Mohammed Bafaquh, Noor Alghanuim, Gmaan Alzhrani, Fatimah A Alghabban, Arwa S AlShamekh, Mohammed Daghriri, Othman T Almutairi, Sarah Bin Abdulqader, Lahbib Soualmi, Najeeb Alomar, Khulood K Alraddadi, Fahd R AlSubaie
{"title":"\"Brain Biopsy Revolution: Unveiling the Core Syringe Technique with Clinical Insights\".","authors":"Mohammed Bafaquh, Noor Alghanuim, Gmaan Alzhrani, Fatimah A Alghabban, Arwa S AlShamekh, Mohammed Daghriri, Othman T Almutairi, Sarah Bin Abdulqader, Lahbib Soualmi, Najeeb Alomar, Khulood K Alraddadi, Fahd R AlSubaie","doi":"10.1016/j.wneu.2024.10.103","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.103","url":null,"abstract":"<p><strong>Background: </strong>Obtaining a definitive pathological diagnosis from brain tissue sampling was challenging due to the small, non-representative sample. This study introduced a novel syringe technique for brain biopsy aimed at enhancing diagnostic accuracy by obtaining core tissue samples that better represent the targeted tissue.</p><p><strong>Methods: </strong>The ten patients with atypical brain lesions underwent the syringe biopsy. After meticulous preoperative planning with neuronavigation, a minimally invasive approach was used: a 3 cm skin incision and a 14 mm burr hole were created. A modified 3-cc syringe was used to create negative pressure and cannulate the brain tissue. The desired sample size (24 cm³) was obtained by controlling the syringe depth and withdrawal. Medical records were reviewed to assess sample analysis results and any complications.</p><p><strong>Results: </strong>The syringe technique successfully yielded adequate tissue samples in 9 out of 10 patients. In one case, the desired tissue could not be retrieved and required a microsurgical approach for removal. In all ten cases, a correct diagnosis was made without significant complications.</p><p><strong>Conclusion: </strong>The preliminary findings suggest that the syringe technique is both safe and effective for obtaining substantial volumes of brain tissue, facilitating accurate pathological evaluation in cases of complex neurological disorders.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong-Bin Chung, Hong Jun Jeon, Jong Young Lee, Se-Hyuck Park
{"title":"Surgical Technique for Performing Endoscopic Carpal Tunnel Release without Converting to an Open Technique, and Analysis of the Reasons for Conversion.","authors":"Dong-Bin Chung, Hong Jun Jeon, Jong Young Lee, Se-Hyuck Park","doi":"10.1016/j.wneu.2024.10.020","DOIUrl":"10.1016/j.wneu.2024.10.020","url":null,"abstract":"<p><strong>Objective: </strong>Endoscopic carpal tunnel release (ECTR) has advantages over open carpal tunnel release (OCTR); however, complications with ECTR are more likely to occur if the surgeon continues the procedure despite encountering difficulties. Techniques to minimize the need for conversion to OCTR have been infrequently discussed in the literature. This study aims to present a technique for performing ECTR without conversion to the open approach and to analyze the reasons for such conversions.</p><p><strong>Methods: </strong>A total of 1160 hands in 771 patients who underwent single-portal ECTR between January 2001 and December 2020 were analyzed. We evaluated the rate and reasons for conversion and compared clinical severity and electrodiagnostic grades between the ECTR and OCTR conversion groups to identify patient characteristics associated with conversion.</p><p><strong>Results: </strong>A total of 18 hands in 17 patients required conversion to OCTR (1.56%). In the first 5 years, 9 out of 251 ECTRs (3.59%) were converted, but since then, the conversion rate significantly decreased with increasing surgical experience. The most common reasons for conversion were poor visualization of the transverse carpal ligament due to the transbursal approach with a hypertrophic synovial membrane. As the preoperative clinical grade worsened, the conversion rate significantly increased. The OCTR conversion rate also tended to rise with more severe electrodiagnostic grades. Outcomes for all 18 wrists were successful at the 6-month follow-up.</p><p><strong>Conclusions: </strong>A thorough subligamentous extrabursal approach is essential for achieving a clear endoscopic view of the transverse carpal ligament and performing ECTR without the need for conversion to open surgery.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Jeoung Kim, Sun Yoon, Sang Kyu Park, Keun Young Park, Joonho Chung, Yong Bae Kim
{"title":"Age-Related Differences in Clinical Characteristics and Outcomes of Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study of 657 Patients.","authors":"Min Jeoung Kim, Sun Yoon, Sang Kyu Park, Keun Young Park, Joonho Chung, Yong Bae Kim","doi":"10.1016/j.wneu.2024.10.016","DOIUrl":"10.1016/j.wneu.2024.10.016","url":null,"abstract":"<p><strong>Background: </strong>Aneurysmal subarachnoid hemorrhage (aSAH) has an incidence of 6-7 per 100,000 person-years. Despite advancements in treatment, 26% of patients die and 19% remain dependent after hemorrhage. Long-term neuropsychological sequelae affect about half of the survivors, significantly affecting their quality of life. This study aims to assess aSAH characteristics and identify predictive factors of clinical outcomes in young patients.</p><p><strong>Methods: </strong>A retrospective study analyzed 657 patients with aSAH treated at 2 South Korean medical centers from January 2011 to December 2023. Data on demographics, comorbidities, smoking history, clinical grades, aneurysm size and location, and outcomes were collected. Outcomes were classified using the modified Rankin Scale, with scores ≤2 indicating good outcomes.</p><p><strong>Results: </strong>The cohort included 233 men and 424 women (male/female ratio 1:1.8). Most patients were middle-aged (74.4%), followed by young (16.7%) and old (8.8%) groups. Young patients showed male predominance (56.8%), lower hypertension (12.7%) and diabetes (1.8%) rates, and higher smoking rates (39.6%). Older patients had higher hypertension (44.6%) and diabetes (23.3%) rates and were predominantly female (69.1%). Aneurysms in young patients were smaller (P = 0.04). Multivariate analysis identified poor Hunt-Hess grade, permanent cerebral infarction, and aneurysmal recurrence or rebleeding as predictors of poor outcomes in young patients. Middle-aged patients had additional predictors, including diabetes and hydrocephalus. In older patients, only poor Hunt-Hess grade was significant.</p><p><strong>Conclusions: </strong>Young patients with aSAH show distinct characteristics and prognostic factors compared with older patients. Despite higher postoperative complications, young patients generally have better outcomes, emphasizing the need for age-specific management strategies in aSAH.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Shakir, Aly Hamza Khowaja, Hammad Atif Irshad, Izza Tahir, Syeda Fatima Shariq, Ali I Rae, Radzi Hamzah, Saksham Gupta, Kee B Park, Syed Ather Enam
{"title":"Infrastructural Barriers to the Neurosurgical Care of Brain Tumors in LMICs: A Systematic Review.","authors":"Muhammad Shakir, Aly Hamza Khowaja, Hammad Atif Irshad, Izza Tahir, Syeda Fatima Shariq, Ali I Rae, Radzi Hamzah, Saksham Gupta, Kee B Park, Syed Ather Enam","doi":"10.1016/j.wneu.2024.10.104","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.104","url":null,"abstract":"<p><strong>Background: </strong>Appropriate surgical infrastructure is important for improving patient outcomes. However, low- and middle-income countries (LMICs) often struggle to provide adequate brain tumor surgery due to fractured infrastructure. This study aims to identify and evaluate the barriers to surgical care infrastructure for brain tumors in LMICs.</p><p><strong>Method: </strong>A comprehensive literature search was conducted from inception to October 20, 2022, using PubMed, Scopus, CINAHL, and Google Scholar. Inclusion criteria were studies that focused on the surgical care of brain tumors in terms of infrastructure in low-resource settings. Studies were excluded if they did not focus on surgical care or were not conducted in LMIC. Data was extracted and analyzed qualitatively.</p><p><strong>Results: </strong>A final analysis of 39 studies showed significant barriers: 66% had poor operating room infrastructure, 32% lacked specialized care centers and imaging facilities, 26% faced long-distance travel issues, 13% had poor public health infrastructure, and 11% had poor referral pathways and lacked advanced diagnostic facilities. Additionally, 3% had an uneven distribution of quality centers and inadequate ward capacity. Proposed strategies include cross-border collaboration (29%), optimizing existing resources (29%), improving referral pathways (7%), resource sharing within hospitals, and acquiring surgical devices through donations (7%).</p><p><strong>Conclusion: </strong>The review highlights key barriers in infrastructure while providing effective neurosurgical care to brain tumors in LMICs. To overcome these challenges, targeted strategies need to be implemented by stakeholders, policymakers, and health ministries.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Subarachnoid Hemorrhage Due to Vertebral Artery Dissection Following Spontaneous Coronary Artery Dissection on the Same Day: A Clinical Image.","authors":"Ichiro Maeda, Taichiro Imahori, Shigeru Miyake","doi":"10.1016/j.wneu.2024.10.024","DOIUrl":"10.1016/j.wneu.2024.10.024","url":null,"abstract":"<p><p>A woman in her 60s with well-controlled dyslipidemia presented with anterior chest pain. The electrocardiogram, chest radiograph, and echocardiogram were unremarkable; however, cardiac enzymes levels were elevated. Coronary angiography performed after dual antiplatelet therapy revealed spontaneous coronary artery dissection (SCAD). On the same day, the patient complained of mild headache that was initially treated as migraine. Hours later, the patient reported severe headache, followed by a decline in consciousness. Computed tomography of the head showed subarachnoid hemorrhage, while the angiography revealed bilateral vertebral artery dissection. The ruptured right vertebral artery dissecting aneurysm was treated with coil embolization. Despite treatment, the patient died 7 days later. Autopsy confirmed dissections of the coronary and vertebral arteries. Although SCAD is rare, it often coexists with extracoronary vascular abnormalities due to systemic arterial fragility. Therefore, consider cerebrovascular disorders and promptly implementing diagnostic and management strategies in patients with SCAD and headaches is necessary.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helen Karimi, Nicholas Taylor, Jainith Patel, Liana Wiepert, Ron I Riesenburger, James Kryzanski
{"title":"Practice Pattern Variations in the Use of Neuromonitoring, Image Guidance, and Robotics for Lumbar Pedicle Screw Placement Based on a Nationwide Neurosurgery Survey.","authors":"Helen Karimi, Nicholas Taylor, Jainith Patel, Liana Wiepert, Ron I Riesenburger, James Kryzanski","doi":"10.1016/j.wneu.2024.10.017","DOIUrl":"10.1016/j.wneu.2024.10.017","url":null,"abstract":"<p><strong>Objective: </strong>Lumbar pedicle screw placement surgery involves various assistive technologies, including fluoroscopic, stereotactic, or robotic navigation and intraoperative neuromonitoring (IONM). We aimed to discern neurosurgeons' preferences for screw placement techniques and IONM utility, while also considering the influence of experience.</p><p><strong>Methods: </strong>A survey was distributed to members of the Congress of Neurological Surgeons using REDCap software, collecting demographic data and querying preferred techniques for screw placement and IONM modalities. Opinions on IONM use during stereotactic or robotic navigation were also obtained. Responses were analyzed using Pearson's Chi-square and analysis of variance tests via R software.</p><p><strong>Results: </strong>Of 188 responses, 35.5% (n = 67) reported 1-10 years of experience and 64.5% (n = 121) reported ≥ 11 years. Less experienced neurosurgeons used stereotactic navigation more than those with greater experience (P < 0.001). Seasoned neurosurgeons used fluoroscopic guidance more often (P = 0.038). Less experienced neurosurgeons employed 1.69 (± 0.11) techniques for their fixation surgeries compared to 1.50 (± 0.0.8) for more experienced neurosurgeons. Robotic navigation utilization was low and comparable between the groups. Surgeons employing multiple techniques used triggered electromyography the most (62.1%, P = 0.024). No strong opinions emerged on the necessity of multimodality IONM with robotic or stereotactic navigation.</p><p><strong>Conclusions: </strong>This national survey shows that stereotactic navigation is the predominant technique for pedicle screw placement among less experienced neurosurgeons, with seasoned neurosurgeons leaning toward fluoroscopic guidance. Robotic guidance was the least used technique with no observed difference based on experience. Neurosurgeons employing multiple techniques use IONM the most, compared with surgeons who only use stereotactic navigation and/or robotic guidance.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason M Frerich, Christopher F Dibble, Christine Park, Stephen M Bergin, C Rory Goodwin, Muhammad M Abd-El-Barr, Christopher I Shaffrey, Khoi D Than
{"title":"Proximal lumbar anterior column realignment for iatrogenic sagittal plane adult spinal deformity correction: a retrospective case series.","authors":"Jason M Frerich, Christopher F Dibble, Christine Park, Stephen M Bergin, C Rory Goodwin, Muhammad M Abd-El-Barr, Christopher I Shaffrey, Khoi D Than","doi":"10.1016/j.wneu.2024.10.109","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.109","url":null,"abstract":"<p><strong>Background and objectives: </strong>Anterior column realignment (ACR) is a powerful minimally invasive surgery (MIS) technique to restore sagittal alignment in adult spinal deformity (ASD). This can accomplish similar segmental lordosis restoration as 3-column osteotomy with less blood loss and comparable complication rates. ACR can be performed at adjacent disease segments in the proximal lumbar spine in revision cases. However, two-thirds of physiologic lordosis occurs between L4-S1, and concerns remain about altered lumbar morphology. We evaluated patients who underwent proximal lumbar ACR for iatrogenic flatback deformity.</p><p><strong>Methods: </strong>A total of 19 consecutive patients who underwent L1-2 or L2-3 ACR were retrospectively analyzed. All patients were treated with lateral MIS interbody technique, followed by posterior reconstruction with Smith-Peterson osteotomy (SPO). Pre- and post-operative radiographic and clinical outcomes were obtained.</p><p><strong>Results: </strong>Mean follow-up was 19-months. All but one patient had a history of prior lumbar or lumbo-sacral fusion. SVA and PI-LL decreased from 11.9 cm to 6.1 cm (p<0.0001) and 34.2° to 12.8° (p<0.0001). Segmental lordosis increased from -2.7° to 21.9° (p<0.0001). Proximal lumbar lordosis (PLL) increased from -0.4° to 22.6° (p<0.0001), and lordosis distribution index (LDI) decreased from 79.5% to 48.9% (p<0.0001). Mean ODI and NPRS back pain decreased from 58.0 to 36.2 (p=0.0041) and 7.9 to 3.4 (p<0.0001). PROMIS-10 Physical and Mental Health T-scores increased from 34.1 to 43.3 (p=0.0049) and 40.4 to 45.0 (p=0.0993). Major complication rate was 15.8%. One patient required revision for mechanical failure. There were no permanent neurological or vascular injuries.</p><p><strong>Conclusion: </strong>Proximal lumbar ACR plus SPO can achieve sagittal correction with low major complication rates in patients with ASD and prior distal fusion. Differentially increasing PLL and lowering LDI did not have deleterious effects on radiographic or clinical outcomes. Further work is needed to understand the effect of proximal ACR in the surgical management of ASD.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Basics of Artificial Intelligence with Applications in Healthcare and Neurosurgery.","authors":"John M Abrahams","doi":"10.1016/j.wneu.2024.10.105","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.105","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atsushi Kuwano, Manabu Tamura, Hidetsugu Asano, Tomoko Yamaguchi, Jose Gomez-Tames, Takakazu Kawamata, Ken Masamune, Yoshihiro Muragaki
{"title":"Visualizing intraoperative transcranial motor-evoked potentials during glioma surgery for predicting postoperative paralysis prognosis.","authors":"Atsushi Kuwano, Manabu Tamura, Hidetsugu Asano, Tomoko Yamaguchi, Jose Gomez-Tames, Takakazu Kawamata, Ken Masamune, Yoshihiro Muragaki","doi":"10.1016/j.wneu.2024.10.110","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.110","url":null,"abstract":"<p><strong>Purpose: </strong>The primary goals of glioma surgery are maximal tumor resection and preservation of brain function. Intraoperative motor-evoked potential (MEP) monitoring is commonly used to predict and minimize postoperative paralysis. However, studies on intraoperative MEP trends and postoperative paralysis are scarce. This study aimed to determine the relationship between intraoperative MEP trends and postoperative paralysis.</p><p><strong>Methods: </strong>This retrospective study evaluated 229 patients with supratentorial glioma without preoperative paralysis who underwent tumor resection surgery under general anesthesia at our institution between October 2019 and December 2022. Intraoperative transcranial MEP monitoring was performed, and the entire MEP trends on affected and unaffected sides was visualized. Postoperative paralysis and patient-related factors were analyzed.</p><p><strong>Results: </strong>Postoperative paralysis occurred in 36 patients, with the paralysis improving over time and being permanent in 30 and 6 patients, respectively. In the improvement group, the temporary decrease in transcranial MEP rapidly improved. Even when the MEPs were <50% of the control value, fluctuations indicating improvement were observed after the decrease. However, in the permanent paralysis group, transcranial MEP remained consistently <50% of the control value until the end of surgery, after its initial decrease. The significant factors contributing to permanent paralysis were tumor localization close to the pyramidal tract (p = 0.0304) and postoperative cerebral infarction in the pyramidal tract (p = 0.0009).</p><p><strong>Conclusions: </strong>The overall intraoperative MEP trend can reflect the risk of postoperative paralysis during glioma surgery. Thus, visualizing this trend can provide a better understanding of the prognosis of postoperative paralysis.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dylan Chiche, Luc Taillandier, Marie Blonski, Sophie Planel, Tiphaine Obara, René Anxionnat, Fabien Rech
{"title":"DTI analysis of the peritumoral zone of diffuse low-grade gliomas in progressing patients.","authors":"Dylan Chiche, Luc Taillandier, Marie Blonski, Sophie Planel, Tiphaine Obara, René Anxionnat, Fabien Rech","doi":"10.1016/j.wneu.2024.10.111","DOIUrl":"https://doi.org/10.1016/j.wneu.2024.10.111","url":null,"abstract":"<p><strong>Background: </strong>DLGGs are rare brain tumors transforming to higher grade even with surgery, chemotherapy and radiotherapy. Their preferential infiltration of WM tracts, beyond tumor boundaries on FLAIR, make difficult to plan focal treatment such as surgery, radiotherapy and monitor response to chemotherapy. DTI might reflect this infiltration of WM tracts. The aim of our study is to assess how DTI signal in the peritumoral zone might be modified before FLAIR tumor progression appears at one-year follow-up.</p><p><strong>Methods: </strong>The study retrospectively enrolled five patients who met inclusion criteria: DTI with 25 directions, T1 and FLAIR at initial imaging; FLAIR at one-year follow-up. Patients with surgery, radiotherapy and chemotherapy completed less than 2 years before initial imaging were excluded. FLAIR tumor progression, named progression mask, was assessed by subtracting tumor masks between initial imaging and one-year follow-up. Initial DTI signal was analyzed within this progression mask and compared with the healthy contralateral side.</p><p><strong>Results: </strong>Tumor progression was confirmed for the five patients at one year. All patients showed pre-existing DTI signal abnormalities within the progression mask. Mean FA (p = 0.03) was lower in the progression mask, whereas MD, AD and RD mean (p = 0.03) was higher in the progression mask, compared to healthy side.</p><p><strong>Conclusion: </strong>This study shows pre-existing DTI signal abnormalities in regions with tumor progression at one year. Such abnormalities could correspond to a tumor infiltration not yet visible on FLAIR. This might be helpful to predict tumor progression and allow to adapt the therapeutic strategy.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}