Recent advances in bioactive wound dressings.

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Wound Repair and Regeneration Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI:10.1111/wrr.13233
Md Golam Nur, Mustafijur Rahman, Tanvir Mahady Dip, Md Hasibul Hossain, Nusrat Binta Hossain, Sara Baratchi, Rajiv Padhye, Shadi Houshyar
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Abstract

Traditional wound dressings, despite their widespread use, face limitations, such as poor infection control and insufficient healing promotion. To address these challenges, bioactive materials have emerged as a promising solution in wound care. This comprehensive review explores the latest developments in wound healing technologies, starting with an overview of the importance of effective wound management, emphasising the need for advanced bioactive wound dressings. The review further explores various bioactive materials, defining their characteristics. It covers a wide range of natural and synthetic biopolymers used to develop bioactive wound dressings. Next, the paper discusses the incorporation of bioactive agents into wound dressings, including antimicrobial and anti-inflammatory agents, alongside regenerative components like growth factors, platelet-rich plasma, platelet-rich fibrin and stem cells. The review also covers fabrication techniques for bioactive wound dressings, highlighting techniques like electrospinning, which facilitated the production of nanofibre-based dressings with controlled porosity, the sol-gel method for developing bioactive glass-based dressings, and 3D bioprinting for customised, patient-specific dressings. The review concludes by addressing the challenges and future perspectives in bioactive wound dressing development. It includes regulatory considerations, clinical efficacy, patient care protocol integration and wound healing progress monitoring. Furthermore, the review considers emerging trends such as smart materials, sensors and personalised medicine approaches, offering insights into the future direction of bioactive wound dressing research.

生物活性伤口敷料的最新进展。
传统的伤口敷料尽管被广泛使用,但也面临着一些局限性,如感染控制不佳和促进愈合的能力不足。为应对这些挑战,生物活性材料已成为伤口护理领域前景广阔的解决方案。本综述探讨了伤口愈合技术的最新发展,首先概述了有效伤口管理的重要性,强调了对先进生物活性伤口敷料的需求。该综述进一步探讨了各种生物活性材料,明确了它们的特性。它涵盖了用于开发生物活性伤口敷料的各种天然和合成生物聚合物。接下来,论文讨论了在伤口敷料中加入生物活性剂的问题,包括抗菌剂和消炎剂,以及生长因子、富血小板血浆、富血小板纤维蛋白和干细胞等再生成分。综述还涉及生物活性伤口敷料的制造技术,重点介绍了电纺丝等技术,这些技术有助于生产具有可控孔隙率的纳米纤维基敷料;溶胶-凝胶法用于开发生物活性玻璃基敷料;三维生物打印用于定制患者专用敷料。综述最后探讨了生物活性伤口敷料开发所面临的挑战和未来前景。其中包括监管方面的考虑、临床疗效、患者护理方案整合和伤口愈合进展监测。此外,综述还考虑了智能材料、传感器和个性化医疗方法等新兴趋势,为生物活性伤口敷料研究的未来方向提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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