中华口腔医学杂志最新文献

{"title":"[Lacrimal duct obstruction caused by maxillary odontogenic cyst invading lacrimal fossa: a case report].","authors":"H W Xu, P G Du, C Sun, Y H Wang, L Xu, Z H Liu, Q Q Zhang","doi":"10.3760/cma.j.cn112144-20240322-00120","DOIUrl":"10.3760/cma.j.cn112144-20240322-00120","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in tooth development studies based on single-cell RNA sequencing].","authors":"N Jiang, X T Zhu, Y Liu","doi":"10.3760/cma.j.cn112144-20240927-00363","DOIUrl":"10.3760/cma.j.cn112144-20240927-00363","url":null,"abstract":"<p><p>Tooth development is a complex process of the orderly interaction between epithelium originating from the ectoderm and mesenchyme derived from cranial neural crest cells, which not only depends on cell genes regulatory network but also involves crosstalk between cells and their surrounding environment. Even within the same type of cellular populations, obvious heterogeneity may be observed. Single-cell RNA sequencing is a novel technology aimed at sequencing the transcriptome of individual cell. As a critical bridge linking genetic information from the genome to the functional proteome, transcriptome analysis at the single-cell level enables a deeper understanding of cellular heterogeneity and organ developmental trajectories. This approach provides a powerful tool for elucidating complex biological processes and identifying potential therapeutic targets. Here, we summarize the latest advances in employing single-cell RNA sequencing analysis to the process of tooth development, which will help provide insights into a better understanding of prosthodontics and regeneration.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress in research on the role of calcium ion transport in dental biomineralization].","authors":"Q Q Liu, D Q Yang","doi":"10.3760/cma.j.cn112144-20241002-00371","DOIUrl":"10.3760/cma.j.cn112144-20241002-00371","url":null,"abstract":"<p><p>Tooth development is a complex biomineralization process formed through the interaction between epithelial tissue and mesenchymal tissue. The Ca²⁺ transport channel is the intrinsic regulatory mechanism of this process, which regulates the concentration of Ca²⁺ inside and outside the cell in time and space, thereby affecting the biological functions of various cells and the growth of extracellular hydroxyapatite. This article reviews the researches on the effects of Ca²⁺ transport in tooth biomineralization and corresponding cell development in recent years, with the aim of providing ideas and basis for the prevention of tooth developmental defects, assisting in early clinical diagnosis, and improving treatment methods.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"81-87"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Single-cell spatiotemporal atlas of tooth development: progress and prospects].","authors":"X C Li, X S Wu","doi":"10.3760/cma.j.cn112144-20241010-00377","DOIUrl":"10.3760/cma.j.cn112144-20241010-00377","url":null,"abstract":"<p><p>Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minutes of the 17th Annual Meeting of Society of Cariology and Endodontology, Chinese Stomatological Association].","authors":"L Yue, L Zhang","doi":"10.3760/cma.j.cn112144-20241022-00392","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20241022-00392","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"101-102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress on the application of polypeptide hydrogels in drug sustained/controlled release].","authors":"X R Fang, H R Zou","doi":"10.3760/cma.j.cn112144-20241113-00428","DOIUrl":"10.3760/cma.j.cn112144-20241113-00428","url":null,"abstract":"<p><p>In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release. It summarizes the research hotspots in the selection and design principles of peptides, optimization strategies for peptide concentrations, and hydrogel construction techniques. Furthermore, the principles and mechanisms underlying the sustained/controlled drug release from polypeptide hydrogels are elucidated, and the detection methods applicable to different sustained/controlled release systems are summarized. The article also prospects the application potential of peptide hydrogels in the field of drug delivery and offers insights for subsequent in-depth research.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research and prospect of application of artificial intelligence technology in oral and maxillofacial surgery].","authors":"R Y Chen, R Y Zhang, J Wang","doi":"10.3760/cma.j.cn112144-20240611-00238","DOIUrl":"10.3760/cma.j.cn112144-20240611-00238","url":null,"abstract":"<p><p>Artificial intelligence (AI) technology is a scientific and technological field that focuses on the research and development of systems that simulate, extend, and expand human intelligence activities. This field encompasses various applications such as image recognition, language processing, expert systems, and robotics. The advancement of AI has greatly improved the quality and efficiency of medical work, particularly in areas like medical imaging, clinical decision support, precision medicine, and healthcare management. These advancements have contributed to the establishment of more effective healthcare systems.Within the realm of AI in healthcare, the application of AI technology in oral and maxillofacial surgery continues to evolve, with scenarios such as assisting in the interpretation and analysis of dental medical images, predicting and diagnosing early oral and maxillofacial tumors, aiding in minimally invasive surgery, designing ideal and personalized surgical plans, and simplifying medical management tasks. Oral and maxillofacial surgeons, as well as radiologists, should embrace and utilize these emerging technologies, actively adapting to environmental changes and updates, and driving forward the development of the field of oral and maxillofacial surgery.In summary, the integration of AI into oral and maxillofacial surgery presents significant opportunities for advancing patient care, surgical efficiency, and medical research in this specialized area of medicine. This technological partnership has the potential to reshape the landscape of oral and maxillofacial healthcare, benefiting both practitioners and patients.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Distribution characteristics and proteomic analysis of glioma-associated oncogene homolog 1 positive cells during mouse orthodontic tooth movement].","authors":"A Q Liu, L S Zhang, X Y Huang, Y Cao, X Y Cai, F Jin","doi":"10.3760/cma.j.cn112144-20240509-00192","DOIUrl":"10.3760/cma.j.cn112144-20240509-00192","url":null,"abstract":"<p><p><b>Objective:</b> To explore the distribution characteristics of glioma-associated oncogene homolog 1 (Gli1) positive cells during orthodontic tooth movement process and conduct a proteomic analysis of these cells. <b>Methods:</b> Forty Gli1-LacZ transgenic mice were used to establish an in <i>vivo</i> orthodontic tooth movement (OTM) model for labeling Gli1 positive cells in Gli1-LacZ transgenic mice (OTM group) and an unforced control group, with tooth movement distance measured using micro-CT. The spatial relationship and distribution characteristics of Gli1 positive cells and H-type vessels of CD31 and endomucin (EMCN) in periodontal tissues were detected by immunofluorescence staining. Twenty Gli1-membrane-targeted tandem dimer Tomato (mT)/membrane-targeted green fluorescent protein (mG) double-genotype mice were bred and Gli1 positive cells were sorted for proteomic sequencing after tamoxifen induction. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases were used for enrichment analysis. <b>Results:</b> The micro-CT three-dimensional reconstruction results showed that the mesial movement of the maxillary first molar in mice after 7 days of force application was (69±15) μm, indicating the successful establishment of the Gli1-LacZ transgenic mouse OTM model. Immunofluorescence staining showed that the blood vessels in periodontal tissue were mostly H-type vessels of CD31 and EMCN. The blood vessels in the periodontal tissues are predominantly H-type vessels positive for both CD31 and EMCN. The percentage of Gli1 positive cells in the OTM group, expressed as (54.5±13.2)%, and the relative fluorescence intensity, expressed as 2.6±0.9, were both significantly greater than those in the control group, which had a Gli1 positive cell percentage of (36.3±9.1)% (<i>t=</i>3.60<i>, P=</i>0.002) and a relative fluorescence intensity of 1.0±0.3 (<i>t</i>=5.20, <i>P</i><0.001). In contrast to the control group where only a small number of Gli1 positive cells were consistent with the distribution of H-type vessels, in the OTM group the number of Gli1 positive cells increased on the tension side were closely associated with the spatial distribution of H-type vessels. GO enrichment analysis of biological processes found that a large number of proteins in Gli1 positive cells were enriched in pathways such as angiogenesis and tissue remodeling. KEGG enrichment analysis found that related proteins were mainly enriched in pathways related to angiogenesis and Gli1, such as hypoxia-inducing factor 1 signaling pathway, vascular endothelial growth factor signaling pathway and hedgehog signaling pathway. <b>Conclusions:</b> The number of Gli1 positive cells increased on tension side and were closely related to H-type blood vessels in response to mechanical force during orthodontic tooth movement. This may be related to profile of inducing blood vessel formation and tissue remodeling.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical treatment difficulties and strategies for palatogingival groove].","authors":"R T Shi, B X Hou","doi":"10.3760/cma.j.cn112144-20241110-00422","DOIUrl":"10.3760/cma.j.cn112144-20241110-00422","url":null,"abstract":"<p><p>Palatogingival groove (PGG) is a common developmental deformity, which is prone to retain plaque, leading to local periodontal inflammation. Furthermore, the infection can spread to the dental pulp tissue through the PGG, eventually resulting in combined periodontal-endodontic lesions. The treatment methods include PGG treatment, periodontal treatment, endodontic treatment, etc. The abnormal anatomical structure of PGG will influence the treatment and prognosis of the affected tooth. Teeth with combined periodontal-endodontic lesions often have poor curative effect and prognosis. How to early intervene and improve its prognosis has become a hot and difficult issue for dentists in recent years. This article analyzes the challenges in the treatment of PGG and puts forward the corresponding strategies, so as to provide reference for the clinical diagnosis and treatment of PGG.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minutes of the 17th Annual Meeting of Society of Cariology and Endodontology, Chinese Stomatological Association].","authors":"L Yue, L Zhang","doi":"10.3760/cma.j.cn112144-20241022-00392","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20241022-00392","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}