Wound Repair and Regeneration最新文献_第9页

Rapid angiogenic hydrogel nanofiber scaffold promotes random flap regeneration and modulates inflammation. 快速血管生成水凝胶纳米纤维支架促进随机皮瓣再生和调节炎症。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70028

Junyan Liang, Yang Zou, Haiyan Ju, Yonggang Lv

引用次数: 0

Correction to "Suppression of TRIM72-mediated endoplasmic reticulum stress facilitates FOXM1 promotion of diabetic ulcer healing". 更正“抑制trim72介导的内质网应激促进FOXM1促进糖尿病溃疡愈合”。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70024

引用次数: 0

Intervention effects of low-level laser therapy (LLLT) on grade I-II ulcers in diabetic foot patients: A meta-analysis. 低水平激光治疗（LLLT）对糖尿病足患者I-II级溃疡的干预效果：一项荟萃分析

IF 3.4 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70021

Binxiong Chen, Zizhe Lin, Songyun Zou, Congcong Huang, Yueming Liu, Shi Xu

{"title":"Intervention effects of low-level laser therapy (LLLT) on grade I-II ulcers in diabetic foot patients: A meta-analysis.","authors":"Binxiong Chen, Zizhe Lin, Songyun Zou, Congcong Huang, Yueming Liu, Shi Xu","doi":"10.1111/wrr.70021","DOIUrl":"10.1111/wrr.70021","url":null,"abstract":"This study aims to systematically evaluate the effect of low-level laser therapy on grade I-II diabetic foot ulcers. We conducted a systematic search of the PubMed, Embase, Web of Science, EBSCO, Cochrane, ClinicalKey, Ovid Medline, Sinomed, CNKI, and WANFANG databases for studies assessing the efficacy of low-level laser therapy for diabetic foot ulcers, with a cutoff date of 15 September 2024. Two researchers independently selected relevant studies and extracted data, utilising RevMan 5.4 software to perform a meta-analysis. A total of 11 studies involving 657 participants with grade I-II diabetic foot ulcers were included. In patients with grade I-II diabetic foot ulcers, low-level laser therapy significantly increased the complete healing rate (RR = 4.97, 95% CI: 2.65-9.32, p < 0.00001), the wound shrinkage area (MD = 7.76, 95% CI: 6.51-9.0, p <0.00001), and the wound bacterial clearance rate (RR = 3.72, 95% CI: 2.16-6.39, p <0.00001) compared to the control group, while also reducing the infection rate (RR = 0.11, 95% CI: 0.01-0.8, p <0.03). Low-level laser therapy is an effective adjuvant therapy that accelerates wound healing in patients with grade I-II diabetic foot ulcers. However, further research is necessary to validate its effects on wound area reduction rate and healing time.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70021"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of keloid vasculature by tissue clearing and 3D imaging. 瘢痕疙瘩血管系统的组织清理和三维成像综合分析。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70015

Long Nguyen, Teruyuki Dohi, Haruko Watanabe-Takano, Shigetomo Fukuhara, Rei Ogawa

{"title":"Comprehensive analysis of keloid vasculature by tissue clearing and 3D imaging.","authors":"Long Nguyen, Teruyuki Dohi, Haruko Watanabe-Takano, Shigetomo Fukuhara, Rei Ogawa","doi":"10.1111/wrr.70015","DOIUrl":"10.1111/wrr.70015","url":null,"abstract":"Keloids are a complex type of scar tissue formed by exaggerated wound healing, characterised by the overgrowth of thick fibrous tissue beyond the original wound boundary. While the crucial relationship between keloid formation and the vascular system has been highlighted, conflicting findings have been reported regarding the characterisation of keloid vasculature. Here, we successfully characterised the detailed three-dimensional (3D) structure of vasculature in keloid tissues using tissue clearing methods combined with 3D imaging. First, we compared two optical tissue clearing methods, the clear, unobstructed brain imaging cocktails and computational analysis and immunolabelling-enabled 3D imaging of solvent-cleared organ protocols, and found the latter to provide greater transparency of keloid scars. We then conducted a detailed 3D vascular analysis using light sheet and confocal fluorescence microscopy. In normal skin, capillary loops and the superficial vascular plexus were located in the papillary layer and at the boundary between the papillary and reticular layers, respectively. However, the density of these vessels was higher in keloid scars than in normal skin. The reticular layer of normal skin exhibited fewer blood vessels. In contrast, keloid scars exhibited significantly thickened dermal reticular layers, with the upper reticular layer showing significantly greater vascularisation. The lower reticular layer of keloid scars also exhibited vertically aligned blood vessels, although their density was lower than in the upper reticular layer. These results indicate that excessive vascularisation is predominantly induced in the papillary and upper reticular layers of keloid scars, which might contribute to keloid pathogenesis. The technique described here has the potential to serve as a crucial template for future pathological analyses of abnormal scars.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70015"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of clinical practice guidelines and other best practice recommendations for pressure injury risk assessment in the United States. 对美国压力损伤风险评估的临床实践指南和其他最佳实践建议进行系统回顾。

IF 3.4 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70016

Anna Serafin, Sara Graziadio, Vladica Velickovic, Thurid-Christiane Milde, Jacqueline Dinnes, Alice Sitch, April Coombe, Laurie McNichol, David G Armstrong, Heather Lueck, Jan Kottner

{"title":"A systematic review of clinical practice guidelines and other best practice recommendations for pressure injury risk assessment in the United States.","authors":"Anna Serafin, Sara Graziadio, Vladica Velickovic, Thurid-Christiane Milde, Jacqueline Dinnes, Alice Sitch, April Coombe, Laurie McNichol, David G Armstrong, Heather Lueck, Jan Kottner","doi":"10.1111/wrr.70016","DOIUrl":"10.1111/wrr.70016","url":null,"abstract":"Preventing pressure injuries (PIs) remains the most effective way to reduce their burden. A key element of prevention is the assessment of PI risk. The study aimed to investigate whether guidance documents relevant to the United States (US) advocated for specific risk assessment recommendations. We conducted a systematic review of guidance documents published between 2010 and 2024. Embase, Medline, Cinahl, and four key organisational websites were systematically searched to retrieve relevant articles. Two independent reviewers screened the articles for inclusion. One reviewer extracted the data, and a second reviewer checked all extracted data. Three reviewers assessed the guidance documents quality using the Appraisal of Guidelines for Research & Evaluation (AGREE II) tool. A narrative synthesis was used to describe and summarise findings. Six clinical practice guidelines (CPGs) and eight other best practice recommendations were included. The median scores of most AGREE II domains were higher for CPGs compared to other best practice recommendations. Risk assessment was consistently positioned as a critical first step in the prevention of PIs, emphasising its role in identifying at-risk individuals and informing targeted interventions. Although risk assessment was presented as a crucial step in PI risk prevention, there was no clear and unanimous recommendation for a specific risk assessment strategy across all guidance documents, either for the general population or for specific subgroups of patients in US healthcare settings. These findings suggest a need for national consensus on concepts, implementation, and language addressing PI risk assessment.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70016"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scar changes over time after artificial dermis grafting for full-thickness temporal defects following skin cancer excision: A colorimetric and anthropometric study. 皮肤肿瘤切除后全层颞部缺损人工真皮移植后疤痕随时间的变化：一项比色和人体测量学研究。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70013

Kyu-Il Lee, Woo-Sung Kim, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong

{"title":"Scar changes over time after artificial dermis grafting for full-thickness temporal defects following skin cancer excision: A colorimetric and anthropometric study.","authors":"Kyu-Il Lee, Woo-Sung Kim, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong","doi":"10.1111/wrr.70013","DOIUrl":"10.1111/wrr.70013","url":null,"abstract":"Advances in biotechnology have introduced artificial dermis as an alternative to autologous tissue reconstruction. Our group has employed artificial dermis grafting for full-thickness temporal defects to overcome the limitations of traditional reconstructive methods, such as local flaps and skin grafts. This study evaluates the changes in colour matching and the degree of scar contraction following artificial dermis grafting and explores its potential for reconstructing such defects. This retrospective study included 25 patients who underwent artificial dermis grafting after skin cancer excision in the temporal region. Colour differences between the scar and surrounding skin were quantified using dE2000 scores. Scar contraction was assessed by measuring scar areas. These two parameters were evaluated intraoperatively, immediately after wound healing, and at 3, 6, and 12 months post-healing. The dE2000 scores immediately after healing and at 3, 6, and 12 months were 15.4 ± 7.4, 14.9 ± 6.8, 10.4 ± 4.6, and 6.3 ± 2.0, respectively (p < 0.01). According to reference values, the colour mismatch was rated as \"fair\" until 6 months post-healing and as \"very good\" at 12 months. The amounts of scar contraction immediately after healing and at 3, 6, and 12 months were 55.3 ± 10.5%, 65.6 ± 8.6%, 32.5 ± 15.9%, and 20.6 ± 14.8%, respectively (p < 0.01). These findings indicate that artificial dermis grafting for full-thickness temporal defects initially leads to significant colour mismatch and scar contraction. However, both parameters improve over time, achieving favourable outcomes within 12 months. Artificial dermis grafting may be a viable option for reconstructing skin and soft tissue defects in the temporal region.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70013"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "The Infected Diabetic Foot: Analysis of Diabetic and Non-diabetic Foot Infections". 《糖尿病足感染：糖尿病足感染与非糖尿病足感染分析》评论。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70017

Mostafa Javanian, Mohammad Barary, Ali Alizadeh Khatir, Soheil Ebrahimpour

引用次数: 0

2025 WHS Abstract Session List Key. 2025 WHS抽象会话列表密钥。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70018

引用次数: 0

Sociodemographic predictive factors of increased hospital stay and cost among hospitalised patients with pressure injuries-National Inpatient Sample 2009-2019 (pooled sample). 压力性损伤住院患者住院时间和费用增加的社会人口学预测因素——2009-2019年全国住院患者样本（汇总样本）

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70027

Siri Choragudi, Robert S Kirsner

{"title":"Sociodemographic predictive factors of increased hospital stay and cost among hospitalised patients with pressure injuries-National Inpatient Sample 2009-2019 (pooled sample).","authors":"Siri Choragudi, Robert S Kirsner","doi":"10.1111/wrr.70027","DOIUrl":"https://doi.org/10.1111/wrr.70027","url":null,"abstract":"Pressure injuries (PIs) pose a significant health burden, particularly among hospitalised patients. Understanding the sociodemographic factors influencing length and cost of hospital stay is crucial for addressing healthcare disparities. This study investigated the associations between sociodemographic factors and hospital stay outcomes among patients with pressure injuries in the United States from 2009 to 2019. Using the National Inpatient Sample (NIS), we analysed data from 1,252,729 patients with pressure injuries. We performed survey-weighted multivariable linear regression to assess the impact of sociodemographic factors on hospital stay duration and costs. Minority racial groups, lower-income patients, and those with non-Medicare insurance experienced longer hospital stays and higher costs. Older age groups (≥30 years) had shorter stays and lower costs. Significant disparities exist in hospital outcomes for patients with pressure injuries. Targeted interventions are needed to address these inequalities and improve patient care.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70027"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro wound healing effects of postbiotics derived from the gut microbiota of long-lived blind mole rats, a model of healthy ageing. 从长寿盲鼹鼠（健康衰老模型）肠道微生物群中提取的后生物制剂的体外伤口愈合效果。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70023

Hazal K Demirhan, Zeynep B Aksoy, Basar Karaca, Teoman Kankilic, Kamil C Akcali, Fadime Kiran

{"title":"In vitro wound healing effects of postbiotics derived from the gut microbiota of long-lived blind mole rats, a model of healthy ageing.","authors":"Hazal K Demirhan, Zeynep B Aksoy, Basar Karaca, Teoman Kankilic, Kamil C Akcali, Fadime Kiran","doi":"10.1111/wrr.70023","DOIUrl":"https://doi.org/10.1111/wrr.70023","url":null,"abstract":"Chronic wounds represent a global public health burden to patients and healthcare professionals worldwide. Considering the unmet need for safe and effective therapeutic approaches for wound healing, research on discovering new bioactive materials that support all stages of wound healing is gaining importance. In this study, the wound-healing activity of postbiotics obtained from Limosilactobacillus reuteri EIR/Spx-2, isolated from the gut microbiota of long-lived blind mole rats (Nannospalax xanthodon), was investigated. Our results demonstrated that postbiotics exhibited a strong inhibitory effect against important skin pathogens, eliminated their biofilm formation, and downregulated the expression of genes involved in their quorum-sensing regulatory mechanisms. Furthermore, treatment with postbiotics resulted in a significant increase (23.82% ± 2.11%) in L929 fibroblast cell proliferation. Additionally, postbiotics applied on scratched fibroblast monolayer significantly accelerated the re-epithelialization by 66.78% ± 3.74%. The treatment also increased the mRNA expression and protein levels of COL1A1 in the early healing phase. Moreover, the intracellular ROS levels of L929 cells suppressed by H2O2 were significantly reduced, which could be attributed to the content of flavonoids (4.8 mg/g) and phenolic compounds (7.12 mg/g) in postbiotics, as well as their DPPH scavenging activity. After treatment with postbiotics, the mRNA levels of IL-6 (5.77-fold) and TNF-α (1.76-fold) and the amount of NO (79.25% ± 3.18%) were significantly decreased in LPS-induced murine macrophages. The diverse metabolite profile of postbiotics, as characterised using chromatographic techniques, exhibited a strong correlation with their biological activity across all stages of the wound healing process, highlighting their potential as promising candidates for wound healing applications.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70023"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0