Wellcome Open Research最新文献

{"title":"The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies.","authors":"Simonne Wright, Virginia Chiocchia, Olufisayo Elugbadebo, Ouma Simple, Toshi A Furukawa, Claire Friedrich, Charlotte Austin, Hossein Dehdarirad, David Gilbert, Jaycee Kennett, Edoardo G Ostinelli, Jennifer Potts, Fiona Ramage, Emily Sena, Spyridon Siafis, Claire Stansfield, James Thomas, Francesca Tinsdeall, Thomy Tonia, Malcolm Macleod, Andrea Cipriani, Georgia Salanti, Soraya Seedat","doi":"10.12688/wellcomeopenres.23033.2","DOIUrl":"10.12688/wellcomeopenres.23033.2","url":null,"abstract":"<p><strong>Background: </strong>Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies.</p><p><strong>Methods: </strong>We Included controlled human and non-human studies involving searches of multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed for risk of bias, and reconciled by two independent reviewers. The primary outcome for human studies was PTSD symptom severity, while outcomes of interest for non-human studies included freezing behaviour, fear memory, fear generalization, startle response, and locomotion. Data were synthesised with random-effects meta-analysis.</p><p><strong>Results: </strong>Eleven human studies and 14 non-human studies met the eligibility criteria. Results of human studies showed that exercise was not associated with symptom severity improvement compared to control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 to 0.07). High-intensity exercise reduced PTSD symptoms scores more than moderate-intensity exercise. There was insufficient data to examine the effects of exercise on functional impairment, PTSD symptom clusters, and PTSD remission. Only three studies, all at high risk of bias, examined mechanisms of exercise with inconclusive results. Results of non-human studies showed that exercise was associated with improvement in all behavioural outcomes, including locomotor activity (SMD 1.30, 95% CI 0.74 to 1.87, 14 studies), and changes in several neurobiological markers, including increase in brain-derived neurotrophic factor (SMD 1.79, 95% CI 0.56 to 3.01).</p><p><strong>Conclusions: </strong>While non-human studies provide compelling evidence for the beneficial effects of exercise, human trials do not. Evidence from non-human studies suggest that exercise might increase the levels of brain-derived neurotrophic factor, enhance cognitive appraisal, and improve perceived exertion. Overall, the paucity of data on the effectiveness of exercise in PTSD and mechanisms of action underscore the need for rigorous trials.</p><p><strong>Registration: </strong>The protocol was registered with PROSPERO (ID:453615; 22.08.2023).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"720"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The types of school attended by the ALSPAC children from1997 to 2011 (ages 5 to 19 years): A Focus on Christian Faith Schools.","authors":"Hamid Reza Tohidinik, Mark Mumme, Jean Golding","doi":"10.12688/wellcomeopenres.23025.2","DOIUrl":"10.12688/wellcomeopenres.23025.2","url":null,"abstract":"<p><p>The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal study following ~14,000 children from pregnancy through until adulthood. They were all born to women resident during pregnancy in a geographic area which comprised the city of Bristol, surrounding suburbs, rural areas, villages and towns. During their childhood almost all attended either state or private schools. The present Data Note describes the basic details of the schools attended by the cohort of children born in 1991-2, obtained by linking the names of the cohort children to the schools they attended during each school year and then anonymising the data. Details include the size of school in terms of the number of children enrolled, school sex composition, whether it is a Christian faith school (including the type of faith), whether it is fee-paying, and whether it is a boarding school. This document includes details as to how scientists can obtain the data for analysis in regard to other aspects of the children involved.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>\"I always wondered if my baby is able to feel my love for them\" -</i>  Development and pilot testing of two behavioural feedback strategies designed to improve maternal self-efficacy.","authors":"Alessandra Prioreschi, Deborah M James, Rebecca M Pearson, Antonia Smith, Shane A Norris, Kirsten L Rennie","doi":"10.12688/wellcomeopenres.23564.2","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23564.2","url":null,"abstract":"<p><strong>Background: </strong>The aim of this pilot study was to describe the development of, and test the acceptability and feasibility of providing feedback on two behaviours in the context of supportive approaches to improve maternal self-efficacy. We hypothesised that providing individual behavioural feedback to mothers in a socially vulnerable context, when later embedded in supportive intervention approaches, may improve maternal self-efficacy and ultimately promote infant development.</p><p><strong>Methods: </strong>Feedback was developed following expert consultation with working groups, and included graphical feedback on mother and infant movement behaviours measured using accelerometry, as well as video feedback of mother-infant interactions using first person observation head cameras. Mothers wore the devices for one week, following which individual feedback on movement behaviours and mother-infant interactions was delivered at the Chris Hani Baragwanath Academic Hospital. We adapted an established and published strengths based approach as a guide for health workers to feedback video and accelerometer data. Feasibility and acceptability were tested by conducting focus group discussions with a sample of 8 mothers of infants aged 4-months from South Africa using a semi-structured interview guide.</p><p><strong>Results: </strong>Mothers included in this study were generally single, unemployed, and less than half had completed formal schooling. Most mothers had two or more children, and lived in informal housing (such as shacks and small, temporary prefabricated structures) with only outdoor toilet facilities available. The feedback was found to be both feasible, and largely acceptable in this context and compliance was 100%.</p><p><strong>Conclusion: </strong>We have been able to develop feedback with the potential to sensitise mothers to their infants' behaviours. When embedded in a supportive intervention, these feedback modalities have the potential to improve mother's self-efficacy through increasing feelings of competence and reflexive functioning.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Drosophila</i> AHR limits tumor growth and stem cell proliferation in the intestine.","authors":"Minghua Tsai, Jiawei Sun, Cyrille Alexandre, Michael Shapiro, Adrien Franchet, Ying Li, Alex P Gould, Jean-Paul Vincent, Brigitta Stockinger, Nicola Laura Diny","doi":"10.12688/wellcomeopenres.23515.3","DOIUrl":"10.12688/wellcomeopenres.23515.3","url":null,"abstract":"<p><strong>Background: </strong>The aryl hydrocarbon receptor (AHR) plays important roles in intestinal homeostasis, limiting tumour growth and promoting differentiation in the intestinal epithelium. Spineless, the <i>Drosophila</i> homolog of AHR, has only been studied in the context of development but not in the adult intestine.</p><p><strong>Methods: </strong>The role of Spineless in the <i>Drosophila</i> midgut was studied by overexpression or inactivation of Spineless in infection and tumour models and RNA sequencing of sorted midgut progenitor cells.</p><p><strong>Results: </strong>We show that <i>spineless</i> is upregulated in the adult intestinal epithelium after infection with <i>Pseudomonas entomophila</i> ( <i>P</i>. <i>e</i>.). Spineless inactivation increased stem cell proliferation following infection-induced injury. Spineless overexpression limited intestinal stem cell proliferation and reduced survival after infection. In two tumour models, using either <i>Notch</i> RNAi or constitutively active Yorkie, Spineless suppressed tumour growth and doubled the lifespan of tumour-bearing flies. At the transcriptional level it reversed the gene expression changes induced in Yorkie tumours, counteracting cell proliferation and altered metabolism.</p><p><strong>Conclusions: </strong>These findings demonstrate a new role for Spineless in the adult <i>Drosophila</i> midgut and highlight the evolutionarily conserved functions of AHR/Spineless in the control of proliferation and differentiation of the intestinal epithelium.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Vestal Cuckoo Bee, <i>Bombus vestalis</i> (Geoffroy, 1785).","authors":"Liam M Crowley","doi":"10.12688/wellcomeopenres.24004.1","DOIUrl":"10.12688/wellcomeopenres.24004.1","url":null,"abstract":"<p><p>We present a genome assembly from a haploid male specimen of <i>Bombus vestalis</i> (Vestal Cuckoo Bee; Arthropoda; Insecta; Hymenoptera; Apidae). The genome sequence has a total length of 280.01 megabases. Most of the assembly (91.96%) is scaffolded into 25 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 24.37 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,600 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"218"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening respectful communication with patients and colleagues in neonatal units - developing and evaluating a communication and emotional competence training for nurse managers in Kenya.","authors":"Peris Musitia, Mwanamvua Boga, Dorothy Oluoch, Ane Haaland, Jacinta Nzinga, Mike English, Sassy Molyneux","doi":"10.12688/wellcomeopenres.18006.1","DOIUrl":"10.12688/wellcomeopenres.18006.1","url":null,"abstract":"<p><strong>Introduction: </strong>Effective communication is essential to delivering compassionate, high-quality nursing care. The intensive, stressful and technical environment of a new-born unit (NBU) in a low-resource setting presents communication-related challenges for nurses, with negative implications for nurse well-being, team relationships and patient care. We adapted a pre-existing communication and emotional competence course with NBU nurse managers working in Kenya, explored its' value to participants and developed a theory of change to evaluate its' potential impact.</p><p><strong>Methods: </strong>18 neonatal nurse managers from 14 county referral hospitals helped adapt and participated in a nine-month participatory training process. Training involved guided 'on the job' self-observation and reflection to build self-awareness, and two face-to-face skills-building workshops. The course and potential for future scale up was assessed using written responses from participant nurses (baseline questionnaires, reflective assignments, pre and post workshop questionnaires), workshop observation notes, two group discussions and nine individual in-depth interviews.</p><p><strong>Results: </strong>Participants were extremely positive about the course, with many emphasizing its direct relevance and applicability to their daily work. Increased self-awareness and ability to recognize their own, colleagues' and patients' emotional triggers, together with new knowledge and practical skills, reportedly inspired nurses to change; in turn influencing their ability to provide respectful care, improving their confidence and relationships and giving them a stronger sense of professional identity.</p><p><strong>Conclusion: </strong>Providing respectful care is a major challenge in low-resource, high-pressure clinical settings but there are few strategies to address this problem. The participatory training process examined addresses this challenge and has potential for positive impacts for families, individual workers and teams, including worker well-being. We present an initial theory of change to support future evaluations aimed at exploring if and how positive gains can be sustained and spread within the wider system.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":" ","pages":"223"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11066535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43138817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP).","authors":"Christine Sekaggya-Wiltshire, Eva Agnes Laker Odongpiny, Francis Williams Ojara, Isabella Kyohairwe, Reuben Kiggundu, Hope Mackline, Catriona Waitt, Aida N Kawuma, Allan Kengo, Allan Buzibye, Noela Owarwo, Francis Kakooza, Andrew Kambugu","doi":"10.12688/wellcomeopenres.22707.2","DOIUrl":"10.12688/wellcomeopenres.22707.2","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to become the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibiotics contribute to this crisis. People living with HIV (PLWH) are particularly vulnerable to AMR with potential drug-drug interactions between antiretroviral and antimicrobial agents against common organisms like <i>Mycobacterium tuberculosis.</i> There is limited data on the concentrations of commonly used antimicrobial agents in people living with HIV in resource-limited settings. Therapeutic Drug Monitoring (TDM) offers a promising approach to optimize antibiotic dosing and improve treatment outcomes for those with sub-optimal drug concentrations. TDM has been recommended for PLWH on anti-tuberculosis treatment due to sub-optimal drug concentrations found in a significant proportion of those with TB.</p><p><strong>Objectives: </strong>The main objectives of this study are to determine the concentrations of selected antimicrobial agents in people living with HIV requiring antimicrobial therapy and to assess the utility of therapeutic drug monitoring in achieving therapeutic targets for PLWH receiving rifampicin and isoniazid for the treatment of tuberculosis.</p><p><strong>Methods: </strong>This prospective observational study will enroll adult PLWH receiving amoxicillin, azithromycin, ciprofloxacin, rifampicin, isoniazid, or ceftriaxone. Concentrations of these antibiotics will be measured locally using validated liquid chromatography mass spectrometry methods and high-performance liquid chromatography with ultraviolet detection. TDM with dose adjustment will be performed in a subset of participants on TB treatment. Pharmacokinetic parameters will be estimated using non-linear mixed effects models.</p><p><strong>Results: </strong>This study was reviewed and approved by the research and ethics committee in February 2024. Participant enrolment began in September 2024.</p><p><strong>Conclusions: </strong>We anticipate that the findings from this research will characterize pharmacokinetic and pharmacodynamics relationships to predict treatment response for optimal antimicrobial therapeutic and anti-tuberculosis dosing among people living with HIV (PLWH).</p><p><strong>Clinical registration: </strong>The study is registered with Pan African Clinical Trials Registry, registration number PACTR202409710100607, registration date 07 August 2024, pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31764.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"694"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies.","authors":"Simonne Wright, Toshi A Furukawa, Malcolm Macleod, Ouma Simple, Olufisayo Elugbadebo, Virginia Chiocchia, Claire Friedrich, Edoardo G Ostinelli, Jennifer Potts, Fiona J Ramage, Spyridon Siafis, Claire Stainsfield, Francesca Tinsdeall, James Thomas, Andrea Cipriani, Georgia Salanti, Soraya Seedat","doi":"10.12688/wellcomeopenres.19903.3","DOIUrl":"10.12688/wellcomeopenres.19903.3","url":null,"abstract":"<p><strong>Background: </strong>Exercise can play an important role in reducing symptom severity and improving functional impairment in patients with posttraumatic stress disorder (PTSD). However, the precise mechanisms underpinning the effect of exercise in PTSD management are not fully understood. This living systematic review aims to synthesize and triangulate the evidence from non-human and human studies to gain insight into the biopsychosocial mechanisms through which exercise reduces symptom severity and functional impairment.</p><p><strong>Methods: </strong>Independent searches will be conducted in electronic databases to identify eligible studies. Two reviewers will independently conduct the study selection, data extraction, and risk of bias assessment. We will extract outcome data and variables that can act as effect modifiers or as mediators of the effect of exercise. For the non-human studies, outcome data will include the non-human equivalents of PTSD symptom clusters. For human studies, the primary outcome will be PTSD symptom severity. The secondary outcomes will be avoidance symptom severity, reexperiencing symptom severity, hyperarousal symptom severity, negative cognitions and mood severity, functional impairment, loss of PTSD diagnosis, and dropout rates.To explain the biopsychosocial mechanisms through which exercise affects the outcome of interest, we will extract effects that relate to the impact of exercise on potential mediating variables and the effect of the later outcomes. Comparison of within-study direct and indirect effects obtained from mediation analysis, when reported, will provide insight into the importance of the examined mediator.If appropriate, we will synthesize study results using meta-analyses. We will examine potential effect modifiers of the total exercise effect to understand better the impact of exercise on PTSD symptoms and function impairment (when possible). The evidence about the potential mediators of the association between exercise and PTSD-related outcomes will be considered in a consensus meeting when sufficient evidence is available.</p><p><strong>Protocol registration: </strong>PROSPERO-ID: 453615.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"8 ","pages":"494"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZC3HC1 has functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket.","authors":"Bethany M Bartlett, Juan Carlos Acosta, Wendy A Bickmore","doi":"10.12688/wellcomeopenres.23711.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23711.1","url":null,"abstract":"<p><strong>Background: </strong>The nuclear basket is a 'fishtrap'-like structure on the nucleoplasmic face of the nuclear pore complex which has been implicated in diverse functions including RNA export, heterochromatin organisation, and mitosis. Recently, a novel component of the nuclear basket, ZC3HC1, has been described. The localisation of ZC3HC1 to nuclear pores has been reported to occur reciprocally with TPR, a major structural component of the nuclear basket.</p><p><strong>Methods: </strong>Using siRNA-mediated knock down, immunofluorescence and RNA sequencing we compare the consequences of depleting two proteins of the nuclear pore basket - TPR and ZC3HC1.</p><p><strong>Results: </strong>We show that in human fibroblasts, although ZC3HC1 localisation to nuclear pores is TPR-dependent, TPR localises to pores regardless of the presence of ZC3HC1. We demonstrate that knockdown of TPR and ZC3HC1 produce distinct transcriptional profiles.</p><p><strong>Conclusions: </strong>Our results suggest that there is little overlap in function between these two nuclear basket proteins in human diploid fibroblasts.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"188"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the short-beaked common dolphin, <i>Delphinus delphis</i> Linnaeus, 1758.","authors":"Nicholas J Davison, Phillip A Morin","doi":"10.12688/wellcomeopenres.23918.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23918.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Delphinus delphis</i> (short-beaked common dolphin; Chordata; Mammalia; Artiodactyla; Delphinidae). The genome sequence has a total length of 2,663.52 megabases. Most of the assembly (88.76%) is scaffolded into 23 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled, with a length of 16.39 kilobases. Gene annotation of this assembly at Ensembl identified 17,797 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"178"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}