World neurosurgery最新文献

{"title":"Optimizing Microcatheter Loop Correction: A Study on Anchoring Techniques with DFT Flow Diverters and Stent Retrievers in Aneurysm Treatment.","authors":"Necat İslamoğlu, Ali Can Yalçın, İlker Çöven, Osman Kızılkılıç","doi":"10.1016/j.wneu.2025.124303","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124303","url":null,"abstract":"<p><strong>Background: </strong>Treating complex aneurysms, particularly in distal vessels, often involves loop catheterization, which can fail due to challenging anatomy. Alternative anchoring techniques using retrievable and flow diverter stents have shown promise but lack comprehensive evaluation in these scenarios. This study investigates the efficacy of anchoring techniques with retrievable and flow diverter stents for correcting catheter loops in complex aneurysm cases, especially in distal vessels.</p><p><strong>Methods: </strong>A retrospective analysis of 380 aneurysm cases treated endovascularly identified 50 as complex, where outflow artery catheterization via a loop technique was required. In 14 cases where standard maneuvers failed, two anchoring techniques were employed: (1) Stent Retrieval Anchor, deploying a stent retriever to secure and correct the microcatheter, and (2) Flow Diverter Anchor, using a partially deployed flow diverter stent to achieve the same. Outcomes were assessed for technical success, complications, and vessel patency.</p><p><strong>Results: </strong>Stent anchoring was successful in all 14 cases (100% technical success) with no complications such as aneurysm perforation, stent thrombosis, or vessel obstruction. Both techniques provided adequate radial force for stable anchoring in distal vessels, allowing stent deployment without the need for a microcatheter exchange.</p><p><strong>Conclusion: </strong>Anchoring techniques using retrievable and flow diverter stents provide a safe, efficient solution for managing complex aneurysms, particularly in distal vessels. This approach eliminates the need for catheter exchanges, potentially reducing procedure time and complication risks. Further multicenter studies are recommended to validate these findings.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124303"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovation Fatigue in Spine Surgery: Are We Doing Too Much, Too Fast?","authors":"Mansour Mathkour, Ziya L Gokaslan, R John Hurlbert","doi":"10.1016/j.wneu.2025.124295","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124295","url":null,"abstract":"<p><p>Innovation is often seen as the hallmark of surgical progress. Yet in spine surgery, the rapid turnover of new implants, techniques, and technologies has created a quiet fatigue among surgeons, educators, and institutions. This Perspective examines the cultural and professional cost of unchecked innovation and calls for a more measured, data-driven approach that prioritizes long-term outcomes and sustainable adoption over novelty alone.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124295"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced patient selection for percutaneous transluminal angioplasty and stenting for severe symptomatic stenosis of the subclavian artery: Quantitative evaluation with DHI and SF-36 questionnaires.","authors":"Chun-Chao Huang, Cheng-Chih Hsieh, Hsin-Fan Chiang, Shih-Yang Wei, Chia-Hung Wu, Te-Ming Lin, Jung-Hsuan Chen, Wei-An Tai, Feng-Chi Chang","doi":"10.1016/j.wneu.2025.124287","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124287","url":null,"abstract":"<p><strong>Objectives: </strong>This study was designed to quantitatively evaluate the clinical effectiveness of percutaneous transluminal angioplasty and stenting(PTAS) in patients with severe symptomatic stenosis of the subclavian artery(SSS/SA) via the DHI and SF-36 questionnaires.</p><p><strong>Methods: </strong>This was a reanalysis of a prospective, single-center study which was conducted from 2015 to 2024. The inclusion criteria were (1) patients who had significant stenosis (≧70%) of a single subclavian artery(SA), (2) medically refractory symptoms, (3) abnormal blood flow patterns in the ipsilateral vertebral artery on dynamic sonographic images, and (4) no other possible causes of dizziness. The questionnaires, including the DHI and SF-36, were administered one month before and approximately 6 months after the PTAS. The responder was defined as any improvement in DHI.</p><p><strong>Results: </strong>Thirty-two patients were enrolled. The DHI score was 23.2±14.4 before PTAS and 8.4±9.4 at 6 months after PTAS for SSS/SA(p-value<0.001). The scores for the VT and MH domains of the SF-36 were 53.4±14.1 and 51.5±11.0 before PTAS and 60.0±11.3 and 55.6±10.4(p-values=0.009 and 0.036), respectively, at 6 months after PTAS. The 26 responders had significantly higher DHI scores and higher scores for the RP and BP subscales on the SF-36 than the 6 nonresponders did.</p><p><strong>Conclusion: </strong>PTAS can effectively treat SSS/SA and therefore relieve dizziness and improve quality of life in affected patients. The degree of improvement was especially significant in patients who had SSS/SA, experienced dizziness, and had a better quality of life, thus patients with SSS/SA who are most likely to benefit from PTAS should be selected.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124287"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Factors Associated with Ambulatory Function Following Percutaneous Endoscopic Lumbar Discectomy in Patients with L5-S1 Foraminal Stenosis.","authors":"Yanrong Tian, Donghui Cao, Xusheng Li, Yan Ma, Xiao Zhang, Xi Zhu, Wenbo Gu, Yu Yang, Pengcheng Mao, Haifeng Yuan","doi":"10.1016/j.wneu.2025.124289","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124289","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the factors influencing postoperative ambulatory function in patients with L5-S1 foraminal stenosis who underwent percutaneous endoscopic lumbar discectomy (PELD).</p><p><strong>Methods: </strong>This retrospective study was conducted on the clinical data of 146 patients with L5-S1 foraminal stenosis who underwent percutaneous endoscopic lumbar discectomy (PELD) at the General Hospital of Ningxia Medical University between January 2023 and February 2024. The 6-minute walk distance (6MWD) test evaluated ambulatory function at 3 months postoperatively. Demographic characteristics, clinical features, comorbidities, and surgery-related parameters were collected. Univariate analysis and Pearson correlation tests were performed using the 6MWD at 3 months as the dependent variable. Variables with statistical significance (P < 0.05) were then entered into a multivariate linear regression analysis to identify independent predictors and establish a predictive model.</p><p><strong>Results: </strong>A total of 146 patients with L5-S1 foraminal stenosis were retrospectively analyzed. Univariate analysis showed that educational level had a significant impact on the 6-minute walk distance (6MWD) at 3 months postoperatively (P < 0.001). Pearson correlation analysis revealed that postoperative 6MWD was significantly correlated with age, body weight, lower limb pain visual analog scale (VAS) score, preoperative 6MWD (assessed one day before surgery), and preoperative low back pain VAS score (P < 0.05). Multivariate linear regression analysis identified preoperative 6MWD, age, and body weight as independent predictors of postoperative 6MWD (P < 0.05). The predictive equation derived from the regression model was as follows: Postoperative 6MWD at 3 months=163.498+(0.885×Preoperative 6MWD)-(0.515×Age)-(0.775×Body Weight) CONCLUSION: Multiple factors influence ambulatory function following percutaneous endoscopic lumbar discectomy (PELD) in patients with L5-S1 foraminal stenosis. A better preoperative 6-minute walk distance (6MWD), younger age, and lower body weight were associated with improved postoperative 6MWD outcomes.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124289"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to the Letter to the Editor Regarding: Pathogenic Variants and Prognosis in Meningiomas: A Systematic Review and Meta-Analysis.","authors":"Rubén David Dos Reis Zuniga, Gabriel Sant'Ana Carrijo, Matheus Rocha do Vale, Beatriz Alves, Glaucia da Veiga, Paulo Henrique Pires de Aguiar, Fernando Luiz Affonso Fonseca","doi":"10.1016/j.wneu.2025.124296","DOIUrl":"10.1016/j.wneu.2025.124296","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124296"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous versus traditional fixation for fracture patients with Ankylosing spinal disorders: a meta-analysis.","authors":"Jiaxiao Shi, Jiaxin Shen, Wei Guo, Chaochao Zhang, Fangfang Wang","doi":"10.1016/j.wneu.2025.124290","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124290","url":null,"abstract":"<p><strong>Objective: </strong>With the advancement of surgical technology and the refinement of minimally invasive techniques, the emergence of novel technologies has exerted a discernible impact on conventional approaches. Currently, percutaneous internal fixation guided by X-ray fluoroscopy has been employed in patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH), presenting a challenge to traditional open surgery. Our objective was to conduct a comprehensive literature review aiming to evaluate the potential surgical advantages associated with percutaneous internal fixation.</p><p><strong>Design: </strong>The databases PubMed, EMBASE, Cochrane Library, and CNKI (China National Knowledge Infrastructure) were systematically searched to identify both randomized and non-randomized studies focusing on fracture patients with ankylosing spinal disorders.</p><p><strong>Main results: </strong>The analysis included ten studies comparing clinical indexes. Percutaneous internal fixation technology demonstrated overall feasibility in terms of operative time, intraoperative blood loss, postoperative bed rest duration, hospitalization duration, and complications (P<0.05). However, there were no significant differences between the two groups in VAS score, MacNab score, cobb Angle of injured segment and vertebral height at 6 months and 1 year after operation (P> 0.05).</p><p><strong>Conclusions: </strong>Based on the current evidence, percutaneous internal fixation demonstrates clear advantages over open internal fixation. However, considering the limited quality of some studies, it is imperative to conduct additional high-quality randomized controlled trials to further validate these findings.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124290"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Predictive Model for Kummell's Disease.","authors":"Yiliang Song, Houling Zhao, Shisheng Liu, Qi Liu, Yucheng Qi, Gang Wei, Hongliang Song","doi":"10.1016/j.wneu.2025.124293","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124293","url":null,"abstract":"<p><strong>Background: </strong>Kümmell's disease (KD) is a recognized complication of osteoporotic thoracolumbar vertebral compression fractures (OVCFs), but the risk factors for progression from OVCFs to KD remain unclear.</p><p><strong>Methods: </strong>This retrospective study included 104 patients with OVCFs from a tertiary hospital between January 2020 and December 2023. Patients were divided into a case group (56 patients with KD) and a control group (48 patients without KD). Data on 24 variables, including demographics, fracture characteristics, and biochemical markers, were collected and analyzed using SPSS 25.0 software. Statistical methods included independent samples t-test, Mann-Whitney U test, chi-square test, Fisher's exact test, and binary logistic regression.</p><p><strong>Results: </strong>Univariate analysis identified five significant factors related to KD onset: age, vertebral length, intervertebral foramen width, alkaline phosphatase, and albumin. Binary logistic regression analysis revealed three independent risk factors for KD: vertebral length, alkaline phosphatase, and albumin.</p><p><strong>Conclusion: </strong>When treating OVCF patients, clinicians should consider comprehensive factors. Patients with high alkaline phosphatase levels, longer fractured vertebrae, and low albumin levels should be closely monitored. Targeted interventions, such as early surgery, enhanced nutrition, and optimized anti-osteoporosis plans, may reduce KD risk and improve patient outcomes.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124293"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Treatment of Cryptogenic Brain Abscesses: mNGS and Imaging for Recurrence Control.","authors":"Xiao-Yu Zheng, Dong-Yue Li, Meng-Hui Li, Mao-Ying Zhang, Jian-Cheng Liao","doi":"10.1016/j.wneu.2025.124288","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124288","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the precision diagnosis and treatment strategies for cryptogenic brain abscesses (CBA), integrating multimodal imaging (320-slice CT + 3.0T MRI) and metagenomic next-generation sequencing (mNGS) technology to optimize treatment regimens and control recurrence risk.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 88 patients with cryptogenic brain abscesses admitted to the Department of Neurosurgery, the First Affiliated Hospital of Jinan University from January 2014 to August 2023. The patients were defined as having no clear infection source, acute onset, and negative or delayed-positive bacterial cultures. They were divided into a medication group (16 cases), a surgical puncture group (15 cases), and a surgical resection group (57 cases) according to treatment modalities. Fisher's exact test, Kruskal-Wallis test, and multivariate logistic regression were used to analyze the factors related to efficacy and recurrence.</p><p><strong>Results: </strong>The cure rate in the surgical resection group (98.2%, 56/57) was significantly higher than that in the surgical puncture group (86.7%, 13/15) and the medication group (68.8%, 11/16) (P<0.001). The recurrence rates were 0% in the surgical resection group, 13.3% (2/15) in the puncture group, and 43.8% (7/16) in the medication group (P<0.001). Multivariate regression analysis showed that an abscess diameter ≤2.5 cm (95%CI: 1.12-9.43, P<0.05)and mixed infections was an independent risk factor for recurrence. The pathogen detection rate was increased to 84.1% (74/88) by mNGS, which was significantly higher than that of traditional culture (44.3%, 39/88, P<0.001).</p><p><strong>Conclusion: </strong>Combined multimodal imaging and mNGS serve as the core modalities for early diagnosis of CBA. Surgical resection significantly improves cure rates and reduces recurrence risk, particularly suitable for patients with abscesses larger than 2.5 cm in diameter or mixed infections.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124288"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Tool for Early Neurological Deterioration in Acute Minor Vertebrobasilar Occlusive Stroke Managed Medically.","authors":"Baolin Du, Wei Li, Jingwen Sun, Yeteng Zhang, Jun Hong","doi":"10.1016/j.wneu.2025.124304","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124304","url":null,"abstract":"<p><strong>Objective: </strong>We sought to construct a scoring model to predict early neurological worsening (END) among minor vertebrobasilar occlusive strokes (National Institutes of Health Stroke Scale [NIHSS] score < 6) following best medical management (BMM).</p><p><strong>Methods: </strong>Between January 2019 and June 2024, 137 patients were recruited from a single center. END was characterized by a ≥ 4-point rise in NIHSS within 72 hours, without intracranial hemorrhage. Logistic regression analysis identified predictors for END, which were used to construct a scale. External validation was performed using a separate cohort from another hospital during the same study period (n=81). Model performance was assessed using receiver operating characteristic (ROC) curve analysis, area under the curve (AUC), calibration plots, and Brier score.</p><p><strong>Results: </strong>END occurred in 41 patients (29.9%). Independent predictors for END were fluctuating symptoms (adjusted odds ratio [aOR] = 1.64, assigned 1 point), proximal vertebrobasilar occlusion (aOR = 2.59, assigned 2 points), and Tmax > 6 seconds volumes (aOR = 1.87, assigned 1 point) (all P < 0.001). The predictive scale showed excellent discrimination in the derivation cohort (AUC = 0.921, 95% confidence interval [CI]: 0.882-0.965) and good calibration (Brier score = 0.103). The derivation and validation cohorts were similar in most baseline characteristics. Significant differences were observed in symptom evolution, intravenous thrombolysis usage, and occlusion sites. External validation in an independent cohort yielded an AUC of 0.857 (0.825-0.934) and a Brier score of 0.130.</p><p><strong>Conclusions: </strong>This externally validated scale provided a practical tool to identify high-risk END patients for targeted interventions.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124304"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility of prepsoas oblique lumbar interbody fusion (OLIF) at L5/S1 level --- a radiographic and clinical research.","authors":"Pengchao Yang, Yimin Dong, Pengju Wang, Yong Xu, Honglei Kang, Feng Li, Hanfeng Guan","doi":"10.1016/j.wneu.2025.124294","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124294","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective clinical study with prospective data collection.</p><p><strong>Objective: </strong>To investigate the feasibility of prepsoas OLIF at L5-S1 level and propose a new practical framework for approach selection of OLIF51.</p><p><strong>Methods: </strong>The feasibility of left-sided and right-sided prepsoas approaches was graded as easy, advanced and difficult depending on retraction distance (RD) and perivascular adipose tissue (PAT) in the radiographic study. The classification results were summarized and the OLIF51 approach selection framework was proposed to guide the subsequent clinical research. The clinical outcomes and incidence of complications were compared between two groups in which the inpatients underwent OLIF51 from 2019 to 2022.</p><p><strong>Results: </strong>Among the 200 consecutive randomized outpatients who met the inclusion criteria, the easy, advanced and difficult cases of left-sided prepsoas were 19, 158 and 23 respectively with right-sided prepsoas (40, 160, 0). Guided by the proposed framework, 65 inpatients underwent left-sided prepsoas OLIF51 were enrolled in group A and 71 inpatients underwent right-sided prepsoas OLIF51 were enrolled in group B. There was no significant difference in demographic and preoperative follow-up results. The ORT for OLIF51 alone was shorter in group B than group A. Operations were successfully completed in all patients of group B. In group A, sufficient exposure was not achieved in four patients(6.2%). Ligation of the iliolumbar vein was needed for adequate exposure in 16(24.6%) patients from group A and 14(19.7%) from group B. Postoperative clinical outcomes were improved and not significantly different between two groups.</p><p><strong>Conclusion: </strong>Prepsoas OLIF51 is feasible, which can serve as alternative approaches for anterior interbody fusion of L5-S1 according to preoperative imaging evaluation. Although there is no difference in the therapeutic effect between two groups, the right-sided prepsoas approach was preferred with its greater feasibility and advantages.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124294"},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}