Wound Repair and Regeneration最新文献

Effectiveness of Photobiomodulation and Exercise-Based Rehabilitation on Pain and Functional Recovery in Patients With Rotator Cuff Pathology. 光生物调节和运动康复对肩袖病变患者疼痛和功能恢复的效果。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70043

G Arun Maiya, Anupama Harihar, Grace Maria Joseph, Esha Arora, Praveen Arany, Rene Jean Bensadoun, Nicolette Nadene Houreld, Liisa Laakso

{"title":"Effectiveness of Photobiomodulation and Exercise-Based Rehabilitation on Pain and Functional Recovery in Patients With Rotator Cuff Pathology.","authors":"G Arun Maiya, Anupama Harihar, Grace Maria Joseph, Esha Arora, Praveen Arany, Rene Jean Bensadoun, Nicolette Nadene Houreld, Liisa Laakso","doi":"10.1111/wrr.70043","DOIUrl":"https://doi.org/10.1111/wrr.70043","url":null,"abstract":"Rotator cuff (RC) pathology encompasses a wide range of conditions, which include bursitis, tendinitis, tendinosis, partial thickness tears and full-thickness tears. To treat painful musculoskeletal problems, low-level laser therapy (LLLT) has been employed as a non-pharmacological alternative. Photobiomodulation (PBM), which uses light-emitting diodes (LEDs) and other photo-emitting devices, is a minimally invasive approach used to treat a wide range of conditions. The purpose of this pre-post study design is to evaluate the effectiveness of PBM and exercise-based rehabilitation on pain and functional recovery in patients with RC pathology. Twenty of the thirty-seven patients who were tested for shoulder disorders and found to have RC pathology were included in the study. The patients' pain levels were measured using the Numerical Pain Rating Scale (NPRS) both at baseline and 6 weeks later. The mean ± standard deviation of NPRS was calculated, data was checked for normal distribution, and the Wilcoxon rank test was conducted to compare the values. Our study showed a statistically significant reduction in pain scores from baseline (7.33 ± 0.79) to 6 weeks (2.50 ± 0.69), p < 0.001 of PBM and exercise-based rehabilitation. The knowledge about the evidence regarding the effectiveness of PBM, along with exercise-based rehabilitation, is critical.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70043"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturally Derived Biomaterial-Based Microneedles With Microenvironment-Response Potential for Diabetic Wound Healing. 具有微环境反应潜力的天然生物材料微针用于糖尿病伤口愈合。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70049

Xu Gong, Zong-Lin Li, Rui-Peng Cai, Zhen Xiang, Yan-Bin Peng, Yan Chen, Ornella Parolini, Yong-Can Huang

{"title":"Naturally Derived Biomaterial-Based Microneedles With Microenvironment-Response Potential for Diabetic Wound Healing.","authors":"Xu Gong, Zong-Lin Li, Rui-Peng Cai, Zhen Xiang, Yan-Bin Peng, Yan Chen, Ornella Parolini, Yong-Can Huang","doi":"10.1111/wrr.70049","DOIUrl":"https://doi.org/10.1111/wrr.70049","url":null,"abstract":"Delayed wound healing and non-healing wounds are common in diabetic patients due to the hostile microenvironments and complex pathophysiology of diabetic wounds. Addressing these challenges remains a significant concern for clinicians and researchers. Recently, microneedle technology has emerged as an effective, minimally invasive delivery system for treating diabetic wounds, offering ease of use and efficient drug delivery. Naturally derived biomaterial-based microneedles have demonstrated excellent biocompatibility, degradability, and low toxicity, enhancing the healing process by providing mechanical support and delivering antimicrobial agents, growth factors, and antioxidants. Some microneedles are designed to adapt to the specific microenvironments of diabetic wounds, leading to improved healing outcomes. This review summarises the design and development of naturally derived biomaterial-based microneedles for diabetic wound healing and discusses the mechanisms of action in response to varying diabetic wound conditions. The review also addresses critical considerations for developing microenvironment-response microneedles, highlighting implications for translational medicine. Collectively, interdisciplinary collaboration and technological innovation have advanced the creation of these microenvironment-response microneedles using natural biomaterials, which hold significant potential for improving diabetic wound healing.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70049"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current State-Of-Play of the EU Advanced Therapy Medicinal Product (ATMP) Field, With an Emphasis on Belgian Human Cell and Tissue Products. 欧盟先进治疗药物产品（ATMP）领域的现状，重点是比利时人类细胞和组织产品。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70039

Gilbert Verbeken, Lieke Convents, Nicolas Delmotte, Jean-Pierre Draye, Serge Jennes, Alain Vanderkelen, Griet Nijs, Philippe Lewalle, Etienne Baudoux, Olivier Cornu, Ineke Vanlaere, Anne Pierlot, Thomas Rose, Jean-Paul Pirnay

{"title":"Current State-Of-Play of the EU Advanced Therapy Medicinal Product (ATMP) Field, With an Emphasis on Belgian Human Cell and Tissue Products.","authors":"Gilbert Verbeken, Lieke Convents, Nicolas Delmotte, Jean-Pierre Draye, Serge Jennes, Alain Vanderkelen, Griet Nijs, Philippe Lewalle, Etienne Baudoux, Olivier Cornu, Ineke Vanlaere, Anne Pierlot, Thomas Rose, Jean-Paul Pirnay","doi":"10.1111/wrr.70039","DOIUrl":"10.1111/wrr.70039","url":null,"abstract":"The late 1980s saw the emergence of experimental therapies based on human cell and tissue products (HCTPs) within academic and hospital settings, several of them wound healing related. In 2008, the European Commission introduced the Regulation on advanced therapy medicinal products (ATMPs), defining many of these HCTPs as ATMPs, and more specifically as somatic cell therapy medicinal products (sCTMPs) or tissue-engineered products (TEPs). In 2013, we predicted that the ATMP regulation would adversely impact Member States' health care systems and would threaten the sustainability of many HCTPs provided by public health institutions. To assess the current ATMP state of play and investigate whether these predictions ultimately came true, we consulted relevant scientific and trade literature and official competent authority reports and surveyed the former Belgian HCTP producers. We found that the ATMP Regulation produced 19 authorised ATMPs, with 16 of them (84.2%) belonging to the gene therapy medicinal product (GTMP) class and only 3 HCTPs (15.8%), 2 TEPs and 1 sCTMP. List prices varied according to the ATMP class, with public health insurances struggling to reimburse ATMPs, especially the exuberantly priced GTMPs. This led to marketing authorization withdrawals, and crowd funding approaches and lotteries to determine who would receive lifesaving treatments. A hospital exemption (HE) scheme was enacted to protect ATMPs not intended for commercial exploitation. Whilst limited financial resources generally hampered HE utilisation by public actors, stringent regulatory policies made it virtually impossible in Belgium, resulting in meaningful HCTPs no longer being available to surgeons and their patients.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70039"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world outcomes of acellular fish skin grafts for chronic wounds: A retrospective analysis of effectiveness and costs. 无细胞鱼皮移植治疗慢性伤口的实际效果：有效性和成本的回顾性分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70019

Pavlo Dinter, Lina Weiss, Alexander A Navarini, Simon M Mueller

{"title":"Real-world outcomes of acellular fish skin grafts for chronic wounds: A retrospective analysis of effectiveness and costs.","authors":"Pavlo Dinter, Lina Weiss, Alexander A Navarini, Simon M Mueller","doi":"10.1111/wrr.70019","DOIUrl":"https://doi.org/10.1111/wrr.70019","url":null,"abstract":"Chronic wounds (CW) are a major public health problem. Acellular fish skin grafts (AFSG) are increasingly used in advanced wound care, but data on their effectiveness and costs in real-world settings are scarce. We therefore retrospectively analysed the wound surface area (WSA), pain scores, and AFSG-related costs in patients with CW over a 12-week follow-up period. In this single-centre observational study, we analysed two datasets of 34 (full dataset) and 22 (WSA-dataset) CW patients treated with AFSG in a university hospital. Of 34 AFSG-treated patients (mean age 75.9 ± 11.4 years, 44.0% females) with 50 CW of various aetiologies (median ulcer duration 32 weeks), 66.6% experienced pain improvement at 12 weeks. Of 22 patients, 19 (86.4%) showed a mean reduction in WSA of -60.7% ± 143.8% (p = 0.0025); 36.4% of CW were healed. AFSG-related costs were 1232.3 EUR/patient and 130.4 EUR/reduced cm2 (n = 22), which was 6.5 times more cost-effective compared to previous study results using living cellular skin substitutes. During 12 weeks of follow-up in a real-world setting, AFSG resulted in reduced WSA in most patients, improved pain in two-thirds, and healed CW in one-third. AFSG may be more cost-effective than other products, but prospective head-to-head comparisons are needed.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70019"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat Graft as Regenerative Treatment of Facial Manifestations of Systemic Sclerosis: A Systematic Review on the Role of Adipose Tissue-Derived Stem Cells and on Surgical Outcomes to Define a New Standardised Injection Protocol. 脂肪移植作为系统性硬化症面部表现的再生治疗：对脂肪组织来源干细胞的作用和手术结果的系统回顾，以确定新的标准化注射方案。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70045

A Arena, S Troise, F De Francesco, M Apolito, U Committeri, G Salzano, A Romano, P Bonavolontà, V Abbate, R Nocini, G Dell'Aversana Orabona

{"title":"Fat Graft as Regenerative Treatment of Facial Manifestations of Systemic Sclerosis: A Systematic Review on the Role of Adipose Tissue-Derived Stem Cells and on Surgical Outcomes to Define a New Standardised Injection Protocol.","authors":"A Arena, S Troise, F De Francesco, M Apolito, U Committeri, G Salzano, A Romano, P Bonavolontà, V Abbate, R Nocini, G Dell'Aversana Orabona","doi":"10.1111/wrr.70045","DOIUrl":"10.1111/wrr.70045","url":null,"abstract":"Facial symptoms of systemic sclerosis (SSc)-such as reduced skin elasticity, fibrosis and microstomy-significantly impact quality of life. In recent years, autologous fat grafting has emerged as a promising treatment for these issues, but determining the optimal timing and techniques for fat injection remains a challenge for surgeons. Our study aimed to perform a systematic review of the available literature to establish a standardised protocol for this procedure. We reviewed all relevant studies published up to 18 August 2023, focusing specifically on diffuse facial scleroderma. In addition to clinical reports, we included articles discussing the pathophysiological mechanisms behind the effects of adipose stem cells. A total of 18 articles were analysed, revealing a range of methods and timelines for the procedure. The volume of fat injected varied from 6 cc for perioral treatment to 72 cc for a full-face approach, with treatment intervals ranging from one session per year to one every 3 months. On average, around 50% of the fat was reabsorbed within 6 months. Adipose stem cells were identified as a key factor in both tissue regeneration and fat resorption rates. This review supports the effectiveness of autologous fat grafting for facial scleroderma, emphasising the role of adipose stem cells. For optimal results, two procedures spaced 3-6 months apart, followed by annual maintenance, are recommended. Consistent fat volumes in different facial areas are essential to achieve longer-lasting outcomes and minimise resorption.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70045"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

54th Annual Meeting of the Japanese Society for Wound Healing. 第54届日本伤口愈合学会年会。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70034

引用次数: 0

Global Epidemiology, Burden, and Future Projections of Decubitus Ulcers: A Comprehensive Analysis From 1990 to 2050. 褥疮的全球流行病学、负担和未来预测：1990年至2050年的综合分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70048

Yungang Hu, Yaling Zhao, Huimin Wu, Guanqun Wan, Xiaolin Li, Qi Zeng, Yuming Shen

{"title":"Global Epidemiology, Burden, and Future Projections of Decubitus Ulcers: A Comprehensive Analysis From 1990 to 2050.","authors":"Yungang Hu, Yaling Zhao, Huimin Wu, Guanqun Wan, Xiaolin Li, Qi Zeng, Yuming Shen","doi":"10.1111/wrr.70048","DOIUrl":"https://doi.org/10.1111/wrr.70048","url":null,"abstract":"Decubitus ulcers are common, hard-to-heal skin ulcers characterised by a high incidence, rapid progression, and a tendency to recur after healing. However, data on the burden and trends of this disease are limited. This study aimed to analyse the epidemiological characteristics and disease burden of decubitus ulcers from 1990 to 2021, and predict their future trends from 2022 to 2050. We retrieved decubitus ulcers data from 204 countries and regions worldwide from the Global Burden of Disease Study 2021 between 1990 and 2021. We analysed the prevalence, incidence, disability-adjusted life years (DALYs), age-standardised rates (ASRs), and estimated annual percentage changes at the global, regional, and national levels. Additionally, we examined global trends by age, sex, and socio-demographic index (SDI). Finally, we used the autoregressive integrated moving average and exponential smoothing models to predict future trends of the disease burden from 2022 to 2050. Globally, from 1990 to 2021, the incidence and prevalence of cases, deaths, and DALYs associated with decubitus ulcers revealed an increasing trend, while the corresponding ASRs exhibited a decreasing trend. Among all age groups, the elderly had the highest incidence, prevalence, and mortality rates. Regionally, high-income North America had the highest age-standardised incidence and prevalence rates; Southern Sub-Saharan Africa had the highest age-standardised death rate; and Eastern Sub-Saharan Africa had the highest age-standardised DALY rate. In terms of SDI, regions with a higher SDI had the highest age-standardised incidence and prevalence rates, while their mortality rates and DALYs were lower. By integrating the prediction results from the two models, we found that the incidence and prevalence of cases, deaths, and DALYs for both sexes will continue to increase from 2022 to 2050. However, the ASRs are expected to remain relatively stable in the future.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70048"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Vitabiotic: An Alternative Approach to Diabetic Foot". 对“维生素：糖尿病足的另一种治疗方法”的评论。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70035

Zeinab Mohseni Afshar, Farhad Bagherian, Mohammad Barary, Arefeh Babazadeh, Soheil Ebrahimpour

引用次数: 0

A review on smart dressings with advanced features. 具有先进功能的智能敷料综述。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70014

Neda Akhavan-Kharazian, Hossein Izadi-Vasafi, Masih Tabashiri-Isfahani, Hossein Hatami-Boldaji

{"title":"A review on smart dressings with advanced features.","authors":"Neda Akhavan-Kharazian, Hossein Izadi-Vasafi, Masih Tabashiri-Isfahani, Hossein Hatami-Boldaji","doi":"10.1111/wrr.70014","DOIUrl":"https://doi.org/10.1111/wrr.70014","url":null,"abstract":"Wound care is a multifaceted and collaborative process, and chronic wounds can have significant repercussions on a patient's well-being and impose a financial burden on the healthcare industry. While traditional wound dressings can effectively facilitate healing, their limitations in addressing the intricacies of the wound healing process remain a formidable obstacle. Smart wound dressings have emerged as a promising solution to tackle this challenge, offering numerous advantages over conventional dressings, such as real-time monitoring of wound healing and enhanced wound care management. These advanced medical dressings incorporate microelectronic sensors that can monitor the wound environment and provide timely interventions for accelerated and comprehensive healing. Furthermore, advancements in drug delivery systems have enabled real-time monitoring, targeted therapy, and controlled release of medications. Smart wound dressings exhibit versatility, as they are available in various forms and can be utilised for treating different types of acute or chronic wounds. Ultimately, the development of innovative wound care technologies and treatments plays a vital role in addressing the complexities presented by wounds and enhancing patients' quality of life. This review sheds light on the diverse types of smart dressings and their distinctive features, emphasising their potential in advancing the field of wound care.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70014"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Successful Is AI in Developing Postsurgical Wound Care Education Material? 人工智能在开发术后伤口护理教育材料方面有多成功？

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70041

Yeliz Sürme, Handan Topan, Gülseren Maraş Baydoğan

{"title":"How Successful Is AI in Developing Postsurgical Wound Care Education Material?","authors":"Yeliz Sürme, Handan Topan, Gülseren Maraş Baydoğan","doi":"10.1111/wrr.70041","DOIUrl":"10.1111/wrr.70041","url":null,"abstract":"ChatGPT can be used as an aid in education, research and clinical management. This study was conducted using the ChatGPT 4.0 program to develop artificial intelligence-supported wound care education material that can be read and understood by patients discharged after surgery. In this methodological study, while creating wound care education material, the education needs of the patients were determined first. Then, the education content was created in the ChatGPT 4 program. Expert opinion was taken for the clarity, applicability, accuracy and quality of the education content. The Turkish readability index of the education material was found to be 68.9 and easily understandable. The Automated Readability Index was found to be 9.29, the Simple Measure of Gobbledygook 7.89, the Flesch-Kincaid 8.07, the Flesch Reading Ease 59.0 and the Average Reading Level Consensus 9.99, which are frequently used in health literature. The PEMAT understandability and applicability score averages were determined 93.90 ± 6.11 (84-100) and 90.20 ± 8.66, respectively. The Global Quality Scale score average was found to be 4.40 ± 0.69. This study reveals that ChatGPT provides understandable, applicable, accurate and high-quality postoperative wound care education material.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70041"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0