Wound Repair and Regeneration最新文献_第2页

Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review. 比较机械和酶分离脂肪基质血管部分的方法：系统综述。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1111/wrr.13228

Mustafa Uguten, Nanouk van der Sluis, Linda Vriend, J H Coert, Martin C Harmsen, Berend van der Lei, Joris A van Dongen

{"title":"Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review.","authors":"Mustafa Uguten, Nanouk van der Sluis, Linda Vriend, J H Coert, Martin C Harmsen, Berend van der Lei, Joris A van Dongen","doi":"10.1111/wrr.13228","DOIUrl":"10.1111/wrr.13228","url":null,"abstract":"The stromal vascular fraction of adipose tissue has gained popularity as regenerative therapy for tissue repair. Both enzymatic and mechanical intraoperative SVF isolation procedures exist. To date, the quest for the preferred isolation procedure persists, due to the absence of standardised yield measurements and a defined clinical threshold. This systematic review is an update of the systematic review published in 2018, where guidelines were proposed to improve and standardise SVF isolation procedures. An elaborate data search in MEDLINE (PubMed), EMBASE (Ovid) and the Cochrane Central Register of Controlled Trials was conducted from September 2016 to date. A total of 26 full-text articles met inclusion criteria, evaluating 33 isolation procedures (11 enzymatic and 22 mechanical). In general, enzymatic and mechanical SVF isolation procedures yield comparable outcomes concerning cell yield (2.3-18.0 × 105 resp. 0.03-26.7 × 105 cells/ml), and cell viability (70%-99% resp. 46%-97.5%), while mechanical procedures are less time consuming (8-20 min vs. 50-210 min) and cost-efficient. However, as most studies used poorly validated outcome measures on SVF characterisation, it still remains unclear which intraoperative SVF isolation method is preferred. Future studies are recommended to implement standardised guidelines to standardise methods and improve comparability between studies.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"1008-1021"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study. 腿部静脉溃疡与膝关节骨性关节炎之间的关系：孟德尔随机研究

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-10-23 DOI: 10.1111/wrr.13229

Deyi Pan, Runqiao Yang, Yalan Zhang, Yuemei Chen, Yuhui Wang, Shixiong Xu

{"title":"Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study.","authors":"Deyi Pan, Runqiao Yang, Yalan Zhang, Yuemei Chen, Yuhui Wang, Shixiong Xu","doi":"10.1111/wrr.13229","DOIUrl":"10.1111/wrr.13229","url":null,"abstract":"To gain a clearer understanding of the relationship between venous leg ulcers (VLUs) and knee osteoarthritis (KOA), we performed a two-sample, bidirectional Mendelian randomization (MR) analysis in this study. The present MR was carried out using summary data from publicly available genome-wide association studies. After filtering single-nucleotide polymorphism (SNP), we applied a variety of MR methods including inverse variance weighted (IVW), MR egger, weighted mode, and weighted median. IVW analysis revealed that the genetic association between VLUs and KOA was not significant (β = -0.017; SE 0.039; p = 0.658). In agreement with the IVW analysis, the findings of the weighted median estimator (β = -0.017; SE 0.052, p = 0.751), MR egger (β = 0.057; SE 0.084; p = 0.513), and weighted mode (β = 0.060; SE 0.078; p = 0.456) indicated the absence of a significant genetic association between VLUs and KOA. Furthermore, reverse causality analysis suggested a lack of genetic relationship between KOA and VLUs. In conclusion, the present MR study does not suggest a causal relationship or reverse causal relationship between VLUs and KOA.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"895-903"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts Oral Presentations ETRS-WHS-SKINTERM Congress 2024 in Amersfoort. 2024 年阿默斯福特 ETRS-WHS-SKINTERM 大会口头报告摘要。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 DOI: 10.1111/wrr.13225

引用次数: 0

Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis. 皮肤替代物在烧伤和烧伤疤痕重建中的疗效：系统回顾和荟萃分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.1111/wrr.13226

Anna S van den Bosch, Robin A F Verwilligen, Anouk Pijpe, Eelke Bosma, Cees H van der Vlies, Ymke Lucas, George L Burchell, Paul P M van Zuijlen, Esther Middelkoop

{"title":"Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis.","authors":"Anna S van den Bosch, Robin A F Verwilligen, Anouk Pijpe, Eelke Bosma, Cees H van der Vlies, Ymke Lucas, George L Burchell, Paul P M van Zuijlen, Esther Middelkoop","doi":"10.1111/wrr.13226","DOIUrl":"10.1111/wrr.13226","url":null,"abstract":"Dermal substitutes have been introduced in burn care to improve wound healing outcomes; however, their use remains limited in standard treatments. This systematic review and meta-analysis aimed to evaluate the outcomes of dermal substitutes in patients with burns and patients requiring burn scar reconstruction and subsequently contribute to optimising the integration of dermal substitutes into clinical practice and reducing the knowledge gap. A comprehensive search across various databases included human studies from peer-reviewed journals on dermal substitutes for deep dermal and full-thickness burns, and scar reconstruction across all ages. Data from comparative trials were extracted, focusing on patient and wound characteristics, treatment specifics, and outcomes related to wound healing and scar quality. Meta-analysis was performed on trials reporting similar post-burn measures, with statistical heterogeneity assessed. Outcomes were presented using mean differences or odds ratios with 95% confidence intervals. A total of 31 comparative trials were included. The overall quality of the studies was considered moderate. The meta-analysis indicated delayed re-epithelialization 4-7 days after treatment with a collagen-elastin matrix compared to split-thickness skin graft in acute burns (-7.30%, p = 0.02). Significant improvement in subjective scar quality was observed with acellular dermal matrix compared to split-thickness skin graft in acute burn wounds 6 months post-operative (-1.95, p <0.01). While acknowledging the initially delayed wound healing, incorporating dermal substitutes into the surgical treatment of burn patients holds promise for enhancing scar quality. However, future research must prioritise outcome measure uniformity, address variations in dermal substitute application, and standardise indications for consistent and effective practices.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"960-978"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice. 橄榄油中的多酚羟基酪醇能改善糖尿病小鼠皮肤伤口的愈合。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1111/wrr.13217

Matheus Silva Duarte, Victor Müller Fuhro, Jeane de Souza Nogueira, Bruna Romana-Souza

{"title":"Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice.","authors":"Matheus Silva Duarte, Victor Müller Fuhro, Jeane de Souza Nogueira, Bruna Romana-Souza","doi":"10.1111/wrr.13217","DOIUrl":"10.1111/wrr.13217","url":null,"abstract":"The imbalance in oxidant production and chronic inflammation are the main mechanisms that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of antioxidants could improve diabetic wound healing. This study aimed to understand the effects of extra virgin olive oil (EVOO) or hydroxytyrosol (HT) in skin wound healing under diabetic conditions. Skin wounds in streptozotocin-induced diabetic mice were topically treated with HT. Some diabetic animals were fed with a diet rich in EVOO. Wounds were harvested 7 days later. In in vitro assays, fibroblasts and macrophages were treated with high levels of glucose and HT. The EVOO or HT promoted wound closure and collagen deposition in diabetic mouse wounds. The EVOO or HT reduced the number of infiltrated neutrophils, tumour necrosis factor-α, lipid peroxidation, and nuclear factor erythroid 2-related factor 2 in diabetic mouse wounds. The EVOO or HT also increased the number of macrophages with anti-inflammatory phenotype and interleukin-10 in diabetic mouse wounds. In the in vitro assays, HT promoted the fibroblast migration, collagen gel contraction, and switched macrophages to an anti-inflammatory phenotype under high glucose conditions. In conclusion, the diet supplementation with EVOO or topical application of HT promotes skin wound healing under diabetic conditions and can be a possible therapeutic tool for the treatment of those lesions.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"904-915"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel multi-spectral short-wave infrared imaging for assessment of human burn wound depth. 用于评估人体烧伤创面深度的新型多光谱短波红外成像技术。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI: 10.1111/wrr.13221

Johanna Nunez, Sergey Mironov, Bingchun Wan, Alaa Hazime, Audra Clark, Chiaka Akarichi, Kareem Abdelfattah, Sneha Korlakunta, Samuel Mandell, Brett Arnoldo, Rodney Chan, Jeremy Goverman, Ryan Huebinger, Caroline Park, Bret Evers, Deborah Carlson, Omer Berenfeld, Benjamin Levi

{"title":"Novel multi-spectral short-wave infrared imaging for assessment of human burn wound depth.","authors":"Johanna Nunez, Sergey Mironov, Bingchun Wan, Alaa Hazime, Audra Clark, Chiaka Akarichi, Kareem Abdelfattah, Sneha Korlakunta, Samuel Mandell, Brett Arnoldo, Rodney Chan, Jeremy Goverman, Ryan Huebinger, Caroline Park, Bret Evers, Deborah Carlson, Omer Berenfeld, Benjamin Levi","doi":"10.1111/wrr.13221","DOIUrl":"10.1111/wrr.13221","url":null,"abstract":"Burn depth determination is critical for patient care but is currently lacking accuracy. Recent animal studies showed that Short Wave Infrared (SWIR) imaging can distinguish between superficial and deep burns. This is a first human study correlating reflectance of multiple SWIR bands using a SWIR assessment tool (SWAT) with burn depth classifications by surgeons and histology. Burns and adjacent normal skin in 11 patients with thermal injuries were imaged with visual and narrow bands centred at 1200, 1650, 1940 and 2250 nm and biopsies were taken from select areas. Reflectance intensities for each band in 273 regions of interest (ROI) were divided by the normal skin reflectance and combined into three Reflectance Indices (RIs). In addition, burns in ROIs and biopsies were classified by five surgeons and three pathologists, respectively, as superficial partial, deep partial, or full thickness. Results show that for burn depth increase classified by the surgeons, reflectance increased at 1200 and 2250, decreased at 1940, and didn't change at 1650 nm. In contrast, all three RIs increase with burn depth and predict the deep and full depths ROIs representing operable regions (Area Under Curve >0.6507, p < 0.0001). Pathologists' classification matched surgeons' classification of burn category only in eight of 21 biopsies (38.1%), but reflectance at all bands and one RI for all deep partial and full thickness biopsies were larger than in non-biopsy normal and superficial partial thickness ROIs (p < 0.0118). In conclusion, multi-spectral imaging with a new SWAT is a promising approach for evaluation of burn wound depth.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"979-991"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of silkworm sericin in wound healing applications. 蚕丝素在伤口愈合方面的治疗潜力。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1111/wrr.13216

Monika Prakash, Chandraprabha Mathikere Naganna, Vivek Radhakrishnan, Prathik Somayaji, Leah Sabu

{"title":"Therapeutic potential of silkworm sericin in wound healing applications.","authors":"Monika Prakash, Chandraprabha Mathikere Naganna, Vivek Radhakrishnan, Prathik Somayaji, Leah Sabu","doi":"10.1111/wrr.13216","DOIUrl":"10.1111/wrr.13216","url":null,"abstract":"Chronic wounds are characterised by an imbalance between pro and anti-inflammatory signals, which result in permanent inflammation and delayed re-epithelialization, consequently hindering wound healing. They are associated with bacterial infections, tissue hypoxia, local ischemia, reduced vascularization and MMP-9 upregulation. The global prevalence of chronic wounds has been estimated at 40 million in the adult population, with an alarming annual growth rate of 6.6%, making it an increasingly significant clinical problem. Sericin is a natural hydrophilic protein obtained from the silkworm cocoon. Due to its biocompatibility, biodegradability, non-immunogenicity and oxidation resistance, coupled with its excellent affinity for target biomolecules, it holds great potential in wound healing applications. The silk industry discards 50,000 tonnes of sericin annually, making it a readily available material. Sericin increases cell union sites and promotes cell proliferation in fibroblasts and keratinocytes, thanks to its cytoprotective and mitogenic effects. Additionally, it stimulates macrophages to release more therapeutic cytokines, thus improving vascularization. This review focuses on the biological properties of sericin that contribute towards enhanced wound healing process and its mechanism of interaction with important biological targets involved in wound healing. Emphasis is placed on diverse wound dressing products that are sericin based and the utilisation of nanotechnology to design sericin nanoparticles that aid in chronic wound management.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"916-940"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing. 什么是蜕皮？确定蜕皮的蛋白质组和微生物组成及其对伤口愈合的影响。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-04-01 DOI: 10.1111/wrr.13170

Elizabeth C Townsend, J Z Alex Cheong, Michael Radzietza, Blaine Fritz, Matthew Malone, Thomas Bjarnsholt, Karen Ousey, Terry Swanson, Gregory Schultz, Angela L F Gibson, Lindsay R Kalan

{"title":"What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing.","authors":"Elizabeth C Townsend, J Z Alex Cheong, Michael Radzietza, Blaine Fritz, Matthew Malone, Thomas Bjarnsholt, Karen Ousey, Terry Swanson, Gregory Schultz, Angela L F Gibson, Lindsay R Kalan","doi":"10.1111/wrr.13170","DOIUrl":"10.1111/wrr.13170","url":null,"abstract":"Slough is a well-known feature of non-healing wounds. This pilot study aims to determine the proteomic and microbiologic components of slough as well as interrogate the associations between wound slough components and wound healing. Ten subjects with slow-to-heal wounds and visible slough were enrolled. Aetiologies included venous stasis ulcers, post-surgical site infections and pressure ulcers. Patient co-morbidities and wound healing outcome at 3-months post-sample collection was recorded. Debrided slough was analysed microscopically, through untargeted proteomics, and high-throughput bacterial 16S-ribosomal gene sequencing. Microscopic imaging revealed wound slough to be amorphous in structure and highly variable. 16S-profiling found slough microbial communities to associate with wound aetiology and location on the body. Across all subjects, slough largely consisted of proteins involved in skin structure and formation, blood-clot formation and immune processes. To predict variables associated with wound healing, protein, microbial and clinical datasets were integrated into a supervised discriminant analysis. This analysis revealed that healing wounds were enriched for proteins involved in skin barrier development and negative regulation of immune responses. While wounds that deteriorated over time started off with a higher baseline Bates-Jensen Wound Assessment Score and were enriched for anaerobic bacterial taxa and chronic inflammatory proteins. To our knowledge, this is the first study to integrate clinical, microbiome, and proteomic data to systematically characterise wound slough and integrate it into a single assessment to predict wound healing outcome. Collectively, our findings underscore how slough components can help identify wounds at risk of continued impaired healing and serves as an underutilised biomarker.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"783-798"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WOUND-Q questionnaire: Translational and cross-cultural adaptation for Brazilian Portuguese. WOUND-Q 问卷：针对巴西葡萄牙语的翻译和跨文化调整。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-16 DOI: 10.1111/wrr.13220

Cristina P Camargo, Bruno Y Matsumoto, Matheus S Apolinário, Rolf Gemperli

{"title":"WOUND-Q questionnaire: Translational and cross-cultural adaptation for Brazilian Portuguese.","authors":"Cristina P Camargo, Bruno Y Matsumoto, Matheus S Apolinário, Rolf Gemperli","doi":"10.1111/wrr.13220","DOIUrl":"10.1111/wrr.13220","url":null,"abstract":"Studies shows that 1%-2% of world population will develop chronic skin wound in their lifetime. Nowadays, the patient report outcome measure (PROM) questionnaires are used to evaluate the patient's quality of life. However, several PROM's questionnaires analyse specific chronic wounds. In this sense, WOUND-Q toll was designed to evaluate all types of wounds. Because of the WOUND-Q wide applicability, the use of WOUND-Q is helpful for other countries. This study aimed to translate and adapt WOUND-Q tool for Brazilian Portuguese language. Two independent translators translated the WOUND-Q questionnaire from English to Brazilian Portuguese. Then these translators build Version 1 (T1) and version 2 (T2). In a consensus meeting, a third senior author defined the final version. In the back translation process, an English proficient translator translated the Brazilian Portuguese version to the original version. After another consensus, a final version was defined. Then, our group performed a cognitive test to validate this version. After the first translation, the comparison of version T1 and T2 achieved an intraclass correlation coefficient of 77%. The back translation showed the need of few adjustments. For the cognitive test, the mean age was 44.1 ± 9.3 years. Only one question was changed to improve comprehensiveness. In the review phase, few adjustments were performed to the final Brazilian Portuguese version, mostly regarding verbal tense and prepositions. In conclusion, this study successfully translated and adapted the WOUND-Q questionnaire for a Brazilian Portuguese version.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"1028-1032"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaerobic bacteria in chronic wounds: Roles in disease, infection and treatment failure. 慢性伤口中的厌氧菌：在疾病、感染和治疗失败中的作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1111/wrr.13208

Alison Coluccio, Francia Lopez Palomera, Melanie A Spero

{"title":"Anaerobic bacteria in chronic wounds: Roles in disease, infection and treatment failure.","authors":"Alison Coluccio, Francia Lopez Palomera, Melanie A Spero","doi":"10.1111/wrr.13208","DOIUrl":"10.1111/wrr.13208","url":null,"abstract":"Infection is among the most common factors that impede wound healing, yet standard treatments routinely fail to resolve chronic wound infections. The chronic wound environment is largely hypoxic/anoxic, and wounds are predominantly colonised by facultative and obligate anaerobic bacteria. Oxygen (O2) limitation is an underappreciated driver of microbiota composition and behaviour in chronic wounds. In this perspective article, we examine how anaerobic bacteria and their distinct physiologies support persistent, antibiotic-recalcitrant infections. We describe the anaerobic energy metabolisms bacteria rely on for long-term survival in the wound environment, and why many antibiotics become less effective under hypoxic conditions. We also discuss obligate anaerobes, which are among the most prevalent taxa to colonise chronic wounds, yet their potential roles in influencing the microbial community and wound healing have been overlooked. All of the most common obligate anaerobes found in chronic wounds are opportunistic pathogens. We consider how these organisms persist in the wound environment and interface with host physiology to hinder wound healing processes or promote chronic inflammation. Finally, we apply our understanding of anaerobic physiologies to evaluate current treatment practices and to propose new strategies for treating chronic wound infections.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"840-857"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0