><p>Within the treatment process of modern stomatology, obtaining exquisite preoperative information is the key to accurate intraoperative planning with implementation and prognostic judgment. However, traditional single mode image has obvious shortcomings, such as \"monotonous contents\" and \"unstable measurement accuracy\", which could hardly meet the diversified needs of oral patients. Multimodal medical image fusion (MMIF) technique has been introduced into the studies of stomatology in the 1990s, aiming at realizing personalized patients' data analysis through multiple fusion algorithms, which combines the advantages of multimodal medical images while laying a stable foundation for new treatment technologies. Recently artificial intelligence (AI) has significantly increased the precision and efficiency of MMIF's registration: advanced algorithms and networks have confirmed the great compatibility between AI and MMIF. This article systematically reviews the development history of the multimodal image fusion technique and its current application in stomatology, while analyzing technological progresses within the domain combined with the background of AI's rapid development, in order to provide new ideas for achieving new advancements within the field of stomatology.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1209-1216"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenic gene identification and clinical management in an amelogenesis imperfecta family].","authors":"S T Yang, L W Zheng, M Wan","doi":"10.3760/cma.j.cn112144-20250429-00164","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250429-00164","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1190-1194"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establishment of a mouse model of traumatic temporomandibular joint ankylosis].","authors":"N Li, T Y Lyv, Y M Heng, C K Liu, Y Y Guo, T G Deng, K J Hu","doi":"10.3760/cma.j.cn112144-20250321-00095","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250321-00095","url":null,"abstract":"<p><p><b>Objective:</b> A C57/BL6 mouse model of traumatic temporomandibular joint ankylosis (TTMJA) was established through composite trauma to lay the foundation for studying the pathophysiology of TTMJA. <b>Methods:</b> This study was conducted from January 2024 to February 2025. Forty-two 4-weeks old C57/BL6 mice, numbered 1 to 42, are randomly assigned to a control group (<i>n</i>=21) and an experimental group (<i>n</i>=21) using a computer-generated random number sequence. The experimental group undergoes modeling surgery on the left temporomandibular joint (TMJ), while the control group is routinely raised without special treatment. At 12 weeks post-surgery, the TMJ complex of both groups is assessed via body weight and mouth opening measurements, gross observation, micro-CT, and histological staining to evaluate model establishment. <b>Results:</b> At 12 weeks post-operation, in the experimental group, the body weight of mice [(27.75±1.08) g] did not show a significant difference compared with that of the control group [(30.80±0.29) g](<i>t</i>=0.54,<i>P</i>=0.610). The maximum vertical passive mouth opening [(1.70±0.26) mm] in the experimental group was significantly lower than that in the control group [(3.43±0.21) mm](<i>t</i>=8.92,<i>P</i><0.001). Gross observation indicated that the right TMJ structure of the experimental-group mice was normal, while irregular hyperplasia occurred in the left TMJ complex. Micro-CT revealed that at 12 weeks post-operation, the right joint structure of the experimental-group mice was normal, with regular condyles and glenoid fossae. On the left side, a large amount of bone hyperplasia occurred on the lateral side of the joint in the condyles and glenoid fossae, forming two irregular bone masses, and there was an uncalcified radiolucent zone between the bone masses. In histological staining, no new cartilage or bone tissue was observed in the left joint space of the control-group mice, and the articular disc structure was normal. In the experimental-group mice, obvious new cartilage and calcified bone tissue were visible on the lateral side of the left joint space. A bone bridge was formed between the condyles and glenoid fossae, the articular disc structure disappeared, and bony ankylosis occurred. <b>Conclusions:</b> In this experiment, a TTMJA model of C57/BL6 mice was initially established by removing the articular disc and damaging part of the fibrous cartilage of the glenoid fossae and condyles, providing a reliable experimental platform for further research on the pathogenesis of TTMJA.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1162-1168"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of transient receptor potential vanilloid 1 expression in rat MIA-induced temporomandibular joint osteoarthritis].","authors":"L Q Xu, H H Jiang, X Long, W Fang","doi":"10.3760/cma.j.cn112144-20250401-00115","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250401-00115","url":null,"abstract":"<p><p><b>Objective:</b> Exploring the changes in the expression of transient receptor potential vanilloid 1 (TRPV1) in the peripheral and central nervous system in rats temporomandibular joint osteoarthritis (TMJOA) and its relationship with TMJOA pain<b>.</b> <b>Methods:</b> From February 2024 to April 2025, 48 healthy male Sprague Dawley rats were randomly divided into a control group and an experimental group, with 24 rats in each group. Each group is further divided into three groups (2-week, 4-week, and 6-week groups) using a random number table method, with 8 animals in each group. After bilateral injection of sodium iodoacetate (MIA) into the temporomandibular joint (TMJ) cavity to establish a TMJOA model, the TMJ condyle, trigeminal ganglion (TG), trigeminal nucleus caudate (TNC), and hippocampal tissue were collected. Pain threshold detector von Frey silk was used to evaluate the head withdrawal threshold (HWT) of rats, and HE staining and Micro CT scanning were used to observe the histological changes of TMJ. Immunohistochemical staining was used to detect the expression of TRPV1 in TG and hippocampal tissues, as well as the expression of glial fibrillar acidic protein (GFAP) in TNC. <b>Results:</b> On the first day after modeling, the HWT of rats significantly decreased and then gradually increased. From day 7 to day 14, HWT decreased again, and after day 14, HWT gradually increased (<i>P<</i>0.001). HE staining and Micro CT revealed that in the second week after modeling, the arrangement of condylar bone trabeculae was disordered, the trabeculae became thinner, the bone marrow cavity became larger, and then the trabeculae became thicker and the bone marrow cavity became smaller. The number of TRPV1 positive cells in TG of TMJOA rats reached its peak in the second week of modeling, and then gradually decreased in the fourth and sixth weeks (<i>P<</i>0.001), with no statistically significant difference in the control group (<i>P=</i>0.941). The number of GFAP positive cells in TNCs of TMJOA rats significantly increased, reaching its peak in the second week of modeling and gradually decreasing in the fourth and sixth weeks (<i>P<</i>0.001). There was no statistically significant difference between the control group (<i>P=</i>0.720). The number of TRPV1 positive cells in the hippocampus of TMJOA rats significantly increased. The number of TRPV1 positive cells reached its peak in the second week of modeling, and then gradually decreased in the fourth and sixth weeks (<i>P<</i>0.001). There was no statistically significant difference between the control group (<i>P=</i>0.776). <b>Conclusions:</b> In the MIA induced rat TMJOA model, the expression of TRPV1 in TG and hippocampal tissue, as well as the expression of GFAP in TNC, were upregulated, which may be involved in the occurrence and development of TMJOA pain and related to the development of TMJOA lesions.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1169-1175"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Influence of scanning aid material and post space parameters on the trueness of intraoral scanners for post space: an <i>in vitro</i> study].","authors":"J B Zou, K Huang, L Yin","doi":"10.3760/cma.j.cn112144-20250426-00156","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250426-00156","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effects of different post space parameters and scanning aid material on the trueness of digital impressions of post spaces obtained by two intraoral scanners, thereby providing a reference for clinically determining the conditions under which post spaces are suitable for digital impression technology. &lt;b&gt;Methods:&lt;/b&gt; This study varied three variables of post space models of residual crowns: opening diameter, post space depth and adjacent tooth status,with specific settings: opening diameter were set at two levels (2.0 and 2.5 mm);post space depth was set at three levels (8.0, 10.0, and 12.0 mm); and adjacent tooth status were set at three levels [bilateral adjacent teeth present (A), unilateral adjacent tooth present (B), and bilateral adjacent teeth absent (C)]. A total of 18 model groups were prepared. Eighteen samples were printed using a three-dimensional printing instrument. Combined with scanning aid material, direct &lt;i&gt;in vitro&lt;/i&gt; scanning of these post space models was performed using intraoral scanners (IOS) A (Trios 5) and B (Primescan connect), with 10 replicates per group (&lt;i&gt;n&lt;/i&gt;=10). The scanned data were sequentially imported into reverse engineering software. The original design data of the models served as true values, and best-fit comparisons were performed. By calculating the average root mean square error (RMSE) values, the trueness of digital impressions of post spaces with different morphologies obtained by the two scanners was evaluated, both with and without the use of scanning aid material. &lt;b&gt;Results:&lt;/b&gt; Under the experimental conditions set in this study, for IOS A, only the sample groups with opening diameter-post space depth-adjacent tooth status combinations of (2.0 8.0 ABC, 2.5 8.0 ABC, 2.5-10.0-ABC) could be identified, with RMSE results ranging from 46.5 to 365.0 μm. After adding scanning aid materials,RMSE results ranging from 46.0 to 185.0 μm, the trueness of the sample groups (2.0-8.0-A, 2.5-10.0-A) was significantly improved by more than 100 μm, and an additional sample group (2.5-12.0-C) could be identified. For IOS B, the identifiable sample groups included all 18 sample groups, with RMSE results ranging from 38.8 to 106.0 μm. After the addition of scanning aid materials, RMSE results ranging from 37.6 to 110.2 μm, the identifiable sample groups remained unchanged. Post space opening diameter, post space depth, and adjacent tooth status all had significant effects on the trueness of post space digital impressions for both IOS A and IOS B (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Scanning aid materials had a significant effect on IOS A (&lt;i&gt;P&lt;/i&gt;&lt;0.05) but no significant effect on IOS B (&lt;i&gt;P&lt;/i&gt;&gt;0.05). &lt;b&gt;Conclusions:&lt;/b&gt; IOS B exhibited superior post space scanning performance compared to IOS A, and its trueness for clinically common post spaces could meet clinical requirements. IOS A has certain requirements for post space opening diameter, post space depth, and adjacent tooth status. F","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1144-1151"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical study on prognosis and occlusal evaluation of large area caries of deciduous molars restored by Hall technique].","authors":"P C He, Y T Li, S W Wang, X Zhou, Y Zhou, Y Liu, L W Zheng","doi":"10.3760/cma.j.cn112144-20250301-00059","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250301-00059","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the prognosis of Hall technique and traditional metal pre-crown restoration technique, and to follow up the occlusal changes before and after treatment with Hall technique, so as to provide reference for the promotion of Hall technique. &lt;b&gt;Methods:&lt;/b&gt; Children who visited the Department of Pediatric Dentistry, West China Hospital of Stomatology, of Sichuan University from May 2021 to December 2022 were screened according to the inclusion and exclusion criteria. The therapeutic effects of the two groups were followed up at three time points: 1, 2 and 3 months after operation. The observation results were divided into three outcomes: success (crown in place, no symptoms of pulpitis or periapical periodontitis, no obvious abnormality in occlusion, no need for further treatment), partial failure (crown falling off or crown broken, tooth defect can be repaired, reversible pulpitis) and complete failure (irreversible pulpitis or periapical periodontitis, crown falling off and tooth defect irreparable), and statistical analysis was made. At the same time, the Hall technique group was followed up at five time points before operation, immediately after operation, 2 weeks after operation, 4 weeks after operation and 8 weeks after operation respectively, and the occlusion was analyzed by Dental Prescale Ⅱ system. The vertical dimension of occlusion (VDO), overbite coverage and canine relationship were recorded and compared. Three-dimensional finite element method was used to model and analyze the stress of the teeth treated with traditional metal pre-crown treatment and Hall scheme, and the differences between them were compared. &lt;b&gt;Results:&lt;/b&gt; Finally, 21 children were included in the Hall technique treatment group, including 12 boys and 9 girls, with age of (5.0±1.4) years. There were 22 children in the traditional metal pre-crown group, including 15 boys and 7 girls, with age of (5.1±1.3) years. There were 0 cases of complete failure and 0 cases of partial failure in the Hall scheme group, 0 cases of complete failure and 0 cases of partial failure in the traditional pre-crown group. There were 0 cases of complete failure and 1 case of partial failure in the Hall scheme group, 0 cases of complete failure and 0 cases of partial failure in the traditional pre-crown group. Hall scheme group failed completely in 1 case and partially in 1 case 3 months after operation, while the traditional pre-crown group failed completely in 0 cases and partially in 0 cases 3 months after operation. There was no significant difference in the incidence of primary index/complete failure and secondary index/partial failure between Hall scheme group and traditional pre-crown group (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). The occlusal area and occlusal force of children treated with Hall scheme decreased immediately after operation compared with that before operation, but gradually recovered to the preoperative level at 2 and 4 weeks after operation, in which th","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1109-1119"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the pathogenesis and treatment of craniofacial fibrous dysplasia].","authors":"S Wang, K H Li, Z X Liu, X D Wang","doi":"10.3760/cma.j.cn112144-20250515-00183","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250515-00183","url":null,"abstract":"<p><p>Craniofacial fibrous dysplasia (CFD) is a rare skeletal disorder characterized by the abnormal replacement of normal bone tissue with fibrous tissue. This article provides a systematic review of the latest advancements in the genetic basis, molecular mechanisms, clinical manifestations, and diagnostic and therapeutic strategies of CFD. Elucidate, which leads to bone homeostasis imbalance and fibrotic abnormalities. It focuses on the molecular mechanisms underlying multi-pathway network dysregulation induced by GNAS gene mutations and explores the roles of key molecules like cAMP-response element binding protein, interleukin-6 and Fibroblast growth factor 23 in disease progression. Additionally, it evaluates the limitations of traditional treatments and the translational potential of novel strategies, including targeted therapies, offering a theoretical foundation for clinical practice and future research directions.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 10","pages":"1195-1202"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}