从伤口到毛囊：揭示伤口诱导的毛囊新生的机制和分子网络。

IF 3.4 3区医学 Q2 CELL BIOLOGY

Wound Repair and Regeneration Pub Date : 2025-09-01 DOI:10.1111/wrr.70093

Mingwei Shang, Ziyuan Tang, Weining Huang, Zhongrong Liu

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引用次数: 0

摘要

伤口诱导的毛囊新生（WIHN）是在特定哺乳动物中观察到的一种再生过程，涉及皮肤损伤后新毛囊的形成。虽然表现出与胚胎毛囊发育的相似性，但WIHN也表现出显著的差异。尽管在阐明其潜在机制方面付出了相当大的努力，但WIHN的几个方面仍不清楚。全面了解控制这一过程的因素和信号通路，有望开发针对人类无毛疤痕形成的新型治疗干预措施。

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From Wound to Hair Follicle: Unravelling the Mechanisms and Molecular Networks in Wound-Induced Hair Follicle Neogenesis.

Wound-induced hair follicle neogenesis (WIHN), a regenerative process observed in select mammals, involves the formation of new hair follicles following skin injury. Although exhibiting similarities to embryonic hair follicle development, WIHN also presents notable distinctions. Despite considerable efforts to elucidate its underlying mechanisms, several aspects of WIHN remain unclear. A comprehensive understanding of the factors and signalling pathways governing this process holds promise for developing novel therapeutic interventions targeting hairless scar formation in humans.

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来源期刊

Wound Repair and Regeneration 医学-皮肤病学

CiteScore

5.90

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.