Gillian Santorelli, Dan Lewer, Krishnarajah Nirantharakumar, Siang Ing Lee, Katherine Phillips, Rosemary R C McEachan, John Wright
{"title":"生命过程中常见健康状况的出现:来自布拉德福德出生家庭队列的证据。","authors":"Gillian Santorelli, Dan Lewer, Krishnarajah Nirantharakumar, Siang Ing Lee, Katherine Phillips, Rosemary R C McEachan, John Wright","doi":"10.12688/wellcomeopenres.20992.2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants.</p><p><strong>Methods: </strong>21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity.</p><p><strong>Results: </strong>The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]).</p><p><strong>Conclusions/discussion: </strong>This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"210"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134723/pdf/","citationCount":"0","resultStr":"{\"title\":\"The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort.\",\"authors\":\"Gillian Santorelli, Dan Lewer, Krishnarajah Nirantharakumar, Siang Ing Lee, Katherine Phillips, Rosemary R C McEachan, John Wright\",\"doi\":\"10.12688/wellcomeopenres.20992.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants.</p><p><strong>Methods: </strong>21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity.</p><p><strong>Results: </strong>The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]).</p><p><strong>Conclusions/discussion: </strong>This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.</p>\",\"PeriodicalId\":23677,\"journal\":{\"name\":\"Wellcome Open Research\",\"volume\":\"9 \",\"pages\":\"210\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134723/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wellcome Open Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12688/wellcomeopenres.20992.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wellcome Open Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/wellcomeopenres.20992.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort.
Background: Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants.
Methods: 21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity.
Results: The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]).
Conclusions/discussion: This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.
Wellcome Open ResearchBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
5.50
自引率
0.00%
发文量
426
审稿时长
1 weeks
期刊介绍:
Wellcome Open Research publishes scholarly articles reporting any basic scientific, translational and clinical research that has been funded (or co-funded) by Wellcome. Each publication must have at least one author who has been, or still is, a recipient of a Wellcome grant. Articles must be original (not duplications). All research, including clinical trials, systematic reviews, software tools, method articles, and many others, is welcome and will be published irrespective of the perceived level of interest or novelty; confirmatory and negative results, as well as null studies are all suitable. See the full list of article types here. All articles are published using a fully transparent, author-driven model: the authors are solely responsible for the content of their article. Invited peer review takes place openly after publication, and the authors play a crucial role in ensuring that the article is peer-reviewed by independent experts in a timely manner. Articles that pass peer review will be indexed in PubMed and elsewhere. Wellcome Open Research is an Open Research platform: all articles are published open access; the publishing and peer-review processes are fully transparent; and authors are asked to include detailed descriptions of methods and to provide full and easy access to source data underlying the results to improve reproducibility.