Wellcome Open Research最新文献

{"title":"The chromosomal genome sequence of the marine sponge <i>Diacarnus erythraeanus</i> Kelly-Borges & Vacelet, 1995, and its associated microbial metagenome sequences.","authors":"Laura Steindler, Martha Alejandra Durán Canché, Micha Ilan, Rinat Bar-Shalom, Jose Victor Lopez, Ute Hentschel, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.24763.2","DOIUrl":"10.12688/wellcomeopenres.24763.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual <i>Diacarnus erythraeanus</i> (sponge; Porifera; Demospongiae; Poecilosclerida; Podospongiidae). The genome sequence has a total length of 140.86 megabases. Most of the assembly (98.57%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 19.34 kilobases in length. Sixty-four binned genomes were generated from the metagenome assembly, of which 46 were classified as high-quality metagenome assembled genomes (MAGs). The microbial signature is typical of HMA sponges, including the Pseudomonadota, Chloroflexota and Acidobacteriota as dominant phyla and several candidate phyla (Poribacteria, Binatota, Latescibacterota) as well as the archaeal clade Nitrosopumilaceae in lower abundance.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"466"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Lesser Horseshoe Bat, <i>Rhinolophus hipposideros</i> (Bechstein, 1800) (Chiroptera: Rhinolophidae).","authors":"Ine Alvarez van Tussenbroek, Sonja C Vernes, Haris Nicolaou, Emma C Teeling, Meike Mai, Myrtani Pieri","doi":"10.12688/wellcomeopenres.26210.1","DOIUrl":"10.12688/wellcomeopenres.26210.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Rhinolophus hipposideros</i> (Lesser Horseshoe Bat; Chordata; Mammalia; Chiroptera; Rhinolophidae). The assembly contains two haplotypes with total lengths of 2 171.31 megabases and 2 240.90 megabases. Most of haplotype 1 (96.52%) is scaffolded into 29 chromosomal pseudomolecules, including the X sex chromosome. Most of haplotype 2 (93.46%) is scaffolded into 29 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled, with a length of 16.85 kilobases. Gene annotation of this assembly on Ensembl identified 18 700 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"212"},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing implementation strategies for improving infection prevention and control in acute healthcare facilities in Malawi: A formative study protocol.","authors":"Dorica Ng'ambi, Tara Tancred, Nicholas Feasey, Wilned Zoto Hara, Owen Musopole, Thomasena O'Byrne","doi":"10.12688/wellcomeopenres.24040.4","DOIUrl":"10.12688/wellcomeopenres.24040.4","url":null,"abstract":"<p><strong>Background: </strong>Healthcare associated infections (HAIs) are infections that patients acquire while receiving treatment and are not present during admission. The prevalence of HAIs is typically higher (15%) in low-and middle-income countries than that in high-income countries (7%). HAIs present a significant burden on patients, families, and health systems as they contribute to longer hospital stays, increased healthcare costs, and antimicrobial resistance. HAIs can be prevented or reduced by implementing infection prevention and control (IPC) measures. However, IPC measures are often poorly implemented due to resource shortages, lack of training, and other systemic challenges. The goals of this formative study were twofold: 1. to carry out a situational analysis of IPC practices for HAI control in three hospitals in Southern Malawi, highlighting specific bottlenecks and enablers of IPC practices; and 2. to co-design tailored implementation strategies based on insights from situational analysis using participatory approaches with key IPC stakeholders to support more consistent and effective IPC implementation at the study sites.</p><p><strong>Methods: </strong>The study will be conducted in three health facilities in Malawi representing different healthcare levels: Queen Elizabeth Central Hospital, Zomba Central Hospital, and Chikwawa District Hospital. For situational analysis, six data collection tools will be used: a desk review of IPC policies and guidelines, the World Health Organization IPC Assessment Framework, participant and non-participant structured observations, interviews, and focus group discussions. The participatory component involves a three-day co-design workshop. Participants in both study components will include healthcare workers, support staff, policymakers, patients, and patient caregivers (guardians). Descriptive statistics will be used to analyse the quantitative data. A thematic framework analysis using NVivo 12 will be done on the qualitative data. The findings will be disseminated through workshops, academic publications, and stakeholder meetings.</p><p><strong>Conclusion: </strong>Multifaceted IPC implementation strategies tailored to the context of each hospital will be designed.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"223"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults.","authors":"Daniel Silman, Amy Flaxman, Mehreen Datoo, Nick J Edwards, Fernando Ramos-Lopez, Celia Mitton, Catherine Mair, Duncan Bellamy, Georgina Bowyer, Richard Morter, Benedict Halbroth, Navin Venkatraman, Pedro M Folegatti, Julia Marshall, Ian Poulton, Amelia Bajer, Ahmed M Salman, Eleanor Berrie, Jake Baum, Andrew M Blagborough, Wendy Crocker, Rachel Roberts, Alison M Lawrie, Alexandra J Spencer, Sarah C Gilbert, Katie J Ewer, Adrian V S Hill","doi":"10.12688/wellcomeopenres.22900.2","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22900.2","url":null,"abstract":"<p><strong>Background: </strong>Induction of CD8 ⁺ T-cells using viral vectors is a promising strategy in developing effective vaccines against pre-erythrocytic malaria. A recent comparative assessment of candidate antigens using this approach in a mouse model had identified Liver Stage Antigen 1 (LSA1) and Liver Stage Associated Protein 2 (LSAP2) as more protective than TRAP and CSP antigens, which have been the dominant focus of clinical testing. We proposed that combining these within a novel dual antigenic insert (LS2), encoded alongside an orthologous immunogenic domain from invariant chain in ChAdOx1, and the F11 promoter in MVA, could translate to protective clinical efficacy against malaria.</p><p><strong>Methods: </strong>We conducted a non-randomised, open-label, dose escalation phase I/IIa study in UK adults, vaccinating a small lead-in group with ChAdOx1 LS2 5x10 ⁹ vp (group 1; n = 3) and subsequently a heterologous prime-boost group with ChAdOx1 LS2 2.5x10 ¹⁰ vp and MVA LS2 2x10 ⁸ pfu (group 2; n = 10). Group 2 volunteers and 6 unvaccinated controls underwent Controlled Human Malaria Infection (CHMI) delivered by mosquito bite and standardized follow-up.</p><p><strong>Results: </strong>Vaccination with ChAdOx1 LS2 (both low and full doses) and MVA LS2 were generally well tolerated with solicited symptoms observed similar to previous vectored vaccines and no Severe Adverse Events (SAEs). Immunogenicity of the prime-boost schedule as measured by IFN-γ ELISpot was high showing median response of 4473 SFC/10 ⁶ PBMC at the pre-challenge timepoint, covering a broad range of potential determinants. All vaccinated volunteers became infected with malaria during CHMI with a median time to diagnosis of 13 days compared to 13.25 days in controls.</p><p><strong>Conclusions: </strong>Though this study further indicates ChAd/MVA as a safe, highly effective platform for driving CD8 ⁺ responses specific to liver-stage malaria antigens, the promise of LSA1 and LSAP2 as potential candidates shown preclinically has not translated to protection from infection in humans.Clinical Trial Registration ClinicalTrials.gov (Ref: NCT03203421), date of registration, 3 ^rd July 2017.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"734"},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community and health systems learning: critical realist evaluation of the VAPAR 'learning platform' in rural South Africa 2015-25.","authors":"Sophie Witter, Lucia D'Ambruoso, Maria van der Merwe, Jennifer Hove, Nombuyiselo Nkalanga, Denny Mabetha, Gerhard Goosen, Jerry Sigudla, Stephen Tollman","doi":"10.12688/wellcomeopenres.23381.3","DOIUrl":"10.12688/wellcomeopenres.23381.3","url":null,"abstract":"<p><p>Background Learning platforms can strengthen primary healthcare (PHC) by integrating community knowledge with system decision-making, but evidence on how they work in low-resource settings is limited. This study presents a realist evaluation of the Verbal Autopsy with Participatory Action Research (VAPAR) learning platform in rural Mpumalanga, South Africa (2015-25). VAPAR aimed to embed participatory evidence generation and shared learning within routine district processes to support more equitable, community-linked PHC. Methods A realist design was used to synthesise data from five action-learning cycles (2017-23), a preceding pilot (2015-16), and an engagement and uptake phase (2023-25). Data included cycle reports, participatory outputs, verbal autopsy (VA) analyses, 22 endline interviews, policy, strategy and planning documents. Using a co-developed theory of change, qualitative data were coded to examine context-mechanism-outcome patterns. Mechanisms were identified and refined through cross-cycle comparison, triangulation, and stakeholder validation. Results VAPAR was contextually responsive, adapting to shocks such as COVID-19 and progressively embedding within the district health system. Through regular dialogue, the platform activated generative mechanisms of trust-building, role clarity and recognition, collective sense-making, and strengthened agency, particularly among Community Health Workers (CHWs), whose skills, confidence and legitimacy expanded. These mechanisms operated within an enabling structural context shaped by PHC reforms that strengthened the District Health System and Ward-Based Primary Health Care Outreach Teams, alongside trade-union action for CHW absorption into public service. Institutionalisation followed through Mpumalanga's revitalised Health Promotion Programme, with adaptation to additional provinces and for outbreak response and emergency obstetric care. Outcomes were interpreted through context-mechanism-outcome patterns, illustrating how participatory learning becomes embedded in decentralised health systems. Conclusions Over a decade, VAPAR demonstrated how structured, participatory learning can reshape relationships, strengthen community-linked PHC, and support institutionalisation of routine, evidence-informed practice in decentralised health systems. The findings offer transferable lessons for sustaining learning platforms in resource-constrained settings.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"135"},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot protocol for surveillance of infection and antibiotic prescribing in primary healthcare across the globe: Antibiotic Prescribing in Primary Healthcare Point Prevalence Survey (APC-PPS).","authors":"Aislinn Cook, Jan Goelen, Catrin E Moore, Jennifer Martin, Koen B Pouwels, Michael Sharland","doi":"10.12688/wellcomeopenres.23420.2","DOIUrl":"10.12688/wellcomeopenres.23420.2","url":null,"abstract":"<p><p>Little data is available from the primary healthcare setting in low- and middle-income countries to describe the burden of clinical infections and antibiotic prescribing proportions for those infections. The AWaRe Antibiotic Book provides a framework for assessing antibiotic prescribing in primary healthcare but requires understanding both frequency of clinical infections and their antibiotic prescribing proportions. The Antibiotic Prescribing in Primary Healthcare Point Prevalence Survey (APC-PPS) project is a series of point prevalence surveys conducted at primary healthcare facilities in LMICs to capture the frequency of consultation for different clinical infections and diagnoses and the frequency and type of antibiotic prescribing associated with these infections in primary healthcare facilities. This study aims to assess the feasibility of using a PPS methodology to collect data on clinical presentation and antibiotic prescribing in primary healthcare settings. The data collected are necessary to be able to summarise relative frequencies of presentation of different clinical infections and antibiotic prescribing practices to inform global estimates of antibiotic use and inform the development of surveillance methods and representative sampling frames. Each site will conduct 6-8 point prevalence surveys over the course of 12 months. Completely anonymous data on age, sex, relevant comorbidities, infection symptoms and diagnoses and antibiotic prescription are collected for patients of all ages with acute infection symptoms (up to 14 days of symptoms) who present to the facility on the day of the survey. No identifiable data will be collected from individuals. Data is collected via ODK Collect and stored in a secure ODK Cloud server hosted by City St. George's, University of London. Sites will be active between early 2023- mid 2025, with regular interim data analysis scheduled and final data analysis planned by mid 2026. All required local and national ethical and regulatory approvals will be obtained prior to sites starting.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: the SMRU Refugee and Migrant Pregnancy Study in Western Thailand and Eastern Myanmar.","authors":"Rose McGready, Nicholas J White, François H Nosten","doi":"10.12688/wellcomeopenres.25582.2","DOIUrl":"10.12688/wellcomeopenres.25582.2","url":null,"abstract":"<p><p>Background Marginalised populations face significant health risks in pregnancy with reduced access to preventive and life-saving services due to conflict and migration. Infectious disease risk is high and the double burden of malnutrition increases risk from non-communicable disease although only weak epidemiological data supports this in refugees and migrant communities. This manuscript describes the SMRU Refugee and Migrant Pregnancy Cohort commencing nearly 40 years ago, established in response to the very high rate of <i>Plasmodium falciparum</i> maternal mortality in refugee camps on the Thailand Myanmar border Methods Pregnant women who registered to antenatal care clinics of the Shoklo Malaria Research Unit from 1986 to 2024 living in marginalised communities of refugee and migrants were the eligible population. Pregnancies were prospectively followed from enrolment through to childbirth. Types of data include: 1) medical and obstetric records including patient characteristics, pregnancy progress and birth outcomes and 2) investigations (such as HIV). Results Among 94,645 pregnancies maternal mortality was 176 per 100,000 livebirths (120/68,024). Embedded cohorts included observational and clinical trials, providing evidence on the optimisation of treatment of malaria in pregnancy and on the rapid changes towards non-communicable diseases in refugees and migrants. Low mean height (151.4 cm), well below European and American populations from which the majority of guidelines have been created, questions appropriateness, such as gestational weight gain in pregnancy. A broad scope of research findings including tropical infections impacting pregnancy outcomes, mental health and suicide, a shared platform of \"-omics\" of Karen and Burmese women from first trimester, and practice of care in low-income settings have emerged and been shared. Conclusions The SMRU Refugee and Migrant Pregnancy Cohort findings have had significant local and international impact including changing the World Health Organisation Malaria Treatment Guidelines in pregnancy; and establishing a range of guidelines and tools improving maternal-child health practices.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the zebra danio, <i>Danio rerio</i> (Hamilton, 1822) SAT strain (Cypriniformes: Danionidae).","authors":"Kerstin Howe, Caroline Howard, Shane A McCarthy, Jonathan M D Wood","doi":"10.12688/wellcomeopenres.24569.2","DOIUrl":"10.12688/wellcomeopenres.24569.2","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Danio rerio</i> (zebra danio; Chordata; Actinopteri; Cypriniformes; Danionidae). The genome sequence has a total length of 1 413.66 megabases. Most of the assembly (99.85%) is scaffolded into 25 chromosomal pseudomolecules. The mitochondrial genome was also assembled, with a length of 16.6 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"330"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a rove beetle, <i>Tachyporus hypnorum</i> (Fabricius, 1775) (Coleoptera: Staphylinidae).","authors":"Roger Booth, Maxwell V L Barclay","doi":"10.12688/wellcomeopenres.26176.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.26176.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Tachyporus hypnorum</i> (rove beetle; Arthropoda; Insecta; Coleoptera; Staphylinidae). The genome sequence has a total length of 531.37 megabases. Most of the assembly (63.74%) is scaffolded into 13 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled, with a length of 19.75 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"182"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Common Purple & Gold, <i>Pyrausta purpuralis</i> Linnaeus, 1758 (Lepidoptera: Crambidae).","authors":"Ian Sims","doi":"10.12688/wellcomeopenres.24884.2","DOIUrl":"10.12688/wellcomeopenres.24884.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Pyrausta purpuralis</i> (Common Purple & Gold; Arthropoda; Insecta; Lepidoptera; Crambidae). The genome sequence has a total length of 837.24 megabases. Most of the assembly (94.81%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled, with a length of 15.31 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"512"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}