Veterinary and comparative oncology最新文献_第8页

CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX-5+ Tumour-Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours. 肿瘤肥大细胞中CD30的表达以及CD30+、CD3+和PAX-5+肿瘤浸润淋巴细胞的存在作为犬皮肤肥大细胞瘤的预后标志物

IF 1.8 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-06-01 Epub Date: 2026-02-25 DOI: 10.1111/vco.70058

Fernanda Ramalho Ramos, Janayna Maria Parente Serafim, Bethânia Almeida Gouveia, Pedro Luiz Porfirio Xavier, Juliano Rodrigues Sangalli, Heidge Fukumasu, Ricardo de Francisco Strefezzi

{"title":"CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX-5+ Tumour-Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours.","authors":"Fernanda Ramalho Ramos, Janayna Maria Parente Serafim, Bethânia Almeida Gouveia, Pedro Luiz Porfirio Xavier, Juliano Rodrigues Sangalli, Heidge Fukumasu, Ricardo de Francisco Strefezzi","doi":"10.1111/vco.70058","DOIUrl":"10.1111/vco.70058","url":null,"abstract":"Canine cutaneous mast cell tumour (MCT) is the most common skin neoplasm in dogs, with histopathology serving as both the diagnostic and primary prognostic tool. However, identifying reliable biomarkers is essential for improving clinical decision-making. CD30, a member of the TNF receptor superfamily, is well-characterised in human haematopoietic malignancies. However, its role in canine MCTs remains unclear. This study aimed to evaluate CD30 expression in neoplastic mast cells and tumour-infiltrating lymphocytes (TILs), and to assess its prognostic significance in canine cutaneous MCTs. Immunohistochemical analysis of CD30, CD3, and PAX-5 was performed on 53 samples, and RNA sequencing was conducted to assess CD30 transcript levels in 17 cases. CD30 was detected in 94.6% of neoplastic mast cells, with strong staining observed in 35 cases and weak staining in 18. Strong CD30 expression (p = 0.0051), CD30+ TIL counts (p = 0.0105) and the diffuse infiltrate distribution pattern of CD3+ TILs (p = 0.0497) were associated with shorter post-surgical survival. RNA sequencing confirmed higher CD30 (TNFRSF8) gene expression levels in high-risk tumours (logFC = 2.3182; FDR = 0.0405). These findings suggest that CD30 is a promising biomarker with potential prognostic value in canine cutaneous MCTs.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"341-352"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rescue Protocols for Canine Non-Indolent B Cell Lymphoma: A Systematic Review. 犬非无痛B细胞淋巴瘤的抢救方案：系统综述。

IF 1.8 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-06-01 Epub Date: 2026-02-08 DOI: 10.1111/vco.70048

Claire Marie Cannon, Peter Bennett

{"title":"Rescue Protocols for Canine Non-Indolent B Cell Lymphoma: A Systematic Review.","authors":"Claire Marie Cannon, Peter Bennett","doi":"10.1111/vco.70048","DOIUrl":"10.1111/vco.70048","url":null,"abstract":"Canine lymphoma is a heterogenous group of diseases. The most common subtype is diffuse large B cell lymphoma (DLBCL), though definitive diagnosis beyond non-indolent = multicentric B cell lymphoma is not often achieved in clinical practice as it requires histopathology. Most dogs respond well to standard-of-care multiagent chemotherapy (CHOP) but relapse and eventual CHOP-resistance is likely. Less commonly there is a lack of complete response to initial CHOP treatment. CHOP-resistant cases are treated with rescue chemotherapy protocols, of which many are published, but the most effective is unknown. In this systematic review we aimed to determine the most effective rescue chemotherapy protocol for dogs with multicentric non-indolent B cell lymphoma resistant to initial chemotherapy with a CHOP-based protocol. After initial screening, 65 full-text articles were reviewed. However, outcomes for the population of interest could not be identified in any, leaving our research question unanswered. Future publications of rescue treatment for canine lymphoma should report outcomes separately for groups of dogs where disease characteristics and prior treatment may affect outcome.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"416-419"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorine-18 Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Detection of Lymph Node Metastasis in Canine Mast Cell Tumour. 氟-18氟脱氧葡萄糖-正电子发射断层扫描/计算机断层扫描检测犬肥大细胞瘤淋巴结转移。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1111/vco.70040

Alison C Williams, Monique N Mayer, Ryan M Dickinson, Sally L Sukut, Valerie S MacDonald-Dickinson, Jerome Gagnon

{"title":"Fluorine-18 Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Detection of Lymph Node Metastasis in Canine Mast Cell Tumour.","authors":"Alison C Williams, Monique N Mayer, Ryan M Dickinson, Sally L Sukut, Valerie S MacDonald-Dickinson, Jerome Gagnon","doi":"10.1111/vco.70040","DOIUrl":"10.1111/vco.70040","url":null,"abstract":"Lymph node (LN) metastasis has been associated with shorter survival times in dogs with mast cell tumour (MCT), and treatment of metastatic LN with lymphadenectomy or irradiation has been demonstrated to improve outcomes. Identification of metastatic LN in dogs with MCT is therefore of both prognostic and therapeutic significance. The aim of this prospective, exploratory study was to investigate whether fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) is a useful staging tool for the detection of metastatic LN in dogs with cutaneous or subcutaneous MCT, using histopathology as the gold standard. Sixteen client-owned dogs with cytologically or histologically confirmed cutaneous or subcutaneous MCTs underwent full-body 18F-FDG-PET/CT followed by surgical removal and histopathology of the primary tumour and regional LN(s). The maximum standard uptake value (SUVmax) of the tumour and LN(s) was measured. Primary tumours were graded using both the Patnaik and Kiupel grading systems, and mitotic count was tabulated. LNs were categorised based on Weishaar's histologic criteria for nodal metastasis. Eighteen primary tumours were excised: six subcutaneous and 12 cutaneous MCTs. Of 33 excised regional LNs, 18 (55%) were categorised as metastatic (≥ HN2). There was no difference between the median SUVmax of metastatic (3.88) and nonmetastatic LNs (3.16) (p = 0.41). SUVmax was positively correlated with the mitotic count of the primary tumour (p = 0.02). The results of this exploratory study suggest that 18F-FDG-PET/CT may not be useful for identifying metastatic LNs in canine MCT.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"197-207"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Optical Coherence Tomography for Metastatic Lymph Node Identification in Canine Oral Malignant Melanoma. 光学相干断层扫描对犬口腔恶性黑色素瘤转移淋巴结鉴别的评价。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1111/vco.70037

Yi-Fan Shen, Janis M Lapsley, Gabrielle Fontes, Carley Johnson, Hannah Weaver, Jocosa Yasenchack, Christina Orona, Nikesh Patel, Jorge Santa Mignucci, Ryan Jennings, Laura E Selmic

{"title":"Evaluation of Optical Coherence Tomography for Metastatic Lymph Node Identification in Canine Oral Malignant Melanoma.","authors":"Yi-Fan Shen, Janis M Lapsley, Gabrielle Fontes, Carley Johnson, Hannah Weaver, Jocosa Yasenchack, Christina Orona, Nikesh Patel, Jorge Santa Mignucci, Ryan Jennings, Laura E Selmic","doi":"10.1111/vco.70037","DOIUrl":"10.1111/vco.70037","url":null,"abstract":"Canine oral malignant melanoma (OMM) has a high potential for lymph node (LN) metastasis. Standard care involves surgical excision of the OMM with sentinel and draining LNs regardless of metastatic status but carries the risk of complications. Optical coherence tomography (OCT) is a rapid, noninvasive imaging modality that has been evaluated for LN metastasis detection in human breast cancer but not yet translated to canines. The purpose of this study was to (1) compare OCT imaging features from nonmetastatic and metastatic LNs with corresponding histopathology and (2) evaluate the diagnostic accuracy of OCT imaging in identifying metastatic LNs. Thirteen dogs with OMM were prospectively enrolled and sentinel LNs were identified by indirect computed tomography lymphography. OMM and draining LNs were surgically removed. Excised LNs (n = 50) from thirteen dogs were imaged with OCT and submitted for histopathology. OCT images of 18 LNs from the first five enrolled dogs were compared to histopathology to identify image features of metastatic and nonmetastatic LNs and identify images for observer training. The subsequent OCT images of 32 LNs of eight dogs were used to generate a test set for six observers with varying OCT experience for assessment of diagnostic accuracy. The sensitivity, specificity, and correct classification rate of OCT imaging for OMM LN metastasis in dogs was 75% (95% CI: 61.2%-85.1%), 76.6% (95% CI: 70.1%-82.0%), and 76.3% (95% CI: 70.5%-81.2%), respectively. OCT image features of nonmetastatic and metastatic LNs show diagnostic potential for intraoperative detection of OMM LN metastasis.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"167-176"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145857969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Melanocytic Tumours: Linking Portuguese Dogs and Cats to Human Cases. 黑素细胞肿瘤的比较研究：将葡萄牙狗和猫与人类病例联系起来。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-12-10 DOI: 10.1111/vco.70031

Catarina Alves Pinto, Ana Isabel Ribeiro, João Niza-Ribeiro, Carlos Alberto Palmeira de Sousa, Katia Pinello, Andreia Alexandra Ferreira Santos

{"title":"A Comparative Study of Melanocytic Tumours: Linking Portuguese Dogs and Cats to Human Cases.","authors":"Catarina Alves Pinto, Ana Isabel Ribeiro, João Niza-Ribeiro, Carlos Alberto Palmeira de Sousa, Katia Pinello, Andreia Alexandra Ferreira Santos","doi":"10.1111/vco.70031","DOIUrl":"10.1111/vco.70031","url":null,"abstract":"Melanocytic tumours (MT) occur in both humans and companion animals, presenting an opportunity for comparative oncology research. Thus, this study provides a comprehensive epidemiological analysis comparing MT in Portuguese dogs, cats and humans. Data were obtained from the Portuguese National Cancer Registry (RON) (2011-2021) and Vet-OncoNet (2020-2023), utilising standardised oncological classification systems (ICD-O-3.2 and Vet-ICD-O-canine-1). The results indicate that Melanoma was the most frequently diagnosed MT across all three species, while melanocytomas were common in dogs but rare in cats and humans. A higher incidence rate (IR) for MT was observed in dogs (IR = 16.1) compared to humans (IR = 8.1) and cats (IR = 6.3), and neutered dogs (10.8 years) were diagnosed at significantly older ages than intact ones (9.9 years). Shar-Peis (RR = 14.2, p < 0.001) had the highest RR compared to mixed-breed dogs, followed closely by Rhodesian Ridgebacks (RR = 12.2, p < 0.001) and Golden Retrievers (RR = 6.4, p < 0.001). Spatial analysis revealed significant clustering of MT cases in humans and dogs, with a strong geographical overlap (BLISA = 0.345, p < 0.001) in urban regions. This study provides the first epidemiological comparison of MT in these three species in Portugal, underscoring the sentinel role of companion animals in human oncology and the relevance of comparative oncology in translational cancer research.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"105-120"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from the 2025 Veterinary Cancer Society (VCS) Annual Conference, 25-27 September 2025. 2025年兽医癌症协会（VCS）年会摘要，2025年9月25-27日。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 DOI: 10.1111/vco.70050

引用次数: 0

Prognostic Value of a Histopathological Scoring System and the Ki67 Proliferation Index in Dogs With Phaeochromocytoma. 组织病理学评分系统和Ki67增殖指数对嗜铬细胞瘤犬的预后价值。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-09-03 DOI: 10.1111/vco.70021

Marit F van den Berg, Aitor Martínez Ruiz, Maurice M J M Zandvliet, Sebastiaan A van Nimwegen, Hans S Kooistra, Sara Galac, Guy C M Grinwis

{"title":"Prognostic Value of a Histopathological Scoring System and the Ki67 Proliferation Index in Dogs With Phaeochromocytoma.","authors":"Marit F van den Berg, Aitor Martínez Ruiz, Maurice M J M Zandvliet, Sebastiaan A van Nimwegen, Hans S Kooistra, Sara Galac, Guy C M Grinwis","doi":"10.1111/vco.70021","DOIUrl":"10.1111/vco.70021","url":null,"abstract":"Canine phaeochromocytomas (PCCs) are neuroendocrine tumours with malignant potential. Metastatic disease remains the sole definitive evidence of malignancy. Histopathological criteria to predict long-term survival have not been established in dogs. This study evaluated the reproducibility and prognostic value of histopathological parameters derived from human scoring systems, along with the Ki67 proliferation index (PI), in dogs after adrenalectomy for PCC. Tumour samples from 41 dogs were assessed by a veterinary pathologist and pathology resident. Of 10 histopathological parameters examined, only necrosis, tumour cell spindling, and extension into adipose tissue achieved sufficient inter- and intra-observer agreement (≥ 0.40) for inclusion in survival analyses, while Ki67 PI demonstrated excellent reproducibility (≥ 0.95). A composite histopathological score was generated by summing these three parameters and a dichotomised Ki67 PI (optimal cutoff 18%), as determined by ROC analysis. Among the 41 dogs, eight died within 2 weeks postoperatively, leaving 33 long-term survivors with four tumour-related events. Kaplan-Meier analysis showed significantly poorer survival (p < 0.001) in dogs with a high Ki67 PI (≥ 18%), whereas the composite score showed a borderline significant association with outcome in Cox regression (p = 0.056; hazard ratio 2.80). Overall, dogs surviving the immediate postoperative period demonstrated a favourable prognosis (mean overall survival of 2456 days). These findings suggest that, in this cohort with few tumour-related events, the dichotomised Ki67 PI alone may serve as a clinically applicable prognosticator for canine PCC. However, further research in larger populations is needed to determine whether a composite score adds prognostic value and guides postoperative management.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"11-20"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Evaluation of the Sysmex XN-1000V Lymphocyte Fluorescence for Differentiating Canine Nodal Large B-Cell and T-Cell Lymphoma. Sysmex XN-1000V淋巴细胞荧光鉴别犬淋巴结大b细胞和t细胞淋巴瘤的诊断价值

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1111/vco.70032

Javier Martínez-Caro, Marta Lemos, Beatriz Agulla, Ignacio Amarillo-Gómez, Josep Pastor

{"title":"Diagnostic Evaluation of the Sysmex XN-1000V Lymphocyte Fluorescence for Differentiating Canine Nodal Large B-Cell and T-Cell Lymphoma.","authors":"Javier Martínez-Caro, Marta Lemos, Beatriz Agulla, Ignacio Amarillo-Gómez, Josep Pastor","doi":"10.1111/vco.70032","DOIUrl":"10.1111/vco.70032","url":null,"abstract":"Canine lymphoma is a common haematopoietic neoplasm. Immunophenotype is a major prognostic factor and may influence treatment recommendations. This study assessed the diagnostic performance of the Sysmex XN-1000V white blood cell differential (WDF) scattergram to differentiate canine nodal large B-cell and T-cell lymphoma, using the percentage of highly fluorescent cells (%HFC) and visual WDF scattergram evaluation. A retrospective study was conducted on data from cases of cytologically diagnosed canine large cell lymphoma. Cases had concurrent lymph node aspirate cell suspensions in saline that were analysed using the Sysmex XN-1000V and multiparametric flow cytometry (FC) for lymphoma classification as B or T-cell. Large B-cell lymphomas (n = 86) showed significantly higher %HFC compared to large T-cell lymphomas (n = 17), with a median (IQR) of 50% (36-84) and 9.7% (3.9-19), respectively. The ROC analysis showed an AUC of 0.93, with an optimal cutoff of < 24.15 %HFC for identifying T-cell lymphoma, achieving 88.24% sensitivity, 87.21% specificity, 57.69% PPV and 97.40% NPV. The following data is expressed as 'overall-percentage-agreement (kappa value)'. Using the previous cutoff, the agreement between the %HFC classification and FC was 88.24% (κ = 0.76). Regarding the WDF scattergram evaluation, the intra- and inter-observer agreement were 86.27% (κ = 0.71) and 67.65% (κ = 0.55), respectively. Agreement between the WDF scattergram evaluation and FC was 77.45% (κ = 0.55), and improved to 90.63% (κ = 0.74) when just the confident cases were used. In conclusion, a preliminary assessment of the phenotype of canine nodal large cell lymphoma can be made using either the visual inspection of the WDF scattergram or the %HFC. This could serve as a cost-effective, fast screening tool while awaiting definitive flow cytometry results.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"121-127"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome and Toxicity Profile of Stereotactic Body Radiation Therapy for Adrenal Tumours in Dogs. 立体定向放射治疗犬肾上腺肿瘤的疗效和毒性分析。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1111/vco.70035

Lily Thorsen, Kimberley Law, Jillian Walz, Valerie Morales Coll, Ada Naramor, Charles Maitz, Lyndsay Kubicek, Zebulon Thorsen, Jishnu Rao Gutti, Marilia Takada

{"title":"Outcome and Toxicity Profile of Stereotactic Body Radiation Therapy for Adrenal Tumours in Dogs.","authors":"Lily Thorsen, Kimberley Law, Jillian Walz, Valerie Morales Coll, Ada Naramor, Charles Maitz, Lyndsay Kubicek, Zebulon Thorsen, Jishnu Rao Gutti, Marilia Takada","doi":"10.1111/vco.70035","DOIUrl":"10.1111/vco.70035","url":null,"abstract":"Stereotactic body radiation therapy (SBRT) has become a non-invasive alternative option for canine adrenal tumours with high surgical risks; however, its clinical benefits and risks are still to be fully understood. The goal of this multi-institutional retrospective study was to describe the clinical outcome and safety of SBRT for the treatment of 21 dogs with adrenal tumours. Ten were suspected pheochromocytomas, two adenocarcinomas, and the diagnosis was unknown in nine dogs. Vascular invasion was present in 81% of cases (17/21). Thirteen dogs received 3 fractions of 6 to 11 Gy, 7 received 5 fractions of 6 to 9 Gy, and 1 received 4 fractions of 6 Gy. For the 20 patients with follow-up imaging, 9 (43%) had partial response, 10 (47%) stable disease, and 1 (5%) progressive disease. Progression-free survival was 16.8 months (95% CI: 3.4-23), and overall survival time was 16.8 months (95% CI: 3.7-23.7). Twelve patients (57%) experienced acute adverse events (AEs); of those, seven were gastrointestinal grade ≥ III, including one grade V. Late AEs were suspected in seven dogs (33%), including gastrointestinal grade V in four of them. A total of five dogs (24%) died from radiation-related toxicities. Although SBRT seems to be effective against adrenal tumours, it was associated with a high morbidity and mortality rate, suggesting that re-evaluation of radiation therapy protocols is necessary for maintaining patient safety.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"150-159"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Favourable Prognostic Significance of HER2 Mutations in Canine Pulmonary Adenocarcinoma Following Surgical Resection. 犬肺腺癌手术切除后HER2突变对预后的有利意义。

IF 1.9 2区农林科学

Veterinary and comparative oncology Pub Date : 2026-03-01 Epub Date: 2025-09-04 DOI: 10.1111/vco.70020

Masanao Ichimata, Yumiko Kagawa, Atsushi Toshima, Masaya Igase, Takuya Mizuno

{"title":"Favourable Prognostic Significance of HER2 Mutations in Canine Pulmonary Adenocarcinoma Following Surgical Resection.","authors":"Masanao Ichimata, Yumiko Kagawa, Atsushi Toshima, Masaya Igase, Takuya Mizuno","doi":"10.1111/vco.70020","DOIUrl":"10.1111/vco.70020","url":null,"abstract":"Human epidermal growth factor receptor 2 (HER2) gene mutations have been reported in 5% to 38% of canine pulmonary adenocarcinomas (cPACs), most commonly as V659E mutations in exon 20. However, their prognostic and predictive significance remains unclear. This retrospective, single-centre cohort study investigated the frequency of HER2 mutations in surgically resected cPACs and their association with clinical outcomes. Between 2005 and 2021, lung masses histologically diagnosed as cPACs were collected and subjected to direct sequencing of HER2 exons 20 and 21. A total of 72 dogs were enrolled, with successful HER2 gene analysis in 69 cases. HER2 exon 20 missense mutations were identified in 20 dogs (29.0%), including 18 harbouring the previously reported V659E hotspot mutation within the transmembrane domain. Homozygous mutations were detected in 13 dogs. Univariable analysis revealed associations between progression-free interval (PFI) and clinical signs, tumour size classification, lymph node metastasis, surgical margin status, and histologic grade. Overall survival time (OST) was associated with age, clinical signs, tumour size > 7 cm, histologic subtype, lymph node metastasis, and margin status. In multivariable analysis, tumour size classification and margin status remained significantly associated with PFI, while age, tumour size > 7 cm, and histologic subtype were independently associated with OST. Notably, the presence of HER2 mutations was significantly associated with prolonged PFI in both univariable and multivariable analyses, although no significant association with OST was observed. These findings suggest that HER2 mutation status may serve as a favourable prognostic marker for disease progression in surgically resected cPACs.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0