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Corrigendum to “The Crane Technique in Cortical Bone Trajectory Screw Lumbar Fusion: Efficacy and Predictors of Spondylolisthesis Reduction” “皮质骨轨迹螺钉腰椎融合术中的Crane技术:腰椎滑脱复位的疗效和预测因素”的勘误表
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-09 DOI: 10.1016/j.wneu.2025.123905
Kuan-Jung Chen , Jung-Ying Chiang , Chih-Ying Wu , Chien-Yuan Wang , Hsiang-Ming Huang
{"title":"Corrigendum to “The Crane Technique in Cortical Bone Trajectory Screw Lumbar Fusion: Efficacy and Predictors of Spondylolisthesis Reduction” <Available Online 5 February 2025, Version of Record 5 February 2025.>","authors":"Kuan-Jung Chen ,&nbsp;Jung-Ying Chiang ,&nbsp;Chih-Ying Wu ,&nbsp;Chien-Yuan Wang ,&nbsp;Hsiang-Ming Huang","doi":"10.1016/j.wneu.2025.123905","DOIUrl":"10.1016/j.wneu.2025.123905","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"197 ","pages":"Article 123905"},"PeriodicalIF":1.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facet distraction distance independently predicts cage subsidence following anterior cervical discectomy and fusion. 小关节突撑开距离独立预测颈椎前路椎间盘切除术和融合后椎笼沉降。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-06 DOI: 10.1016/j.wneu.2025.123960
Chengkun Zhao, Shijie Wang, Jingjing Zhang, Hegang Niu, Yun Cao, Cailiang Shen, Yinshun Zhang
{"title":"Facet distraction distance independently predicts cage subsidence following anterior cervical discectomy and fusion.","authors":"Chengkun Zhao, Shijie Wang, Jingjing Zhang, Hegang Niu, Yun Cao, Cailiang Shen, Yinshun Zhang","doi":"10.1016/j.wneu.2025.123960","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.123960","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the relationship between facet distraction distance (FDD) and cage subsidence following anterior cervical discectomy and fusion (ACDF).</p><p><strong>Methods: </strong>This retrospective study included patients who underwent ACDF for degenerative cervical disease at our institution between 2020 and 2023. Preoperative computed tomography (CT) scans were used to assess Hounsfield unit (HU) values, reflecting bone mineral density (BMD). Disc distraction distance (DDD) and FDD were measured using preoperative, immediate postoperative, and final follow-up radiographs. Multivariate logistic regression analysis was performed to identify independent risk factors for cage subsidence.</p><p><strong>Results: </strong>A total of 80 patients were included in the study. Compared to the non-subsidence group, the subsidence group demonstrated significantly greater DDD (p = 0.001) and FDD (p < 0.001), as well as lower HU values (p = 0.014). Multivariate logistic regression analysis identified lower HU values, greater DDD, and greater FDD as independent risk factors for subsidence. Receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) for FDD was 0.762, with an optimal threshold of 0.66.</p><p><strong>Conclusions: </strong>FDD is an independent predictor of cage subsidence following ACDF. To reduce the risk of subsidence, over-distraction of the interfacet space should be avoided.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123960"},"PeriodicalIF":1.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor Regarding " A Bibliometric Analysis of Sitting Position and Air Embolism in Neurosurgery: Top 100 Most Cited Articles" 致编辑关于“坐姿与神经外科空气栓塞的文献计量分析:100篇被引用最多的文章”的信。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-05 DOI: 10.1016/j.wneu.2025.123959
Jibo Zhang
{"title":"Letter to the Editor Regarding \" A Bibliometric Analysis of Sitting Position and Air Embolism in Neurosurgery: Top 100 Most Cited Articles\"","authors":"Jibo Zhang","doi":"10.1016/j.wneu.2025.123959","DOIUrl":"10.1016/j.wneu.2025.123959","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"197 ","pages":"Article 123959"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Cervical Spine Surgery in the USA - A National Database Analysis. 美国颈椎手术趋势-国家数据库分析。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-05 DOI: 10.1016/j.wneu.2025.123961
Muhammad Talal Ibrahim, James Caid Kirven, Venkat Kavuri, Elizabeth Yu, Varun Kumar Singh
{"title":"Trends in Cervical Spine Surgery in the USA - A National Database Analysis.","authors":"Muhammad Talal Ibrahim, James Caid Kirven, Venkat Kavuri, Elizabeth Yu, Varun Kumar Singh","doi":"10.1016/j.wneu.2025.123961","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.123961","url":null,"abstract":"<p><strong>Introduction: </strong>Anterior cervical discectomy and fusion (ACDF), posterior cervical instrumented fusion (PCF), laminectomy/foraminotomy/facetectomy (LFF), and cervical disc arthroplasty (CDA) are commonly performed cervical spine procedures. This study aims to identify the trends in cervical spine surgery on the utilization of ACDF, PCF, LFF, and CDA in the US over the past decade. A secondary aim of this study is to describe the average reimbursements received for these interventions.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted using the PearlDiver database in patients undergoing ACDF, LFF, PCF, and CDA from 2010 to 2022. Yearly number of procedures from 2010 to 2022 and average reimbursement per patient were reported for all four cohorts. PearlDiver's built-in statistical package and R Studio were used to report the results and create a choropleth map.</p><p><strong>Results: </strong>Out of 1.2 million cervical spine surgeries, ACDF was most common (61.6%), followed by LFF (22.1%), PCF (14.0%), and CDA (3.4%). ACDF, LFF, and PCF were common in patients aged 55 - 74, while CDA was more common in patients aged ≤ 54. The number of cervical spine surgeries grew from 86,272 to 96,976, while the number of ACDFs fell from 60,435 to 51,012. LFF, PCF, and CDA continued to increase in frequency until 2022. The average inflation-adjusted yearly percentage change in reimbursements was -9% per year.</p><p><strong>Conclusion: </strong>ACDF has been the most popular cervical spine surgery, but its frequency is now declining. CDA is gaining popularity, particularly among younger patients. Moreover, average per-patient inflation-adjusted reimbursements have been effectively decreasing over time.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123961"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of pneumocephalus on electrode location after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. 脑积水对帕金森病患者丘脑下核深部脑刺激后电极定位的影响。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-04 DOI: 10.1016/j.wneu.2025.123958
Yi Wang, Hongliang Mao, Xiaoming Kong, Liangchen Yu, Jianyu Nie, Yue Liu, Hongwei Cheng
{"title":"Effects of pneumocephalus on electrode location after deep brain stimulation of the subthalamic nucleus in Parkinson's disease.","authors":"Yi Wang, Hongliang Mao, Xiaoming Kong, Liangchen Yu, Jianyu Nie, Yue Liu, Hongwei Cheng","doi":"10.1016/j.wneu.2025.123958","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.123958","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of pneumocephalus on electrode positioning following subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>A retrospective analysis was performed on 111 patients who underwent bilateral STN-DBS at the First Affiliated Hospital of Anhui Medical University. Preoperative MRI and postoperative CT scans were utilized to assess electrode positions and pneumocephalus volume. The brain imaging data were standardized to the Montreal Neurological Institute (MNI) space for precise comparison. Statistical analyses were performed to identify factors influencing the volume of pneumocephalus.</p><p><strong>Results: </strong>This study found that pneumocephalus absorption significantly affects electrode positioning, leading to a forward and upward shift. A higher degree of brain atrophy and a higher number of microelectrode recording (MER) passages were significantly correlated with increased pneumocephalus volume and more pronounced electrode displacement.</p><p><strong>Conclusion: </strong>Pneumocephalus plays a critical role in electrode displacement during STN-DBS surgery. Minimizing cerebrospinal fluid (CSF) loss and careful planning of MER passages are essential for improving surgical accuracy. Further studies with larger sample sizes and multicenter data are needed to validate these findings and increase their generalizability.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123958"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply to the Letter to the Editor Regarding: "The Association of Bone Mineral Density with Distal Junctional Kyphosis and Distal Junctional Failure After Multilevel Spine Fusions: A Systematic Review and Meta-Analysis" 回复 "重新评估脊柱手术中的骨密度:用人工智能克服人类学的局限性 "的回信。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-04 DOI: 10.1016/j.wneu.2025.123956
Luke L. Jouppi , Clifford Pierre , Zeyad Daher , Bryan G. Anderson , Donald David Davis , Neel Patel , Julius Gerstmeyer , Gautam Rao , Daniel Norvell , Giorgio Cracchiolo , Amir Abdul-Jabbar , Rod Oskouian , Jens R. Chapman
{"title":"In Reply to the Letter to the Editor Regarding: \"The Association of Bone Mineral Density with Distal Junctional Kyphosis and Distal Junctional Failure After Multilevel Spine Fusions: A Systematic Review and Meta-Analysis\"","authors":"Luke L. Jouppi ,&nbsp;Clifford Pierre ,&nbsp;Zeyad Daher ,&nbsp;Bryan G. Anderson ,&nbsp;Donald David Davis ,&nbsp;Neel Patel ,&nbsp;Julius Gerstmeyer ,&nbsp;Gautam Rao ,&nbsp;Daniel Norvell ,&nbsp;Giorgio Cracchiolo ,&nbsp;Amir Abdul-Jabbar ,&nbsp;Rod Oskouian ,&nbsp;Jens R. Chapman","doi":"10.1016/j.wneu.2025.123956","DOIUrl":"10.1016/j.wneu.2025.123956","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"197 ","pages":"Article 123956"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated Analysis of Surface Roughness and Waviness in Vertebral Bodies by CT: Implications for Device Design in Spine Surgery. CT对椎体表面粗糙度和波浪度的自动分析:脊柱外科设备设计的意义。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-03 DOI: 10.1016/j.wneu.2025.123951
Seth M Meade, Gabrielle Scariano, Michael Shost, Swetha J Sundar, Ajit A Krishnaney, David Dudzinski, Erik Waldorff, Assem Sultan, Thomas E Mroz, Michael P Steinmetz, Edward C Benzel, Ghaith Habboub
{"title":"Automated Analysis of Surface Roughness and Waviness in Vertebral Bodies by CT: Implications for Device Design in Spine Surgery.","authors":"Seth M Meade, Gabrielle Scariano, Michael Shost, Swetha J Sundar, Ajit A Krishnaney, David Dudzinski, Erik Waldorff, Assem Sultan, Thomas E Mroz, Michael P Steinmetz, Edward C Benzel, Ghaith Habboub","doi":"10.1016/j.wneu.2025.123951","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.123951","url":null,"abstract":"<p><strong>Objective: </strong>The interactions between interbody devices, corpectomy cages, and vertebral bodies are influenced by surface characteristics such as roughness and waviness, impacting fusion quality and patient outcomes. Understanding vertebral surface morphology is crucial for improving cage design and avoiding complications like subsidence, neural injury, and re-operation. This study aims to characterize the variability in vertebral morphology along the spine.</p><p><strong>Methods: </strong>A retrospective analysis of a spinal CT scan database of 159 patients (mean age 59±17) from an open-source database, encompassing 1895 vertebral bodies, was performed. Vertebral morphology was analyzed using an automated pipeline and clustered based on roughness and waviness to identify unique morphologic subgroups.</p><p><strong>Results: </strong>Mean surface roughness (MSR) was highest in the cervical, upper thoracic, and lower lumbar spine, while mean surface waviness (MSW) peaked in the lower lumbar spine. Clustering revealed heterogeneous subgroups below C6, while the upper cervical spine had more homogeneous morphology (high roughness, low waviness). MSR and MSW were negatively correlated with sagittal slope at C3-6 and C7-T1. MSR was positively correlated with sagittal slope at T2-T11 and L4-L5, while MSW was positively correlated from T12-L3.</p><p><strong>Conclusions: </strong>This study presents an automated method to measure MSR and MSW of spinal vertebral bodies. These parameters could aid in simulating the interaction between interbody devices and vertebral bodies preoperatively to allow for optimization of device design to enhance osseous integration. Future work will explore the relationship between these measures and clinical outcomes, particularly fusion quality.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123951"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Lumbar Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis 腰椎棘突劈裂椎板切除术与传统椎板切除术治疗腰椎管狭窄的比较:一项系统回顾和荟萃分析。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-02 DOI: 10.1016/j.wneu.2025.123954
Junjie Chen , Jieyang Zhu , Yi Jiang , Kanling Jiang , Jinyu Zhu , Zhenqi Lou
{"title":"Comparison of Lumbar Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis","authors":"Junjie Chen ,&nbsp;Jieyang Zhu ,&nbsp;Yi Jiang ,&nbsp;Kanling Jiang ,&nbsp;Jinyu Zhu ,&nbsp;Zhenqi Lou","doi":"10.1016/j.wneu.2025.123954","DOIUrl":"10.1016/j.wneu.2025.123954","url":null,"abstract":"<div><h3>Background</h3><div>This meta-analysis compared the clinical efficacy of lumbar spinous process-splitting laminectomy (LSPSL) and conventional laminectomy (CL) for lumbar spinal stenosis (LSS) for treating lumbar stenosis.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive literature review on PubMed, Embase, Cochrane library, and CNKI until March 2024 to identify studies that compared LSPSL with CL for the treatment of LSS. This meta-analysis was carried out with the use of RevMan 5.3 software.</div></div><div><h3>Results</h3><div>Eight studies comprising 801 patients (431 for LSPSL, 370 for CL) were included in this meta-analysis. Comparable outcomes in terms of visual analog scale, Japanese Orthopedic Association scores, Japanese Orthopedic Association recovery rate, Oswestry disability index were noted after surgery. No significant differences were observed in operative time, intraoperative blood loss, complication rates, and re-operation rates. However, LSPSL presented a significantly lower muscular dystrophy rate than CL (weighted mean difference: −16.61, 95% confidence interval: [−21.60, −11.64], <em>P</em> &lt; 0.00001, I<sup>2</sup> = 0%;).</div></div><div><h3>Conclusions</h3><div>Based on this meta-analysis, both LSPSL and CL can provide a comparably clinical outcomes and complication rates for the treatment of LSS. However, LSPSL demonstrated a superior advantage in terms of muscular dystrophy rate.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"197 ","pages":"Article 123954"},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Ethics and Resources on the Allocation of Traumatic Brain Injury Surgery: A Survey of Neurosurgeons Within Low- and Middle-Income Countries and High-Income Countries 伦理和资源对外伤性脑损伤手术分配的影响:对低收入和高收入国家神经外科医生的调查。
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-01 DOI: 10.1016/j.wneu.2025.123950
Jasmine G. Hughes , Charis A. Spears , Margot Kelly-Hedrick , Katie Solarz , Mareshah Sowah , Nathan A. Shlobin , Deen Garba , Michael M. Haglund , Deborah Koltai , Anthony T. Fuller
{"title":"The Impact of Ethics and Resources on the Allocation of Traumatic Brain Injury Surgery: A Survey of Neurosurgeons Within Low- and Middle-Income Countries and High-Income Countries","authors":"Jasmine G. Hughes ,&nbsp;Charis A. Spears ,&nbsp;Margot Kelly-Hedrick ,&nbsp;Katie Solarz ,&nbsp;Mareshah Sowah ,&nbsp;Nathan A. Shlobin ,&nbsp;Deen Garba ,&nbsp;Michael M. Haglund ,&nbsp;Deborah Koltai ,&nbsp;Anthony T. Fuller","doi":"10.1016/j.wneu.2025.123950","DOIUrl":"10.1016/j.wneu.2025.123950","url":null,"abstract":"<div><h3>Background</h3><div>Scarce resource allocation in traumatic brain injury (TBI) care is ethically challenging. We surveyed neurosurgeons about their views on surgical decision-making in TBI in resource-limited settings.</div></div><div><h3>Methods</h3><div>Neurosurgeons and trainees completed an online survey about surgical decision-making for TBI when neurosurgical capacity is limited. The survey included questions about the impact of patient-level factors (such as the patient's need for surgery or potential for improvement in mortality) and system-level factors (such as operating theater and bed space availability) on decision-making, as well as the perceived fairness of several resource allocation principles when applied to TBI surgery.</div></div><div><h3>Results</h3><div>The 63 respondents were from low- and/or middle-income countries (27%) and high-income countries (73%, n = 46). Most neurosurgeons (61%, n = 35/57) reported the patient's need for surgery as the primary patient-level driver of decision-making, and operating room space was the main system-level factor (71%, n = 35/49). Neurosurgeons generally thought sickest-first and prognosis were the fairest resource allocation principles.</div></div><div><h3>Conclusions</h3><div>Respondents generally prioritized their patients' need for surgery, projected benefits, and system considerations such as operating theater capacity in their decision to operate. Respondents prioritized both the sickest patients and those with the best prognosis in the setting of limited surgical capacity. Future research should explore how to work towards an agreed-upon framework for decision-making in resource-scarce settings in a just and equitable way.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"197 ","pages":"Article 123950"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Population-Based Cohort Study of Glioblastoma (World Health Organization Grade 4 Gliomas) in Ontario: Continued Improvement in Care over 25 Years
IF 1.9 4区 医学
World neurosurgery Pub Date : 2025-04-01 DOI: 10.1016/j.wneu.2025.123821
Shervin Taslimi , Susan Brogly , Timothy P. Hanna , Jonas Shellenberger , Marlo Whitehead , Ryan Alkins
{"title":"A Population-Based Cohort Study of Glioblastoma (World Health Organization Grade 4 Gliomas) in Ontario: Continued Improvement in Care over 25 Years","authors":"Shervin Taslimi ,&nbsp;Susan Brogly ,&nbsp;Timothy P. Hanna ,&nbsp;Jonas Shellenberger ,&nbsp;Marlo Whitehead ,&nbsp;Ryan Alkins","doi":"10.1016/j.wneu.2025.123821","DOIUrl":"10.1016/j.wneu.2025.123821","url":null,"abstract":"<div><h3>Objective</h3><div>Grade 4 glioma is the most common and fatal primary malignant brain tumor in adults. We sought to describe the evolution of care and survival of patients with glioblastoma in a single-payer Canadian provincial health care system over a 24-year period.</div></div><div><h3>Methods</h3><div>Adult patients &gt;18 years old with pathologically or clinically diagnosed glioblastoma (based on fourth or earlier edition of World Health Organization classification) in Ontario between 1994 and 2018 were identified and followed until death or study end point of 2 years through provincial administrative health data. Patient characteristics, type of treatment, survival, and time spent in the hospital were compared across time periods, age groups, and centers.</div></div><div><h3>Results</h3><div>We included 9487 patients with glioblastoma treated from 1994 to 2018. Median survival and 2-year survival rate improved over the study period from 6.4 to 9.4 months and 10% to 18%, respectively. Older age was associated with shorter survival (median survival of 12 months at 65–74 years vs. 3 months at &gt; 85 years), less aggressive therapy, and a higher proportion of remaining lifetime spent in the hospital (more than one third of patients &gt;75 years spend ≥50% their remaining survival in hospital). Time in the hospital decreased by 8.9 days (95% confidence interval 8.53–9.25) over the study period. Significant heterogeneity exists in patient management and outcome between regional treatment centers.</div></div><div><h3>Conclusions</h3><div>The real-world prognosis for grade 4 glioma remains poor. However, an increased proportion of patients receiving maximal therapy is associated with a small but meaningful improvement in survival and decreased time in the hospital for all but the oldest patients.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"196 ","pages":"Article 123821"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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