IF 3.8 3区 医学 Q2 CELL BIOLOGY
Alireza Sadeghi-Avalshahr, Simin Nazarnezhad, Halimeh Hassanzadeh, Mahboubeh Kazemi Noughabi, Negar Namaei-Ghasemnia, Mehdi Jalali
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引用次数: 0

摘要

对复杂的伤口愈合过程进行详细研究后发现,伤口愈合过程就像一曲精心编排的交响乐,伤口部位的相关细胞经过精密计算后相互协作。各种细胞因子、趋化因子、生长因子和小生物分子(如抗菌肽)共同发挥着多米诺骨牌般的作用,成功地完成了伤口愈合过程。因此,使用仅含有一种具有特定性质和功能的添加剂的伤口敷料,似乎并不能特别有效地治疗慢性伤口环境中常见的复杂情况。使用含有各种添加剂的多功能敷料在促进伤口愈合过程中显示出良好的效果。这篇综合评论文章探讨了此类敷料中集成添加剂的协同效应,旨在提供对其综合治疗潜力的最新认识。通过分析最新进展和研究成果,本综述揭示了不同添加剂之间错综复杂的相互作用、作用机制及其对伤口愈合结果的累积影响。此外,综述还讨论了在伤口护理中使用综合疗法的重要性,并强调了伤口愈合管理领域研究和临床实践的潜在未来方向和影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synergistic effects of incorporated additives in multifunctional dressings for chronic wound healing: An updated comprehensive review.

Detailed reviewing of the complicated process of wound healing reveals that it resembles an orchestrated symphony via a precise and calculated collaboration of relevant cells at the wound site. The domino-like function of various cytokines, chemokines, growth factors and small biological molecules such as antibacterial peptides all come together to successfully execute the wound healing process. Therefore, it appears that the use of a wound dressing containing only a single additive with specific properties and capabilities may not be particularly effective in treating the complex conditions that are usual in the environment of chronic wounds. The use of multifunctional dressings incorporating various additives has shown promising results in enhancing wound healing processes. This comprehensive review article explores the synergistic effects of integrated additives in such dressings, aiming to provide an updated understanding of their combined therapeutic potential. By analysing recent advancements and research findings, this review sheds light on the intricate interactions between different additives, their mechanisms of action and their cumulative impact on wound healing outcomes. Moreover, the review discusses the importance of utilising combined therapies in wound care and highlights the potential future directions and implications for research and clinical practice in the field of wound healing management.

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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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