Wound Repair and Regeneration最新文献_第6页

Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly. 基于天然多糖的低温凝胶伤口敷料可完美粘附在不规则的伤口上，实现快速止血和轻松拆卸。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-17 DOI: 10.1111/wrr.13173

Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang

{"title":"Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly.","authors":"Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang","doi":"10.1111/wrr.13173","DOIUrl":"10.1111/wrr.13173","url":null,"abstract":"Skin injuries can have unexpected surfaces, leading to uneven wound surfaces and inadequate dressing contact with these irregular surfaces. This can decrease the dressing's haemostatic action and increase the healing period. This study recommends the use of sticky and flexible cryogel coverings to promote faster haemostasis and efficiently handle uneven skin wounds. Alginate cryogels have a fast haemostatic effect and shape flexibility due to their macroporous structure. The material demonstrates potent antibacterial characteristics and enhances skin adherence by adding grafted chitosan with gallic acid. In irregular defect wound models, cryogels can cling closely to uneven damage surfaces due to their amorphous nature. Furthermore, their macroporous structure allows for quick haemostasis by quickly absorbing blood and wound exudate. After giving the dressing a thorough rinse, its adhesive strength reduces and it is simple to remove without causing any damage to the wound. Cryogel demonstrated faster haemostasis than gauze in a wound model on a rat tail, indicating that it has considerable potential for use as a wound dressing in the biomedical area.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"393-406"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway. 多奈哌齐通过激活 HIF-1α/VEGF 信号通路促进皮瓣存活。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-29 DOI: 10.1111/wrr.13176

Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Lin

{"title":"Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway.","authors":"Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Lin","doi":"10.1111/wrr.13176","DOIUrl":"10.1111/wrr.13176","url":null,"abstract":"Flaps are mainly used to repair wounds in the clinical setting but can sometimes experience ischaemic necrosis postoperatively. This study investigated whether donepezil, an acetylcholinesterase inhibitor, can enhance the survival rate of flaps. We randomly allocated 36 rats into control, low-dose (3 mg/kg/day), and high-dose (5 mg/kg/day) groups. On Postoperative day 7, we assessed flap viability and calculated the mean area of viable flap. After euthanizing the rats, we employed immunological and molecular biology techniques to examine the changes in flap tissue vascularization, apoptosis, autophagy, and inflammation. Donepezil enhanced the expression of hypoxia-inducible factor and vascular endothelial growth factor to facilitate angiogenesis. In addition, it elevated the expression of LC3B, p62, and beclin to stimulate autophagy. Furthermore, it increased the expression of Bcl-2 while reducing the expression of Bax, thus inhibiting apoptosis. Finally, it had anti-inflammatory effects by reducing the levels of IL-1β, IL-6, and TNF-α. The results suggest that donepezil can enhance the viability of randomly generated skin flaps by upregulating HIF-1α/VEGF signalling pathway, facilitating vascularization, inducing autophagy, suppressing cell apoptosis, and mitigating inflammation within the flap tissue.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"500-510"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in inpatient burden from pressure injuries in the United States: Cross-sectional study National Inpatient Sample 2009-2019. 美国压伤住院病人负担趋势：2009-2019年全国住院病人抽样横断面研究。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI: 10.1111/wrr.13182

Siri Choragudi, Luis F Andrade, Narges Maskan Bermudez, Olivia Burke, Brianna Christina Sa, Robert S Kirsner

{"title":"Trends in inpatient burden from pressure injuries in the United States: Cross-sectional study National Inpatient Sample 2009-2019.","authors":"Siri Choragudi, Luis F Andrade, Narges Maskan Bermudez, Olivia Burke, Brianna Christina Sa, Robert S Kirsner","doi":"10.1111/wrr.13182","DOIUrl":"10.1111/wrr.13182","url":null,"abstract":"Pressure injuries are a significant comorbidity and lead to increased overall healthcare costs. Several European and global studies have assessed the burden of pressure injuries; however, no comprehensive analysis has been completed in the United States. In this study, we investigated the trends in the burden of pressure injuries among hospitalised adults in the United States from 2009 to 2019, stratified by sociodemographic subgroups. The length of admission, total cost of hospitalisation, and sociodemographic data was extracted from the National Inpatient Sample provided by the Healthcare Cost and Utilisation Project, Agency for Healthcare Research and Quality. Overall, the annual prevalence of pressure injuries and annual mean hospitalisation cost increased ($69,499.29 to $102,939.14), while annual mean length of stay decreased (11.14-9.90 days). Among all races, minority groups had higher average cost and length of hospitalisation. Our findings suggest that while the length of hospitalisation is decreasing, hospital costs and prevalence are rising. In addition, differing trends among racial groups exist with decreasing prevalence in White patients. Further studies and targeted interventions are needed to address these differences, as well as discrepancies in racial groups.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"487-499"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

53rd Annual Meeting of the Japanese Society for Wound Healing. 第 53 届日本伤口愈合学会年会。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 DOI: 10.1111/wrr.13183

引用次数: 0

2024 WHS Abstract Session List Key. 2024 年世界卫生大会摘要会议列表密钥。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-07-01 DOI: 10.1111/wrr.13166

引用次数: 0

The proliferative effects of stem cells from apical papilla-conditioned medium on rat corneal endothelial cells. 顶端乳头调节培养基中的干细胞对大鼠角膜内皮细胞的增殖作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2024-02-28 DOI: 10.1111/wrr.13161

Kimia Rahimiyan, Mohammad Hossein Nasr Esfahani, Fereshteh Karamali

{"title":"The proliferative effects of stem cells from apical papilla-conditioned medium on rat corneal endothelial cells.","authors":"Kimia Rahimiyan, Mohammad Hossein Nasr Esfahani, Fereshteh Karamali","doi":"10.1111/wrr.13161","DOIUrl":"10.1111/wrr.13161","url":null,"abstract":"The cornea, positioned at the forefront of the eye, refracts the light for focusing images on the retina. Damage to this transparent structure can lead to various visual disorders. The corneal endothelial cells (CECs) are crucial for transparency and homeostasis, but lack the ability to reproduce. Significant damage results in structure destruction and vision impairment. While extensive research has aimed at the restoring the corneal endothelial layer, including endothelial proliferation for functional monolayers remains challenging. Our previous studies confirmed the proliferative activity of stem cells from apical papilla-conditioned medium (SCAP-CM) on the retinal pigmented epithelium as a single cell layer. This study investigates how SCAP-CM influences the proliferation and migration of CECs. Our results introduced Matrigel, as a new matrix component for in vitro culture of CECs. Moreover, 60% of SCAP-CM was able to stimulate CEC proliferation as well as migrate to repair wound healing during 24 h. Confluent CECs also expressed specific markers, ATP1a1, ZO-1 and CD56, indicative of CEC characteristics, aligning with the recapitulation of differentiation when forming a homogenous monolayer at the same level of isolated CECs without in vitro culture. These findings suggested that SCAP-CM administration could be useful for future preclinical and clinical applications.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"292-300"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of the usability and durability of 3D printed versus standard suture materials. 评估 3D 打印与标准缝合材料的可用性和耐用性。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2024-03-27 DOI: 10.1111/wrr.13175

Thang T Nguyen, Jason G Langenfeld, Benjamin C Reinhart, Elizabeth I Lyden, Abraham S Campos, Michael C Wadman, Matthew R Jamison, Stephen A Morin, Aaron N Barksdale

{"title":"An evaluation of the usability and durability of 3D printed versus standard suture materials.","authors":"Thang T Nguyen, Jason G Langenfeld, Benjamin C Reinhart, Elizabeth I Lyden, Abraham S Campos, Michael C Wadman, Matthew R Jamison, Stephen A Morin, Aaron N Barksdale","doi":"10.1111/wrr.13175","DOIUrl":"10.1111/wrr.13175","url":null,"abstract":"The capability to produce suture material using three-dimensional (3D) printing technology may have applications in remote health facilities where rapid restocking of supplies is not an option. This is a feasibility study evaluating the usability of 3D-printed sutures in the repair of a laceration wound when compared with standard suture material. The 3D-printed suture material was manufactured using a fused deposition modelling 3D printer and nylon 3D printing filament. Study participants were tasked with performing laceration repairs on the pigs' feet, first with 3-0 WeGo nylon suture material, followed by the 3D-printed nylon suture material. Twenty-six participants were enrolled in the study. Survey data demonstrated statistical significance with how well the 3D suture material performed with knot tying, 8.9 versus 7.5 (p = 0.0018). Statistical significance was observed in the 3D-printed suture's ultimate tensile strength when compared to the 3-0 Novafil suture (274.8 vs. 199.8 MPa, p = 0.0096). The 3D-printed suture also demonstrated statistical significance in ultimate extension when compared to commercial 3-0 WeGo nylon suture (49% vs. 37%, p = 0.0215). This study was successful in using 3D printing technology to manufacture suture material and provided insight into its usability when compared to standard suture material.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"229-233"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed electrospun fibres for wound healing. 3D打印的用于伤口愈合的电纺纤维。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2023-10-10 DOI: 10.1111/wrr.13119

Xilin Ye, Enshuo Zhang, Yaqin Huang, Feng Tian, Jiajia Xue

引用次数: 0

Film-forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the Wnt/β-catenin pathway. 含有胆固醇肉豆蔻酸酯和小檗碱的成膜聚合物溶液通过 Wnt/β-catenin 通路介导褥疮修复。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI: 10.1111/wrr.13158

Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li

{"title":"Film-forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the Wnt/β-catenin pathway.","authors":"Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li","doi":"10.1111/wrr.13158","DOIUrl":"10.1111/wrr.13158","url":null,"abstract":"Pressure ulcer (PU) is a worldwide problem that is difficult to address because of the related inflammatory response, local hypoxia, and repeated ischaemia/reperfusion, causing great suffering and financial burden to patients. Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with berberine (BBR), with anti-inflammatory and antibacterial effects, as a drug and used hydroxypropyl methylcellulose and polyvinylpyrrolidone K30 as carriers to construct a novel film-forming polymeric solution (S8 + BBR FFPS), comprehensively study its reparative effect on PU and explore the potential mechanism in rat PU models. The results showed that S8 + BBR FFPS inhibits excessive inflammatory response, promotes re-epithelialization, and promotes hair follicle growth during the healing process of PU, which may be related to the activation of the Wnt/β-catenin signalling pathway by S8 + BBR FFPS to mediate hair follicle stem cell proliferation and maintain skin homeostasis. Therefore, S8 + BBR FFPS may be a potential candidate for the treatment of chronic skin injury, and its association with the Wnt/β-catenin signalling pathway may provide new ideas to guide the design of biomaterial-based wound dressings for chronic wound repair.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"279-291"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human keratin matrices promote wound healing by modulating skin cell expression of cytokines and growth factors. 人类角蛋白基质通过调节皮肤细胞对细胞因子和生长因子的表达，促进伤口愈合。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-05-01 Epub Date: 2024-01-02 DOI: 10.1111/wrr.13137

Allison N Ramey-Ward, Howard P Walthall, Shakesia Smith, Thomas H Barrows

{"title":"Human keratin matrices promote wound healing by modulating skin cell expression of cytokines and growth factors.","authors":"Allison N Ramey-Ward, Howard P Walthall, Shakesia Smith, Thomas H Barrows","doi":"10.1111/wrr.13137","DOIUrl":"10.1111/wrr.13137","url":null,"abstract":"A wide variety of biomaterials has been developed to assist in wound healing, including acellular animal and human-derived protein matrices. However, millions of patients worldwide still suffer from non-healing chronic wounds, demonstrating a need for further innovation in wound care. To address this need, a novel biomaterial, the human keratin matrix (HKM), was developed, characterised, and tested in vitro and in vivo. HKM was found to be degradation-resistant, and a proteomics analysis showed it to be greater than 99% human keratin proteins. PCR revealed adult human epidermal keratinocytes (HEKa) grown in contact with HKM showed increased gene expression of keratinocyte activations markers such as Epidermal Growth Factor (EGF). Additionally, a cytokine microarray demonstrated culture on HKM increased the release of cytokines involved in wound inflammatory modulation by both HEKa cells and adult human dermal fibroblasts (HDFa). Finally, in a murine chronic wound model, full-thickness wounds treated weekly with HKM were smaller through the healing process than those treated with human amniotic membrane (AM), bovine dermis (BD), or porcine decellularized small intestinal submucosa (SIS). HKM-treated wounds also closed significantly faster than AM- and SIS-treated wounds. These data suggest that HKM is an effective novel treatment for chronic wounds.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"257-267"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0