World Journal of Gastrointestinal Surgery最新文献

{"title":"Programmed cell death receptor 1 inhibitor Pembrolizumab in the treatment of advanced gastric cancer.","authors":"Xue-Mei Yi, Hong-Qiao Cai, Yan Jiao","doi":"10.4240/wjgs.v17.i2.100257","DOIUrl":"10.4240/wjgs.v17.i2.100257","url":null,"abstract":"<p><p>This editorial discusses Christodoulidis <i>et al</i>'s article, which appeared in the most recent edition. The clinical trials have demonstrated the programmed cell death receptor 1 (PD-1) inhibitor Pembrolizumab involved combination therapy can improve the efficacy of advanced gastric cancer (AGC). Pembrolizumab combined with chemotherapy can enhance its sensitivity, and further eliminate tumor cells that develop resistance to chemotherapy. The combination of Pembrolizumab and Trastuzumab targeting human epidermal growth factor receptor 2 showed improved prognosis. The overall toxic effects of Pembrolizumab are significantly lower than traditional chemotherapy, and the safety is controllable. PD-1 inhibitor Pembrolizumab sheds a light on the treatment of AGC and brings new hope to the clinical practice.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"100257"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing invasiveness in liver surgery-where is the limit?","authors":"Ivan Romic, Ivan Separovic, Dora Grgic, Igor Petrovic, Josip Mavrek, Hrvoje Silovski","doi":"10.4240/wjgs.v17.i2.101852","DOIUrl":"10.4240/wjgs.v17.i2.101852","url":null,"abstract":"<p><p>In this article, we comment on the article by Wang <i>et al</i> published in the recent issue of the <i>World Journal of Gastroenterology Surgery</i>. Most prominent advancements in liver surgery in the last two decades are related to refinements in surgical technique (extraglissonean approach) and advancements in surgical technology (laparoscopy and robotics). In this article, authors present both these aspects: Laparoscopic segmentectomy using extraglissonean approach. Furthermore, they describe segmental resections of all 8 segments which is the main novelty that can be observed in the article. By now, extraglissonean approach was thoroughly described mainly in hepatectomies or lateral sectionectomies. Various \"hilar gates\" are defined which allows safe liver resection by ligating Glissonean pedicles first which is then followed by parenchymal resection. We here focus on past, present and future perspectives of extraglissonean approach and laparoscopic liver resections and comment the value of the presented article.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"101852"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of <i>Saccharomyces boulardii</i> in combination with sulfasalazine in ulcerative colitis patients demonstrates significant effectiveness.","authors":"Chun-Chun Yang, Sui Zhang, Rui Zhang, Ya-Nan Zhao, Da-Wei Yang, Ming-Yue Yang, Li-Jing Huang","doi":"10.4240/wjgs.v17.i2.102342","DOIUrl":"10.4240/wjgs.v17.i2.102342","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ulcerative colitis (UC) is a complex inflammatory bowel disease, and its etiology and pathogenesis remain incompletely elucidated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To analyze the effects of &lt;i&gt;Saccharomyces boulardii&lt;/i&gt; in combination with sulfasalazine on intestinal microbiota and intestinal barrier function in patients with UC.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis of clinical data from 127 UC patients admitted to our hospital between January 2021 and January 2023 was conducted. All patients met complete inclusion and exclusion criteria. Based on the treatment interventions received, they were divided into a control group (&lt;i&gt;n&lt;/i&gt; = 63) and an observation group (&lt;i&gt;n&lt;/i&gt; = 64). Both groups of patients received routine treatment upon admission. The control group received sulfasalazine in addition to routine interventions, while the observation group received a combination of &lt;i&gt;Saccharomyces boulardii&lt;/i&gt; on the basis of the control group's treatment. The clinical efficacy, improvement in symptoms, modified Baron endoscopic scores, quality of life \"inflammatory bowel disease questionnaire (IBDQ)\", levels of intestinal microbial indicators (such as &lt;i&gt;Lactobacillus&lt;/i&gt;, &lt;i&gt;Bifidobacterium&lt;/i&gt;, &lt;i&gt;Enterococcus&lt;/i&gt;, and &lt;i&gt;Escherichia coli&lt;/i&gt;), intestinal mucosal barrier function indicators [diamine oxidase (DAO), lipopolysaccharide (LPS), D-lactic acid (D-LA)], and adverse reaction occurrences were compared between the two groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) Clinical efficacy: The total effective rate in the control group was 79.37%, while in the observation group, it was 93.75%, significantly higher than that of the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); (2) Improvement in symptoms: The observation group showed significantly lower relief time for abdominal pain, diarrhea, rectal bleeding, fever symptoms, and mucosal healing time compared to the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); (3) Baron endoscopic scores and IBDQ scores: Before treatment, there was no significant difference in Baron endoscopic scores and IBDQ scores between the two groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). However, after treatment, the observation group showed significantly lower Baron endoscopic scores and higher IBDQ scores compared to the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); (4) Levels of intestinal microbial indicators: Before treatment, there was no significant difference in the levels of &lt;i&gt;Lactobacillus&lt;/i&gt;, &lt;i&gt;Bifidobacterium&lt;/i&gt;, &lt;i&gt;Enterococcus&lt;/i&gt;, and &lt;i&gt;Escherichia coli&lt;/i&gt; between the two groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). After treatment, the levels of Lactobacillus and Bifidobacterium in the observation group were significantly higher than those in the control group, while the levels of &lt;i&gt;Enterococcus&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt; were significantly lower than those in the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); (5) Levels of intestinal mucosal barrier function indicators: Before treatment, there was no significant difference in the levels of DAO","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"102342"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel surgical approach - cadaveric inferior vena cava graft reconstruction following leiomyosarcoma resection: A case report.","authors":"Hadeel A AlOmran, Bayan AlMatar, Mohammed AlMonsained, Shoukat Bojal, Hammam Momani, Mohammed S AlQahtani","doi":"10.4240/wjgs.v17.i2.101775","DOIUrl":"10.4240/wjgs.v17.i2.101775","url":null,"abstract":"<p><strong>Background: </strong>Inferior vena cava (IVC) leiomyosarcomas are rare and aggressive tumors. Complete cure depends on achieving R0 resection, which often requires circumferential resection and reconstruction. Synthetic grafts have traditionally been used when venous continuity must be restored. However, the use of cadaveric IVC grafts for reconstruction has not been widely reported.</p><p><strong>Case summary: </strong>Herein, we present the case of a 64-year-old woman diagnosed with an intrahepatic IVC leiomyosarcoma with local invasion. The patient responded favorably to chemotherapy and subsequently underwent an <i>en bloc</i> right hepatectomy, retrohepatic IVC resection, and reconstruction with an interpositional cadaveric IVC graft. Serial imaging follow-ups until 2 years after the operation showed persistent patency of the graft and no graft-related complications.</p><p><strong>Conclusion: </strong>Cadaveric IVC grafts are an alternative to synthetic grafts for reconstruction, with acceptable outcomes. Larger, long-term studies are necessary to validate these findings.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"101775"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for postoperative ileus: Advancement and underlying mechanisms.","authors":"Yang Ye, Xi-Yan Xin, Ze-Jun Huo, Yu-Tian Zhu, Rui-Wen Fan, Hao-Lin Zhang, Yu Gao, Hong-Bo Shen, Dong Li","doi":"10.4240/wjgs.v17.i2.99160","DOIUrl":"10.4240/wjgs.v17.i2.99160","url":null,"abstract":"<p><p>Postoperative ileus (POI) remains a prevalent and significant challenge following abdominal surgeries, precipitating patient distress, prolonged hospital stays, and escalated medical expenditures. Conventionally addressed <i>via</i> pharmacological interventions, POI is increasingly being explored through adjunctive therapeutic strategies, with acupuncture gaining recognition as a promising option. Acupuncture has demonstrated encouraging potential in promoting gastrointestinal motility in patients with POI. Moreover, recent research has shed light on the therapeutic mechanisms underlying its efficacy. This article aims to present a comprehensive overview of acupuncture as a treatment for POI, highlighting advancements in clinical research and recent elucidations of its mechanistic underpinnings. It aspires to contribute a pivotal reference point for scholars and enthusiasts keen on garnering a deeper understanding of acupuncture's role in managing POI.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"99160"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common bile duct stump stones and recurrent acute pancreatitis after Roux-en-Y choledochojejunostomy in a child: A case report.","authors":"Jian-Feng Li, Min-Jian Xie, Jin-Xiu Wei, Cheng-Ning Yang, Guang-Wen Chen, Li-Qun Li, Yi-Na Zhao, Li-Jian Liu, Sheng Xie","doi":"10.4240/wjgs.v17.i2.102105","DOIUrl":"10.4240/wjgs.v17.i2.102105","url":null,"abstract":"<p><strong>Background: </strong>Pancreaticobiliary maljunction (PBM) is a rare congenital abnormality in pancreaticobiliary duct development. PBM is commonly found in children, and it often leads to acute pancreatitis and other diseases as a result of pancreaticobiliary reflux. Roux-en-Y choledochojejunostomy is a common surgical method for the treatment of PBM, but there are several associated complications that may occur after this operation.</p><p><strong>Case summary: </strong>The patient, a 12-year-old female, was hospitalized nearly 20 times in 2021 for recurrent acute pancreatitis. In 2022, she was diagnosed with PBM and underwent laparoscopic common bile duct resection and Roux-en-Y choledochojejunostomy in a tertiary hospital. In the first year after surgery, the patient had more than 10 recurrent acute pancreatitis episodes. After undergoing abdominal computed tomography and other examinations, she was diagnosed with \"residual bile duct stones and recurrent acute pancreatitis\". On January 30, 2024, the patient was admitted to our hospital due to recurrent upper abdominal pain and was cured through endoscopic retrograde cholangiopancreatography.</p><p><strong>Conclusion: </strong>This article reports a case of a child with distal residual common bile duct stones and recurrent acute pancreatitis after Roux-en-Y choledochojejunostomy for PBM. The patient was cured through endoscopic retrograde cholangiopancreatography.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"102105"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting post-hepatectomy liver failure using a nomogram based on portal vein width, inflammatory indices, and the albumin-bilirubin score.","authors":"Ke Sun, Jiang-Bin Li, Ya-Feng Chen, Zhong-Jie Zhai, Lang Chen, Rui Dong","doi":"10.4240/wjgs.v17.i2.99529","DOIUrl":"10.4240/wjgs.v17.i2.99529","url":null,"abstract":"<p><strong>Background: </strong>Post-hepatectomy liver failure (PHLF) after liver resection is one of the main complications causing postoperative death in patients with hepatocellular carcinoma (HCC). It is crucial to help clinicians identify potential high-risk PHLF patients as early as possible through preoperative evaluation.</p><p><strong>Aim: </strong>To identify risk factors for PHLF and develop a prediction model.</p><p><strong>Methods: </strong>This study included 248 patients with HCC at The Second Affiliated Hospital of Air Force Medical University between January 2014 and December 2023; these patients were divided into a training group (<i>n</i> = 164) and a validation group (<i>n</i> = 84) <i>via</i> random sampling. The independent variables for the occurrence of PHLF were identified by univariate and multivariate analyses and visualized as nomograms. Ultimately, comparisons were made with traditional models <i>via</i> receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>In this study, portal vein width [odds ratio (OR) = 1.603, 95%CI: 1.288-1.994, <i>P</i> ≤ 0.001], the preoperative neutrophil-to-lymphocyte ratio (NLR) (OR = 1.495, 95%CI: 1.126-1.984, <i>P</i> = 0.005), and the albumin-bilirubin (ALBI) score (OR = 8.868, 95%CI: 2.144-36.678, <i>P</i> = 0.003) were independent risk factors for PHLF. A nomogram prediction model was developed using these factors. ROC and DCA analyses revealed that the predictive efficacy and clinical value of this model were better than those of traditional models.</p><p><strong>Conclusion: </strong>A new Nomogram model for predicting PHLF in HCC patients was successfully established based on portal vein width, the NLR, and the ALBI score, which outperforms the traditional model.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"99529"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of perioperative probiotic intervention on recovery following intestinal surgery.","authors":"Yang Wu, Xin Zhang, Guan-Qiao Wang, Yan Jiao","doi":"10.4240/wjgs.v17.i2.97503","DOIUrl":"10.4240/wjgs.v17.i2.97503","url":null,"abstract":"<p><p>Restoring the balance of gut microbiota has emerged as a critical strategy in treating intestinal disorders, with probiotics playing a pivotal role in maintaining bacterial equilibrium. Surgical preparations, trauma, and digestive tract reconstruction associated with intestinal surgeries often disrupt the intestinal flora, prompting interest in the potential role of probiotics in postoperative recovery. Lan <i>et al</i> conducted a prospective randomized study on 60 patients with acute appendicitis, revealing that postoperative administration of <i>Bacillus licheniformis</i> capsules facilitated early resolution of inflammation and restoration of gastrointestinal motility, offering a novel therapeutic avenue for accelerated postoperative recovery. This editorial delves into the effects of perioperative probiotic supplementation on physical and intestinal recovery following surgery. Within the framework of enhanced recovery after surgery, the exploration of new probiotic supplementation strategies to mitigate surgical complications and reshape gut microbiota is particularly intriguing.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"97503"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal biliary diversion using appendix during liver transplantation for progressive familial intrahepatic cholestasis type 1: A case report.","authors":"Jia-Qi Song, Tao Zhou, Yi Luo, Yuan Liu","doi":"10.4240/wjgs.v17.i2.101239","DOIUrl":"10.4240/wjgs.v17.i2.101239","url":null,"abstract":"<p><strong>Background: </strong>Progressive familial intrahepatic cholestasis type 1 (PFIC-1) is a genetic cholestatic disease causing end-stage liver disease, which needs liver transplantation (LT). Simultaneous biliary diversion (BD) was recommended to prevent allograft steatosis after transplantation, while increasing the risk of infection. Here, an attempt was made to perform BD using appendix to prevent bacterial translocation after LT.</p><p><strong>Case summary: </strong>An 11-month-old boy diagnosed with PFIC-1 received ABO compatible living donor LT due to refractory jaundice and pruritus. His mother donated her left lateral segment with a graft-to-recipient weight ratio of 2.9%. Internal BD was constructed during LT using the appendix by connecting its proximal end with the intrahepatic biliary duct and the distal end with colon. Biliary leakage was suspected on the 5^th day after transplantation and exploratory laparotomy indicated biliary leakage at the cutting surface of liver. The liver function returned to normal on the 9^th day post-operation and maintained normal during the 15-month follow-up. Cholangiography at 10 months after transplantation confirmed the direct secretion of bile into colon. Computerized tomography scan (4 months and 10 months) and liver biopsy (10 months) indicated no steatosis in the allograft. No complaint of recurrent diarrhea, infection or growth retardation was reported during follow-up.</p><p><strong>Conclusion: </strong>Internal BD using appendix during LT is effective in preventing allograft steatosis and post-transplant infection in PFIC-1 recipients.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"101239"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of comprehensive perioperative nursing on pain intensity, complication rates, and comfort levels in patients undergoing gallstone surgery.","authors":"Chen-Yan Bao, Xiao-Kun Ding, Qiao-Fei Qi, Peng Ye, Ze-Jun Fang","doi":"10.4240/wjgs.v17.i2.99826","DOIUrl":"10.4240/wjgs.v17.i2.99826","url":null,"abstract":"<p><strong>Background: </strong>Surgery is the gold standard for gallstone treatment. Nevertheless, the complications associated with the surgical procedure can exert diverse and adverse impacts on patients' health and quality of life to varying extents. Hence, it is essential to offer perioperative care to patients undergoing gallstone surgery.</p><p><strong>Aim: </strong>To examine the impact of perioperative comprehensive nursing on pain intensity, complication rates, and patient comfort in individuals undergoing gallstone surgery.</p><p><strong>Methods: </strong>From February 2022 to February 2024, 195 patients who underwent gallstone surgery at Sanmen People's Hospital were selected and divided into two groups: A control group receiving routine nursing care (95 patients) and a research group receiving perioperative comprehensive nursing (100 patients). Key postoperative recovery indicators, including time to first postoperative anal exhaust, oral food intake, and ambulation, were observed, along with pain intensity (measured by the numeric rating scale), complication rate (bleeding, incision infection, recurrence), patient comfort (assessed using the visual analogue scale), and quality of life (measured by the World Health Organization Quality of Life-BREF).</p><p><strong>Results: </strong>The research group showed significantly shorter times to first postoperative anal exhaust, oral intake, and ambulation. Moreover, numeric rating scale pain scores in the research group were markedly lower post-nursing, and the total complication rate was significantly reduced compared to the control group. Furthermore, comfort levels improved considerably in the research group, and World Health Organization Quality of Life-BREF scores across the physical, psychological, social, and environmental domains were significantly higher compared to the control group following nursing care.</p><p><strong>Conclusion: </strong>Perioperative comprehensive nursing effectively enhances postoperative recovery in patients undergoing gallstone surgery, reducing pain, lowering complications, and improving patient comfort and quality of life, which deserves clinical application.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 2","pages":"99826"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}