From Wound to Hair Follicle: Unravelling the Mechanisms and Molecular Networks in Wound-Induced Hair Follicle Neogenesis.

Abstract

Wound-induced hair follicle neogenesis (WIHN), a regenerative process observed in select mammals, involves the formation of new hair follicles following skin injury. Although exhibiting similarities to embryonic hair follicle development, WIHN also presents notable distinctions. Despite considerable efforts to elucidate its underlying mechanisms, several aspects of WIHN remain unclear. A comprehensive understanding of the factors and signalling pathways governing this process holds promise for developing novel therapeutic interventions targeting hairless scar formation in humans.