Wound Repair and Regeneration最新文献_第6页

A pro-reparative bioelectronic device for controlled delivery of ions and biomolecules. 用于控制离子和生物分子输送的生物电子设备。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-05-25 DOI: 10.1111/wrr.13191

Narges Asefifeyzabadi, Tiffany Nguyen, Houpu Li, Kan Zhu, Hsin-Ya Yang, Prabhat Baniya, Andrea Medina Lopez, Anthony Gallegos, Hao-Chieh Hsieh, Harika Dechiraju, Cristian Hernandez, Kaelan Schorger, Cynthia Recendez, Maryam Tebyani, John Selberg, Le Luo, Elana Muzzy, Cathleen Hsieh, Alexie Barbee, Jonathan Orozco, Moyasar A Alhamo, Michael Levin, Elham Aslankoohi, Marcella Gomez, Min Zhao, Mircea Teodorescu, Roslyn Rivkah Isseroff, Marco Rolandi

{"title":"A pro-reparative bioelectronic device for controlled delivery of ions and biomolecules.","authors":"Narges Asefifeyzabadi, Tiffany Nguyen, Houpu Li, Kan Zhu, Hsin-Ya Yang, Prabhat Baniya, Andrea Medina Lopez, Anthony Gallegos, Hao-Chieh Hsieh, Harika Dechiraju, Cristian Hernandez, Kaelan Schorger, Cynthia Recendez, Maryam Tebyani, John Selberg, Le Luo, Elana Muzzy, Cathleen Hsieh, Alexie Barbee, Jonathan Orozco, Moyasar A Alhamo, Michael Levin, Elham Aslankoohi, Marcella Gomez, Min Zhao, Mircea Teodorescu, Roslyn Rivkah Isseroff, Marco Rolandi","doi":"10.1111/wrr.13191","DOIUrl":"10.1111/wrr.13191","url":null,"abstract":"Wound healing is a complex physiological process that requires precise control and modulation of many parameters. Therapeutic ion and biomolecule delivery has the capability to regulate the wound healing process beneficially. However, achieving controlled delivery through a compact device with the ability to deliver multiple therapeutic species can be a challenge. Bioelectronic devices have emerged as a promising approach for therapeutic delivery. Here, we present a pro-reparative bioelectronic device designed to deliver ions and biomolecules for wound healing applications. The device incorporates ion pumps for the targeted delivery of H+ and zolmitriptan to the wound site. In vivo studies using a mouse model further validated the device's potential for modulating the wound environment via H+ delivery that decreased M1/M2 macrophage ratios. Overall, this bioelectronic ion pump demonstrates potential for accelerating wound healing via targeted and controlled delivery of therapeutic agents to wounds. Continued optimization and development of this device could not only lead to significant advancements in tissue repair and wound healing strategies but also reveal new physiological information about the dynamic wound environment.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"709-719"},"PeriodicalIF":3.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the role of dermal sheath cells in wound healing and fibrosis. 探索真皮鞘细胞在伤口愈合和纤维化中的作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.1111/wrr.13206

Bing Zhu, Lu Liang, Lihua Hui, Yaojun Lu

引用次数: 0

Expression of Concern: The Effects of Zinc Supplementation on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: A Randomized, Double-blind, Placebo-controlled Trial. 表达关注：补锌对糖尿病足溃疡患者伤口愈合和代谢状态的影响：随机、双盲、安慰剂对照试验。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI: 10.1111/wrr.13214

引用次数: 0

Placenta-derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks. 胎盘间充质干细胞通过外泌体蛋白相互作用网络促进糖尿病伤口愈合

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1111/wrr.13199

Cheng Peng, Hongbo Xu, Quan Zhuang, Jinya Liu, Yinhe Ding, Qiyu Tang, Zheng Wang, Kai Yao

{"title":"Placenta-derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks.","authors":"Cheng Peng, Hongbo Xu, Quan Zhuang, Jinya Liu, Yinhe Ding, Qiyu Tang, Zheng Wang, Kai Yao","doi":"10.1111/wrr.13199","DOIUrl":"10.1111/wrr.13199","url":null,"abstract":"There is a lack of effective treatment options for diabetic refractory wounds, which presents a critical clinical issue that needs to be addressed urgently. Our research has demonstrated that human placenta-derived mesenchymal stem cells (plaMSCs) facilitate the migration and proliferation of HaCat cells, thereby enhancing diabetic wound healing primarily via the exosomes derived from plaMSCs (plaMSCs-Ex). Using label-free proteomics, plaMSCs and their exosomes were analysed for proteome taxonomic content in order to explore the underlying effective components mechanism of plaMSCs-Ex in diabetic wound healing. Differentially expressed proteins enriched in plaMSCs-Ex were identified and underwent bioinformatics analysis including GO annotation, KEGG pathway enrichment, gene set enrichment analysis (GSEA) and protein-protein interaction analysis (PPI). Results showed that the proteins enriched in plaMSCs-Ex are significantly involved in extracellular matrix organisation, epithelium morphogenesis, cell growth, adhesion, proliferation and angiogenesis. PPI analysis filtered 2 wound healing-related clusters characterised by hub proteins such as POSTN, FN1, SPARC, TIMP1, SERPINE1, LRP1 and multiple collagens. In brief, the exosomal proteins derived from plaMSCs reveal diverse functions of regeneration and tissue remodelling based on proteomics analysis and potentially play a role in diabetic wound healing.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"638-651"},"PeriodicalIF":3.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone lactylation regulates autophagy of hyperplastic scar fibroblasts by inhibiting the transcriptional activity of phosphatase and tensin homologue. 组蛋白乳酰化通过抑制磷酸酶和天丝同源物的转录活性调节增生瘢痕成纤维细胞的自噬。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-05-19 DOI: 10.1111/wrr.13188

Xiaosong Liu, Biao Wang

{"title":"Histone lactylation regulates autophagy of hyperplastic scar fibroblasts by inhibiting the transcriptional activity of phosphatase and tensin homologue.","authors":"Xiaosong Liu, Biao Wang","doi":"10.1111/wrr.13188","DOIUrl":"10.1111/wrr.13188","url":null,"abstract":"Hyperplastic scar (HS) is an overreaction of tissue to skin injury caused by local fibroblast proliferation and excessive collagen production. Histone posttranslational modification patterns are important epigenetic processes that control various biological activities. This study was designed to investigate the effects of histone lactylation on HS and the underlying mechanism. Western blot was used to analyse the lactylation level in HS patients and fibroblasts (HSFs). In vitro experiments, western blot, cell counting kit-8, and immunofluorescence staining were performed to detect the collagen level, cell viability, and autophagy, respectively. The relationship between snai2 (SLUG) and phosphatase and tensin homologue (PTEN) was assessed by RNA immunoprecipitation and dual-luciferase reporter assays. The results showed that the histone lactylation level was upregulated in HS tissues and HSFs. HSFs showed increased collagen production and cell viability, and decreased autophagy. Silencing of lactate dehydrogenase A (LDHA) promoted the transcription of PTEN by inhibiting SLUG, thus promoting autophagy. Knockdown of LDHA inhibited collagen deposition and cell viability, and increased autophagy in HSFs, and the results were reversed after PTEN inhibition. In summary, histone lactylation inhibited the transcription activity of PTEN by promoting SLUG, thereby suppressing autophagy and promoting collagen deposition and cell viability of HSFs, which might provide effective therapeutic strategies in HS.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"725-734"},"PeriodicalIF":3.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin fibrosis is accompanied by increased expression of secreted frizzled-related protein-2. 皮肤纤维化伴随着分泌型皱纹相关蛋白-2 的表达增加。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI: 10.1111/wrr.13211

David M Dolivo, Adrian E Rodrigues, Lauren S Sun, Thomas A Mustoe, Seok Jong Hong, Robert D Galiano

引用次数: 0

The effect of anatomic location on porcine models of burn injury and wound healing. 解剖位置对猪烧伤和伤口愈合模型的影响。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-05-22 DOI: 10.1111/wrr.13190

Aiping Liu, J Z Alex Cheong, Sameeha Hassan, Matthew B Wielgat, Jennifer J Meudt, Elizabeth Catherine Townsend, Dhanansayan Shanmuganayagam, Lindsay R Kalan, Angela Gibson

{"title":"The effect of anatomic location on porcine models of burn injury and wound healing.","authors":"Aiping Liu, J Z Alex Cheong, Sameeha Hassan, Matthew B Wielgat, Jennifer J Meudt, Elizabeth Catherine Townsend, Dhanansayan Shanmuganayagam, Lindsay R Kalan, Angela Gibson","doi":"10.1111/wrr.13190","DOIUrl":"10.1111/wrr.13190","url":null,"abstract":"Porcine models are frequently used for burn healing studies; however, factors including anatomic location and lack of standardised wound methods can impact the interpretation of wound data. The objectives of this study are to examine the influence of anatomical locations on the uniformity of burn creation and healing in porcine burn models. To optimise burn parameters on dorsal and ventral surfaces, ex vivo and in situ euthanized animals were first used to examine the location-dependence of the burn depth and contact time relationship. The location-dependent healing in vivo was then examined using burn and excisional wounds at dorsal, ventral, caudal and cranial locations. Lactate dehydrogenase (LDH) and H&E were used to assess burn depth and wound re-epithelialization. We found that burn depth on the ventral skin was significantly deeper than that of the dorsal skin at identical thermal conditions. Compared with burns created ex vivo, burns created in situ immediately post-mortem were significantly deeper in the ventral location. In live animals, 2 out of 12 burn wounds were fully re-epithelialized after 14 days in contrast to complete re-epithelialization of all excisional wounds. Among the burn wounds, those at the cranial-dorsal site exhibited faster healing than at the caudal-dorsal site. This study showed that anatomical location is an important consideration for the consistency of burn depth creation and healing. These data support symmetric localization of treatment and control for comparative assessment of burn healing in porcine models to prevent misinterpretation of results and increase the translatability of findings to humans.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"675-685"},"PeriodicalIF":3.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of systematic reviews of clinical studies of platelet-rich plasma for venous ulcers. 富血小板血浆治疗静脉溃疡临床研究系统综述。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1111/wrr.13201

Tianbo Shi, Shouci Hu, Jing Hui, Yue Ji, Yalan Zhang

引用次数: 0

Self-improving dystrophic epidermolysis bullosa with a novel heterozygous missense variant in the COL7A1 gene in a Taiwanese family. 台湾一个家族中COL7A1基因的新型杂合子错义变异导致的自发性萎缩性表皮松解症。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-02-28 DOI: 10.1111/wrr.13159

Yi-Chia Tsai, Wei-Ting Tu, Chun-Lin Su, Yu-Wen Cheng, Pei-Ling Chi, Chao-Kai Hsu, Yang-Yi Chen

引用次数: 0

MRSA infection, re-infection and clinical outcomes in diabetic foot infections. 糖尿病足感染中的 MRSA 感染、再感染和临床结果。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-02-28 DOI: 10.1111/wrr.13164

Mehmet A Suludere, Orhan K Öz, Lee C Rogers, Dane K Wukich, Matthew Malone, Lawrence A Lavery

{"title":"MRSA infection, re-infection and clinical outcomes in diabetic foot infections.","authors":"Mehmet A Suludere, Orhan K Öz, Lee C Rogers, Dane K Wukich, Matthew Malone, Lawrence A Lavery","doi":"10.1111/wrr.13164","DOIUrl":"10.1111/wrr.13164","url":null,"abstract":"The aim was to investigate methicillin-resistant Staphylococcus aureus (MRSA) incidence, conversion and outcomes in diabetic foot infections (DFIs). This is a pooled patient-level analysis of combined data sets from two randomised clinical trials including 219 patients admitted to the hospital with moderate or severe DFIs. Intraoperative bone and tissue cultures identified bacterial pathogens. We identified pathogens at index infections and subsequent re-infections. We identified MRSA conversion (MSSA to MRSA) in re-infections. MRSA incidence in index infections was 10.5%, with no difference between soft tissue infections (STIs) and osteomyelitis (OM). MRSA conversion occurred in 7.7% of the re-infections in patients who initially had MSSA in their cultures. Patients with re-infection were 2.2 times more likely to have MRSA compared to the first infection (10.5% vs. 25.8%, relative risk [RR] = 2.2, p = 0.001). Patients with MRSA had longer antibiotic treatment during the 1-year follow-up, compared to other pathogens (other 49.8 ± 34.7 days, MRSA 65.3 ± 41.5 days, p = 0.04). Furthermore, there were no differences in healing, time to heal, length of stay, re-infection, amputation, re-ulceration, re-admission, surgery after discharge and amputation after discharge compared to other pathogens. The incidence of MRSA at the index was 10.5% with no difference in STI and OM. MRSA incidence was 25.8% in re-infections. The RR of having MRSA was 2.2 times higher in re-infections. Patients with MRSA used more antibiotics during the 1-year follow-up. Furthermore, there were no differences in clinical outcomes compared to other bacterial pathogens.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"377-383"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0