Effect of comorbid gastroesophageal reflux disease on laryngopharyngeal reflux disease: Clinical characteristics and risk factors.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastrointestinal Surgery Pub Date : 2025-09-27 DOI:10.4240/wjgs.v17.i9.108715

Dan-Dan Xu

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引用次数: 0

Abstract

Background: Research thoroughly examining how gastroesophageal reflux disease (GERD) affects clinical presentations in patients with laryngopharyngeal reflux disease (LPRD) and exploring the associated triggers is limited.

Aim: To investigate the effect of comorbid GERD on the clinical characteristics of patients with LPRD and determine risk contributors.

Methods: In total, 150 patients with LPRD admitted between October 2022 and October 2024 were divided into the GERD (n = 74) or non-GERD (n = 76) group based on their comorbid GERD status. The clinical data collected included age, sex, body mass index (BMI), marital status, smoking, alcohol consumption, and eating habits in the 3-hour window before sleep. The following reflux-related symptoms were recorded: (1) Hoarseness/voice disorders; (2) Persistent throat clearing; (3) Excessive phlegm/postnasal drip; (4) Difficulty swallowing food or water; (5) Postprandial or supine coughing; (6) Breathing difficulties; (7) Bothersome cough; (8) Throat foreign body sensation; (9) Heartburn, chest pain; and (10) Stomach pain. The Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) tools were used. Binary logistic regression identified contributors to GERD in LPRD.

Results: Compared with the non-GERD group, the GERD group, with a notably higher BMI, included greater proportions of older patients, female patients, smokers, and alcohol users and a higher prevalence of bothersome cough, heartburn, chest pain, and stomach pain; however, excessive phlegm or postnasal drip was less common. Additionally, patients with LPRD and comorbid GERD had notably higher RSI and RFS scores. Age (P = 0.017), sex (P = 0.029), smoking (P = 0.012), and alcohol consumption (P = 0.036) were significant triggers for GERD comorbidity in LPRD.

Conclusion: Comorbid GERD exacerbates clinical manifestations of patients with LPRD. Advanced age, female sex, smoking, and alcohol consumption predispose patients with LPRD to GERD development.

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合并症胃食管反流病对咽喉反流病的影响：临床特点及危险因素。

背景：深入研究胃食管反流病（GERD）如何影响喉咽反流病（LPRD）患者的临床表现并探索相关触发因素的研究有限。目的：探讨合并症胃食管反流对LPRD患者临床特征的影响，确定其危险因素。方法：选取2022年10月至2024年10月收治的150例LPRD患者，根据合并GERD情况分为GERD组（n = 74）和非GERD组（n = 76）。收集的临床数据包括年龄、性别、体重指数（BMI）、婚姻状况、吸烟、饮酒和睡前3小时内的饮食习惯。记录了以下与反流相关的症状：(1)声音嘶哑/声音障碍；(2)持续清喉；(3)痰多/鼻后滴涕；(4)吞咽食物或水困难；(5)餐后或仰卧咳嗽；(6)呼吸困难；(7)恼人的咳嗽；(8)咽喉异物感；(9)烧心、胸痛；（10）胃痛。使用反流症状指数（RSI）和反流发现评分（RFS）工具。二元逻辑回归确定了LPRD中GERD的贡献者。结果：与非GERD组相比，GERD组的BMI明显更高，包括老年患者、女性患者、吸烟者和饮酒者的比例更高，以及令人烦恼的咳嗽、胃灼热、胸痛和胃痛的患病率更高；然而，痰多或鼻后滴涕不太常见。此外，LPRD和合并症GERD患者的RSI和RFS评分明显更高。年龄（P = 0.017）、性别（P = 0.029）、吸烟（P = 0.012）和饮酒（P = 0.036）是LPRD患者GERD合并症的重要诱因。结论：合并GERD加重了LPRD患者的临床表现。高龄、女性、吸烟和饮酒使LPRD患者易患GERD。

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来源期刊

World Journal of Gastrointestinal Surgery Multiple-

自引率

5.00%

发文量

111