Wound Repair and Regeneration最新文献

{"title":"Contact Pressure Under Traditional Foam and Novel Thermoplastic Elastomer Negative Pressure Wound Therapy Interfaces.","authors":"Michael S Shuler, Colton C Mowers, Meera M Dhodapkar, Mitchell Greenberg, David Ngendahimana, Brett A Freedman","doi":"10.1111/wrr.70157","DOIUrl":"10.1111/wrr.70157","url":null,"abstract":"<p><p>Negative pressure wound therapy relies on suction, commonly set to -125 mmHg, to evacuate wound fluid, but dysvascular and pressure injuries often respond unpredictably. Newton's third law indicates that negative pressure applies an equal and opposite contact pressure on the wound surface, and this study quantified this contact pressure across dressing types, wound configurations and suction levels. Using a porcine explant model, central and peripheral contact pressure measurements were obtained beneath black reticulated open cell foam, white foam and a novel thermoplastic elastomer dressing across plexiglass, intact skin, shallow and deep wounds under -50, -75 and -125 mmHg. Contact pressure increased proportionally with negative pressure, and multivariable modelling demonstrated that dressing type, wound type and suction level significantly influenced pressure, with negative pressure explaining most of the variance (0.77 and 0.68). Thermoplastic elastomer at -50 mmHg in deep wounds produced the lowest contact pressure, whereas black reticulated open cell foam and white foam at -125 mmHg generated elevated contact pressures of approximately +125 to +195 mmHg. These findings show that black reticulated open cell foam at conventional -125 mmHg can create hypoperfusion conditions, whereas thermoplastic elastomer consistently produces the lowest pressures and may enhance perfusion at lower suction levels, offering a physiologic explanation for improved clinical outcomes in dysvascular and pressure injuries treated with reduced negative pressure.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70157"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes.","authors":"Kayla Howard, Priyanka Dhanraj, Kayleigh Armstrong, Mari van de Vyver","doi":"10.1111/wrr.70153","DOIUrl":"10.1111/wrr.70153","url":null,"abstract":"<p><p>Topically applied autologous blood clot therapy (TABCT) is a low-cost regenerative modality proposed for complex wounds, yet its biological mechanism of action remains poorly defined. We investigated whether factors released from autologous blood clots promote peripheral blood mononuclear cell (PBMC) chemotaxis and fibroblast migration, and whether these effects are altered in individuals with metabolic syndrome/type 2 diabetes (MetS/DM). Twenty-two participants (controls n = 12; MetS/DM n = 10) were recruited. Autologous clots were generated ex vivo, cultured for 24 h, and the secretome analysed for total protein, PDGF-BB, P-selectin and CCL-5. PBMC basal activation (ROS production, phagocytosis, migration, Ca²⁺ flux) was assessed, followed by live-cell chemotaxis assays. Human dermal fibroblast migration was evaluated using a scratch assay. MetS/DM-derived PBMCs demonstrated heightened basal activation, including increased ROS production, migration velocity and sustained intracellular Ca²⁺ flux. Clots from MetS/DM participants released less total protein but significantly higher P-selectin levels, consistent with platelet hyperactivation. Despite containing measurable growth factors, clot-derived secretomes did not significantly enhance PBMC migration velocity or distance travelled, although directionality modestly increased. Similarly, secretome exposure failed to stimulate fibroblast-mediated wound closure (< 30% closure across groups). Pretreatment of blood with metformin, prednisone or amoxicillin had negligible effects on secretome composition or functional outcomes. These findings demonstrate that while TABCT-derived secretomes exhibit chemotactic properties, they do not substantially promote immune cell recruitment or fibroblast migration in vitro. The clinical benefits of TABCT may therefore be attributable primarily to its fibrin scaffold properties rather than bioactive factor release. Further mechanistic and translational studies are warranted.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70153"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folinic Acid Improves Healing of Diabetic Foot Ulcers.","authors":"Glenn D Hoke, Annjanette Stone, Michael A Bauer, Weleetka C Carter, Megan R Newsom, Joseph V Boykin","doi":"10.1111/wrr.70141","DOIUrl":"10.1111/wrr.70141","url":null,"abstract":"<p><p>A novel folinic acid (FA) wound treatment (FAWT) significantly (p < 0.05) improved healing (re-epithelialization) of chronic diabetic foot ulcers (DFUs). In a double-blind RCT, 10 (n = 10) chronic DFU subjects received daily topical treatment in either the Control group [(n = 5); PluroGel] or the FAWT group [(n = 5); PluroGel with FA 2.5%]. After 12 weeks, FAWT subjects experienced significantly (p < 0.05) greater %-DFU area reduction (88% [SD: 16]) vs. Control (40% [SD: 39]), respectively. Proteomic analysis of keratinocytes (KCs) pre- and post-FAWT, using Reverse Phase Proteomic Array (RPPA), documented significantly decreased levels of HMGB1 (High Mobility Group Box1) protein and activated IL-1B protein at 12 weeks after FAWT as compared to Control. RPPA also documented significantly decreased activating phosphorylation of SAP/JNK3 (T183/Y185) and p38 MAPK (T180/Y182) levels after FAWT as compared to Control. These findings suggested decreased activation and possible reduction of NFKB/p65 and p38 MAPK following FAWT that could decrease proinflammatory gene expression. Genomic DNA-methylation analysis of KCs identified significantly decreased FAWT-induced methylation at gene expression regulatory sites for multiple microRNAs (MiRNA) associated with regulating proinflammatory responses. FAWT-induced decreased methylation levels in MiRNAs suggested increased expression and their potential to inhibit protein translation. These MiRNAs are predicted to target multiple mitogen-activated protein kinase (MAPK) pathways. These MAPK pathways mediate signalling from proinflammatory cell surface receptors (such as RAGE, TLRs and IL1R), altering gene expression. FAWT-induced inhibition of MAPK-signalling may lessen NFKB/p65 and p38 MAPK induction of proinflammatory gene expression, reflected in the significantly decreased protein levels of HMGB1 and IL-1B. The data suggest FAWT-induced coordinated expression of multiple anti-inflammatory MiRNAs associated with impaired MAPK-signalling that resulted in decreased expression of HMGB1 and IL1B and this process may facilitate DFUs' transition from an inflammatory state to wound repair, enabling KCs to regulate their proliferative phase, migration and the promotion of DFU re-epithelialization.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70141"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendritic Cell-Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing.","authors":"Kento Takaya, Yukari Nakajima, Shigeki Sakai, Keisuke Okabe, Noriko Aramaki-Hattori, Ryoichi Mori, Kazuo Kishi","doi":"10.1111/wrr.70143","DOIUrl":"10.1111/wrr.70143","url":null,"abstract":"<p><p>Following tissue injury, diverse cell populations, including immune cells such as dendritic cells, converge at the damaged site. They actively contribute to scar formation through intricate crosstalk with fibroblasts, exceeding their role as antigen-presenting entities. Consequently, they are emerging as promising therapeutic targets. Through single-cell RNA sequencing analysis of adult murine scar tissue, we identified the gene expression of myristoylated alanine-rich C-kinase substrate-like 1 (MARCKSL1) within dendritic cell clusters localised in fibrotic regions. Using our proprietary mouse fetal wound healing model, we observed a distinct accumulation of MARCKSL1-positive dendritic cells at the wound margins during the developmental stage, coinciding with the onset of scar formation. Stimulation with transforming growth factor beta 1 (TGF-β1), serving as a mimic of wound-induced signalling, enhanced MARCKSL1 expression in mouse dendritic cells. Co-culturing TGF-β1-stimulated dendritic cells with fibroblasts promoted fibroblast differentiation into myofibroblasts, whereas this effect was markedly diminished in dendritic cells transduced with MARCKSL1 shRNA. Moreover, mice treated with a MARCKSL1 inhibitor (MANS peptide) exhibited significantly attenuated scar formation compared with controls. Overall, these findings demonstrated that MARCKSL1 expression in dendritic cells modulates fibroblast activity and is associated with fibrotic responses during wound healing. Regulation of MARCKSL1 dynamics in dendritic cells could offer a potential therapeutic avenue for scar prevention and regenerative wound healing.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70143"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Microbial Infection in Pyoderma Gangrenosum: Comparable Rates to Venous Ulcers in a Retrospective Cohort.","authors":"Katelyn S Stenger, Elise S Burger","doi":"10.1111/wrr.70161","DOIUrl":"https://doi.org/10.1111/wrr.70161","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a neutrophilic dermatosis traditionally regarded as a sterile inflammatory ulcer; however, positive wound cultures are frequently encountered in clinical practice and may complicate or delay diagnosis and management. Data regarding bacterial superinfection in PG remain limited. The objective of this study was to determine the frequency and spectrum of microbial involvement in PG ulcers compared with venous ulcers. We performed a retrospective cohort study of patients evaluated at the University of Utah between June 2012 and June 2025. Electronic medical records were queried using International Classification of Diseases codes to identify patients with PG or venous ulcers, with diagnosis confirmed by manual chart review. Ulcers were included if at least one bacterial wound swab or tissue culture had been obtained. Isolated organisms were recorded, and associations between ulcer type and organism isolation were analysed using Fisher's exact test. The cohort included 292 patients (143 PG, 149 venous ulcers). Secondary microbial growth occurred in 50.3% of PG ulcers and 50.3% of venous ulcers. Pseudomonas aeruginosa was isolated in 11.9% of PG ulcers and 9.4% of venous ulcers (p = 0.57). Staphylococcus species were the most frequently identified organisms in both groups. No statistically significant difference in overall culture positivity or Pseudomonas isolation was observed between ulcer types. These findings demonstrate that PG ulcers are not uniformly sterile, with approximately half demonstrating microbial superinfection. Infection rates were comparable to those observed in venous ulcers, suggesting that secondary microbial involvement is common across chronic wound types. Positive cultures should not preclude the diagnosis of PG, and recognition of superinfection may support appropriate antimicrobial use while avoiding diagnostic delay.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70161"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incisional Hernia Development: Wound Healing Gone Wrong?","authors":"Asim A Abbas, Paul Gunning, Srinivas Chintapatla, Roland Kröger","doi":"10.1111/wrr.70131","DOIUrl":"10.1111/wrr.70131","url":null,"abstract":"<p><p>Incisional hernia (IH) is a common complication of abdominal surgeries, characterised by the protrusion of abdominal contents through a weakened surgical scar. Despite advancements in surgical techniques and biomaterials, IH remains a significant clinical and economic burden, with recurrence rates reaching up to 32% after repair. This unusually high number, despite many years of research focused on the improvement of surgical techniques, requires a better understanding of the potential origins of IH occurrence. This must implicate the tissues involved in scar formation of the abdominal wall for a better understanding of how these tissues are affected by the incision and what can potentially affect the most optimal wound healing. This work aimed to provide a comprehensive summary of the current knowledge regarding the ultrastructure of the abdominal wall and how incisions affect its mechanical integrity.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70131"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Statins on Wound Healing. A Systematic Review and Meta-Analysis of Preclinical Evidence.","authors":"Ana M Pachano-Bravo, Ovya Ganesan, Stephanie Mueller, Dennis P Orgill","doi":"10.1111/wrr.70133","DOIUrl":"https://doi.org/10.1111/wrr.70133","url":null,"abstract":"<p><p>Wound healing is a complex process increasingly compromised by aging and comorbidities. Statins are widely used therapeutic agents and have shown promising pleiotropic effects that may enhance wound repair. Our aim is to examine the effects of statins on wound healing in animal models through a quantitative synthesis of preclinical evidence. A systematic review of PubMed, Web of Science and Embase was performed to identify in vivo preclinical experimental studies comparing statin treatment versus vehicle in mammalian animal models of any age or sex with experimentally induced wounds. Multiple independent, blinded reviewers oversaw the study selection, data extraction and quality assessment, following PRISMA (1), SYRCLE (2) and CAMARADES guidelines. Of 220 abstracts screened, 54 full-text articles were assessed for eligibility, and 12 experimental studies published between 2012 and 2026 were included in our meta-analysis. These studies, conducted on mammalian animal models, involved a total of 262 animals and provided 131 comparisons across 14 experiments. Wound closure outcomes were assessed via morphometric analyses between days 9 and 14. Our findings indicate that statin treatment significantly enhances wound size reduction compared to control, with a pooled standardised mean difference (SMD) of 1.79 (95% CI: 0.63-2.95, p = 0.0040). These results provide robust preclinical evidence that statin treatment enhances wound healing in mammalian models. These results support the therapeutic potential of statins in wound care, highlighting the need for further research to elucidate their underlying mechanisms and to facilitate the translation of these preclinical insights into clinical practice.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70133"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Healing Effect of Photobiomodulation on Venous Leg Ulcers: A Systematic Review and Meta-Analysis.","authors":"Aqella Rasul, Frederik Plum, Katrine Elisabeth Karmisholt, Klaus Kirketerp-Møller","doi":"10.1111/wrr.70144","DOIUrl":"10.1111/wrr.70144","url":null,"abstract":"<p><p>Venous leg ulcers are common, costly and often slow to heal despite standard management. Photobiomodulation has been proposed as an adjuvant therapy to enhance wound repair. This systematic review and meta-analysis aimed to evaluate the effect of photobiomodulation on healing outcomes in venous leg ulcers. A comprehensive search of PubMed, Embase, Web of Science and Cochrane Library (1990-2024) identified randomised controlled trials evaluating photobiomodulation in adults with venous leg ulcers. Two reviewers independently screened studies (n = 3824) and assessed eligibility according to predefined inclusion and exclusion criteria (n = 34). Data were extracted from the included studies (n = 11), and the risk of bias was assessed using the Cochrane RoB 2 tool. A random-effects meta-analysis was conducted for the absolute change in ulcer area. Eleven trials were included, comprising 615 randomised patients, where 340 had venous leg ulcers. Patients who completed follow-up contributed to the healing outcomes (intervention n = 169, controls n = 167). All studies were evaluated to have some or high concerns for risk of bias. Four trials contributed data to the meta-analysis showing that photobiomodulation did not significantly reduce ulcer area compared with controls (Mean Difference 3.77 cm², 95% CI -4.45 to 11.99; p = 0.37) and heterogeneity was substantial (τ² = 65.37; I² = 96%). Current evidence does not demonstrate a statistically significant benefit of photobiomodulation on venous leg ulcer healing. High heterogeneity, small sample sizes and methodological limitations reduce confidence in the pooled estimate. Standards for photobiomodulation therapy in venous leg ulcers are still missing, and well-designed RCTs are needed to clarify the therapeutic potential of photobiomodulation.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70144"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble CD83 Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human 3D in Vitro Wound Healing Model.","authors":"Christian Hollard, Katrin Peckert-Maier, Moritz Ronicke, Pia Sinner, Fabian Stritt, Tobias Spöttl, Petra Mühl-Zürbes, Stefan Wirtz, Cornelia Erfurt-Berge, Alexander Steinkasserer, Dmytro Royzman","doi":"10.1111/wrr.70158","DOIUrl":"https://doi.org/10.1111/wrr.70158","url":null,"abstract":"<p><p>Chronic wounds, as defined by prolonged inflammation and impaired healing, represent a major and growing healthcare challenge worldwide. Currently, only limited therapeutic options are available to address this condition. This study investigates the potential of soluble CD83 (sCD83), an immunomodulatory molecule, to facilitate wound healing in a human in vitro wound model. This model incorporates keratinocytes, fibroblasts, and macrophages in a three-dimensional skin construct and was exposed to chronic wound fluid (CWF) to induce an inflammatory and impaired-healing environment. Treatment with sCD83 resulted in a significant acceleration of wound closure, enhanced macrophage polarisation towards a pro-regenerative phenotype, and an increase in the production of growth factors such as VEGF and TGF-β. These effects were also observed under inflammatory conditions induced by CWF, which otherwise impaired healing and sustained a pro-inflammatory environment. Furthermore, sCD83 enhanced markers associated with epidermal stem cell activity and diminished the expression of pro-inflammatory mediators, underscoring its immunomodulatory and pro-regenerative properties within this human 3D in vitro model. Together, these results demonstrate that sCD83 can attenuate inflammatory responses and improve regenerative processes in a CWF-induced impaired healing environment in vitro. Our findings provide the basis for further preclinical studies to unravel the clinical potential of sCD83 as a novel treatment option for chronic and hard-to-heal wounds.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70158"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI Highlights the Hypervascularity of Breast Keloids.","authors":"Candice N Thompson, Bruce Daniel, Hermann Peter Lorenz, Irene L Wapnir","doi":"10.1111/wrr.70148","DOIUrl":"https://doi.org/10.1111/wrr.70148","url":null,"abstract":"<p><p>Keloids are benign fibroproliferative lesions resulting from abnormal wound healing, forming at sites of cutaneous injury or surgical incisions, not infrequently occurring following breast surgery. Five patients with keloid scars on their breasts, who underwent subsequent breast MRIs following breast surgery are described. Details on breast imaging studies, clinical course, pathology findings and therapeutic interventions were abstracted from the electronic medical records. Enhancement on MRI was qualitatively, not quantitively, determined on peak phase sequences. Regression of enhancement corresponding to the clinical attenuation of a hypertrophic scar was observed in one case three years postoperatively. This study demonstrates that breast keloid surgical scars are associated with exuberant neovascularisation.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"34 2","pages":"e70148"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}