Wound Repair and Regeneration最新文献

{"title":"WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines.","authors":"Lawrence A Lavery, Mehmet A Suludere, Chris E Attinger, Matthew Malone, Gu Eon Kang, Peter A Crisologo, Edgar J Peters, Lee C Rogers","doi":"10.1111/wrr.13133","DOIUrl":"10.1111/wrr.13133","url":null,"abstract":"","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"34-46"},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrobium officinale Kinura et Migo glycoprotein promotes skin wound healing by regulating extracellular matrix secretion and fibroblast proliferation on the proliferation phase.","authors":"Jia Li, Qian Zhao, Xiaoyu Gao, Tianyi Dai, Zilin Bai, Jun Sheng, Yang Tian, Zhongbin Bai","doi":"10.1111/wrr.13144","DOIUrl":"10.1111/wrr.13144","url":null,"abstract":"<p><p>Dendrobium officinale Kinura et Migo (DOKM) has a variety of medicinal applications; however, its ability to promote wound healing has not been previously reported. The purpose of this study is to investigate the proliferative phase of the wound-healing effect of DOKM glycoprotein (DOKMG) in rats and to elucidate its mechanism of action in vitro. In the present study, the ointment mixture containing DOKMG was applied to the dorsal skin wounds of the full-thickness skin excision rat model, and the results showed that the wound healing speed was faster in the proliferative phase than vaseline. Histological analysis demonstrates that DOKMG promoted the re-epithelialization of wound skin. Immunofluorescence staining and quantitative polymerase chain reaction assays revealed that DOKMG promotes the secretion of Fibronectin and inhibits the secretion of Collagen IV during the granulation tissue formation period, indicating that DOKMG could accelerate the formation of granulation tissue by precisely regulating extracellular matrix (ECM) secretion. In addition, we demonstrated that DOKMG enhanced the migration and proliferation of fibroblast (3T6 cell) in two-dimensional trauma by regulating the secretion of ECM, via a mechanism that may implicate the AKT and JAK/STAT pathways under the control of epidermal growth factor receptor (EGFR) signalling. In summary, we have demonstrated that DOKMG promotes wound healing during the proliferative phase. Therefore, we suggest that DOKMG may have a potential therapeutic application for the treatment and management of cutaneous wounds.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"55-66"},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHS guidelines for the treatment of pressure ulcers-2023 update.","authors":"Lisa J Gould, Jenny Alderden, Rummana Aslam, Adrian Barbul, Kath M Bogie, Mohamed El Masry, Letitia Y Graves, E Foy White-Chu, Amany Ahmed, KerriAnn Boanca, Jessica Brash, Katie R Brooks, Wendy Cockron, Susan M Kennerly, Aaron K Livingston, Jeni Page, Catherine Stephens, Velena West, Tracey L Yap","doi":"10.1111/wrr.13130","DOIUrl":"10.1111/wrr.13130","url":null,"abstract":"<p><p>The major populations at risk for developing pressure ulcers are older adults who have multiple risk factors that increase their vulnerability, people who are critically ill and those with spinal cord injury/disease. The reported prevalence of pressure ulcers in the United States is 2.5 million. However, this estimate is derived from acute care facilities and does not include people who are living at home or in nursing facilities. Despite the implementation of hospital and facility-based preventive measures, the incidence of pressure ulcers has not decreased in decades. In addition to the burden of pain, infection and death, it is estimated that hospital-acquired pressure ulcers cost the health system $26.8 billion annually with over 50% of the cost attributed to treating Stage 3 and 4 pressure injuries. Thus, it is critical to examine the literature and develop guidelines that will improve the outcomes of this complex and costly condition. This guideline update is a compendium of the best available evidence for the treatment of Pressure Ulcers published since the last update in 2015 and includes a new section based on changing demographics entitled 'Palliative wound care for seriously ill patients with pressure ulcers'. The overall goal of the Wound Healing Society Guideline project is to present clear, concise and commercial free guidelines that clinicians can use to guide care, that researchers can use to develop studies that will improve treatment and that both clinicians and researchers can use to understand the gaps in our knowledge base.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"6-33"},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Recent advances in the induced pluripotent stem cell-based skin regeneration”","authors":"","doi":"10.1111/wrr.13135","DOIUrl":"https://doi.org/10.1111/wrr.13135","url":null,"abstract":"<p>Choudhury S., Surendran N., Das A. Recent advances in the induced pluripotent stem cell-based skin regeneration. <i>Wound Rep Reg</i>. 2021; <b>29</b>(5): 697–710. https://doi.org/10.1111/wrr.12925.</p>\u0000<p>In the article cited above, the authors have identified an error in the affiliation as specified below:</p>\u0000<p>The affiliation should be corrected as follows:</p>\u0000<p>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.</p>\u0000<p>We apologise for this error.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"12 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138631294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for venous ulceration in patients with varicose veins of lower extremities","authors":"Chaonan Yin, Fang Tang, Jiahui Lao, Yang Yang, Mingzhuo Li, Jia Cao, Ru Song, Peng Wu, Yibing Wang","doi":"10.1111/wrr.13139","DOIUrl":"https://doi.org/10.1111/wrr.13139","url":null,"abstract":"The aim of this case–control study was to explore the potential risk factors for venous ulceration in patients with varicose veins of lower extremities and to establish a simplified diagnostic score model. Seventy subjects with varicose veins of lower extremities and venous ulceration were compared with 1164 controls with varicose veins of lower extremities and no history of venous ulceration. Stepwise multivariate logistic regression analysis was used to identify the risk factors for venous ulceration. The steps in developing the diagnostic score model were based on the Framingham Heart study. The area under the receiver operating characteristic curve (AUC) was calculated to assess the diagnostic ability of the diagnostic score model. Multivariate analysis showed that men, overweight, obesity, longer duration varicose veins, deep venous valve insufficiency, low lymphocyte counts, and high fibrinogen concent were independently associated with an increased risk of venous ulceration. The AUC for the diagnostic score model was 0.75, which indicated good discriminatory ability. Special attention should be paid to the high-risk group of patients with lower extremity varicose veins. The diagnostic score model might be a useful screening tool for clinicians, policy makers, and patients.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"21 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138631277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing Profiles in Patients with a Chronic Diabetic Foot Ulcer: An Exploratory Study with Machine Learning","authors":"M. Graça Pereira, Margarida Vilaça, Diogo Braga, Ana Madureira, Jéssica Da Silva, Diana Santos, Eugénia Carvalho","doi":"10.1111/wrr.13141","DOIUrl":"https://doi.org/10.1111/wrr.13141","url":null,"abstract":"Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic, and social challenges. Therefore, early identification of patients with a high-risk profile would be important to prompt adequate treatment and more successful health outcomes. This study explores risk assessment profiles for DFU healing and healing prognosis, using machine learning predictive approaches and decision trees algorithms. Patients were evaluated at baseline (T0; <i>N</i> = 158) and two months later (T1; <i>N</i> = 108) on sociodemographic, clinical, biochemical, and psychological variables. The performance evaluation of the models comprised F1-score, accuracy, precision, and recall. Only profiles with F1-score &gt; 0.7 were selected for analysis. According to the two profiles generated for DFU healing, the most important predictive factors were illness representations on T1 IPQ-B (IPQ-B ≤ 9.5 and &lt; 10.5) and the DFU duration (≤ 13 weeks). The two predictive models for DFU healing prognosis suggest that biochemical factors are the best predictors of a favorable healing prognosis, namely IL-6, microRNA-146a-5p, and PECAM-1 at T0, and angiopoietin-2 at T1. Illness representations at T0 (IPQ-B ≤ 39.5) also emerged as a relevant predictor for healing prognosis. Results emphasize the importance of DFU duration, illness perception, and biochemical markers to predict healing in chronic non-healing DFU. Future research is needed to confirm and test the obtained predictive models.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"104 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138572880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of factors affecting the healing process of venous ulcers: a 12-week longitudinal study","authors":"Paulina Mościcka, Justyna Cwajda-Białasik, Arkadiusz Jawień, Wojciech Jaraczewski, Maria T. Szewczyk","doi":"10.1111/wrr.13140","DOIUrl":"https://doi.org/10.1111/wrr.13140","url":null,"abstract":"The process of healing venous ulcers is complex and influenced by many factors. By identifying the risk factors that influence a slower healing process, it is possible to predict impending delays and plan an individualized care plan. We analyzed our database of patients with venous ulcers and identified clinical and demographic factors that delay the healing process. The research analyzed the medical records of 754 patients with VLUs at Chronic Wound Treatment Unit of the University Hospital treated between 2001 and 2019.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"7 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138572479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Communications.","authors":"","doi":"10.1111/wrr.13132","DOIUrl":"10.1111/wrr.13132","url":null,"abstract":"","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"31 Suppl 1 ","pages":"S4-S58"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor in response to 'Tian K, Ye J, Zhong Y, Jia Z, Xu W, Gao S, Cao S, Li K, Wu L. Autologous i-PRF promotes healing of radiation-induced skin injury. Wound Repair Regen. 2023;31:454-463'.","authors":"Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Balaji Manohar, Sukhbir Singh Chopra","doi":"10.1111/wrr.13125","DOIUrl":"10.1111/wrr.13125","url":null,"abstract":"","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"729-730"},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secretome of stem cells from human exfoliated deciduous teeth (SHED) and its extracellular vesicles improves keratinocytes migration, viability, and attenuation of H₂ O₂ -induced cytotoxicity.","authors":"Juliana Girón Bastidas, Natasha Maurmann, Juliete Nathali Scholl, Augusto Ferreira Weber, Raíssa Padilha Silveira, Fabricio Figueiró, Marco Augusto Stimamiglio, Bruna Marcon, Alejandro Correa, Patricia Pranke","doi":"10.1111/wrr.13131","DOIUrl":"10.1111/wrr.13131","url":null,"abstract":"<p><p>Therapies for wound healing using the secretome and extracellular vesicles (EVs) of mesenchymal stem/stromal cells have been shown to be successful in preclinical studies. This study aimed to characterise the protein content of the secretome from stem cells from human exfoliated deciduous teeth (SHED) and analyse the in vitro effects of SHED-conditioned medium (SHED-CM) and SHED extracellular vesicles (SHED-EVs) on keratinocytes. EVs were isolated and characterised. The keratinocyte viability and migration of cells treated with SHED-EVs and conditioned medium (CM) were evaluated. An HaCaT apoptosis model induced by H₂ O₂ in vitro was performed with H₂ O₂ followed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and live/dead assays. Finally, the expression of vascular endothelial growth factor (VEGF) in keratinocytes treated with secretome and EVs was evaluated by immunofluorescence staining and confirmed with RT-qPCR. SHED-EVs revealed a cup-shaped morphology with expression of the classical markers for exosomes CD9 and CD63, and a diameter of 181 ± 87 nm. The internalisation of EVs by HaCaT cells was confirmed by fluorescence microscopy. Proteomic analysis identified that SHED-CM is enriched with proteins related to stress response and development, including cytokines (CXCL8, IL-6, CSF1, CCL2) and growth factors (IGF2, MYDGF, PDGF). The results also indicated that 50% CM and 0.4-0.6 μg/mL EVs were similarly efficient for improving keratinocyte viability, migration, and attenuation of H₂ O₂ -induced cytotoxicity. Additionally, expression of VEGF on keratinocytes increased when treated with SHED secretome and EVs. Furthermore, VEGF gene expression in keratinocytes increased significantly when treated with SHED secretome and EVs. Both SHED-CM and SHED-EVs may therefore be promising therapeutic tools for accelerating re-epithelialization in wound healing.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"827-841"},"PeriodicalIF":3.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}