Wellcome Open Research最新文献

{"title":"The genome sequence of the confused eyebright, <i>Euphrasia confusa</i> Pugsley.","authors":"Alex D Twyford","doi":"10.12688/wellcomeopenres.23301.1","DOIUrl":"10.12688/wellcomeopenres.23301.1","url":null,"abstract":"<p><p>We present a genome assembly from a tetraploid specimen of the confused eyebright, <i>Euphrasia confusa</i> (Streptophyta; Magnoliopsida; Lamiales; Orobanchaceae). The genome sequence has a total length of 976.50 megabases. Most of the assembly is scaffolded into 22 chromosomal pseudomolecules, supporting the specimen being an allotetraploid (2 <i>n</i> = 4 <i>x</i> = 44). There are two mitochondrial genome scaffolds with lengths of 329.69 and 112.33 kilobases, and the plastid genome is 144.97 kilobases long.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"662"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The BSSO Foundry: A community of practice for ontologies in the behavioural and social sciences.","authors":"Janna Hastings, Lisa Zhang, Paulina Schenk, Robert West, Björn Gehrke, William R Hogan, Bruce Chorpita, Marie Johnston, Marta M Marques, Thomas L Webb, Harriet M Baird, Geert Crombez, Susan Michie","doi":"10.12688/wellcomeopenres.23230.1","DOIUrl":"10.12688/wellcomeopenres.23230.1","url":null,"abstract":"<p><p>There has been a rapid expansion in the quantity and complexity of data, information and knowledge created in the behavioural and social sciences, yet the field is not advancing understanding, practice or policy to the extent that the insights warrant. One challenge is that research often progresses in disciplinary silos and is reported using inconsistent and ambiguous terminology. This makes it difficult to integrate and aggregate findings to produce cumulative bodies of knowledge that can be translated to applied settings. Ontologies can address these challenges; their development and use have the potential to accelerate the behavioural and social sciences. Ontologies can facilitate communication through precise specification and dissemination of terms, and enable efficient data integration, sharing, comparison and analysis. The widespread use of ontologies in the biomedical and biological sciences has led to multiple successes. It is time now for the behavioural and social sciences to follow that lead. In recent years, a number of ontologies have been developed within the behavioural and social sciences; however, efforts have tended to be isolated, with limited resources to support developers and those who work (or would like to work) with and use ontologies. There is a need for coordination and exchange to reduce duplication of work and leverage the value of a community to support the interoperability of these ontologies (linking of entities across domains and datasets). We have therefore initiated the Behavioural and Social Sciences Ontology (BSSO) Foundry, a community of practice and online repository for the development, adoption and use of ontologies in the behavioural and social sciences. The BSSO Foundry aligns with and builds upon the model provided by the Open Biological and Biomedical Ontology Foundry. We describe this new initiative and how to join and contribute to the community of interoperable ontologies for the behavioural and social sciences.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"656"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Scalloped Hook-tip moth, <i>Falcaria lacertinaria</i> (Linnaeus, 1758).","authors":"Andy Griffiths, Tom Prescott","doi":"10.12688/wellcomeopenres.23258.1","DOIUrl":"10.12688/wellcomeopenres.23258.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Falcaria lacertinaria</i> (the Scalloped Hook-tip; Arthropoda; Insecta; Lepidoptera; Drepanidae). The genome sequence has a total length of 300.20 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled and is 16.07 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,709 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"659"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Tenthredo amoena</i> Gravenhorst, 1807.","authors":"Steven Falk, Liam M Crowley, Andrew Green","doi":"10.12688/wellcomeopenres.23298.1","DOIUrl":"10.12688/wellcomeopenres.23298.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female shiny-headed wasp-sawfly, <i>Tenthredo amoena</i> (Arthropoda; Insecta; Hymenoptera; Tenthredinidae). The genome sequence has a total length of 199.80 megabases. Most of the assembly (99.95%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 33.96 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"660"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga-based lifestyle intervention for antenatal depression (YOGA-D): study protocol for a pilot randomized controlled trial.","authors":"Rahul Shidhaye, Vidyadhar Bangal, Hemant Bhargav, Chitra Thanage, Suryabhan Gore, Shamal Talole, Kalyani Shinde, Swapnali Palande, Unnati Thete, Sonali Shelke, Geeta Gholap, Suchita Nisal, Soni Gargade, Swanand Tilekar, Nilam Behere, Kalpesh Game, Vaibhav Murhar, Rahul Kunkulol, Shirley Telles","doi":"10.12688/wellcomeopenres.22493.2","DOIUrl":"10.12688/wellcomeopenres.22493.2","url":null,"abstract":"<p><strong>Background: </strong>Depression during pregnancy is associated with pre-term labor, low birthweight, post-partum depression and adverse child outcomes. There are concerns about the safety of anti-depressant medications during pregnancy. Many pregnant women with antenatal depression are neither aware about their depression nor do they have access to non-pharmacological interventions for depression. Evidence suggests that pre-natal yoga can improve antenatal depression. Yoga is native to the Indian culture and women can practice yoga as a 'self-care' intervention with minimal training. There is no study till date on the efficacy of yoga on antenatal depression in pregnant women in a low resource (rural) setting in India. This pilot randomized controlled trial aims to study the feasibility, acceptability, and preliminary efficacy of a <b>YOGA</b>-based lifestyle intervention for Antenatal <b>D</b>epression (YOGA-D) in Maharashtra, India.</p><p><strong>Methods: </strong>We will undertake a single-blind individual randomized parallel group-controlled pilot trial with 1:1 allocation ratio. Adult women with 12-26 weeks of pregnancy, without any obstetric or medical complications will be randomly allocated to either the active intervention group (Yoga-Sanskar (YS)) or the Enhanced Usual Care (EUC) group. Trained yoga instructors will teach a pre-defined yoga sequence to the participants in the YS arm. In the EUC arm, participants will receive a single session of health education. We will assess trial feasibility using the recruitment, retention, and study completion rates. The primary outcome of depression will be measured using the translated Marathi version of the Patient Health Questionnaire-9. Assessments will be at the baseline, three-months post-randomization, and post-delivery.</p><p><strong>Discussion: </strong>This study will help us to understand the barriers in implementation of a yoga-based intervention for antenatal depression in a low-resource/rural setting in Maharashtra, India. Based on the learnings of this pilot trial, we plan to undertake an explanatory randomized controlled trial in the next few months.</p><p><strong>Registration: </strong>CTRI ( CTRI/2024/05/067176; 10/05/2024).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"326"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Common Wainscot moth, <i>Mythimna pallens</i> Linnaeus, 1758.","authors":"Stephanie Holt, Laura Sivess, Inez Januszczak, Gavin R Broad, Chris Fletcher","doi":"10.12688/wellcomeopenres.23320.1","DOIUrl":"10.12688/wellcomeopenres.23320.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Mythimna pallens</i> (the Common Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 719.10 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.33 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,343 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"654"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual experiences and behaviours of the parents in the Avon Longitudinal Study of Parents and Childhood (ALSPAC).","authors":"Yasmin Iles-Caven, Jean Golding","doi":"10.12688/wellcomeopenres.21263.2","DOIUrl":"10.12688/wellcomeopenres.21263.2","url":null,"abstract":"<p><p>The aim of this data note is to describe the sexual experiences, functioning and behaviour data collected from the parent cohorts of the Avon Longitudinal Study of Parents and Children (ALSPAC) occurring during their childhoods and up to 19 years after the birth of the index child. ALSPAC is an ongoing birth cohort which enrolled 14,541 pregnant women living in Avon, an area of southwest England, with expected dates of delivery between April 1991 and December 1992 inclusive. It continues collecting data on these mothers (age range at delivery <16-41 years), their partners (age range at delivery <16-65), and their offspring, so far resulting in 100,000+ phenotype variables. During the index pregnancy the mothers were asked (and at 8 months post-delivery for partners) about their early sexual experiences to identify sexual abuse, the age at which an event first occurred, along with the type of perpetrator (e.g. stranger, relatives, boy/girlfriend). There are also data on these parents' experiences of sexual assault as adults. Both parents were asked also about sexual abuse within a battery of questions identifying Adverse Childhood Events (ACEs). Further longitudinal data described here includes satisfaction with sexual and non-sexual sides of their relationship; sexual functioning; and at seven years post-delivery, both parents were asked to describe their sexual orientation as well as the sex of their partners. These data provide the ability to compare generational differences between parental sexual experiences and behaviours with those of their offspring, as well as allowing comparisons with other longitudinal surveys where similar (or identical) information has been collected such as the National Survey of Sexual Attitudes and Lifestyles (NATSAL-3). This paper forms a companion to a further data note describing similar data collected on the offspring cohort.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Shoulder-striped Wainscot moth, <i>Leucania comma</i> Linnaeus, 1761.","authors":"Stephanie Holt, Laura Sivess, Inez Januszczak, Gavin R Broad, Chris Fletcher, Denise C Wawman","doi":"10.12688/wellcomeopenres.23326.1","DOIUrl":"10.12688/wellcomeopenres.23326.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Leucania comma</i> (the Shoulder-striped Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence spans 751.70 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.37 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,477 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"652"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a soliderfly, <i>Stratiomys singularior</i> (Harris, 1776).","authors":"Olga Sivell, Duncan Sivell, Ryan Mitchell","doi":"10.12688/wellcomeopenres.23294.1","DOIUrl":"10.12688/wellcomeopenres.23294.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female solidierfly, <i>Stratiomys singularior</i> (Arthropoda; Insecta; Diptera; Stratiomyidae). The genome sequence has a total length of 715.20 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.67 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,614 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"646"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual experiences and behaviours in the offspring generation of the Avon Longitudinal Study of Parents and Childhood.","authors":"Yasmin Iles-Caven, Jean Golding","doi":"10.12688/wellcomeopenres.21687.2","DOIUrl":"10.12688/wellcomeopenres.21687.2","url":null,"abstract":"<p><p>Previous research on child/teenage sexual experiences has largely focussed on negative outcomes such as teen pregnancy or acquiring sexually transmitted infections and are mainly cross-sectional. Longitudinal research is required to assess normal sexual development and the attainment of psychologically healthy attitudes towards sexuality. The Avon Longitudinal Study of Parents and Children (ALSPAC) has administered questions on relationships and sexual experiences from the age of 11 years to the index children. This data note describes these data.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"241"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}