Wellcome Open Research最新文献

{"title":"The genome sequence of the Coppice Mining Bee, <i>Andrena helvola</i> (Linnaeus, 1758).","authors":"Steven Falk, Joseph Monks","doi":"10.12688/wellcomeopenres.23746.1","DOIUrl":"10.12688/wellcomeopenres.23746.1","url":null,"abstract":"<p><p>We present a genome assembly from a female <i>Andrena helvola</i> (Coppice Mining Bee; Arthropoda; Insecta; Hymenoptera; Andrenidae). The genome sequence has a total length of 442.47 megabases. Most of the assembly (91.93%) is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.61 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"102"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of an orbweaving spider, <i>Gibbaranea gibbosa</i> (Walckenaer, 1802).","authors":"Liam M Crowley, Craig S Wilding","doi":"10.12688/wellcomeopenres.23751.1","DOIUrl":"10.12688/wellcomeopenres.23751.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Gibbaranea gibbosa</i> (orbweaving spider; Arthropoda; Arachnida; Araneae; Araneidae). The genome sequence has a total length of 2,816.88 megabases. Most of the assembly (98.61%) is scaffolded into 13 chromosomal pseudomolecules, including the X ₁ and X ₂ sex chromosomes. The mitochondrial genome has also been assembled and is 14.1 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"97"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the amphioxus, <i>Branchiostoma lanceolatum</i> (Pallas, 1774).","authors":"Patrick Adkins, John Bishop, Joanna Harley, Peter W H Holland","doi":"10.12688/wellcomeopenres.23671.1","DOIUrl":"10.12688/wellcomeopenres.23671.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Branchiostoma lanceolatum</i> (Amphioxus; Chordata; Leptocardii; Amphioxiformes; Branchiostomatidae). The assembly contains two haplotypes with total lengths of 468.40 megabases and 465.81 megabases, respectively. Most of haplotype 1 (99.34%) is scaffolded into 19 chromosomal pseudomolecules. Haplotype 2 is a scaffold level assembly. The mitochondrial genome has also been assembled and is 15.14 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the European mole, <i>Talpa europaea</i> Linnaeus, 1758.","authors":"Nicola Pearce, Michelle F O'Brien, Rosa Lopez Colom","doi":"10.12688/wellcomeopenres.23759.1","DOIUrl":"10.12688/wellcomeopenres.23759.1","url":null,"abstract":"<p><p>We present a genome assembly from a female <i>Talpa europaea</i> (European mole; Chordata; Mammalia; Eulipotyphla; Talpidae). The assembly contains two haplotypes with total lengths of 2,060.98 megabases and 2,056.47 megabases. Most of haplotype 1 (98.6%) is scaffolded into 17 chromosomal pseudomolecules, including the X sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled and is 16.93 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, risk and impact of ICU readmission on patient outcomes and resource utilisation in tertiary level ICUs in Nepal: A cohort study.","authors":"Diptesh Aryal, Hem Raj Paneru, Sabin Koirala, Sushil Khanal, Subhash Prasad Acharya, Arjun Karki, Dilanthi Gamaga Dona, Rashan Haniffa, Abi Beane, Jorge I F Salluh","doi":"10.12688/wellcomeopenres.18381.3","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.18381.3","url":null,"abstract":"<p><strong>Background: </strong>Readmissions to Intensive Care Units (ICUs) result in increased morbidity, mortality, and ICU resource utilisation (e.g. prolonged mechanical ventilation), and as such, is a widely utilised metric of quality of critical care. Most of the evidence on incidence, characteristics, associated risk factors and attributable outcomes of readmission to ICU are from studies performed in high-income countries This study explores the determinants of risk attributable to ICU readmission in four ICUs in Kathmandu, Nepal.</p><p><strong>Methods: </strong>The registry reported data on case mix, severity of illness, in-ICU interventions (including organ support), ICU outcome, and readmission characteristics. Data were captured in all adult patients admitted between September 2019 and February 2021. Population and ICU encounter characteristics were compared between those with and without readmission. Independent risk factors for readmission were assessed using univariate analysis.</p><p><strong>Results: </strong>In total 2955 patients were included in the study. Absolute ICU readmission rate was 5.69 % (n=168) for all four ICUs. Median time from ICU discharge to readmission was 3 days (IQR=8,1). Of those readmitted, 29.17% (n=49) were discharged at night following their index admission. ICU mortality was higher following readmission to ICU(p=0.016) and mortality was increased further in patients whose primary index discharge was at night(p= 0.019). Primary diagnosis, age, and use of organ support in the first 24hrs of index admission were all independently attributable risk factors for readmission.</p><p><strong>Conclusions: </strong>ICU readmission rates were adversely associated with significantly poorer outcomes, increased ICU resource utilisation. Clinical and organisational characteristics influenced risk of readmission and outcome.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"7 ","pages":"272"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Common Sheetweb Spider <i>Linyphia triangularis</i> (Clerck, 1757).","authors":"Olga Sivell, Duncan Sivell","doi":"10.12688/wellcomeopenres.23754.1","DOIUrl":"10.12688/wellcomeopenres.23754.1","url":null,"abstract":"<p><p>We present a genome assembly from a male <i>Linyphia triangularis</i> (Common Sheetweb Spider Arthropoda; Arachnida; Araneae; Linyphiidae). The genome sequence has a total length of 1,349.10 megabases. Most of the assembly (95.36%) is scaffolded into 13 chromosomal pseudomolecules, including the X ₁ and X ₂ sex chromosomes. The mitochondrial genome has also been assembled and is 15.31 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and related data collected during pregnancy in the Avon Longitudinal Study of Parents and Children (ALSPAC).","authors":"Caroline M Taylor, Kate Northstone, Jean Golding, Louise Jones, Genevieve Buckland, Pauline M Emmett","doi":"10.12688/wellcomeopenres.23464.2","DOIUrl":"10.12688/wellcomeopenres.23464.2","url":null,"abstract":"<p><p>The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal birth cohort study based in the south-west of the UK. Pregnant women resident in and around the city of Bristol with expected delivery dates between 1 April 1991 and 31 December 1992 were invited to take part. The initial number of pregnancies enrolled was 14,541. Four questionnaires were sent to women through the post during pregnancy (including a food frequency questionnaire (FFQ) at 32 weeks) for self-completion; excluding withdrawals and exclusions, 11,978 FFQ records are available (April 2024). The main part of the FFQ at 32 weeks comprised questions on the weekly frequency of consumption of 43 food groups and food items. More detailed questions covered a further eight foods/drinks normally consumed daily. The data were used to derive daily nutrient intakes for each participant. Dietary patterns were derived using principal components analysis. Together with the diverse ALSPAC resource containing detailed data on demographics, lifestyle, environment, genetics and health, these data form a unique resource for the study of: (1) maternal diet in pregnancy, fetal/child development and their life course; (2) women's diet and their life course.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the black-headed gull, <i>Chroicocephalus ridibundus</i> (Linnaeus, 1766).","authors":"Rosa Lopez Colom, Michelle O'Brien","doi":"10.12688/wellcomeopenres.22741.2","DOIUrl":"10.12688/wellcomeopenres.22741.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Chroicocephalus ridibundus</i> (the black-headed gull; Chordata; Aves; Charadriiformes; Laridae). The genome sequence spans 1,417.60 megabases. Most of the assembly is scaffolded into 33 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 16.82 kilobases in length. The genome has been annotated on Ensembl, which reports 15,628 protein coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"399"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Black-veined White butterfly, <i>Aporia crataegi</i> (Linnaeus, 1758).","authors":"Sam Ebdon, Alexander Mackintosh, Konrad Lohse, Alex Hayward, Saad Arif, Rebecca Whitla","doi":"10.12688/wellcomeopenres.17709.2","DOIUrl":"10.12688/wellcomeopenres.17709.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Aporia crataegi</i> (the black-veined white; Arthropoda; Insecta; Lepidoptera; Pieridae). The genome sequence is 230 megabases in span. The complete assembly is scaffolded into 26 chromosomal pseudomolecules, with the Z sex chromosome assembled. Gene annotation of this assembly on Ensembl has identified 10,860 protein coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"7 ","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the lesser earwig, <i>Labia minor</i> (Linnaeus, 1758).","authors":"Liam M Crowley, Mark G Telfer","doi":"10.12688/wellcomeopenres.23739.1","DOIUrl":"10.12688/wellcomeopenres.23739.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Labia minor</i> (the lesser earwig; Arthropoda; Insecta; Dermaptera; Spongiphoridae). The genome sequence spans 604.50 megabases. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules, including the X sex chromosome. Two mitochondrial scaffolds were also assembled.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}