中华口腔医学杂志最新文献

{"title":"[Oral mechanomedicine].","authors":"H Zhang, Y Li, D D Pei, F Xu, A Li","doi":"10.3760/cma.j.cn112144-20240129-00042","DOIUrl":"10.3760/cma.j.cn112144-20240129-00042","url":null,"abstract":"<p><p>In the past decades, we have witnessed considerable advancements in the diagnosis and treatment of oral diseases. However, there still remain significant challenges, such as the regeneration of functional oral tissues. Therefore, new approaches are urgently needed. The oral is a complex biomechanical system where mechanics plays an essential role in the development and functioning of tissues and organs, as well as in the diagnosis and treatment of diseases. Thus, the integration of mechanics into oral disease diagnostics and therapeutics warrants greater attention. To date, the potential of mechanics in oral healthcare has not been sufficiently explored. Recent advancements in biomechanics and mechanobiology within oral medicine have underscored the growing relevance of mechanical theories, analytical methods, innovative technologies, and novel biomaterials in disease diagnosis and treatment. Therefore, this paper proposes the concept of \"Oral Mechanomedicine\" by summarizing research progress both domestically and internationally. It systematically describes the influence and mechanisms of mechanics in the etiology, progression, diagnosis, and treatment of oral diseases across four domains, i.e., oral biomechanics, oral mechanobiology, oral mechanodiagnostics, and oral mechanotherapy. Our aim is to enable more precise diagnoses, effective treatments, and comprehensive oral disease management. Additionally, this paper offers insights into the future trajectory of Oral Mechanomedicine, proposing new theoretical viewpoints and practical approaches to advance the field of oral medicine.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1197-1205"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retrospect on seventy years of Chinese stomatology history research:focusing on papers issued by <i>Chinese Journal of Stomatology</i>].","authors":"J Q Zhang, R X Zhang, Q Yu, S L Wang, J Zhou","doi":"10.3760/cma.j.cn112144-20241023-00395","DOIUrl":"10.3760/cma.j.cn112144-20241023-00395","url":null,"abstract":"<p><p><i>Chinese Journal</i><i>of Stomatology</i> has issued eighty papers on Chinese stomatology history in seventy years. According to three stages of the journal,statistics of the quantity and themes of the issued papers are compiled: the number of issued papers increased while the theme shifted from Chinese stomatology history before 1912 to Chinese contemporary stomatology history. Research methods shifted from the comparatively scanty summary or induction on literature and cultural relics materials to multidisciplinary approaches. Early researches testified the achievments of senior scholars such as Zhou Dacheng and Mao Xiejun in the field while research teams represented by colleges and research institutions have published varied research topics in recent years. As the research deepens, platforms for issuing stomatology papers have been expanded and more subjects have been cross-disciplined. Varieties of academic monographs on stomatology history and stomatology education history have been published, among which Zhou Dacheng's <i>Historic textual research of Chinese stomatology</i> can be regarded as a milestone in the field. Comparing with other fields of stomatology, current research on stomatology history still has much more gaps to fill. The academic community should put more emphasis on talent training, discipline construction, research approaches, museum construction, as well as the cooperation between Chinese and western medical sciences so that to assist in the long-term development of the research.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1185-1192"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[New strategies to prevent and control nerve dysfunction after dental extraction].","authors":"Y H Wang, Y B Cao, J Pan","doi":"10.3760/cma.j.cn112144-20240427-00169","DOIUrl":"10.3760/cma.j.cn112144-20240427-00169","url":null,"abstract":"<p><p>Nerve dysfunction is a common postoperative complication of dental extractions. In dental extraction, the nerves involved mainly include the inferior alveolar nerve, lingual nerve, buccal nerve, chin nerve and nasopalatine nerve. Nerve dysfunction will seriously affect the patient's quality of life and may lead to medical disputes. This review firstly summarizes the clinical manifestations and pathological mechanisms of post-dental extraction nerve dysfunction, then summarizes its clinical risk factors and preventive strategies, then analyzes the clinical characteristics and physiological mechanisms of natural sensory recovery after dental extraction nerve dysfunction, and finally summarizes the cutting-edge therapeutic tools and research directions in the treatment of post-dental extraction nerve dysfunction in recent years. The aim of this article is to comprehensively review the cutting-edge advances in post-dental extraction nerve dysfunction from clinical to molecular mechanisms, and from pathogenesis to prevention and treatment strategies, and seeks to provide reference for oral surgeons in preventing and responding to the treatment of nerve dysfunction after dental extraction.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1272-1278"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress of the study on factors related to orthodontic treatment and the formation of black triangles].","authors":"N Q Yu, S J Wang, H F Tian, X Y Chen","doi":"10.3760/cma.j.cn112144-20240627-00253","DOIUrl":"10.3760/cma.j.cn112144-20240627-00253","url":null,"abstract":"<p><p>Black triangles can be formed due to the defect or absence of the gingival papilla, which increases the risks of food impaction, caries, and periodontal disease, and affects the esthetics of anterior teeth. The incidence of black triangles after orthodontic treatment is from 38% to 58%. The formation of black triangles is influenced by patient-related factors and factors related to orthodontic treatment. This article discusses the factors related to orthodontic treatment and the formation of interdental black triangles and provides reference for preventing the formation of this problem.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1279-1286"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of WW-domain transcription regulator 1 on aging regulation of human dental pulp stem cells].","authors":"D D Li, H J Liu, Y Wang, Z G Chen, X Zhang, W J Li","doi":"10.3760/cma.j.cn112144-20240521-00212","DOIUrl":"10.3760/cma.j.cn112144-20240521-00212","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; Investigating the changes of phenotype and moleculars associated with aging with the increase of passage times of human dental pulp stem cells (hDPSC), to explore the role of WW-containing transcriptional regulator 1 (WWTR1) in the aging mechanism. &lt;b&gt;Methods:&lt;/b&gt; hDPSCs were cultured by tissue block method, and were divided into 4 groups according to the age, algebra, cell knockdown and overexpression of WWTR1 in hDPSCs. Group Ⅰ: hDPSCs from human teeth were further divided into youth group (15-25 years old) and group middle-aged group (40-50 years old) according to different ages. Group Ⅱ: according to different passage, hDPSCs were divided into young cells group (hDPSCs were transmitted to P3 generation), and old cells group (hDPSCs were transmitted to P10 generation). Group Ⅲ: hDPSCs were knocked down of WWTR1, which were further divided into knockdown group and knockdown carrier group. Group Ⅳ: hDPSCs were overexpressed of WWTR1, which were further divided into overexpression group and overexpression carrier group. Real-time fluorescence quantitative PCR (RT-qPCR) was used to detect the changes of WWTR1 expression in groups Ⅰ and Ⅱ, and cell counting kit-8 (CCK-8) was used for groups Ⅱ, Ⅲ, and Ⅳ. Cell proliferation capacity was detected by CCK-8 assay. The ability of osteogenic differentiation was detected by alizarin red staining. Cell senescence positive rate was detected by age-related β-galactosidase staining. The expression levels of age-related genes p53 and p21 were detected by RT-qPCR. &lt;b&gt;Results:&lt;/b&gt; The proportion of senescent cells increased gradually with continuous culture. The proliferation and osteogenic differentiation of hDPSCs in the old group were significantly lower than those in the young group (&lt;i&gt;P&lt;/i&gt;&lt;0.001). The expression levels of senescence related genes p53 (2.09±0.24) and p21 (4.91±0.54) in old cell group were higher than those in young cell group respectively [p53: (1.08±0.09) and p21: (1.09±0.08)] (&lt;i&gt;P&lt;/i&gt;&lt;0.01, &lt;i&gt;P&lt;/i&gt;&lt;0.001). The WWTR1 expression levels of hDPSCs in middle-aged group and old cells group were both decreased compared with those in young group and young cells group (&lt;i&gt;P&lt;/i&gt;&lt;0.01). The proportion of senescent cells in knockdown group (44.50±2.42) was higher than that in knockdown carrier group (22.27±0.56) (&lt;i&gt;P&lt;/i&gt;&lt;0.001). After knocking down WWTR1 in hDPSCs, the expression levels of age-related genes p53 and p21 were up-regulated (&lt;i&gt;P&lt;/i&gt;&lt;0.001), and the abilities of proliferation and osteogenic differentiation in the knockdown group were lower than those in the knockdown carrier group (&lt;i&gt;P&lt;/i&gt;&lt;0.001). The proportion of senescent cells in overexpression empty carrier group (20.40±0.79) was higher than that in overexpression group (10.07±0.61) (&lt;i&gt;P&lt;/i&gt;&lt;0.001). After WWTR1 overexpression ins hDPSCs, the expression levels of age-related genes p53 and p21 were down-regulated, and the proliferation and osteogenic differentiation ability in overexpression group were hig","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1240-1247"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artificial intelligence-supported clear aligner orthodontic technology].","authors":"X J Xie, Y X Bai","doi":"10.3760/cma.j.cn112144-20240729-00298","DOIUrl":"10.3760/cma.j.cn112144-20240729-00298","url":null,"abstract":"<p><p>With the advancement of digital healthcare and artificial intelligence (AI) technologies, the full automation of clear aligner orthodontic technology has become feasible. Significant research findings and commercial applications have emerged in areas such as intelligent diagnosis of multimodal orthodontic data, orthodontic treatment decision-making, automated generation of digital treatment plans, and remote intelligent monitoring. However, in the development and application of AI software, it is imperative to address issues related to clinical risks, target populations, and compliance with medical device software regulations. This article analyzes and summarizes the applications and challenges of AI in clear aligner orthodontic diagnosis, treatment, and production processes. Furthermore, it explores potential future trends in this field, providing valuable insights for clinical reference.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 11","pages":"1075-1079"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Summary of the 1st Academic Conference on Digital Dentistry].","authors":"C B Li, M S Si, Q M Chen","doi":"10.3760/cma.j.cn112144-20240830-00330","DOIUrl":"10.3760/cma.j.cn112144-20240830-00330","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 11","pages":"1181-1184"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Immediate prosthetic rehabilitation of mandibular Kennedy class Ⅱ dentition defect with implant-supported removable partial denture with computer-aided design: a case report].","authors":"N Cheng, W X Shan, T Wen, J Wu","doi":"10.3760/cma.j.cn112144-20240508-00188","DOIUrl":"10.3760/cma.j.cn112144-20240508-00188","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 11","pages":"1140-1144"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mixed reality combined with surgical navigation technology assisted in parapharyngeal space tumors surgery: a clinical study].","authors":"Z N Tang, L H Hu, S Liu, Y Yu, W B Zhang, X Peng","doi":"10.3760/cma.j.cn112144-20240711-00266","DOIUrl":"10.3760/cma.j.cn112144-20240711-00266","url":null,"abstract":"<p><p><b>Objective:</b> To assess the feasibility and application of mixed reality combined with surgical navigation technology in parapharyngeal space tumor surgery, and to provide a reference for the development and promotion of this technology. <b>Methods:</b> In this study, retrospective data collection was conducted on 16 patients with parapharyngeal space tumors who were treated at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from June 2020 to June 2023. The patient's age was (39.6±17.8) years, with 4 males and 12 females. Mixed reality combined with surgical navigation technology was utilized to assist physicians in the treatment of these patients. Mixed reality combined with surgical navigation technology was used to assist physicians in treatment of these patients. The application steps included acquisition of image data, processing of image data [three-dimensional (3D) reconstruction, image fusion, and virtual surgical design], development of surgical navigation plan, connection of mixed reality and navigation system, automatic registration and intraoperative guidance and validation. In the preoperative plan, landmark points were placed on the virtual tumor and surrounding important structures reconstructed using digital software, serving to guide the localization of crucial anatomical structures. Intraoperative positioning deviation, surgical time, intraoperative blood loss, and postoperative complications were recorded and analyzed to evaluate the clinical application effectiveness of mixed reality combined with surgical navigation technology. <b>Results:</b> With the assistance of mixed reality combined with surgical navigation technology, 16 patients successfully underwent tumor resection. All patients were accurately diagnosed preoperatively by 3D reconstruction and image fusion technology, and a comprehensive preoperative plan was formulated; intraoperatively, mixed reality combined with surgical navigation technology was utilized for the localization of important structures. The average localization deviation of 38 landmark points during the operation were (4.43±1.96) mm, with 62% (26/42) of the points having a deviation of ≥0 and<5 mm. The average duration of the operation was (149.6±53.9) min and the blood loss was 70 (45, 150) ml. The average postoperative follow-up was 16 months, and five patients experienced postoperative complications involving facial paralysis, hoarseness, and choking. <b>Conclusions:</b> Mixed reality combined with surgical navigation technology can achieve the three-dimensional visualization of oral and maxillofacial anatomical structures to achieve precise preoperative diagnosis. During surgery, the technology can real-time display the relationship between soft tissue tumors and the surrounding important anatomical structures, guide surgical operation, and enhance the safety of surgery.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 11","pages":"1107-1113"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of botulinum toxin A in the therapeutic applications of oral diseases].","authors":"X Li, X Y Feng, Y Y Shen, J Lin","doi":"10.3760/cma.j.cn112144-20240304-00095","DOIUrl":"10.3760/cma.j.cn112144-20240304-00095","url":null,"abstract":"<p><p>Botulinum toxin A (BTX-A) is a powerful neurotoxin produced by Clostridium botulinum, which can relieve muscle spasm or limit gland secretion by inhibiting the release of acetylcholine at the neuromuscular/glandular junction. In addition, BTX-A can also play a role in the sensory feedback loop, which can ease pain. Currently, dentists are paying more attention to the cosmetic applications of BTX-A in the oral and maxillofacial region, while their understanding of BTX-A's non-cosmetic applications is still insufficient. Although the specific molecular mechanism of BTX-A in oral diseases has not been fully clarified, with the development of evidence-based medicine, more and more clinical evidence has began to support the effectiveness of BTX-A in the therapeutic applications of oral diseases. This article will briefly review the main molecular mechanisms of BTX-A, the latest clinical research progress of BTX-A at home and abroad in the treatment of oral diseases, clinical contraindications and adverse reactions of BTX-A, providing a new idea for the treatment of oral diseases.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 11","pages":"1168-1173"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}