使用膀胱尿道镜确定犬泌尿生殖系统癌放射治疗计划中的肿瘤总体积

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI:10.1111/vco.13002
Clarissa C Freemyer, Tracy L Gieger, Shelly L Vaden, Michael W Nolan
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引用次数: 0

摘要

放射治疗(RT)越来越多地被用于犬泌尿生殖系统癌(CGUC)的最终治疗。在我院,标准方法是照射断层扫描异常组织的肿瘤总体积(GTV),并将临床靶体积(CTV)扩大 2 厘米。膀胱尿道镜检查通常被纳入治疗计划工作流程,但最佳方法尚未确定。这项观察性研究将膀胱尿道镜检查作为一种工具,用于识别可作为 RT 靶点的大体病灶。我们的假设是,在大多数情况下,增加膀胱尿道镜检查所得出的 GTV 会大于仅使用计算机断层扫描(CT)所得出的 GTV。我们回顾了 2013 年至 2023 年间 54 只确诊为 CGUC 的狗的医疗记录;每只狗在 RT 前都使用 CT 和膀胱尿道镜进行了评估。GTV最初定义为对比后矢状面CT扫描中断层明显的病变,然后加上膀胱尿道镜检查发现的病变(怀疑或证实为肿瘤)。膀胱尿道镜检查在 CT 可见病灶的基础上,将 GTV 向尿道远端延伸了中位数 6.5 厘米(范围:1.5-31.8 厘米),因此 54 例病例中有 26 例(48%)的 GTV 扩大。如果在 CT 定义的 GTV 上加上我们标准的 2 厘米 CTV 扩大(不使用膀胱尿道镜检查数据),则有 35% 的病例(19/54)会低估严重异常组织的范围。这些结果表明,将膀胱尿道镜纳入治疗计划工作流程可降低地理漏诊的风险,从而改善局部肿瘤控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of Cystourethroscopy to Define the Gross Tumour Volume in Radiation Treatment Planning for Canine Genitourinary Carcinomas.

Radiotherapy (RT) is increasingly utilised for definitive-intent treatment of canine genitourinary carcinomas (CGUC). At our institution, the standard approach is to irradiate tomographically abnormal tissues gross tumour volume (GTV) plus a clinical target volume (CTV) expansion of 2 cm. Cystourethroscopy is often incorporated into the treatment planning workflow, though an optimal approach has yet to be defined. This observational study evaluated cystourethroscopy as a tool for identifying gross lesions that can be targeted with RT. We hypothesised that in most cases, addition of cystourethroscopy would result in a larger GTV than would be drawn with computed tomography (CT) alone. Medical records from 54 dogs diagnosed with CGUC between 2013 and 2023 were reviewed; each had been evaluated before RT using CT and cystourethroscopy. The GTV was initially defined as the tomographically evident disease on a post-contrast sagittal plane CT scan, and then lesions visualised with cystourethroscopy (suspected or confirmed to be tumour) were added. Beyond what was visible on CT, cystourethroscopy extended the GTV by a median of 6.5 cm distally into the urethra (range: 1.5-31.8 cm) and therefore resulted in GTV enlargement in 26 of 54 (48%) cases. Addition of our standard 2 cm CTV expansion to a CT-defined GTV (without use of data from cystourethroscopy) would have underestimated the extent of grossly abnormal tissue in 35% (19/54) of cases. These results suggest that incorporating cystourethroscopy into treatment planning workflows may improve local tumour control by reducing the risk of a geographic miss.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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