中华口腔医学杂志最新文献

{"title":"[Research progress of tissue engineering scaffold materials in temporomandibular joint disc repair].","authors":"J Luo, B P Fu, X T Jin, T Xu","doi":"10.3760/cma.j.cn112144-20250121-00030","DOIUrl":"10.3760/cma.j.cn112144-20250121-00030","url":null,"abstract":"<p><p>Temporomandibular joint disc (TMJD) is a critical anatomical structure within the maxillofacial region. However, its self-repair ability is limited, which often leads to functional degradation. The development of tissue engineering technology provides a new treatment strategy for TMJD repair, in which the scaffold provides basic physical support and suitable cellular microenvironment. Scaffold materials include naturally derived scaffolds, decellularised extracellular matrix scaffolds and synthetic polymer scaffolds. Currently, advancements in material composite techniques, surface modification, and chemical modification, as well as the optimization of electrospinning and three-dimensional printing technologies, have significantly enhanced the overall performance of the scaffold. These improvements exhibit promising potential for the repair of TMJD with varying degrees of defects. This paper provides an overview of the progress in tissue engineering scaffold materials in repairing of TMJD, focusing on ideal biological properties, material types, scaffold optimization strategies and clinical application. It aims to serve as a reference for the development of scaffold materials and the clinical translation of tissue engineering.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"567-574"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Management of severe soft and hard tissue defects in natural teeth with combined connective tissue graft and regenerative techniques: two case reports].","authors":"H Tong, D Y Xuan, Z Y Xiong, S M Tang, W K Yu, D P Chen","doi":"10.3760/cma.j.cn112144-20241231-00511","DOIUrl":"10.3760/cma.j.cn112144-20241231-00511","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"546-552"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of a risk prediction model for moderate to severe orthodontic-induced inflammatory root resorption of maxillary incisors based on cone beam CT radiomics and clinical features].","authors":"Z G Zuo, T T Fu, X L Li, B Yin, F Qiao, J Y Li, L G Wu","doi":"10.3760/cma.j.cn112144-20241001-00369","DOIUrl":"10.3760/cma.j.cn112144-20241001-00369","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To develop a risk prediction model for moderate to severe orthodontic-induced inflammatory root resorption (OIIRR) of maxillary incisors based on cone beam CT (CBCT) radiomics features and clinical characteristics of the orthodontic patients. &lt;b&gt;Methods:&lt;/b&gt; Clinical and CBCT data from 101 orthodontic patients treated by the same attending orthodontist in the Department of Orthodontics, Stomatology Hospital of Tianjin Medical University from January 2019 to January 2024 were retrospectively collected. The sample included 42 class Ⅰ patients, 52 class Ⅱ patients and 7 class Ⅲ patients [age: (19.7±6.3) years], and a total of 394 maxillary incisors were analyzed. Potential influencing factors for moderate to severe OIIRR (root volume resorption rate≥10%) were collected from the patients' CBCT and medical records, including initial age, gender, treatment duration, Angle's classification, extraction or not, type of orthodontic appliance (fixed or clear aligner), changes in root inclination, root movement distance and direction, pre-treatment cephalometric measurements, pre-treatment root-bone relationship, pre-treatment root length, and pre-treatment radiomics features of the teeth. Univariate analysis was initially performed to screen for factors influencing moderate to severe OIIRR. Subsequently, least absolute shrinkage and selection operator (LASSO) regression, best subset regression, and random forest were used for feature selection to construct the OIIRR risk prediction model. The discrimination, calibration, and net benefit of the three risk prediction models were evaluated, and the optimal model was displayed using a nomogram. &lt;b&gt;Results:&lt;/b&gt; LASSO regression identified clinical features including initial age (LASSO coefficient 0.052), treatment duration (LASSO coefficient 0.024), pre-treatment root length (LASSO coefficient -0.023), and vertical root movement distance (LASSO coefficient -0.029). Initial age and treatment duration were positively correlated with the severity of OIIRR, while root length and vertical root movement distance were negatively correlated. A total of 14 radiomics features were identified, including 2 original image features and 12 wavelet features. Best subset regression identified vertical root movement distance as the clinical feature and 7 radiomics features, including 1 original image feature and 6 wavelet features. The random forest model identified 8 wavelet features as important predictors, and all of which were radiomics features. Model performance evaluation showed that the random forest model had the highest discrimination, calibration, and net benefit, making it the optimal model, with radiomics features being the most important predictors. &lt;b&gt;Conclusions:&lt;/b&gt; Based on the data from this study, radiomics features were identified as the most important predictors by the optimal model for OIIRR risk prediction. Predicting the occurrence of moderate to severe OIIRR before orthodontic tre","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"509-517"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Alert to the overlooked important oral disease: peri-implant diseases].","authors":"X H Feng, J Han, D Shi, H X Meng","doi":"10.3760/cma.j.cn112144-20241214-00480","DOIUrl":"10.3760/cma.j.cn112144-20241214-00480","url":null,"abstract":"<p><p>Peri-implant diseases are inflammatory diseases in the spectrum of oral diseases, which are caused by the dysbiosis of peri-implant flora and the imbalance between microorganism and host. Peri-implant diseases are divided into two types: peri-implant mucositis and peri-implantitis. The diagnostic definition of peri-implant mucositis is based on presence of peri-implant signs of inflammation (redness, swelling, line or drop of bleeding/suppuration following probing) and no additional bone loss following initial healing. The clinical definition of peri-implantitis is based on not only the presence of peri-implant signs of inflammation but also radiographic evidence of bone loss following initial healing. Peri-implant diseases, like periodontitis, have clear etiology, histopathological features, clinical manifestations, and current international consensus diagnostic criteria. This article provides an overview of the etiology, histopathological features, key points of examination and diagnosis, prevention and non-surgical treatment, and surgical treatment of peri-implant diseases. The aim is to raise the awareness of dentists, especially those who specialize in oral implantology and restoration, to have a concept of periodontal and implant health, master the basic theoretical knowledge and prevention and treatment methods of peri-implant diseases, and also inform patients to control plaque and maintain their oral health.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"443-453"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A prospective case series study of alveolar ridge preservation using different bone graft materials in molars with severe periodontitis].","authors":"Y Y Ren, H Y Zhang, W J Hu, T Xu, Y P Wei","doi":"10.3760/cma.j.cn112144-20241231-00512","DOIUrl":"10.3760/cma.j.cn112144-20241231-00512","url":null,"abstract":"<p><p><b>Objective:</b> To compare the clinical effects of using xenogenic bone graft materials with or without collagen components for tooth micro crestal flap-alveolar ridge preservation (MCF-ARP) at molars with severe periodontitis. <b>Methods:</b> This study included patients who visited Department of Periodontology, Peking University School and Hospital of Stomatology from May to November 2023 due to severe periodontitis, requiring tooth extraction and planning for implant-retained prostheses. A total of 24 molars from 24 patients with severe periodontitis were assigned into two groups: the deproteinized bovine bone mineral (DBBM) group and the DBBM with collagen (DBBM-C) group. Twelve affected teeth from 12 patients were included in each group. Both groups underwent minimally invasive tooth extraction and MCF-ARP, with DBBM and DBBM-C implanted in the extraction socket, respectively. Cone beam CT (CBCT) was performed before and 6 months after the surgery for assessing changes of hard tissue. Intraoral scanning was performed before and at 2 weeks, 1 month, 3 months, and 6 months after the surgery for assessing soft tissue contour changes and patterns in both groups. <b>Results:</b> After 6 months of healing, the central bone height increased by (8.35±2.25) mm in the DBBM group and (7.70±2.36) mm in the DBBM-C group. The ridge width at 1 mm apically from the higher bone crest increased by 6.43 (-0.76,7.96) mm in the DBBM group and 6.01 (5.41,7.90) mm in the DBBM-C group. There was no statistically significant difference in the changes of bone height and width between the two groups (all <i>P</i>>0.05). In terms of soft tissue contour changes, although the buccal contour collapses were less in the DBBM-C group, the two groups showed no statistically significant difference (all <i>P</i>>0.05). <b>Conclusions:</b> Within the limitations of this study, it was demonstrated that the clinical effects of MCF-ARP using xenogenic bone graft materials with or without collagen components in molars with severe periodontitis were comparable.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"454-463"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of obesity on alveolar bone resorption and gut microbiota in periodontitis mice].","authors":"L C Zheng, R X Chen, N N Wang, M Wang, J Qian, L L Li, F H Yan","doi":"10.3760/cma.j.cn112144-20241222-00502","DOIUrl":"10.3760/cma.j.cn112144-20241222-00502","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To study the effects of obesity on alveolar bone loss and gut microbiota in mice with periodontitis. &lt;b&gt;Methods:&lt;/b&gt; Twenty-four seven-week-old female C57BL/6J mice were randomly divided into four groups based on table of random numbers (&lt;i&gt;n&lt;/i&gt;=6 in each group): normal-fat diet group (NFD group), high-fat diet group (HFD group), normal-fat diet and periodontitis group (NFD_PD group) and high-fat diet and periodontitis group (HFD_PD group). NFD and HFD groups were fed with normal or high-fat diet for twelve weeks respectively; NFD_PD and HFD_PD groups were induced to periodontitis by ligating the bilateral maxillary second molars with 5-0 silk thread at the fourth week after feeding with normal or high-fat diet respectively. The body weight was measured weekly. The mice were euthanized for collecting the samples at the end of the 12th week. Liver, kidneys, perirenal and retroperitoneal fat were weighed. Serum was collected to detect the level of serum lipids and inflammatory factors. The right maxilla bones were scanned by micro-CT. HE staining was performed to observe the periodontal tissue. The cecum contents were collected for gut microbiota 16S rRNA gene sequencing. Spearman correlation analysis was performed to analyze the correlation between the abundance of gut microbiota and serum inflammatory level and CT value. &lt;b&gt;Results:&lt;/b&gt; After 12 weeks of high-fat diet fed, the body weight of HFD group [(26.52±1.96) g] was significantly higher than that of NFD group [(20.95±0.63) g] (&lt;i&gt;t&lt;/i&gt;=6.63, &lt;i&gt;P&lt;/i&gt;&lt;0.001). The body weight of HFD_PD group [(23.82±1.12) g] was significantly higher than that of NFD_PD group [(20.73±0.47) g] (&lt;i&gt;t&lt;/i&gt;=6.23, &lt;i&gt;P&lt;/i&gt;=0.001). The serum levels of total cholesterol, triglyceride and low density lipoprotein in HFD group and HFD_PD group were significantly higher than those in NFD group and NFD_PD group (&lt;i&gt;P&lt;/i&gt;&lt;0.01). The distance from the cemento-enamel junction to the alveolar bone crest (CEJ-ABC) on the mesial site of maxillary second molar in HFD_PD group [(647.46±47.46) μm] was significantly higher than that in NFD_PD group [(440.48±68.08) μm] (&lt;i&gt;t&lt;/i&gt;=5.58, &lt;i&gt;P&lt;/i&gt;&lt;0.001). HE staining showed that the maxillary second molar attachment loss, collagen fiber destruction and inflammatory cell infiltration were more significant serious in HFD_PD group compared with NFD_PD group. The levels of interleukin (IL)-1β, IL-6 and monocyte chemotactic protein-1 (MCP-1) of serum in HFD_PD group [(17.11±1.92), (31.61±3.20) and (204.42±35.96) ng/L, respectively] were significantly higher than those in NFD_PD group [(10.44±1.65), (19.96±2.09) and (147.36±10.76) ng/L, respectively] (&lt;i&gt;P&lt;/i&gt;&lt;0.001, &lt;i&gt;P&lt;/i&gt;&lt;0.001, &lt;i&gt;P&lt;/i&gt;=0.004). The 16S rRNA gene analysis revealed that the &lt;i&gt;Bacteroides/Firmicutes&lt;/i&gt; ratio in HFD_PD group (4.00±3.30) was significantly higher than that in NFD_PD group (0.62±0.19) (&lt;i&gt;t&lt;/i&gt;=2.50, &lt;i&gt;P&lt;/i&gt;=0.030). The abundance of &lt;i&gt;Oscillospira&lt;/i&gt; in HFD_PD group [(12.25±0.05) %]","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"482-491"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary small cell neuroendocrine carcinoma of sublingual gland with cervical lymph node metastasis : a case report].","authors":"W W Tang, C Q Zhu","doi":"10.3760/cma.j.cn112144-20241204-00454","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20241204-00454","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 4","pages":"421-424"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the role of exosomes in odontogenic differentiation].","authors":"G H Peng, H R Zou","doi":"10.3760/cma.j.cn112144-20240820-00317","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20240820-00317","url":null,"abstract":"<p><p>Exosomes, serving as nanoscale molecular signals for intercellular communication, possess the ability to induce odontogenic differentiation and to promote pulp regeneration. Research on their roles in cell differentiation induction has gradually emerged as a research hotspot in the field of regenerative oral medicine. The diversity in cellular sources and pretreatment methods can influence the biological properties and functions of exosomes, while the selection of combined factors and optimization of scaffold delivery strategies further regulate the efficacy of exosomes during differentiation induction. In light of this, the present article aims to comprehensively review and delve into the multi-factorial regulatory mechanisms of exosomes in facilitating odontoblastic differentiation, aiming to provide valuable insights for the development of strategies in oral tissue engineering and regenerative therapies.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 4","pages":"437-442"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report on modified free gingival graft for the augmentation of keratinized mucosa around implants].","authors":"N Wang, X Liu, Y Wang, Y T Wu","doi":"10.3760/cma.j.cn112144-20250117-00023","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250117-00023","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 4","pages":"409-412"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and future of artificial intelligence in oral esthetics].","authors":"J Chen","doi":"10.3760/cma.j.cn112144-20250116-00021","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250116-00021","url":null,"abstract":"<p><p>Artificial intelligence (AI) has significantly enhanced the precision and efficiency of dental restoration design, smile analysis, and personalized treatment in the field of esthetic dentistry through technologies such as deep learning. This advancement provides patients with more accurate and efficient esthetic treatment solutions. However, its application still faces challenges such as technical limitations, ethical concerns, and insufficient data diversity. In the future, with the integration of high-quality data, optimization of real-time learning technologies, and the advancement of multidisciplinary collaboration, AI is expected to further promote the intelligent and human-centered development of esthetic dentistry, bringing profound and positive impacts to patients and clinical practice.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 4","pages":"326-331"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}