Wound Repair and Regeneration最新文献_第10页

Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing. 含金纳米颗粒的纳米纤维聚己内酯/明胶支架:伤口愈合的物理化学和生物学特性。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-11-24 DOI: 10.1111/wrr.13126

Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi

{"title":"Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing.","authors":"Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi","doi":"10.1111/wrr.13126","DOIUrl":"10.1111/wrr.13126","url":null,"abstract":"In this study, gold nanoparticles were loaded into poly (ε-caprolactone) (PCL)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of PCL/gelatin solution supplemented with synthesized gold nanoparticles (200, 400 and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test and cellular response. In addition to in vivo study, a full-thickness excisional wound in a rat model was used to evaluate the healing effect of prepared scaffolds. Results showed appropriate mechanical properties and porosity of prepared scaffolds. With L929 cells, the PCL/gelatin scaffold containing 400 ppm gold nanoparticles demonstrated the greatest cell growth. In vivo results validated the favorable wound-healing benefits of the scaffold incorporating gold nanoparticles, which triggered wound healing compared to sterile gauze. Our results showed the capability of nanofibrous matrices containing gold nanoparticles for successful wound treatment.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ulrich auf dem Keller (1974-2023). 乌尔里希在地窖里（1974-2023）。

IF 2.9 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-09-29 DOI: 10.1111/wrr.13118

Magnus S Ågren, Boris Hinz, Konstantinos Kalogeropoulos, Christopher M Overall, Hans Smola, Sabine Werner

引用次数: 0

Clinical efficacy and patients' perception of virtual reality during wound care in adults: A systematic review with meta-analysis of randomised clinical trials. 成人伤口护理过程中虚拟现实的临床疗效和患者感知:随机临床试验荟萃分析的系统回顾。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-12-10 DOI: 10.1111/wrr.13128

Masood Mazaheri, Raoul F Crooijmans, Maya Vereen, Eveline M L Corten

{"title":"Clinical efficacy and patients' perception of virtual reality during wound care in adults: A systematic review with meta-analysis of randomised clinical trials.","authors":"Masood Mazaheri, Raoul F Crooijmans, Maya Vereen, Eveline M L Corten","doi":"10.1111/wrr.13128","DOIUrl":"10.1111/wrr.13128","url":null,"abstract":"This study was aimed to review Virtual Reality's (VR) impact on pain, anxiety, opioid usage, physiological and behavioural responses, and patients' experience during wound care (WC) in adults. We searched multiple databases (Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, CINAHL, Scopus and Google Scholar) from inception until January 27th, 2023. Included studies compared VR alone or as an adjunct to standard WC with standard WC or other distraction methods, in adults with burn or non-burn-related wounds. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomised parallel-group and crossover trials. The review followed PRISMA guidelines for reporting. Fourteen studies were eligible for inclusion. The meta-analysis was limited to studies comprising solely of adult participants. VR reduced pain intensity compared to standard WC in all study designs. Despite not being included in the meta-analysis due to reasons such as mixed population or lack of sufficient statistical data, other studies showed significant pain reduction using VR. Additionally, VR improved patients' experience of WC. No clear effect was found on other outcomes including anxiety, opioid usage and physiological and behavioural responses. VR shows promise in reducing acute pain and enhancing patients' experience of WC. The observed variations in the effects of VR at group and individual levels indicate the need for a personalised treatment plan by selecting the right VR for the right patient given at the right time.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating skin colour diversity in the validation of scar assessment tools. 疤痕评估工具验证中的肤色多样性评估。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-10-15 DOI: 10.1111/wrr.13120

Stuti P Garg, Tokoya Williams, Iulianna C Taritsa, Rou Wan, Chirag Goel, Raiven Harris, Kristin Huffman, Robert D Galiano

{"title":"Evaluating skin colour diversity in the validation of scar assessment tools.","authors":"Stuti P Garg, Tokoya Williams, Iulianna C Taritsa, Rou Wan, Chirag Goel, Raiven Harris, Kristin Huffman, Robert D Galiano","doi":"10.1111/wrr.13120","DOIUrl":"10.1111/wrr.13120","url":null,"abstract":"Across scar studies, there is a lack of dark-skinned individuals, who have a predisposition for keloid formation, altered pigmentation and poorer quality of life (QOL). There is a need for patients of colour to be included in scar scale development and validation. In this study, we evaluate the racial diversity of patients included in the validation of scar assessment scales. A systematic review was conducted for articles reporting on the validation of a scar assessment tool. Racial, ethnic and Fitzpatrick skin type (FST) data were extracted. Fifteen scar scale validation studies were included. Nine of the studies did not mention FST, race or ethnicity of the patients. Two of the studies that reported FST or race information only included White patients or included no FST V/VI patients: mapping assessment of scars (MAPS) and University of North Carolina '4P'. Only four studies included non-White patients or dark-skinned patients in the validation of their scar scale: the modified Vancouver Scar Scale (VSS), modified Patient and Observer Scar Assessment Scale (POSAS), acne QOL and SCAR-Q scales. The patients included in the modified VSS validation were 7% and 13% FST V/VI, 14% African in the modified POSAS and 4.5% FST V/VI in the SCAR-Q. We highlight the severe lack of diversity in scar scale validation, with only 4 out of 15 studies including dark-skinned patients. Given the susceptibility of darker-skinned individuals to have poorer scarring outcomes, it is critical to include patients of colour in the very assessment tools that determine their scar prognosis. Inclusion of patients of colour in scar scale development will improve scar assessment and clinical decision-making.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The infected diabetes-related foot: Comparison of erythrocyte sedementation rate/albumin and C-reactive protein/albumin ratios with erythrocyte sedimentation rate and C-reactive protein to differentiate bone and soft tissue infections. 糖尿病相关足部感染：区分骨和软组织感染的CRP/白蛋白和ESR/白蛋白比值与ESR和CRP的比较。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-10-27 DOI: 10.1111/wrr.13121

Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery

{"title":"The infected diabetes-related foot: Comparison of erythrocyte sedementation rate/albumin and C-reactive protein/albumin ratios with erythrocyte sedimentation rate and C-reactive protein to differentiate bone and soft tissue infections.","authors":"Tyler L Coye, Mehmet A Suludere, Gu Eon Kang, P Andrew Crisologo, Matthew Malone, Lee C Rogers, Lawrence A Lavery","doi":"10.1111/wrr.13121","DOIUrl":"10.1111/wrr.13121","url":null,"abstract":"The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM) or soft tissue infection based on bone culture and/or histology. We evaluated the diagnostic accuracy of CRP, ESR, albumin, CRP/albumin and ESR/albumin as biomarkers to diagnose OM in persons with diabetes. The median age was 53 years (74% male). There were 224 diabetes-related patients of which 125 had been diagnosed with osteomyelitis. The ESR/albumin and CRP/albumin ratios cut-points were >17.84 and >1.83, respectively. ESR/albumin and CRP/albumin ratios had similar diagnostic parameters: AUC (0.71, 0.71), sensitivity (70.0%, 57.0%), specificity (62.0%, 75.0%), positive predictive value (67.0%, 71.0%) and negative predictive value (66.0% and 71.0%). In contrast diagnostic efficiency of CRP and ESR were AUC 0.71 and 0.71, sensitivity (45.6%, 71.2%), specificity (85.5%, 60.7%), positive predictive value (70.0%, 65.9%) and negative predictive value (59.5%, 66.4%), respectively. When comparing area under the curves, the results showed that ESR/albumin was not significantly different to ESR alone (Delong test pvs ESR >0.1). Similarly, CRP/albumin was not significantly different to CRP alone (Delong test pvs CRP >0.1). In conclusion, ESR/albumin and CRP/albumin ratios provided comparable results as using ESR and CRP alone.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine scars after caesarean delivery: From histology to the molecular and ultrastructural level. 剖宫产后子宫瘢痕:从组织学到分子和超微结构水平。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-11-20 DOI: 10.1111/wrr.13127

Alexander Paping, Clara Basler, Loreen Ehrlich, Carlo Fasting, Kerstin Melchior, Thomas Ziska, Mario Thiele, Georg N Duda, Sara Timm, Matthias Ochs, Rebecca C Rancourt, Wolfgang Henrich, Thorsten Braun

{"title":"Uterine scars after caesarean delivery: From histology to the molecular and ultrastructural level.","authors":"Alexander Paping, Clara Basler, Loreen Ehrlich, Carlo Fasting, Kerstin Melchior, Thomas Ziska, Mario Thiele, Georg N Duda, Sara Timm, Matthias Ochs, Rebecca C Rancourt, Wolfgang Henrich, Thorsten Braun","doi":"10.1111/wrr.13127","DOIUrl":"10.1111/wrr.13127","url":null,"abstract":"Uterine rupture during a trial of labor after caesarean delivery (CD) is a serious complication for mother and fetus. The lack of knowledge on histological features and molecular pathways of uterine wound healing has hindered research in this area from evolving over time. We analysed collagen content and turnover in uterine scars on a histological, molecular and ultrastructural level. Therefore, tissue samples from the lower uterine segment were obtained during CD from 16 pregnant women with at least one previous CD, from 16 pregnant women without previous CD, and from 16 non-pregnant premenopausal women after hysterectomy for a benign disease. Histomorphometrical collagen quantification showed, that the collagen content of the scar area in uterine wall specimens after previous CD was significantly higher than in the unscarred myometrium of the same women and the control groups. Quantitative real-time PCR of uterine scar tissue from FFPE samples delineated by laser microdissection yielded a significantly higher COL3A1 expression and a significantly lower COL1A2/COL3A1 ratio in scarred uteri than in samples from unscarred uteri. Histological collagen content and the expression of COL1A2 and COL3A1 were positively correlated, while COL1A2/COL3A1 ratio was negatively correlated with the histological collagen content. Transmission electron microscopy revealed a destroyed myometrial ultrastructure in uterine scars with increased collagen density. We conclude that the high collagen content in uterine scars results from an ongoing overexpression of collagen I and III. This is a proof of concept to enable further analyses of specific factors that mediate uterine wound healing.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deeper look at low-frequency contact ultrasonic debridement in the clinical management of patients with diabetic foot ulcers. 低频接触超声清创在糖尿病足溃疡患者临床治疗中的应用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-11-01 Epub Date: 2023-11-22 DOI: 10.1111/wrr.13124

Francisco J Álvaro-Afonso, Sebastián Flores-Escobar, David Sevillano-Fernández, Yolanda García-Álvarez, Marta García-Madrid, José L Lázaro-Martínez

{"title":"A deeper look at low-frequency contact ultrasonic debridement in the clinical management of patients with diabetic foot ulcers.","authors":"Francisco J Álvaro-Afonso, Sebastián Flores-Escobar, David Sevillano-Fernández, Yolanda García-Álvarez, Marta García-Madrid, José L Lázaro-Martínez","doi":"10.1111/wrr.13124","DOIUrl":"10.1111/wrr.13124","url":null,"abstract":"The current study aimed to evaluate the dispersal of solution and microbes (aerosol) in the clinical environment during treatment with Low-frequency contact ultrasonic debridement (LFCUD) with or without suction attachment in patients with diabetic foot ulcers (DFUs). We performed 20 treatments in 10 patients divided into two groups to receive the proposed LFCUD modalities. We measured the microbial load of the environment pre-treatment (sample M1), during treatment with each LFCUD modality (sample M2) and post-treatment (sample M3). The use of LFCUD debridement without a suction attachment results in significantly higher immediate contamination of the clinic environment than the suction attachment, particularly during the procedure (1.70 ± 0.98 log 10 CFU/mL versus 0.77 ± 0.85 log 10 CFU/mL, p = 0.035). When suction is not applied, there are statistically significant differences depending on whether the DFUs are neuropathic or neuroischemic, finding a greater number of microorganisms with high loads in neuropathic DFUs. We found a statistically significant positive correlation between wound area (r = 0.450, p = 0.047) and TBI (r = 0.651, p = 0.006) with the bacterial load during the LFCUD. Based on our results, we recommend using the personal protective equipment required to protect staff members and patients during treatment with LFCUD and using a suction attachment where clinically possible to reduce clinic environmental pollution, especially in neuropathic DFUs and those with larger areas.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research hotspot and trend of chronic wounds: A bibliometric analysis from 2013 to 2022. 慢性创伤研究热点与趋势：2013-2022年文献计量学分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-09-01 Epub Date: 2023-08-19 DOI: 10.1111/wrr.13117

Xinghan Chen, Xiujun Shi, Haitao Xiao, Dongqin Xiao, Xuewen Xu

{"title":"Research hotspot and trend of chronic wounds: A bibliometric analysis from 2013 to 2022.","authors":"Xinghan Chen, Xiujun Shi, Haitao Xiao, Dongqin Xiao, Xuewen Xu","doi":"10.1111/wrr.13117","DOIUrl":"10.1111/wrr.13117","url":null,"abstract":"Chronic wounds have been confirmed as a vital health problem facing people in the global population aging process. While significant progress has been achieved in the study of chronic wounds, the treatment effect should be further improved. The number of publications regarding chronic wounds has been rising rapidly. In this study, bibliometric analysis was conducted to explore the hotspots and trends in the research on chronic wounds. All relevant studies on chronic wounds between 2013 and 2022 were collected from the PubMed database of the Web of Science (WOS) and the National Center for Biotechnology Information (NCBI). The data were processed and visualised using a series of software. On that basis, more insights can be gained into hotspots and trends of this research field. Wound Repair and Regeneration has the highest academic achievement in the field of chronic wound research. The United States has been confirmed as the most productive country, and the University of California System ranks high among other institutions. Augustin, M. is the author of the most published study, and Frykberg, RG et al. published the most cited study. Furthermore, the hotspots of wound research over the last decade were identified (e.g., bandages, infection and biofilms, pathophysiology and therapy). This study will help researchers gain insights into chronic wound research's hotspots and trends accurately and quickly. Moreover, the exploration of bacterial biofilm and the pathophysiological mechanism of the chronic wound will lay a solid foundation and clear direction for treating chronic wounds.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10226174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, prevalence and risk factors of device-related pressure injuries in adult intensive care unit: A meta-analysis of 10,084 patients from 11 countries. 成人重症监护室设备相关压力损伤的发生率、患病率和危险因素：对来自11个国家的10084名患者的荟萃分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-09-01 Epub Date: 2023-08-28 DOI: 10.1111/wrr.13112

Yi-Jie Jia, Fei-Hong Hu, Wan-Qing Zhang, Wen Tang, Meng-Wei Ge, Wang-Qin Shen, Hong-Lin Chen

{"title":"Incidence, prevalence and risk factors of device-related pressure injuries in adult intensive care unit: A meta-analysis of 10,084 patients from 11 countries.","authors":"Yi-Jie Jia, Fei-Hong Hu, Wan-Qing Zhang, Wen Tang, Meng-Wei Ge, Wang-Qin Shen, Hong-Lin Chen","doi":"10.1111/wrr.13112","DOIUrl":"10.1111/wrr.13112","url":null,"abstract":"Device-related pressure injuries (DRPIs) prevail in the intensive care unit (ICU) and have much to do with medical devices and patients' conditions. This meta-analysis aims to systematically assess the incidence, prevalence and risk factors related to DRPIs among adults in ICU. Web of Science, Cochrane Library, MEDLINE, PubMed and CINAHL were searched from inception to March 2023. Observational studies were included, and the Newcastle-Ottawa scale (NOS) was used to assess literature quality. The primary outcomes were the incidence, prevalence and risk factors regarding DRPIs among adults in ICU. The 19 studies conformed to the criteria for inclusion in the review. The estimated pooled incidence of DRPIs was 14.7% (95% CI: 9.7%-19.6%) in 10 studies (4866 participants). The estimated pooled prevalence of DRPIs was 19.0% (95% CI: 13.6%-24.3%) in 9 studies (5218 participants). The most significant risk factor for DRPIs was using mechanical ventilation. The pooled analysis of the four studies showed that DRPIs were more likely to occur in patients who required mechanical ventilation compared with patients who did not use mechanical ventilation (OR: 9.67, 95% CI: 5.03-18.61, p < 0.001) and using vasopressors, age, length of ICU stays, APACHE II score, Braden score, fever, sex, oedema, diabetes and number of medical devices, SOFA score was also related to pressure injuries risk. The incidence and prevalence of DRPIs in adult ICU were high, and the most significant risk factor for DRPIs was using mechanical ventilation. It is imminent to identify patients of increased risk with DRPIs early.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10226201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for vitamin D and the vitamin D receptor in keloid disorder. 维生素D和维生素D受体在瘢痕疙瘩疾病中的作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2023-09-01 Epub Date: 2023-07-27 DOI: 10.1111/wrr.13109

Jennifer M Hahn, Kelly A Combs, Heather M Powell, Dorothy M Supp

{"title":"A role for vitamin D and the vitamin D receptor in keloid disorder.","authors":"Jennifer M Hahn, Kelly A Combs, Heather M Powell, Dorothy M Supp","doi":"10.1111/wrr.13109","DOIUrl":"10.1111/wrr.13109","url":null,"abstract":"Keloids are disfiguring fibroproliferative lesions that can occur in susceptible individuals following any skin injury. They are extremely challenging to treat, with relatively low response rates to current therapies and high rates of recurrence after treatment. Although several distinct genetic loci have been associated with keloid formation in different populations, there has been no single causative gene yet identified and the molecular mechanisms guiding keloid development are incompletely understood. Further, although it is well known that keloids are more commonly observed in populations with dark skin pigmentation, the basis for increased keloid risk in skin of colour is not yet known. Because individuals with dark skin pigmentation are at higher risk for vitamin D deficiency, the role of vitamin D in keloid pathology has gained interest in the keloid research community. A limited number of studies have found lower serum vitamin D levels in patients with keloids, and reduced expression of the vitamin D receptor (VDR) in keloid lesions compared with uninjured skin. Vitamin D has documented anti-inflammatory, anti-proliferative and pro-differentiation activities, suggesting it may have a therapeutic role in suppression of keloid fibrosis. Here we review the evidence supporting a role for vitamin D and VDR in keloid pathology.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10225669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0