Veterinary and comparative oncology最新文献

{"title":"Doxorubicin-induced Cardiotoxicity in Dogs: A Narrative Review.","authors":"Supita Sunpongsri, Tom Roos, Ronette Gerhing, Maurice Zandvliet, Giorgia Santarelli","doi":"10.1111/vco.70124","DOIUrl":"https://doi.org/10.1111/vco.70124","url":null,"abstract":"<p><p>Doxorubicin, an anthracycline widely used in both human and veterinary oncology, is highly effective against a variety of malignancies in dogs, including lymphomas, sarcomas and carcinomas. Despite its efficacy, doxorubicin exposure can be associated with cardiotoxicity, which may present acutely or chronically, potentially leading to severe cardiac arrhythmia and congestive heart failure. Mechanisms underlying cardiotoxicity are multifactorial, including oxidative stress, mitochondrial dysfunction, DNA damage via topoisomerase IIβ, inflammation and dysregulated cell death pathways such as apoptosis, pyroptosis and ferroptosis. In dogs, known risk factors include higher cumulative dose, breed predisposition to idiopathic dilated cardiomyopathy, and higher body weight. Cardiac biomarkers, electrocardiography, echocardiography and other advanced imaging techniques have been employed to detect cardiac changes that can be seen also in the absence of clinical signs. However, current evidence is predominantly derived from experimental and retrospective research, highlighting the need for large prospective clinical studies to strengthen recommendations for monitoring and prevention. A deeper understanding of doxorubicin-induced cardiotoxicity in dogs is needed to identify factors influencing individual susceptibility, clarify the progression from subclinical damage to clinical cardiac dysfunction, and guide future research. Emerging approaches, including advanced echocardiography, microRNAs, proteomic biomarkers and pharmacokinetic modelling, may help improve early detection and guide more individualised dosing to minimise toxicity.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polarization Sensitive Optical Coherence Tomography for Surgical Margin Assessment for Canine Soft Tissue Sarcoma.","authors":"Nikesh Patel, Gabrielle Fontes, Josephine Dornbusch, Morgan Biggo, Andrea Erickson, Natalia Jurcak, Jorge Santana Mignucci, Yi-Fan Shen, Hannah Weaver, Ryan Jennings, Laura E Selmic","doi":"10.1111/vco.70121","DOIUrl":"https://doi.org/10.1111/vco.70121","url":null,"abstract":"<p><p>Soft tissue sarcomas (STSs) and skeletal muscle both appear high scattering on spectral-domain optical coherence tomography (SD-OCT) imaging, which resulted in instances of misclassification by observers in prior soft tissue sarcoma margin assessment studies. Polarization-sensitive optical coherence tomography (PS-OCT) is an extension of OCT that provides additional information about tissue polarization contrast. In this prospective study we wanted to evaluate whether PS-OCT improves tissue differentiation and diagnostic accuracy compared to spectral-domain OCT (SD-OCT) alone. PS-OCT images from surgical margins of 10 resected STS were compared with histopathology to identify characteristic features of normal and neoplastic tissues. Then, six observers of varying OCT image interpretation experience assessed surgical margins from 30 resected STS using SD-OCT alone and SD-OCT combined with PS-OCT. PS-OCT images demonstrated distinct birefringence (optical patterns), corresponding to tissue organization: skeletal muscle exhibited alternating high and low birefringence bands, fascia showed variable birefringence and STS had uniformly low birefringence. Overall diagnostic accuracy was high for both modalities [correct classification rate: SD-OCT alone 93.7% (95% confidence interval (CI): 90.1, 96.0) vs. SD-OCT combined with PS-OCT 92.6% (95% = CI: 89.3, 95.4)]; adding PS-OCT did not significantly improve accuracy across all observers (p = 0.82), though expert observers benefited significantly (p = 0.0018). Interobserver and intraobserver agreement ranged from substantial to near perfect. These findings suggest PS-OCT can be interpreted reliably after brief training and may enhance accuracy for experienced users. Further research should explore structured training and real-time applications for comprehensive surgical margin evaluation.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Application of ⁶⁴CuCl₂ PET/CT: Imaging of Cats With Mammary Carcinoma.","authors":"Vivan A Yang, Joni M Lunceford, Colleen Garrett, Jimmy C Lattimer, Christos Papageorgiou, Charles J Smith, Charles A Maitz, Jeffrey N Bryan, Jessica L Talbott, Michael R Lewis","doi":"10.1111/vco.70125","DOIUrl":"https://doi.org/10.1111/vco.70125","url":null,"abstract":"<p><p>Feline mammary carcinoma (FMC) is an aggressive and highly metastatic cancer that shares molecular and clinical characteristics with human triple-negative breast cancer (TNBC), making it a relevant comparative model for a disease lacking targeted therapies. This study investigated the feasibility and clinical utility of ⁶⁴CuCl₂ PET/CT imaging in cats with naturally occurring mammary carcinoma. Eight cats (seven tumour-bearing, one healthy control) were administered an intravenous dose of ⁶⁴CuCl₂ and underwent whole-body PET/CT imaging. Semi-quantitative analysis was performed using standardized uptake values (SUVs), and tumour-to-muscle ratios were calculated to assess lesion conspicuity. Serum ceruloplasmin concentrations were measured as a marker of systemic copper metabolism. All primary masses were ⁶⁴Cu-avid and conspicuous, with consistently elevated tumour-to-muscle ratios across tumour-bearing cats, allowing clear differentiation between neoplastic and normal tissue. Imaging provided additional staging information by identifying locally invasive and metastatic disease that was not fully evident on physical examination. Physiologic tracer distribution was characterized by high uptake in the liver and gallbladder and low uptake in skeletal muscle, which served as a reliable reference tissue. Serum ceruloplasmin concentrations varied widely and did not correlate with tumour uptake. These findings suggest that ⁶⁴CuCl₂ PET/CT is a feasible functional imaging modality for FMC, potentially aiding in tumour detection. This was an exploratory study, and not all imaging results could be confirmed by cytology or histopathology. Nonetheless, our findings suggest that ⁶⁴CuCl₂ PET/CT should be investigated further as a method for probing copper utilization in FMC.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of an Anti-α_vβ₃ Integrin NIR Fluorescent Probe and Indocyanin Green for Precision Resection of Naturally Occurring Sarcomas in Dogs-A Randomized Blinded Case-Controlled Pilot Study.","authors":"Mirja Christine Nolff, Paula Grest, Frauke Seehusen, Patricia Beer","doi":"10.1111/vco.70116","DOIUrl":"https://doi.org/10.1111/vco.70116","url":null,"abstract":"<p><p>The infiltrative growth of sarcomas represents a challenge for complete resection, as tumour borders are not easily detectable. Fluorescence guided surgery (FGS) allows improved visualization of tumour margins and could improve resection accuracy. Unfortunately, studies validating the impact of FGS are rare, and direct comparisons of different dyes are not available. Dogs (n = 20) that were presented for sarcoma resection were prospectively enrolled and randomized to either receive indocyanine green (ICG, Group 1) or a targeted anti-α_vβ₃ integrin probe (Group 2) prior to surgery. FGS was performed in both groups with the surgeon blinded to treatment. The false positive and false negative rates as well as tumour-to-background ratio (TBR) were calculated for each dye. Correlation of fluorescent area and histologically confirmed tumour extension was determined using the Dice Coefficient (DC). The clinical impact of FGS was determined by assessing the rate of rightfully adapted resections. False positive signal was detected in 9/10 dogs in group 1 and 3/10 dogs in group 2. Mean TBR at skin level was higher in group 2 (4.5 and 5.3) compared to group 1, and this difference reached significance in formalin-fixed tissue (5.3 vs. 2.6, p = 0.016). Correlation of fluorescent signal and histologic tumour extent was strong for both dyes (DC group 1 = 0.64; group 2 = 0.78). Resection of additional neoplastic tissue based on FGS was more frequent in group 2 (3/10 dogs) compared to group 1 (1/10 dogs). The initial results of this study indicate that the targeted anti-α_vβ₃ integrin probe is more tumour selective than ICG in dogs. This pilot as well as the subsequent follow up study are registered at animalstudyregistry.org https://doi.org/10.17590/asr.0000321.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathologic Characterization and Clinical Significance of Lymphovascular Invasion in Canine Thyroid Carcinomas.","authors":"Maureen A Griffin, Brianna Stoyle, Allie Oakes, Brian Flesner, Jennifer A Lenz, Darko Stefanovski, Amy C Durham","doi":"10.1111/vco.70118","DOIUrl":"https://doi.org/10.1111/vco.70118","url":null,"abstract":"<p><p>The association between lymphovascular invasion (LVI) and outcomes in dogs with thyroid carcinoma is inadequately described, and a standardized definition of LVI is lacking. This study's objectives were to histopathologically and immunohistochemically characterize LVI and to evaluate associated clinical outcomes in dogs with thyroid carcinoma. Inclusion criteria were: dogs that underwent thyroidectomy for thyroid carcinoma with available histopathology samples, and a minimum of 1-year postoperative follow-up data or follow-up to death. Thirty dogs with 35 distinct tumours, including 26 follicular and nine medullary, were evaluated. LVI was characterized as intracapsular endothelialized tumour emboli (without adhered fibrin) in 26 samples, intracapsular tumour emboli with adhered fibrin in seven samples, extracapsular tumour emboli without adhered fibrin in 10 samples, and extracapsular tumour emboli with endothelial disruptions and adhered fibrin in three samples. CD31 and Prox1 positive vessels contained endothelialized tumour thrombi in 17 and one sample, respectively. Extracapsular invasion with (non-endothelialized) and without (endothelialized) associated fibrin were associated with a 10-fold (p = 0.001) and 3-fold (p = 0.013) increase in the likelihood of death, respectively. No significant difference in the likelihood of death was noted between cases of extracapsular invasion with or without fibrin (p = 0.31). Intracapsular tumour thrombi with or without associated fibrin and non-endothelialized tumour thrombi were not associated with outcomes in this cohort. These results support that in dogs with thyroid carcinoma, extracapsular LVI with or without associated fibrin thrombi, but not intracapsular LVI, is associated with worse outcomes. Further study is warranted on a larger population of dogs with standardized treatment and follow-up.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerability and Outcome of Medical Treatment in Feline Nasal Carcinomas: A Multi-Institutional Retrospective Study.","authors":"Filomena Amato, Matteo Gobbetti, Antonio Giuliano, Elisabetta Treggiari, Marta Pieri, Irene Bonazzi, Marco Luigi Bianchi, Paola Valenti","doi":"10.1111/vco.70117","DOIUrl":"https://doi.org/10.1111/vco.70117","url":null,"abstract":"<p><p>Carcinomas are the second most common feline intranasal neoplasm. Various treatment options, including radiotherapy, surgery or a combination of both, have been described, but data on medical therapy efficacy are lacking. This retrospective study evaluated the outcome of cats with nasal carcinoma (NC) treated with antineoplastic treatment. Cats with a histopathological or cytopathological diagnosis of NC were included. Patients receiving antineoplastic treatment were compared to patients receiving palliative treatment alone. Response to therapy, median time to progression (MTTP) and median survival time (MST) were described and compared for both groups. Analysed clinical variables included the presence of epistaxis, facial deformity, stage, use of NSAIDs and previous surgical debulking. Thirty-three cats were included in the study: 18 in the antineoplastic treatment group and 15 in the palliative treatment group. Forty-eight percent of the entire population had worsening of the clinical signs, 36% remained stable and 16% showed clinical benefit. MTTP of the entire population was 104 days and MST was 178 days. No statistically significant differences were found between groups for either MTTP (96 vs. 111 days; p = 0.95) or MST (197 vs. 262; p = 0.77). None of the evaluated clinical variables was associated with outcome. In this retrospective study, antineoplastic treatment was not associated with a detectable survival advantage over palliative treatment alone. These findings should be interpreted cautiously given the small sample size and heterogeneity of treatments administered.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision-Guided Therapy for Canine Cancers: An Oasis or a Mirage?","authors":"Jaime F Modiano","doi":"10.1111/vco.70119","DOIUrl":"https://doi.org/10.1111/vco.70119","url":null,"abstract":"","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Comparison of Gastrointestinal Toxicity in Dogs With Lymphoma Receiving Doxorubicin With or Without Prophylactic Trimethoprim-Sulfadiazine.","authors":"Emily Jayne Madden, Catherine Chan","doi":"10.1111/vco.70113","DOIUrl":"https://doi.org/10.1111/vco.70113","url":null,"abstract":"<p><p>Doxorubicin is commonly used in the treatment of canine lymphoma and other malignancies but is associated with adverse effects, including gastrointestinal toxicity and myelotoxicosis. Previous veterinary studies have suggested that prophylactic antimicrobial administration may reduce chemotherapy-associated toxicity and hospitalisation. However, the potential benefits of prophylactic antimicrobials must be balanced against risks, including antimicrobial resistance and dysbiosis. This retrospective study evaluated the effect of prophylactic trimethoprim-sulfadiazine administration on gastrointestinal and haematologic adverse events in dogs with high-grade multicentric lymphoma receiving doxorubicin for the first time. Medical records from three referral hospitals in Queensland, Australia were reviewed for dogs treated between January 2008 and November 2025. Adverse events occurring within 14 days of doxorubicin administration were retrospectively graded using the Veterinary Cooperative Oncology Group Common Terminology Criteria for Adverse Events. Sixty dogs met the inclusion criteria, including 21 dogs receiving prophylactic TMS and 39 receiving no prophylactic antibiotics. Gastrointestinal toxicity occurred in 14/21 (66.7%) dogs receiving TMS compared with 13/39 (33.3%) dogs receiving no antibiotics (p = 0.013). After controlling for lymphoma stage, prophylactic TMS administration was associated with a 3.69-fold increase in the odds of GI toxicity (95% CI 1.13-12.11, p = 0.031). No significant differences were identified between groups in severity of GI toxicity, haematologic toxicity, neutropenia or hospitalisation rates. Prophylactic TMS administration during doxorubicin chemotherapy was associated with increased GI toxicity in this cohort, contrasting with previous reports and supporting the need for prospective evaluation of prophylactic antimicrobial use in contemporary geographically distinct canine chemotherapy populations.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Veterinary Radiation Therapy Adverse Events Among Allied Specialists.","authors":"Juneshine Park, Nicholas Rancilio, Meredith t'Hoen, Rebecca Walton, Keiko Murakami","doi":"10.1111/vco.70114","DOIUrl":"10.1111/vco.70114","url":null,"abstract":"<p><p>Radiation therapy (RT) has become increasingly available in veterinary medicine and practitioners are likely to encounter RT adverse events (AEs). General knowledge and recognition of AEs associated with RT may be variable among allied specialists; therefore, the aim of this study was to evaluate the perception and awareness of AEs associated with RT within the veterinary specialty groups of ACVIM-(Oncology), ACVECC, and ACVR-(Radiation Oncology). A survey was performed via the respective specialty board e-mail list servs between May 14, 2024 and Aug 30, 2024. A total of 189 complete and 13 partially complete responses were included for statistical analysis. Participants evaluated their clinical perceptions and knowledge of veterinary RT on a 1 to 5 scale with 5 indicating strong agreement. Awareness and perception of veterinary RT among ACVIM-(Oncology) and ACVECC specialists was overall positive. Allied specialists with more than 10 years of clinical experience were more confident in their ability to identify and treat AEs. Despite the reported confidence among allied specialists in identifying AEs and overall favourable perception of RT, 35.7% (10/28) of Veterinary Radiation Oncologists reported having a patient euthanized outside of their care due to, in their opinion, treatable acute AEs associated with RT. Favourable perceptions of RT among allied specialists should be leveraged for targeted continuing education focusing on the identification of commonly encountered RT AEs.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Phenotypic and Molecular Characterisation of Feline Oral Squamous Cell Carcinoma Cell Lines Reveals Marked Biological Heterogeneity.","authors":"Qaisar Tanveer, Lisa Y Pang, Colin Farquharson, Gurå Therese Bergkvist","doi":"10.1111/vco.70115","DOIUrl":"10.1111/vco.70115","url":null,"abstract":"<p><p>Feline oral squamous cell carcinoma (FOSCC) is the most common oral malignancy, characterised by aggressive local invasion, frequent bone involvement, and poor prognosis. The limited availability of well-characterised in vitro models has hindered the understanding of tumour heterogeneity and invasive behaviour. This study aimed to establish and comparatively characterise a panel of FOSCC cell lines derived from tumours with and without documented bone invasion to identify intrinsic biological differences. Four FOSCC cell lines were evaluated for epithelial identity, growth kinetics, clonogenicity, migratory capacity and chemosensitivity. All cell lines retained epithelial characteristics, with consistent expression of epithelial markers; however, variation in cytokeratin-19 and vimentin suggested phenotypic heterogeneity and partial epithelial-mesenchymal plasticity. The cell lines demonstrated distinct proliferation rates, doubling times, and clonogenic capacities. Morphologically, these cells displayed varying degrees of peripheral filopodial activity. Functional assays further revealed substantial migratory capacity under both serum-supplemented and serum-free conditions, with differences across cell lines. Chemosensitivity profiling showed heterogeneous responses to targeted and cytotoxic agents, highlighting cell line-specific differences in drug susceptibility and potential intrinsic drug responsiveness. These findings demonstrate that FOSCC cell lines possess distinct biological properties consistent with phenotypic differences. The observed heterogeneity underscores the potential relevance of tumour origin in shaping functional behaviour and highlights the value of using multiple, well-characterised cell line models to better represent disease diversity. This study provides a comprehensive comparative characterisation of four FOSCC cell lines, including a newly established model, and establishes a baseline resource for future mechanistic and translational investigations in feline and comparative oncology.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}