Wound Repair and Regeneration最新文献_第8页

Nanomaterial interventions for wound healing: Current status of preclinical and clinical studies. 纳米材料干预伤口愈合：临床前和临床研究的现状。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70031

Garima Agarwal, Samir Bhargava, Shweta Dumoga

{"title":"Nanomaterial interventions for wound healing: Current status of preclinical and clinical studies.","authors":"Garima Agarwal, Samir Bhargava, Shweta Dumoga","doi":"10.1111/wrr.70031","DOIUrl":"https://doi.org/10.1111/wrr.70031","url":null,"abstract":"Wound healing is a complex, highly coordinated process involving a series of molecular and cellular phases-haemostasis, inflammation, proliferation, and remodelling. These phases are regulated by growth factors such as cytokines and chemokines, coordinating the actions of fibroblasts, keratinocytes, progenitor, and endothelial cells. Disruptions in this process can lead to chronic wounds, an escalating global health issue. Despite advancements, current wound healing technologies face several limitations. Conventional dressings often fail to provide optimal moisture balance, leading to delayed healing. Bioengineered skin substitutes and growth factor therapies, while promising, are restricted by high costs, limited availability, immune rejection, and inconsistent efficacy. Moreover, infection control remains a significant challenge, necessitating alternative strategies that can enhance antimicrobial protection while promoting tissue regeneration. In response, nanotechnology has emerged as a potential game-changer in wound care, offering precise targeting of cells and regulatory molecules, enhanced therapeutic delivery, and tailored interaction with the wound environment. This review explores the role of nanomaterials in wound healing, emphasising their unique physicochemical properties and ability to promote tissue regeneration. We provide an overview of recent advances in nanotechnology, including nanoparticles, nanoengineered scaffolds, and gene and stem cell therapies. Additionally, we highlight the preclinical and clinical advancements of nanotechnology-based treatments, aiming to address the limitations of traditional wound care strategies.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 3","pages":"e70031"},"PeriodicalIF":3.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic mediators in the type 2 diabetes-osteomyelitis pathway: Complementing clinical risk factors with genetic evidence. 代谢介质在2型糖尿病-骨髓炎通路：补充临床危险因素与遗传证据。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-05-01 DOI: 10.1111/wrr.70029

Yijie Gao, Zhiheng Gui, Tao Liu, Lin Peng, Yunxia Du, Yantao Zhao

引用次数: 0

Correction to "Healing of diabetic neuropathic foot ulcers receiving standard treatment in randomised controlled trials: A random effects meta-analysis". 更正“在随机对照试验中接受标准治疗的糖尿病神经性足溃疡的愈合：一项随机效应荟萃分析”。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70010

引用次数: 0

Commentary on "The infected diabetic foot: Incidence and risk factors for dehiscence after surgery for diabetic foot infections". 对“感染的糖尿病足：糖尿病足感染术后裂开的发生率和危险因素”的评论。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70020

Majid Khalilizad, Mohammad Barary, Mostafa Javanian, Danial Hosseinzadeh, Soheil Ebrahimpour

引用次数: 0

Efficacy of photobiomodulation therapy on pain, swelling, and trismus following fixation of mandibular fractures. 光生物调节治疗下颌骨骨折固定后疼痛、肿胀和咬牙的疗效。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70026

Sunil S Nayak, Surbhi Varshney, G Arun Maiya, Kalyana C Pentapati, Shetty Shrija Jaya, Ankita Kar

{"title":"Efficacy of photobiomodulation therapy on pain, swelling, and trismus following fixation of mandibular fractures.","authors":"Sunil S Nayak, Surbhi Varshney, G Arun Maiya, Kalyana C Pentapati, Shetty Shrija Jaya, Ankita Kar","doi":"10.1111/wrr.70026","DOIUrl":"https://doi.org/10.1111/wrr.70026","url":null,"abstract":"Craniofacial fractures pose complex medical and surgical challenges. Prolonged wound healing complicates surgical reconstruction, highlighting the need for methods to enhance tissue healing. This research evaluated the effects of photobiomodulation (PBM) therapy on edema, trismus, and pain following mandibular fracture surgery. This study was approved by the Kasturba Hospital and Kasturba Medical College Institutional Ethics Committee (IEC: 219/2022). Thirty-two participants were signed up and split into two groups, one receiving PBM. Ten 660 nm LEDs with an energy density of 9 J/cm2, Power density (irradiance) of 50 mW/cm2, and nine 905 nm LEDs with an energy density of 13.5 J/cm2, power density (irradiance) of 75 mW/cm2. With a total power of 235 mW, the total dose was 42.3 J, a spot Size of 3.8 cm2, and pulsed at 156 Hz. The mandibular body and angle area were irradiated from the outer skin surface of the Jaw region. The therapy lasted for 3 min and was given for 4 consecutive days starting from the day after surgery. The present study evaluates pain thresholds using an algometer. The facial swelling was measured at two distinct points, the ear's tragus to the labial commissure (T-LC) and the outer canthus of the eye to the mandible's angle (OC-AM), using a ruler. Mouth opening was measured for trismus using a vernier calliper. There was no significant reduction in pain (-0.34 vs. -0.09; p = 0.079) or edema (T-LC: 2.44 vs. 2.13; p = 0.771, OC-AM 2.31 vs. 0.69; p = 0.185) in the PBM-treated group compared to the control group. However, trismus reduction was significantly better in the PBM group (-3.25 vs. -1.31; p < 0.001). In summary, a specific PBM protocol can effectively reduce trismus during recovery from mandibular fractures, with the potential for future optimization to address pain and edema.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70026"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of quince seed mucilage on perineal pain and healing following episiotomy: A randomised, triple-blind, placebo-controlled study. 木瓜籽粘液对会阴切开术后会阴疼痛和愈合的影响：一项随机、三盲、安慰剂对照研究。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70012

Foruzan Sharifipour, Nader Salari, Nasim Jamshidi, Zahra Javanbakht, Faeze Azizi, Shahla Faal Siahkal

{"title":"The effect of quince seed mucilage on perineal pain and healing following episiotomy: A randomised, triple-blind, placebo-controlled study.","authors":"Foruzan Sharifipour, Nader Salari, Nasim Jamshidi, Zahra Javanbakht, Faeze Azizi, Shahla Faal Siahkal","doi":"10.1111/wrr.70012","DOIUrl":"10.1111/wrr.70012","url":null,"abstract":"The incidence of episiotomy in Iran has been reported to be high, resulting in complications such as perineal infection and pain. This study investigates the effects of quince seed mucilage on the healing process and perineal pain. A triple-blinded clinical trial was conducted from October 2023 to August 2024 in Iran, involving 90 primiparous women who were randomly assigned to either the quince gel group or the placebo group for a duration of 14 days, with administration three times daily. The primary outcomes included wound healing and pain, which were evaluated using the REEDA questionnaire and the visual analogue scale. Data analysis was performed utilising SPSS version 25. There were no statistically significant differences found between the groups regarding the REEDA and VAS scores immediately following repair (p > 0.05). However, on day 14, the overall REEDA and VAS scores indicated that wound healing and pain levels in the intervention group were significantly more favourable than those in the control group (p = 0.001 vs. p = 0.002, respectively). This study demonstrates the beneficial impact of quince mucilage on improving wound healing and alleviating pain. The application of this mucilage may facilitate a quicker return to normalcy for mothers.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70012"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further considerations on risk factors for re-infection in diabetic foot osteomyelitis: Insights and recommendations for future research. 糖尿病足骨髓炎再感染危险因素的进一步考虑：对未来研究的见解和建议。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70022

Kun Zhang

引用次数: 0

Buprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard. 丁丙诺啡钝化皮肤暴露于氮芥后的炎症反应和伤口进展。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70009

Jingbo Pang, Emma Santoro, Rita E Roberts, Jeanette Purcell, Jeffrey D Fortman, Timothy J Koh

{"title":"Buprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard.","authors":"Jingbo Pang, Emma Santoro, Rita E Roberts, Jeanette Purcell, Jeffrey D Fortman, Timothy J Koh","doi":"10.1111/wrr.70009","DOIUrl":"10.1111/wrr.70009","url":null,"abstract":"Opioid analgesics are often used to alleviate pain in rodent models of skin wound injury and repair. However, previous studies have demonstrated that opioids can alter the inflammatory response to injury and subsequent wound healing. The purpose of this study was to determine the impact of different formulations of buprenorphine on mouse behaviour, inflammatory response and wound progression following skin exposure to nitrogen mustard (NM). Administration of either short-acting or long-acting formulations of buprenorphine in conjunction with skin NM exposure resulted in body weight loss, reduced activity and behavioural changes. Both short-acting and long-acting formulations also dampened aspects of the inflammatory response to NM exposure, including reduced levels of the chemokines CCL3 and CXCL2 and reduced accumulation of pro-inflammatory macrophages. The diminished inflammatory response was associated with reduced skin injury assessed both externally and histologically. These results have important implications for the use of opioid analgesics in studies involving vesicant exposure as well as the potential for the use of opioids as a countermeasure after NM exposure.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70009"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protection with a collagen wound matrix containing polyhexamethylene biguanide supports innate wound healing in biofilm-infected porcine wounds. 保护胶原伤口基质含有聚六亚甲基双胍支持先天伤口愈合的生物膜感染的猪伤口。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70025

Stephen C Davis, Justin T Avery, Joel Gil, Michael R Solis, Ivan Jozic, Kelly A Kimmerling, Katie C Mowry

{"title":"Protection with a collagen wound matrix containing polyhexamethylene biguanide supports innate wound healing in biofilm-infected porcine wounds.","authors":"Stephen C Davis, Justin T Avery, Joel Gil, Michael R Solis, Ivan Jozic, Kelly A Kimmerling, Katie C Mowry","doi":"10.1111/wrr.70025","DOIUrl":"https://doi.org/10.1111/wrr.70025","url":null,"abstract":"Over 90% of chronic wounds have biofilm infections, making the need for inhibiting reformation of biofilm post-debridement paramount to support progression through the normal phases of wound healing. Herein, we describe a porcine wound model infected with methicillin-resistant Staphylococcus aureus (MRSA) and examine the ability of an antimicrobial barrier composed of native type I collagen and polyhexamethylene biguanide (PCMP) to serve as a barrier to protect wounds and support progression through the innate wound healing cascade. Wounds were inoculated with MRSA and allowed to form a biofilm for 72 h, subjected to standard of care sharp debridement, then either left untreated or received PCMP for 5, 10, 15 or 20 days. Wounds were assessed for bioburden, wound closure and expression of genes related to wound healing. Wounds treated with PCMP exhibited statistically lower MRSA levels compared to untreated controls and achieved 90% closure by 2 weeks of treatment. Gene expression analysis demonstrated that by reducing bacterial load, wounds progressed through the innate wound healing cascade, while untreated wounds exhibited a dampening of the immune response. Additionally, for randomly assigned wounds, PCMP was not reapplied at dressing changes to assess the impact of inconsistent wound protection. At all timepoints, a resurgence in bioburden was observed following removal of PCMP if the wounds had not fully closed. This study highlights the value of PCMP as an antimicrobial barrier and the importance of protecting wounds through closure and resolution.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70025"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymicrobial infection in bone biopsies and relapse in diabetic foot osteomyelitis: The role of soft tissue involvement. 糖尿病足骨髓炎骨组织活检中的多微生物感染和复发：软组织受累的作用。

IF 3.8 3区医学

Wound Repair and Regeneration Pub Date : 2025-03-01 DOI: 10.1111/wrr.70011

Javier Aragón-Sánchez, Gerardo Víquez-Molina, José María Rojas-Bonilla

{"title":"Polymicrobial infection in bone biopsies and relapse in diabetic foot osteomyelitis: The role of soft tissue involvement.","authors":"Javier Aragón-Sánchez, Gerardo Víquez-Molina, José María Rojas-Bonilla","doi":"10.1111/wrr.70011","DOIUrl":"10.1111/wrr.70011","url":null,"abstract":"The purpose of this study was to examine whether polymicrobial infection in bone biopsies is associated with infection relapse following surgery for diabetic foot osteomyelitis. Relapse of infection presents a major challenge in treating diabetic foot osteomyelitis, yet the role of microbiological factors in predicting relapse remains underexplored. We conducted a retrospective analysis of 100 patients treated surgically for diabetic foot osteomyelitis. Bone biopsies were obtained intraoperatively for microbiological and histopathological examination. Relapse was defined as the recurrence of infection in bone or soft tissue necessitating additional surgical intervention or antibiotic therapy. Our findings indicate that soft tissue involvement, rather than polymicrobial infection in bone biopsies, is a significant predictor of relapse, with patients exhibiting soft tissue involvement showing a markedly higher likelihood of relapse. In contrast, polymicrobial growth in bone biopsies was not significantly associated with infection relapse. These results highlight the importance of soft tissue integrity in treatment outcomes and suggest that local tissue damage, rather than microbiological diversity, may play a more critical role in relapse. This study challenges the assumption that polymicrobial infection directly influences relapse risk and raises questions regarding the reliance on wound healing as an indicator of successful infection management. Future studies should focus on refining treatment indicators and exploring comprehensive approaches that address both bone and soft tissue infections to reduce relapse rates and improve patient outcomes.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":"33 2","pages":"e70011"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0