Veterinary and comparative oncology最新文献

Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs. 狗手术边缘胃肠道肿瘤和正常组织的偏振敏感光学相干断层成像特征。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-18 DOI: 10.1111/vco.70001

Hannah L Weaver, Gabrielle S Fontes, Yi-Fan Shen, Ryan Jennings, Janis M Lapsley, Laura E Selmic

{"title":"Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs.","authors":"Hannah L Weaver, Gabrielle S Fontes, Yi-Fan Shen, Ryan Jennings, Janis M Lapsley, Laura E Selmic","doi":"10.1111/vco.70001","DOIUrl":"https://doi.org/10.1111/vco.70001","url":null,"abstract":"The treatment of choice for canine alimentary tract neoplasms is surgical excision, but it can sometimes be difficult to achieve wide margins due to neoplasm location, size, or distribution. Optical coherence tomography (OCT) is a rapid, noninvasive imaging modality that uses light to characterise tissue microstructure to allow identification of different tissue types. Spectral domain (SD)-OCT allows for differentiation based on the total light intensity reflected from the tissue. Polarisation sensitive (PS)-OCT detects the polarisation state of light reflected by the tissues. The polarisation properties are phase retardation, degree of polarisation uniformity (DOPU), and optical axis. Our objective was to qualitatively characterise different tissues at the excision sites of alimentary tract neoplasms using OCT. Oral, liver, and other alimentary tumours including stomach, intestine, and pancreas were imaged. Samples were then fixed in formalin, paraffin embedded and stained with haematoxylin and eosin. OCT images and histology slides were compared, and the tissues were qualitatively described by a single investigator. We hypothesized that PS-OCT imaging would provide distinguishing characteristics of tissue appearances that could be used in the future to train observers or artificial intelligence to identify incomplete margins. Our results showed that alimentary tract tumours have disorganised microstructures on SD-OCT and PS-OCT DOPU, and PS-OCT phase retardation and optical axis values that differ from normal tissues. Thus, these characteristics can be used to differentiate neoplastic and normal tissues at surgical margins.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells. 基于犬组织细胞肉瘤细胞基因表达谱的分子分类。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-11 DOI: 10.1111/vco.13071

Hiroki Sakuma, Hirotaka Tomiyasu, Akiyoshi Tani, Yuko Goto-Koshino, Makoto Bonkobara, Masaru Okuda

{"title":"Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells.","authors":"Hiroki Sakuma, Hirotaka Tomiyasu, Akiyoshi Tani, Yuko Goto-Koshino, Makoto Bonkobara, Masaru Okuda","doi":"10.1111/vco.13071","DOIUrl":"https://doi.org/10.1111/vco.13071","url":null,"abstract":"The molecular abnormalities of canine histiocytic sarcoma (CHS) remain to be elucidated. We previously revealed that the sensitivities to dasatinib and trametinib were significantly various among CHS cell lines, indicating the differences in underlying molecular abnormalities. In the present study, we performed RNA sequencing analysis using 11 CHS cell lines to investigate molecular classifications based on the gene expression profiles (GEPs). The clustering analysis showed that CHS cell lines were divided into two distinct clusters. The comparisons of GEPs between the clusters extracted 675 differentially expressed genes (DEGs), and these DEGs were enriched with those related to the regulations of inflammatory responses. Among these DEGs, differences in the expressions of CCL3, CCL4, CCL7, CLEC7A, and TLR4 genes between the two groups were confirmed by RT-qPCR. Since no significant difference in the activation status of Akt and ERK pathways was observed between the two groups, the NF-κB pathway was focused on and its activation status was examined in the cell lines. As a result, cell lines belonging to one cluster showed nuclear translocation of the p65 protein together with increased release of CCL5 protein, which is a target molecule of the NF-κB pathway, in a cell culture supernatant. These results suggested that the molecular pathology of CHS cells might be divided into two categories depending on the activation status of the NF-κB pathway, and it is necessary to establish precision medicine for each molecular subtype of CHS.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Decreased Kidney Function in Dogs Receiving Carboplatin: A Retrospective Cohort Study of 98 Dogs (2006-2024). 评估接受卡铂的狗肾功能下降：98只狗的回顾性队列研究（2006-2024）。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-05 DOI: 10.1111/vco.13069

Andrew D Yale, Alvina So, Alexandra Guillén, Isabelle Desmas-Bazelle, Francesco Rogato, Rosanne E Jepson

{"title":"Evaluation of Decreased Kidney Function in Dogs Receiving Carboplatin: A Retrospective Cohort Study of 98 Dogs (2006-2024).","authors":"Andrew D Yale, Alvina So, Alexandra Guillén, Isabelle Desmas-Bazelle, Francesco Rogato, Rosanne E Jepson","doi":"10.1111/vco.13069","DOIUrl":"https://doi.org/10.1111/vco.13069","url":null,"abstract":"Decreased kidney function is observed in some people receiving carboplatin, but limited literature explores this in dogs. The aim of this study was to evaluate the incidence and risk factors for decreased kidney function in dogs receiving carboplatin. A single-institute retrospective cohort study compared the incidence of decreased kidney function between non-azotaemic dogs receiving carboplatin and an age- and weight-matched cancer-bearing control group not receiving chemotherapy. Change in creatinine concentration and a linear mixed effects model were used to compare trends in creatinine between groups. Decreased kidney function was defined as a sustained increase in creatinine ≥ 26.5 μmol/L on ≥ 2 consecutive measurements compared to baseline; the VCOG-CTCAE v2 grading system for increased creatinine was also applied. Risk factors were explored. Ninety-eight dogs were included (n = 49/group). There was no difference in median change in creatinine concentration (+2.0 μmol/L; p = 0.311) or creatinine trends (p = 0.958) across the study period between groups. Incidence of decreased kidney function was low and did not significantly differ between groups (carboplatin group n = 4 [8.2%]; control group n = 2 [4.1%]; p = 0.678); no risk factors were identified. There was no difference in the frequency of VCOG grade one (p = 0.731), two (p = 0.641) or three (p = 0.429) creatinine adverse events between groups. Non-azotaemic dogs receiving carboplatin do not have a significantly increased short-term risk of decreased kidney function compared to those not receiving chemotherapy, although the numerical increase in incidence in dogs receiving carboplatin could be clinically relevant. Larger studies should aim to explore this further and investigate carboplatin's impact on subclinical and long-term renal function.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Role of Patient, Tumour and Radiomic Factors Influencing Outcomes in Dogs With Thyroid Cancer Treated With Iodine-131. 患者、肿瘤和放射学因素对碘-131治疗甲状腺癌犬预后的影响

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-04 DOI: 10.1111/vco.13070

Ibrahim Chamseddine, Caitlin Cowan, Lindsay Donnelly, Rebecca J Abergel, Jan Schuemann, Alejandro Bertolet, Charles A Maitz

{"title":"Prognostic Role of Patient, Tumour and Radiomic Factors Influencing Outcomes in Dogs With Thyroid Cancer Treated With Iodine-131.","authors":"Ibrahim Chamseddine, Caitlin Cowan, Lindsay Donnelly, Rebecca J Abergel, Jan Schuemann, Alejandro Bertolet, Charles A Maitz","doi":"10.1111/vco.13070","DOIUrl":"https://doi.org/10.1111/vco.13070","url":null,"abstract":"Radioactive iodine therapy (I-131) is widely used in both human and veterinary medicine for treating thyroid cancer, utilising the common biological behaviour of thyroid tissues. Recognising the need to better understand the prognostic factors affecting heterogeneous treatment outcomes, this retrospective study analysed 32 dogs with thyroid carcinoma treated at the University of Missouri Veterinary Health Center. The study examined variables such as patient demographics, tumour characteristics, and first-order radiomic features. Purposeful feature selection was employed to identify both significant and confounding factors, with a focus on treatment response and survival time. Specific administered activity (SAA) emerged as a significant predictor of treatment response, with higher SAA levels improving odds of response (p value = 0.02, OR = 10.28), while clinical signs and nodal stage (N-stage) were identified as significant confounders. Moreover, metastasis stage (M-stage) (p < 0.01, OR = 0.35) and tumour-to-salivary gland dose uptake ratio (TSGR) significantly affected survival time (p = 0.02, OR = 1.57), with TSGR displaying a notable nonlinear effect. These results underline the importance of refined patient stratification and highlight the potential for personalised dose adjustments to enhance outcomes in canine thyroid cancer.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SHINE - Validation of Near Infrared Fluorescence Lymphography Against Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Dogs With Mast Cell Tumours. 近红外荧光淋巴显像对肥大细胞肿瘤犬前哨淋巴结活检的有效性验证。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1111/vco.13058

L E Chiti, P Beer, S M Ohlerth, S Hartnack, M C Nolff

{"title":"SHINE - Validation of Near Infrared Fluorescence Lymphography Against Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Dogs With Mast Cell Tumours.","authors":"L E Chiti, P Beer, S M Ohlerth, S Hartnack, M C Nolff","doi":"10.1111/vco.13058","DOIUrl":"10.1111/vco.13058","url":null,"abstract":"Lymphoscintigraphy is the gold standard among sentinel lymph node (SLN) mapping techniques. Unfortunately, lymphoscintigraphy is not readily accessible, leading to the need for validation of alternative techniques. The aim of this study is to compare near-infrared fluorescence lymphography (NIRF-L) with lymphoscintigraphy for SLN resection in MCT and assess the impact of intraoperative NIRF guidance. Forty-eight dogs with 60 MCT were included in this prospective, blinded, randomised controlled trial. Dogs underwent preoperative lymphoscintigraphy and were then randomised into two groups: in the treatment group (n = 30) intraoperative NIRF-L was performed; in the control group (n = 30) no intraoperative guidance was implemented. Detection rate, concordance, sensitivity, and negative predictive values were recorded for NIRF-L and lymphoscintigraphy. Surgical time and length of surgical incision were compared between treatment and control groups with the Wilcoxon test (5% significance). Detection rate was 100% for NIRF-L and 98% for lymphoscintigraphy. Discordance occurred in one case. Sensitivity of NIRF-L was 93.7% (95% C.I. 74.3%-99.3%) and negative predictive value ranged between 91.1% and 98.6% with a prevalence of nodal metastases of 61% and 18%. Based on the overlapping of the confidence intervals, NIRF-L was not statistically different to lymphoscintigraphy for sensitivity. Lymphadenectomy was unsuccessful in 4/30 (13%) cases in the control group. Surgical time and incision were significantly shorter in the treatment group (p < 0.001; p = 0.001). Based on our results, NIRF-L is a valid alternative to lymphoscintigraphy for SLN removal in MCT. Moreover, it improves the success of lymphadenectomy, reduces surgical time, and incision length compared to an unguided technique.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"320-329"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant Chemotherapy Is Associated With Prolonged Survival Time in Small-Breed Dogs Undergoing Amputation for Appendicular Osteosarcoma. 辅助化疗与因阑尾骨肉瘤而截肢的小型犬的生存时间延长有关。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-01-11 DOI: 10.1111/vco.13041

Stefano Zanardi, Silvia Sabattini, Federica Rossi, Matteo Rossanese, Paolo Buracco, Vincenzo Montinaro, Marina Aralla, Alfredo Dentini, Elisa Pizzi, Enrico Volpe, Giovanni Tremolada, Laura Marconato

{"title":"Adjuvant Chemotherapy Is Associated With Prolonged Survival Time in Small-Breed Dogs Undergoing Amputation for Appendicular Osteosarcoma.","authors":"Stefano Zanardi, Silvia Sabattini, Federica Rossi, Matteo Rossanese, Paolo Buracco, Vincenzo Montinaro, Marina Aralla, Alfredo Dentini, Elisa Pizzi, Enrico Volpe, Giovanni Tremolada, Laura Marconato","doi":"10.1111/vco.13041","DOIUrl":"10.1111/vco.13041","url":null,"abstract":"Adjuvant chemotherapy is a well-established treatment for large-breed dogs with appendicular osteosarcoma; however, it is unclear if it improves outcomes in small-breed dogs due to limited focused studies. This retrospective study aimed to investigate the oncologic outcomes of dogs weighting less than 15 kg with appendicular osteosarcoma that underwent curative resection with or without postoperative adjuvant chemotherapy. Endpoints were time to distant progression (TTDP) and overall survival (OS). Medical records from multiple institutions were reviewed, and 43 dogs were included in the analysis: 17 underwent surgery alone and 26 also received adjuvant chemotherapy. The median TTDP for all dogs was 265 days, with no significant difference between treatment groups. The median OS for all dogs was 270 days, and it was significantly different between amputated dogs (150 days) and those also receiving adjuvant chemotherapy (353 days, p = 0.002). In our cohort, osteosarcoma in small breeds behaved as aggressive as in large breeds. Adjuvant chemotherapy may prolong survival. Future randomised studies are needed to provide definitive evidence on the necessity of adjuvant chemotherapy to address metastatic spread in small-breed dogs with appendicular osteosarcoma.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"161-167"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Study Evaluating the Outcome and Efficacy of Stereotactic Body Radiation Therapy for the Treatment of Metastatic Abdominal Lymph Nodes in Dogs With Apocrine Gland Anal Sac Adenocarcinoma. 立体定向放射治疗犬大汗腺肛囊腺癌转移性腹部淋巴结的疗效及预后的回顾性研究。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1111/vco.13052

Tiffany W Martin, Theodore Chang, Mary-Keara Boss, Brandan Janssens, Susan M LaRue

{"title":"Retrospective Study Evaluating the Outcome and Efficacy of Stereotactic Body Radiation Therapy for the Treatment of Metastatic Abdominal Lymph Nodes in Dogs With Apocrine Gland Anal Sac Adenocarcinoma.","authors":"Tiffany W Martin, Theodore Chang, Mary-Keara Boss, Brandan Janssens, Susan M LaRue","doi":"10.1111/vco.13052","DOIUrl":"10.1111/vco.13052","url":null,"abstract":"Local treatment for dogs with regional lymph node metastasis secondary to apocrine gland anal sac adenocarcinoma (AGASACA) includes nodal extirpation or radiotherapy. Stereotactic body radiation therapy (SBRT) may provide a definitive intent treatment option for macroscopic nodal disease when surgery is declined or the disease is deemed inoperable. Twenty-five dogs receiving SBRT to the metastatic sacroiliac lymph nodes were retrospectively evaluated. Dogs were staged according to the previously published TNM staging system with 3 stage IIIa, 14 stage 3b, and 8 stage IV. The overall median survival time (MST) was 451 days and the stage did not significantly impact survival (p = 0.31). The overall median event-free survival time was 246 days. Significant positive prognostic factors included male sex, higher dose per fraction, and higher total dose (p = 0.034, 0.0035, 0.0047). Dogs receiving 6-7.5 Gy per fraction with a total dose of 30-37.5 Gy outperformed dogs receiving other protocols. Twelve dogs experienced gait changes in the hind limbs during the late radiation effects period. Resolution of hypercalcemia in 5 dogs was inconsistent and transient. The best response was complete in 21%, partial in 58%, and stable disease in 17% at a median of 100 days. Three dogs (12%) developed progression of treated lymph nodes at 157, 498, and 644 day. Eight dogs (32%) had recurrence of their primary (untreated by radiation) anal sac masses. SBRT was determined to be an effective alternative to surgical excision; however, more investigation is needed to determine the cause of gait changes in the late toxicity period.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"257-266"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotoxic Herbicide Exposures in Golden Retrievers With and Without Multicentric Lymphoma. 患有和未患有多中心淋巴瘤的金毛寻回犬暴露于遗传毒性除草剂的情况。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.1111/vco.13051

Ashleigh N Tindle, Lauren M Krueger, Brenna Swafford, Erin Mani, Camille Danielson, Julia Labadie, Lauren A Trepanier

{"title":"Genotoxic Herbicide Exposures in Golden Retrievers With and Without Multicentric Lymphoma.","authors":"Ashleigh N Tindle, Lauren M Krueger, Brenna Swafford, Erin Mani, Camille Danielson, Julia Labadie, Lauren A Trepanier","doi":"10.1111/vco.13051","DOIUrl":"10.1111/vco.13051","url":null,"abstract":"Canine multicentric lymphoma (CML) is one of the most common malignancies in dogs. Although breed risk is important, environmental factors such as herbicides have also been implicated. The objective of this study was to determine whether genotoxic exposures to the herbicides 2,4-D and glyphosate are associated with CML, using dogs from the Golden Retriever Lifetime Study cohort. We measured urinary concentrations of glyphosate and 2,4-D in golden retrievers with CML and matched unaffected controls at two time points: at the time of diagnosis and 1 year prior to diagnosis. To assess the genotoxic potential of herbicide exposures, we used reverse dosimetry from urinary concentrations to estimate plasma concentrations. We then assessed the genotoxicity of these herbicide concentrations towards healthy canine peripheral blood mononuclear cells (PBMC's) in vitro using the CometChip assay, with and without canine liver microsomes. All dogs had detectable urinary exposures to 2,4-D (7.3-42.9 ng/mg creat) and glyphosate (0.4-80.7 ng/mg creat), with no differences between cases and controls at either time point. Both 2,4-D and glyphosate were genotoxic to canine PBMCs at concentrations of 0.10 μM and higher, with no consistent effects of canine liver microsomes on herbicide genotoxicity. No dogs reached estimated genotoxic plasma concentrations for glyphosate, but 4 of 30 golden retrievers with CML (13.3%) and 2 of 30 control dogs (6.7%) reached estimated genotoxic 2,4-D exposures (p = 0.67).","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"246-256"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tolerability Assessment of Orally Administered Paclitaxel With Encequidar in Dogs With Spontaneous Malignancy. 口服紫杉醇联合恩奎达治疗犬自发性恶性肿瘤的耐受性评价。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-02-26 DOI: 10.1111/vco.13045

Jordan Ziegler, Jacob Cawley, Stephanie Istvan, Saya Press, Samuel Stewart, Chand Khanna, Joelle Fenger

{"title":"Tolerability Assessment of Orally Administered Paclitaxel With Encequidar in Dogs With Spontaneous Malignancy.","authors":"Jordan Ziegler, Jacob Cawley, Stephanie Istvan, Saya Press, Samuel Stewart, Chand Khanna, Joelle Fenger","doi":"10.1111/vco.13045","DOIUrl":"10.1111/vco.13045","url":null,"abstract":"Paclitaxel is an antimitotic agent that targets elements of the cancer phenotype, including cell proliferation, DNA repair, and apoptosis, predicting its broad activity in a spectrum of cancers. An oral paclitaxel formulation has been developed to overcome challenges associated with parenteral administration of this drug, notably the development of Cremophor-induced acute hypersensitivity reactions, which are particularly problematic in dogs. The aim of this open-label, dose-escalating study was to evaluate the tolerability and determine the maximum tolerated dosage (MTD) and dose-limiting toxicity (DLT) of oral paclitaxel when co-administered with the P-glycoprotein pump inhibitor, encequidar, in dogs with cancer. Paclitaxel was administered as a 3-consecutive-day course starting at 90 mg/m2 with encequidar weekly for 3 weeks, using escalation of 30 mg/m2 increments. MTD was established using a rolling-six dose escalation study design, based on the number of dogs experiencing any DLT assessed after each dosing cycle and during a 28-day post-treatment monitoring period. Nineteen client-owned dogs were enrolled. MTD was established at 90 mg/m2 and the most frequent adverse events (AEs) were gastrointestinal, followed by hematologic, with the majority being self-resolving and low grade. VCOG Grades 3 and 4 gastrointestinal toxicity, Grade 4 neutropenia, and acute kidney injury were defined as DLTs at 120 mg/m2. Conclusions of this study define oral paclitaxel MTD in cancer-bearing dogs at 90 mg/m2 when given with encequidar for 3 consecutive days weekly for 3 weeks. Future Phase 2 trials evaluating the therapeutic activity of oral paclitaxel at its MTD co-administered with encequidar in defined tumour histologies are warranted.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"197-204"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Half-Body Radiation Therapy Results in a Prolonged Progression-Free Interval in Canine High-Grade Lymphoma After First Remission. 犬高级别淋巴瘤首次缓解后半体放射治疗导致无进展时间延长。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-03-15 DOI: 10.1111/vco.13050

Yen-Hao Erik Lai, Sarah Lyles, Mark Mitchell, Jayme Looper

{"title":"Half-Body Radiation Therapy Results in a Prolonged Progression-Free Interval in Canine High-Grade Lymphoma After First Remission.","authors":"Yen-Hao Erik Lai, Sarah Lyles, Mark Mitchell, Jayme Looper","doi":"10.1111/vco.13050","DOIUrl":"10.1111/vco.13050","url":null,"abstract":"An optimal protocol of adding wide-field irradiation to multi-agent chemotherapy for dogs with lymphoma has not been established. The aim of this retrospective case-control study was to evaluate the efficacy of a protocol combining chemotherapy and half-body irradiation (HBI) for dogs with high-grade lymphoma. Dogs in the treatment group received cranial HBI 2 weeks after completing the second cycle of the multi-agent chemotherapy protocol. The radiation therapy protocol consisted of 4 Gy/fraction once per day for 2 consecutive days for the cranial half body, followed by the same protocol for the caudal half 2 weeks later. The control group only received multi-agent chemotherapy. All patients were required to have cytological confirmation of high-grade lymphoma and achieve complete remission after two cycles of multi-agent chemotherapy. Fourteen patients receiving HBI and 11 patients in the control group were included. The median progression-free interval (PFI) in the HBI group (1143 days) was significantly longer than that in the control group (316 days, p = 0.004). In the HBI group, dogs with T cell lymphoma had statistically shorter PFI (292 days) than dogs with B cell lymphoma (2127 days, p = 0.0013). The median survival time in the HBI group (1924 days) was significantly longer than that in the chemotherapy-only group (566 days, p = 0.0077). The predictive factors for longer PFI and ST were found in the patients who received HBI and chemotherapy (p = 0.0062 and 0.0252, respectively). For chemotherapy-responding patients that completed a multi-agent protocol, HBI significantly prolonged the time to tumour relapse compared with the chemotherapy-only group.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"236-245"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0