Wellcome Open Research最新文献

{"title":"The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies.","authors":"Simonne Wright, Virginia Chiocchia, Olufisayo Elugbadebo, Ouma Simple, Toshi A Furukawa, Claire Friedrich, Charlotte Austin, Hossein Dehdarirad, David Gilbert, Jaycee Kennett, Edoardo G Ostinelli, Jennifer Potts, Fiona Ramage, Emily Sena, Spyridon Siafis, Claire Stansfield, James Thomas, Francesca Tinsdeall, Thomy Tonia, Malcolm Macleod, Andrea Cipriani, Georgia Salanti, Soraya Seedat","doi":"10.12688/wellcomeopenres.23033.2","DOIUrl":"10.12688/wellcomeopenres.23033.2","url":null,"abstract":"<p><strong>Background: </strong>Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies.</p><p><strong>Methods: </strong>We Included controlled human and non-human studies involving searches of multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed for risk of bias, and reconciled by two independent reviewers. The primary outcome for human studies was PTSD symptom severity, while outcomes of interest for non-human studies included freezing behaviour, fear memory, fear generalization, startle response, and locomotion. Data were synthesised with random-effects meta-analysis.</p><p><strong>Results: </strong>Eleven human studies met the eligibility criteria. Overall, exercise was not associated with symptom severity improvement compared to control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 to 0.07; 8 studies, one at low risk of bias). High-intensity exercise reduced PTSD symptoms scores more than moderate-intensity exercise. There was insufficient data to examine the effects of exercise on functional impairment, PTSD symptom clusters, and PTSD remission. Only three studies, all at high risk of bias, examined mechanisms of exercise with inconclusive results. Exercise was associated with improvement in all behavioural outcomes, including locomotor activity (SMD 1.30, 95% CI 0.74 to 1.87, 14 studies), and changes in several neurobiological markers, including increase in brain-derived neurotrophic factor (SMD 1.79, 95% CI 0.56 to 3.01).</p><p><strong>Conclusions: </strong>While non-human studies provide compelling evidence for the beneficial effects of exercise, human trials do not. Evidence from non-human studies suggest that exercise might increase the levels of brain-derived neurotrophic factor, enhance cognitive appraisal, and improve perceived exertion. Overall, the paucity of data on the effectiveness of exercise in PTSD and mechanisms of action underscore the need for rigorous trials.</p><p><strong>Registration: </strong>The protocol was registered with PROSPERO (ID:453615; 22.08.2023).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"720"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the poplar hawk-moth, <i>Laothoe populi</i>  (Linnaeus, 1758).","authors":"Douglas Boyes, Peter W H Holland","doi":"10.12688/wellcomeopenres.17191.2","DOIUrl":"10.12688/wellcomeopenres.17191.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Laothoe populi</i> (the poplar hawk-moth; Arthropoda; Insecta; Lepidoptera; Sphingidae). The genome sequence is 576 megabases in span. Most of the assembly is scaffolded into 29 chromosomal pseudomolecules, with the W and Z sex chromosome assembled.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"6 ","pages":"237"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru.","authors":"Renzo A Agurto-García, Enrique S Nuñez-Del-Arco, Rodrigo M Carrillo-Larco, J Jaime Miranda, Antonio Bernabe-Ortiz","doi":"10.12688/wellcomeopenres.23077.3","DOIUrl":"10.12688/wellcomeopenres.23077.3","url":null,"abstract":"<p><strong>Background: </strong>The skeletal muscle has mainly a structural function and plays a role in human's metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are associated with baseline sleep duration and disturbances in a resource-constrained adult Peruvian population.</p><p><strong>Materials and methods: </strong>Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee's formula. The exposures were baseline self-reported sleep duration (normal, short and long sleepers) and disturbances (sleep difficulties and awakening at nights). Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported.</p><p><strong>Results: </strong>Data from 2,310 individuals at baseline, mean age 43.4 (SD: 17.2), and 1,163 (50.4%) females were analyzed. Sleep duration was 7.8 (SD: 1.3) hours/day, with 15.3% short sleepers and 11.6% long sleepers, whereas 24.2% reported sleep difficulties and 25.1% awakening at nights. In multivariable model, SMM among short and long sleepers did not vary significantly over time using the Lee's formula; however, SMM was lower at the end of follow-up for long sleepers using bioimpedance (-0.26 kg; 95% CI: -0.47 to -0.06). Sleep disturbances were associated with a gradual SMM reduction: 0.36 kg using bioimpedance and 0.25 kg using the formula at the end of follow-up.</p><p><strong>Conclusions: </strong>Using bioimpedance and formula estimations, sleep disturbances were associated with a reduction of SMM over a period of 2.4 years. Regarding sleep duration, no SMM changes over time were seen in short sleepers, but findings were discordant in long sleepers: a reduction of SMM using bioimpedance, but no change using the formula.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"565"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the True Lover's Knot moth, <i>Lycophotia porphyrea</i> (Denis & Schiffermüller), 1775.","authors":"Jonathan Davis, Andy Griffiths","doi":"10.12688/wellcomeopenres.22897.2","DOIUrl":"10.12688/wellcomeopenres.22897.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Lycophotia porphyrea</i> (the True Lover's Knot; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 542.40 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.39 kilobases in length. Gene annotation of this assembly at Ensembl identified 17,907 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"469"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Global AMR Research Community: Interactive GIS dashboards for AMR data analysis and informed decision-making.","authors":"Stephen Obol Opiyo, Racheal Nalunkuma, Stella Maris Nanyonga, Nathan Mugenyi, Andrew Marvin Kanyike","doi":"10.12688/wellcomeopenres.21010.4","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21010.4","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial Resistance (AMR) poses a global public health challenge, necessitating advanced tools to support data analysis, and visualization. This study introduces interactive Geographic Information System (GIS) dashboards as innovative platforms for AMR data analysis and visualization, offering comprehensive insights into resistance patterns, and geographic distribution across multiple countries, with a specific focus on Africa.</p><p><strong>Methods: </strong>Three GIS dashboards were developed to address key objectives. The first integrates over 860,000 ATLAS data points from 83 countries, providing an interactive platform. Users can filter data by variables such as country, year, and region, enhancing data accessibility and visualization. The second dashboard focuses on the ATLAS dataset for Kenya and Uganda, incorporating detailed variables such as species, sample sources, and resistance phenotypes. The third involves Kampala, Uganda, to fill data gaps, enabling localized analyses through interactive features like geographic mapping and sample breakdowns by year.</p><p><strong>Results: </strong>Sub-Saharan Africa faces three major challenges in handling antimicrobial resistance (AMR) data: limited accessibility for non-technical users, inefficiencies in processing large datasets, and insufficient longitudinal data for analysis. The introduction of interactive dashboards significantly improved AMR data visualization and interpretation across different scales. The global AMR dashboard effectively mapped geographical trends, uncovering critical data gaps, particularly the scarcity of AMR records from Africa. The Kenya and Uganda dashboard revealed key resistance patterns, highlighting the ineffectiveness of Ceftriaxone, Erythromycin, Levofloxacin, and Ampicillin against E. coli isolates. Additionally, the Kampala-specific dashboard, developed using simulated data, demonstrated the potential for localized AMR visualization, providing valuable insights where real-world data is limited. Across all platforms, the dashboards' interactive features enhanced data accessibility and streamlined trend identification, making AMR insights more interpretable, especially for researchers in Sub-Saharan Africa.</p><p><strong>Conclusions: </strong>Interactive GIS dashboards enhance AMR data analysis in Sub-Saharan Africa by improving accessibility, efficiently handling large datasets, and addressing data gaps. Unlike spreadsheets such as Excel, which struggle with large datasets due to computer constraints, dashboards offer dynamic visualization, real-time updates, and intuitive data exploration.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"234"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrastructure, capabilities, and capacities required for clinical trials design and delivery: A rapid scoping review of recommendations and regulations.","authors":"Laura Merson, Karolina Witt, Arishay Hussaini, Ayesha Siddiqui, Eli Harriss, Steve Webb, Patricia Njuguna, Divya K Shah, An-Wen Chan, Robert Terry, Nandi Siegfried, Jeni Stolow, Emmanuelle Denis, Madiha Hashmi","doi":"10.12688/wellcomeopenres.23135.2","DOIUrl":"10.12688/wellcomeopenres.23135.2","url":null,"abstract":"<p><strong>Objective: </strong>Synthesise the published literature and national regulations on infrastructure, capabilities and capacities required to manage and quality assure clinical research.</p><p><strong>Introduction: </strong>The World Health Assembly (WHA) resolution 75.8 (2022) called \"for a strengthened global architecture for coordinated and high-quality clinical trials\". For this remit, infrastructure, capabilities, and capacities needed to design and deliver high-quality clinical trials must be understood and advanced. This rapid scoping review aims to identify the breadth of requirements and recommendations for effective management of clinical trials in regulations, national legislation and the published literature. The findings will be summarised into themes. It will inform a framework for the assessment and development of units undertaking observational studies and interventional clinical trials.</p><p><strong>Inclusion criteria: </strong>Peer-reviewed literature, grey literature, and national legislation that recommends infrastructure, capabilities, and/or capacities needed to manage and quality assure clinical trials. Publications authored by those who design, manage, fund, sponsor, regulate or oversee clinical trials.</p><p><strong>Methods: </strong>Peer-reviewed and grey literature will be identified through Medline, Embase, PsycINFO, and Global Health via Ovid; SCOPUS; the Web of Science Core Collection; and the WHO Global Index Medicus using specific field codes to increase the specificity of the search strings. No date, language, or geographic limits will be applied. Deduplicated titles and abstracts will be screened by two blinded reviewers with discrepancies resolved by a third reviewer. Grey literature may be identified through the peer reviewed literature, supplemented with structured searches of Google and DynaMed. National regulations will be sourced online and from available summaries. Full text literature and regulations will be screened by a single reviewer, with proportionate verification by a second reviewer. Data will be extracted and coded for patterns in NVivo software. All items and codes will be summarised using a thematic framework analysis and identify core constructs within each theme.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"729"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAHELI:  Study and Action on Hysterectomy: Evidence on women's health through the life course in India.  Protocol for a mixed-methods study.","authors":"Sapna Desai, Dipti Govil, Devaki Nambiar, Hemali Heidi Sinha, Archana Roy, Kranti Vora, Josyula K Lakshmi, Archana Kumari, Gita D Mishra, Neerja Bhatla","doi":"10.12688/wellcomeopenres.23084.1","DOIUrl":"10.12688/wellcomeopenres.23084.1","url":null,"abstract":"<p><p>Hysterectomy, removal of the uterus, is a commonly performed surgery for gynaecological morbidities. Emerging evidence indicates that hysterectomy performed before age 45 (early hysterectomy), is associated with considerable risks to women's health. While most evidence on hysterectomy is from high-income settings, national surveys from India report high prevalence of early hysterectomy in specific regions, as well as higher prevalence amongst women in rural areas and with less education. The median age at hysterectomy in India is close to ten years before the onset of natural menopause. India has recently introduced national guidelines to address early hysterectomy, but large evidence gaps on the causes and consequences remain - which in turn limits the potential effectiveness of interventions at the clinical, health system and community level.</p><p><strong>Methods: </strong>SAHELI is a Team Science study that will examine: (i) individual, social and health system determinants of early hysterectomy; (ii) women's treatment pathways to hysterectomy and for gynaecological morbidity in general; and (iii) the consequences of undergoing hysterectomy on women's physical, mental, economic and social well-being across the life course. This mixed-methods study includes population surveys amongst women in ages 25-49 in three high-prevalence states; qualitative health systems research to trace treatment journeys with women, health care providers and other stakeholders; evidence syntheses; and knowledge translation activities to ensure findings inform co-produced strategies and interventions. The study is grounded in a feminist epidemiology approach, aiming to examine individual and structural causes of vulnerability and prioritising the views of women, particularly in knowledge translation.</p><p><strong>Conclusions: </strong>SAHELI, implemented by an all-women, multi-disciplinary team, is the first study in India to examine the causes and consequences of hysterectomy in a life course approach. We aim to influence interventions, policy and future research on women's health, particularly access to quality gynaecological care and comprehensive health services through the life course.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"584"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the common crane, <i>Grus grus</i> (Linnaeus, 1758).","authors":"Michelle F O'Brien, Rosa Lopez Colom","doi":"10.12688/wellcomeopenres.23797.1","DOIUrl":"10.12688/wellcomeopenres.23797.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Grus grus</i> (common crane; Chordata; Aves; Gruiformes; Gruidae). The assembly contains two haplotypes with total lengths of 1,352.26 megabases and 1,291.08 megabases. Most of haplotype 1 (91.85%) is scaffolded into 40 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled and is 18.9 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"119"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the European smelt, <i>Osmerus eperlanus</i> (Linnaeus, 1758).","authors":"Chris Fletcher, David Alexander, Bethany Reed","doi":"10.12688/wellcomeopenres.23789.1","DOIUrl":"10.12688/wellcomeopenres.23789.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Osmerus eperlanus</i> (European smelt; Chordata; Actinopteri; Osmeriformes; Osmeridae). The genome sequence has a total length of 508.70 megabases. Most of the assembly (95.79%) is scaffolded into 28 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.61 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory tract lining fluid copper content contributes to pulmonary oxidative stress in patients with systemic sclerosis.","authors":"Andreas Frølich, Rosamund E Dove, Maria Friberg, Annelie F Behndig, Thomas Sandström, Anders Blomberg, Ian S Mudway","doi":"10.12688/wellcomeopenres.20080.2","DOIUrl":"10.12688/wellcomeopenres.20080.2","url":null,"abstract":"<p><strong>Background: </strong>Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs, mostly affecting young and middle-aged women. Significant questions remain as to its pathogenesis, especially the triggers for the associated interstitial lung disease (SSc-ILD). We examined the extent to which SSc and SSc-ILD were related to oxidative stress and altered metal homeostasis at the air-lung interface.</p><p><strong>Methods: </strong>In this case-control study, we recruited 20 SSc patients, of which 11 had SSc-ILD. Eighteen healthy individuals were recruited as age-matched healthy controls, for a total of 38 study participants. Low molecular weight antioxidants (ascorbate, urate and glutathione), metal transport and chelation proteins (transferrin and ferritin) and metals (Fe and Cu) concentrations, including a measure of the catalytically active metal pool, were determined in respiratory tract lining fluid (RTLF) collected by bronchoalveolar lavage from the SSc group and compared with healthy controls.</p><p><strong>Results: </strong>In the SSc group, 14 individuals were of female sex (70%) and the median age was 57 years (range 35-75). We observed evidence of oxidative stress in the RTLFs of SSc patients, characterised by increased concentrations of glutathione disulphide (GSSG, P<0.01), dehydroascorbate (DHA, P<0.05) and urate (P<0.01). This was associated with elevated RTLF Fe (P=0.07) and Cu (P<0.001), and evidence of a catalytic metal pool, demonstrated by an enhanced rate of ascorbate oxidation in the recovered lavage fluid (p<0.01). Cu concentrations were significantly associated with the ascorbate depletion rate (r=0.76, P<0.001), and GSSG (r=0.38, P<0.05) and protein carbonyl (r=0.44, P<0.01) concentrations. Whilst these markers were all increased in SSc patients, we found no evidence for an association with SSc-ILD.</p><p><strong>Conclusions: </strong>These data confirm the presence of oxidative stress in the airways of SSc patients and, for the first time, suggest that an underlying defect in metal homeostasis at the air-lung interface may play a role in disease progression.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}