中华口腔医学杂志最新文献

{"title":"[Minutes of the 17th Annual Meeting of Society of Cariology and Endodontology, Chinese Stomatological Association].","authors":"L Yue, L Zhang","doi":"10.3760/cma.j.cn112144-20241022-00392","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20241022-00392","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"101-102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress on the application of polypeptide hydrogels in drug sustained/controlled release].","authors":"X R Fang, H R Zou","doi":"10.3760/cma.j.cn112144-20241113-00428","DOIUrl":"10.3760/cma.j.cn112144-20241113-00428","url":null,"abstract":"<p><p>In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release. It summarizes the research hotspots in the selection and design principles of peptides, optimization strategies for peptide concentrations, and hydrogel construction techniques. Furthermore, the principles and mechanisms underlying the sustained/controlled drug release from polypeptide hydrogels are elucidated, and the detection methods applicable to different sustained/controlled release systems are summarized. The article also prospects the application potential of peptide hydrogels in the field of drug delivery and offers insights for subsequent in-depth research.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research and prospect of application of artificial intelligence technology in oral and maxillofacial surgery].","authors":"R Y Chen, R Y Zhang, J Wang","doi":"10.3760/cma.j.cn112144-20240611-00238","DOIUrl":"10.3760/cma.j.cn112144-20240611-00238","url":null,"abstract":"<p><p>Artificial intelligence (AI) technology is a scientific and technological field that focuses on the research and development of systems that simulate, extend, and expand human intelligence activities. This field encompasses various applications such as image recognition, language processing, expert systems, and robotics. The advancement of AI has greatly improved the quality and efficiency of medical work, particularly in areas like medical imaging, clinical decision support, precision medicine, and healthcare management. These advancements have contributed to the establishment of more effective healthcare systems.Within the realm of AI in healthcare, the application of AI technology in oral and maxillofacial surgery continues to evolve, with scenarios such as assisting in the interpretation and analysis of dental medical images, predicting and diagnosing early oral and maxillofacial tumors, aiding in minimally invasive surgery, designing ideal and personalized surgical plans, and simplifying medical management tasks. Oral and maxillofacial surgeons, as well as radiologists, should embrace and utilize these emerging technologies, actively adapting to environmental changes and updates, and driving forward the development of the field of oral and maxillofacial surgery.In summary, the integration of AI into oral and maxillofacial surgery presents significant opportunities for advancing patient care, surgical efficiency, and medical research in this specialized area of medicine. This technological partnership has the potential to reshape the landscape of oral and maxillofacial healthcare, benefiting both practitioners and patients.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Distribution characteristics and proteomic analysis of glioma-associated oncogene homolog 1 positive cells during mouse orthodontic tooth movement].","authors":"A Q Liu, L S Zhang, X Y Huang, Y Cao, X Y Cai, F Jin","doi":"10.3760/cma.j.cn112144-20240509-00192","DOIUrl":"10.3760/cma.j.cn112144-20240509-00192","url":null,"abstract":"<p><p><b>Objective:</b> To explore the distribution characteristics of glioma-associated oncogene homolog 1 (Gli1) positive cells during orthodontic tooth movement process and conduct a proteomic analysis of these cells. <b>Methods:</b> Forty Gli1-LacZ transgenic mice were used to establish an in <i>vivo</i> orthodontic tooth movement (OTM) model for labeling Gli1 positive cells in Gli1-LacZ transgenic mice (OTM group) and an unforced control group, with tooth movement distance measured using micro-CT. The spatial relationship and distribution characteristics of Gli1 positive cells and H-type vessels of CD31 and endomucin (EMCN) in periodontal tissues were detected by immunofluorescence staining. Twenty Gli1-membrane-targeted tandem dimer Tomato (mT)/membrane-targeted green fluorescent protein (mG) double-genotype mice were bred and Gli1 positive cells were sorted for proteomic sequencing after tamoxifen induction. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases were used for enrichment analysis. <b>Results:</b> The micro-CT three-dimensional reconstruction results showed that the mesial movement of the maxillary first molar in mice after 7 days of force application was (69±15) μm, indicating the successful establishment of the Gli1-LacZ transgenic mouse OTM model. Immunofluorescence staining showed that the blood vessels in periodontal tissue were mostly H-type vessels of CD31 and EMCN. The blood vessels in the periodontal tissues are predominantly H-type vessels positive for both CD31 and EMCN. The percentage of Gli1 positive cells in the OTM group, expressed as (54.5±13.2)%, and the relative fluorescence intensity, expressed as 2.6±0.9, were both significantly greater than those in the control group, which had a Gli1 positive cell percentage of (36.3±9.1)% (<i>t=</i>3.60<i>, P=</i>0.002) and a relative fluorescence intensity of 1.0±0.3 (<i>t</i>=5.20, <i>P</i><0.001). In contrast to the control group where only a small number of Gli1 positive cells were consistent with the distribution of H-type vessels, in the OTM group the number of Gli1 positive cells increased on the tension side were closely associated with the spatial distribution of H-type vessels. GO enrichment analysis of biological processes found that a large number of proteins in Gli1 positive cells were enriched in pathways such as angiogenesis and tissue remodeling. KEGG enrichment analysis found that related proteins were mainly enriched in pathways related to angiogenesis and Gli1, such as hypoxia-inducing factor 1 signaling pathway, vascular endothelial growth factor signaling pathway and hedgehog signaling pathway. <b>Conclusions:</b> The number of Gli1 positive cells increased on tension side and were closely related to H-type blood vessels in response to mechanical force during orthodontic tooth movement. This may be related to profile of inducing blood vessel formation and tissue remodeling.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical treatment difficulties and strategies for palatogingival groove].","authors":"R T Shi, B X Hou","doi":"10.3760/cma.j.cn112144-20241110-00422","DOIUrl":"10.3760/cma.j.cn112144-20241110-00422","url":null,"abstract":"<p><p>Palatogingival groove (PGG) is a common developmental deformity, which is prone to retain plaque, leading to local periodontal inflammation. Furthermore, the infection can spread to the dental pulp tissue through the PGG, eventually resulting in combined periodontal-endodontic lesions. The treatment methods include PGG treatment, periodontal treatment, endodontic treatment, etc. The abnormal anatomical structure of PGG will influence the treatment and prognosis of the affected tooth. Teeth with combined periodontal-endodontic lesions often have poor curative effect and prognosis. How to early intervene and improve its prognosis has become a hot and difficult issue for dentists in recent years. This article analyzes the challenges in the treatment of PGG and puts forward the corresponding strategies, so as to provide reference for the clinical diagnosis and treatment of PGG.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minutes of the 17th Annual Meeting of Society of Cariology and Endodontology, Chinese Stomatological Association].","authors":"L Yue, L Zhang","doi":"10.3760/cma.j.cn112144-20241022-00392","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20241022-00392","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 1","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Digital design combined with endoscopic minimally invasive extraction of impacted mandibular third molars with roots in contact with the mandibular canal].","authors":"Y Wang, K N Chen, J Q Jiang, J L Wang, W Zhang, X L Xu","doi":"10.3760/cma.j.cn112144-20240512-00201","DOIUrl":"10.3760/cma.j.cn112144-20240512-00201","url":null,"abstract":"<p><p><b>Objective:</b> To study the clinical efficacy of digital design combined with three-dimensional (3D) printing model minimally invasive extraction of complex impacted mandibular third molars. <b>Methods:</b> Eight patients who visited the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from April 2023 to March 2024 were included, including 3 males and 5 females, aged from 27 to 57 years old. The impacted mandibular third molars of all patients were closely related to the mandibular canal, and part of the dental tissue entered the mandibular canal. Preoperative digital design was used to simulate the intraoperative tooth segmentation and bone removal operation of the power system and the segmented tooth dislocation path, and analyze the tooth extraction resistance. The mandibular teeth, mandibular canal and mandibular model were three-dimensionally printed using light-curing resin inkjet. During the operation, an endoscope was used combined with the 3D printed model to minimally invasively extract the impacted mandibular third molar. Quantitative sensory testing of the patient's lower lip skin on the operated side was performed before surgery, 2 days after surgery, and 7 days after surgery. Clinical data such as operation time were collected. A paired sample t test was performed on the 2 and 7 days postoperative data and the preoperative data to compare the data differences. <b>Results:</b> All 8 patients successfully completed preoperative design, model printing and minimally invasive surgery. The number of teeth segmented in the preoperative design was (4.4±1.3), and the number of teeth segmented in the actual operation was (4.0±1.1). The operation time was (33.3±13.0) min. None of the patients had postoperative numbness of the lower lip or other postoperative complication. It was observed endoscopically that the inferior alveolar neurovascular bundle was exposed in the extraction socket during the operation. The patient's pressure pain threshold 2 days after surgery (0.601±1.170) was significantly lower than before surgery (1.251±1.109) (<i>t</i>=2.83, <i>P</i>=0.025). <b>Conclusions:</b> For complicated impacted mandibular third molars, digital design combined with 3D printing model can be used to perform minimally invasive extraction with the assistance of an endoscope.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1221-1227"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress in diagnosis of peri-implantitis].","authors":"M H Xu, Y J Qian, L Chen, M S Si","doi":"10.3760/cma.j.cn112144-20240525-00218","DOIUrl":"10.3760/cma.j.cn112144-20240525-00218","url":null,"abstract":"<p><p>Peri-implantitis is one of the most common biological complications after implant restoration which is difficult to be cured. Early and correct diagnosis is of great significance for the prevention and treatment of peri-implantitis. Although there have been consensus reports to make guiding suggestions in diagnosis, the diagnostic criteria are not uniform, resulting in many confusions. This review summarizes published consensuses on the diagnosis of peri-implantitis, analyzes the diagnostic values and limitations of traditional examination methods, and summarizes the recent advances in examination methods for peri-implant soft and hard tissues, aiming to provide a reference for clinical diagnosis of peri-implantitis.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1262-1271"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A pilot study on clinical application of three-dimensional morphological completion of lesioned mandibles assisted by generative adversarial networks].","authors":"Y Liang, Q Wang, Y Y Zhang, J J Huan, J Chen, H X Wang, Z Qiu, P X Liu, W J Ren, Y J Ma, C H Jiang, J D Li","doi":"10.3760/cma.j.cn112144-20240930-00367","DOIUrl":"10.3760/cma.j.cn112144-20240930-00367","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the clinical application pathway of the CT generative adversarial networks (CTGANs) algorithm in mandibular reconstruction surgery, aiming to provide a valuable reference for this procedure. &lt;b&gt;Methods:&lt;/b&gt; A clinical exploratory study was conducted, 27 patients who visited the Department of Oral and Maxillofacial Surgery, Xiangya Hospital of Central South University between January 2022 and January 2024 and required mandibular reconstruction were selected. The cohort included 16 males and 11 females, with the age of (46.6±11.5) years; among them, 7 cases involved mandibular defects crossing the midline. The CTGANs generator produced 100 images, and the mean squared error (MSE) was calculated for differences between any two generated images. Preoperative cone-beam CT data from 5 patients were used to construct a labeled test database, divided into groups: normal maxilla, normal mandible, diseased mandible, and noise (each group containing 70 cross-sectional images). The CTGANs discriminator was used to evaluate the loss values for each group, and one-way ANOVA and intergroup comparisons were performed. Using the self-developed KuYe multioutcome-option-network generation system (KMG) software, the three-dimensional (3D) completion area of the mandible under cone-beam CT was defined for the 27 patients. The CTGANs algorithm was applied to obtain a reference model for the mandible. Virtual surgery was then performed, utilizing the fibular segment to reconstruct the mandible and design the surgical expectation model. The second-generation combined bone-cutting and prebent reconstruction plate positioning method was used to design and 3D print surgical guides, which were subsequently applied in mandibular reconstruction surgery for the 27 patients. Postoperative cone-beam CT was used to compare the morphology of the reconstructed mandible with the surgical expectation model and the mandibular reference model to assess the three-dimensional deviation. &lt;b&gt;Results:&lt;/b&gt; The MSE for the CTGANs generator was 2 411.9±833.6 (95%&lt;i&gt;CI&lt;/i&gt;: 2 388.7-2 435.1). No significant difference in loss values was found between the normal mandible and diseased mandible groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05), while both groups demonstrated significantly lower loss values than the maxilla and noise groups (&lt;i&gt;P&lt;/i&gt;&lt;0.001). All 27 patients successfully obtained mandibular reference models and surgical expectation models. In total, 14 162 negative deviation points and 15 346 positive deviation points were observed when comparing the reconstructed mandible morphology with the surgical expectation model, with mean deviations of -1.32 mm (95%&lt;i&gt;CI&lt;/i&gt;:-1.33-&lt;i&gt;-&lt;/i&gt;1.31 mm) and 1.90 mm (95%&lt;i&gt;CI&lt;/i&gt;: 1.04-1.06 mm), respectively. &lt;b&gt;Conclusions:&lt;/b&gt; The CTGANs algorithm is capable of generating diverse mandibular reference models that reflect the natural anatomical characteristics of the mandible and closely match individual patient morphology, thereby facilitat","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1213-1220"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A preliminary investigation of the key parameters of average value articulator based on mandibular movement trajectories in 100 adults with individual normal occlusion].","authors":"S Y Shan, Y J Zhu, J J Wang, A N Wen, Z X Gao, Q Z Qin, W B Li, Y Wang, Y J Zhao","doi":"10.3760/cma.j.cn112144-20240708-00262","DOIUrl":"10.3760/cma.j.cn112144-20240708-00262","url":null,"abstract":"<p><p><b>Objective:</b> To explore the method of obtaining the key parameters of the average value articulator in healthy people based on mandibular movement trajectory data, with a view to providing a reference for the clinical application of the average value articulator. <b>Methods:</b> One hundred healthy volunteers (42 males and 58 females) with individual normal occlusion, aged 18-55 years old, who met the inclusion criteria were recruited from Beijing, and their mandibular movement trajectory data were collected. The left and right sagittal condylar inclination(SCI) and transversal condylar inclination(TCI) were obtained from the values of the articulator parameters which were generated in the mandibular movement analysis system.The SCI and TCI were grouped by gender and calculated separately for the two groups and the overall sample; the gender differences in the two parameters and the differences between the mean values of the two parameters and the average value articulator empirical values (35° for SCI and 15° for TCI) for the overall sample were compared. <b>Results:</b> The differences between SCI (35.8°±7.4°) and TCI [11.2° (11.3°)] in males and the corresponding parameters [35.6°±8.3° and 10.8° (9.5°), respectively] in females were not statistically significant (<i>t</i>=0.10, <i>P</i>=0.922; <i>Z</i>=-0.60, <i>P</i>=0.552); the overall sample SCI (35.7°±7.9°) did not differ statistically from the average value articulator empirical value (<i>t</i>=1.23,<i>P</i>=0.221), and the overall sample TCI [10.9° (10.3°)] was significantly smaller than the average value articulator empirical value (<i>W</i>=5 825.00, <i>P</i><0.001). <b>Conclusions:</b> The mandibular movement trajectory data of 100 adults with individual normal occlusion in this study shows that the gender factor does not affect the setting of the key parameters of the average value articulator, the SCI of the average value articulator empirical values is appropriate, and the TCI has the possibility of being on the large side. In the clinical use of the articulator to assist in the design of restorations, the parameter values should be rationally adjusted according to the actual situation of the patient's dentition and mandibular movement.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"59 12","pages":"1228-1233"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}