Wound Repair and Regeneration最新文献_第7页

The infected diabetic foot: Analysis of diabetic and non-diabetic foot infections. 糖尿病足感染：糖尿病足和非糖尿病足感染分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-01 DOI: 10.1111/wrr.13162

Lawrence A Lavery, Mehmet A Suludere, Easton Ryan, Peter A Crisologo, Arthur Tarricone, Matthew Malone, Orhan K Oz

{"title":"The infected diabetic foot: Analysis of diabetic and non-diabetic foot infections.","authors":"Lawrence A Lavery, Mehmet A Suludere, Easton Ryan, Peter A Crisologo, Arthur Tarricone, Matthew Malone, Orhan K Oz","doi":"10.1111/wrr.13162","DOIUrl":"10.1111/wrr.13162","url":null,"abstract":"The aim of this study was to compare outcomes of moderate and severe foot infections in people with and without diabetes mellitus (DM). We retrospectively evaluated 382 patients (77% with DM and 23% non-DM). We collected demographic data, co-morbidities and one-year outcomes including healing, surgical interventions, number of surgeries, length of stay, re-infection and re-hospitalisation. DM patients required more surgeries (2.3 ± 2.2 vs. 1.7 ± 1.3, p = 0.01), but did not have a longer hospital length of stay during the index hospitalisation (DM 10.9 days ±9.2 vs. non-DM = 8.8 days ±5.8, p = 0.43). After the index hospitalisation, DM patients had increased rates of re-hospitalisation for any reason (63.3% vs. 35.2%, CI 1.9-5.2, OR 3.2, p < 0.01), re-infection at the index wound infection site (48% vs. 30.7%, CI 1.3-3.5, OR 2.1, p < 0.01), re-hospitalisation for a foot pathology (47.3% vs. 29.5%, CI 1.3-3.6, OR 2.1, p < 0.01), and longer times to ulcer healing (151.8 days ±108.8 vs. 108.8 ± 90.6 days, p = 0.04). Patients with DM admitted to hospital with foot infections have worse clinical outcomes during the index hospitalisation and are more likely to have re-infection and re-admission to hospital in the next year.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"360-365"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of VEGF stimulation in diabetic foot ulcers: A systematic review. 刺激血管内皮生长因子对糖尿病足溃疡的影响：系统综述。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-17 DOI: 10.1111/wrr.13171

Frederik S Bang, Veronica Leeberg, Ming Ding, Chris H Dreyer

{"title":"The effect of VEGF stimulation in diabetic foot ulcers: A systematic review.","authors":"Frederik S Bang, Veronica Leeberg, Ming Ding, Chris H Dreyer","doi":"10.1111/wrr.13171","DOIUrl":"10.1111/wrr.13171","url":null,"abstract":"Diabetic foot ulcers are a common and severe complication of diabetes mellitus, and a risk factor for amputation. Because of the vessel insufficiency in diabetic foot ulcers (DFU), vascular endothelial growth factor (VEGF) that simulates angiogenesis is of interest to promote wound healing. This systematic review evaluates the last 16 years of in-vivo studies with VEGF stimulation as a treatment for DFU, developed based on the last published systematic article. A total of 961 articles were identified through databases in two phases. 947 articles were excluded by exclusion criteria, and four articles met our inclusion criteria and were included. The effects of VEGF on wound healing were analysed in all four studies. In three studies, the VEGF-treated wounds showed statistically faster healing than those not treated with VEGF. In one study, the VEGF-treated wounds revealed a positive trend toward faster healing. Furthermore, all four studies were in favor of using VEGF, but concluded that further research is needed. These studies showed a positive trend towards faster healing and was safe when using VEGF topically on humans. Furthermore, viral particles of VEGF seem to have a systematic effect when a dose exceeding 5.0 × 109 vp pr wound. Future research in using VEGF on DFU should focus on VEGF's relevant dosage, release rate, and specific mechanism. This review inspires further research, and a consistent study design is prerequisite such that results are more homogenic and comparable. Much effort is needed to translate the results into our clinical practice.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"384-392"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of open reduction and internal fixation of calcaneus fractures: A database study comparing patients with and without diabetes. 方骨骨折切开复位内固定术的疗效：对比糖尿病患者和非糖尿病患者的数据库研究。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-22 DOI: 10.1111/wrr.13169

Matthew J Johnson, Benjamin M Conover, Robert G Frykberg, Katherine M Raspovic, Lawrence A Lavery, Dane K Wukich

{"title":"Outcomes of open reduction and internal fixation of calcaneus fractures: A database study comparing patients with and without diabetes.","authors":"Matthew J Johnson, Benjamin M Conover, Robert G Frykberg, Katherine M Raspovic, Lawrence A Lavery, Dane K Wukich","doi":"10.1111/wrr.13169","DOIUrl":"10.1111/wrr.13169","url":null,"abstract":"Treatment of calcaneal fractures in patients with diabetes mellitus (DM) is challenging. The purpose of this study was to compare post-operative outcomes after open reduction and internal fixation (ORIF) for calcaneus fracture in patients with complicated DM, uncomplicated DM, and patients without DM. A commercially available de-identified database was queried for all calcaneus fracture diagnoses undergoing ORIF from 2010 to 2021. The patients were separated into three groups for analysis: patients without DM (10,951, 82.6%), uncomplicated DM (1,500, 11.3%) and complicated DM (802, 6.1%). At 1 year, post-operative adverse events were assessed among the three groups. The odds of adverse event(s) for each group were compared between the three groups with and without characteristic matching. In the unmatched cohorts, patients with complicated DM, when compared with patients without DM and patients with uncomplicated DM, had significantly higher rates of all adverse events with exception of DVT. Rates of CNA were significantly higher in patients with complicated DM compared with no DM (OR 107.7 (CI 24.83-467.6) p < 0.0001) and uncomplicated DM (OR 44.26 (CI 3.86-507.93) p = 0.0002). After matching, non-union, AKI, sepsis, surgical site infection, and wound disruption were higher in patients with complicated DM compared with patients without DM. There were no significant differences in the three groups with regard to reoperation, DVT, MI, pneumonia, or below the knee amputation. Patients with DM who underwent ORIF for calcaneus fracture experienced higher rates of post-operative adverse events compared with those patients without DM.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"437-444"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-based non-invasive assessment of suction blister wounds for clinical safety and efficacy. 基于图像的无创吸疱伤口临床安全性和有效性评估。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-21 DOI: 10.1111/wrr.13172

Karl Wallblom, Sigrid Lundgren, Karim Saleh, Artur Schmidtchen, Manoj Puthia

{"title":"Image-based non-invasive assessment of suction blister wounds for clinical safety and efficacy.","authors":"Karl Wallblom, Sigrid Lundgren, Karim Saleh, Artur Schmidtchen, Manoj Puthia","doi":"10.1111/wrr.13172","DOIUrl":"10.1111/wrr.13172","url":null,"abstract":"Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness. We employed this methodology on 16 suction blister wounds used as controls in a clinical phase-1 trial. Our method enabled us to discern and quantify subtle differences between individual wounds concerning healing progress, erythema and wound exudation. The wound healing score exhibited a high inter-rater agreement. There was a robust correlation between the spectrophotometer-measured erythema index and photography-based wound redness, as well as between dressing protein content and photography-based dressing yellowness. In conclusion, this study equips researchers conducting clinical wound studies with reproducible methods that may support future wound research and aid in the development of new treatments.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"343-359"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly. 基于天然多糖的低温凝胶伤口敷料可完美粘附在不规则的伤口上，实现快速止血和轻松拆卸。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-17 DOI: 10.1111/wrr.13173

Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang

{"title":"Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly.","authors":"Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang","doi":"10.1111/wrr.13173","DOIUrl":"10.1111/wrr.13173","url":null,"abstract":"Skin injuries can have unexpected surfaces, leading to uneven wound surfaces and inadequate dressing contact with these irregular surfaces. This can decrease the dressing's haemostatic action and increase the healing period. This study recommends the use of sticky and flexible cryogel coverings to promote faster haemostasis and efficiently handle uneven skin wounds. Alginate cryogels have a fast haemostatic effect and shape flexibility due to their macroporous structure. The material demonstrates potent antibacterial characteristics and enhances skin adherence by adding grafted chitosan with gallic acid. In irregular defect wound models, cryogels can cling closely to uneven damage surfaces due to their amorphous nature. Furthermore, their macroporous structure allows for quick haemostasis by quickly absorbing blood and wound exudate. After giving the dressing a thorough rinse, its adhesive strength reduces and it is simple to remove without causing any damage to the wound. Cryogel demonstrated faster haemostasis than gauze in a wound model on a rat tail, indicating that it has considerable potential for use as a wound dressing in the biomedical area.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"393-406"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway. 多奈哌齐通过激活 HIF-1α/VEGF 信号通路促进皮瓣存活。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-29 DOI: 10.1111/wrr.13176

Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Lin

{"title":"Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway.","authors":"Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Lin","doi":"10.1111/wrr.13176","DOIUrl":"10.1111/wrr.13176","url":null,"abstract":"Flaps are mainly used to repair wounds in the clinical setting but can sometimes experience ischaemic necrosis postoperatively. This study investigated whether donepezil, an acetylcholinesterase inhibitor, can enhance the survival rate of flaps. We randomly allocated 36 rats into control, low-dose (3 mg/kg/day), and high-dose (5 mg/kg/day) groups. On Postoperative day 7, we assessed flap viability and calculated the mean area of viable flap. After euthanizing the rats, we employed immunological and molecular biology techniques to examine the changes in flap tissue vascularization, apoptosis, autophagy, and inflammation. Donepezil enhanced the expression of hypoxia-inducible factor and vascular endothelial growth factor to facilitate angiogenesis. In addition, it elevated the expression of LC3B, p62, and beclin to stimulate autophagy. Furthermore, it increased the expression of Bcl-2 while reducing the expression of Bax, thus inhibiting apoptosis. Finally, it had anti-inflammatory effects by reducing the levels of IL-1β, IL-6, and TNF-α. The results suggest that donepezil can enhance the viability of randomly generated skin flaps by upregulating HIF-1α/VEGF signalling pathway, facilitating vascularization, inducing autophagy, suppressing cell apoptosis, and mitigating inflammation within the flap tissue.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"500-510"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in inpatient burden from pressure injuries in the United States: Cross-sectional study National Inpatient Sample 2009-2019. 美国压伤住院病人负担趋势：2009-2019年全国住院病人抽样横断面研究。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI: 10.1111/wrr.13182

Siri Choragudi, Luis F Andrade, Narges Maskan Bermudez, Olivia Burke, Brianna Christina Sa, Robert S Kirsner

{"title":"Trends in inpatient burden from pressure injuries in the United States: Cross-sectional study National Inpatient Sample 2009-2019.","authors":"Siri Choragudi, Luis F Andrade, Narges Maskan Bermudez, Olivia Burke, Brianna Christina Sa, Robert S Kirsner","doi":"10.1111/wrr.13182","DOIUrl":"10.1111/wrr.13182","url":null,"abstract":"Pressure injuries are a significant comorbidity and lead to increased overall healthcare costs. Several European and global studies have assessed the burden of pressure injuries; however, no comprehensive analysis has been completed in the United States. In this study, we investigated the trends in the burden of pressure injuries among hospitalised adults in the United States from 2009 to 2019, stratified by sociodemographic subgroups. The length of admission, total cost of hospitalisation, and sociodemographic data was extracted from the National Inpatient Sample provided by the Healthcare Cost and Utilisation Project, Agency for Healthcare Research and Quality. Overall, the annual prevalence of pressure injuries and annual mean hospitalisation cost increased ($69,499.29 to $102,939.14), while annual mean length of stay decreased (11.14-9.90 days). Among all races, minority groups had higher average cost and length of hospitalisation. Our findings suggest that while the length of hospitalisation is decreasing, hospital costs and prevalence are rising. In addition, differing trends among racial groups exist with decreasing prevalence in White patients. Further studies and targeted interventions are needed to address these differences, as well as discrepancies in racial groups.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"487-499"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

53rd Annual Meeting of the Japanese Society for Wound Healing. 第 53 届日本伤口愈合学会年会。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 DOI: 10.1111/wrr.13183

引用次数: 0

2024 WHS Abstract Session List Key. 2024 年世界卫生大会摘要会议列表密钥。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 DOI: 10.1111/wrr.13166

引用次数: 0

The proliferative effects of stem cells from apical papilla-conditioned medium on rat corneal endothelial cells. 顶端乳头调节培养基中的干细胞对大鼠角膜内皮细胞的增殖作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2024-02-28 DOI: 10.1111/wrr.13161

Kimia Rahimiyan, Mohammad Hossein Nasr Esfahani, Fereshteh Karamali

{"title":"The proliferative effects of stem cells from apical papilla-conditioned medium on rat corneal endothelial cells.","authors":"Kimia Rahimiyan, Mohammad Hossein Nasr Esfahani, Fereshteh Karamali","doi":"10.1111/wrr.13161","DOIUrl":"10.1111/wrr.13161","url":null,"abstract":"The cornea, positioned at the forefront of the eye, refracts the light for focusing images on the retina. Damage to this transparent structure can lead to various visual disorders. The corneal endothelial cells (CECs) are crucial for transparency and homeostasis, but lack the ability to reproduce. Significant damage results in structure destruction and vision impairment. While extensive research has aimed at the restoring the corneal endothelial layer, including endothelial proliferation for functional monolayers remains challenging. Our previous studies confirmed the proliferative activity of stem cells from apical papilla-conditioned medium (SCAP-CM) on the retinal pigmented epithelium as a single cell layer. This study investigates how SCAP-CM influences the proliferation and migration of CECs. Our results introduced Matrigel, as a new matrix component for in vitro culture of CECs. Moreover, 60% of SCAP-CM was able to stimulate CEC proliferation as well as migrate to repair wound healing during 24 h. Confluent CECs also expressed specific markers, ATP1a1, ZO-1 and CD56, indicative of CEC characteristics, aligning with the recapitulation of differentiation when forming a homogenous monolayer at the same level of isolated CECs without in vitro culture. These findings suggested that SCAP-CM administration could be useful for future preclinical and clinical applications.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"292-300"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0