Wellcome Open Research最新文献

{"title":"The chromosomal genome sequence of the sponge <i>Crambe crambe</i> (Schmidt, 1862) and its associated microbial metagenome sequences.","authors":"Manuel Maldonado, Lucia Pita, Ute Hentschel, Dirk Erpenbeck, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.24154.1","DOIUrl":"10.12688/wellcomeopenres.24154.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual <i>Crambe crambe</i> (Porifera; Demospongiae; Poecilosclerida; Crambeidae). The host genome sequence is 143.20 megabases in span. Most of the assembly is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 19.53 kilobases in length. Several symbiotic prokaryotic genomes were assembled as MAGs, including two relevant sponge symbionts, the <i>Candidatus</i> Beroebacter blanensis/ <i>AqS2</i> clade (Tethybacterales, Gammaproteobacteria) of LMA sponges, and the widely distributed archaeal <i>Nitrosopumilus</i> sp. clade.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"275"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Heath Bumblebee, <i>Bombus jonellus</i> (Kirby, 1802).","authors":"Gavin R Broad, Inez Januszczak, Chris Fletcher","doi":"10.12688/wellcomeopenres.24256.1","DOIUrl":"10.12688/wellcomeopenres.24256.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Bombus jonellus</i> (Heath Bumblebee; Arthropoda; Insecta; Hymenoptera; Apidae). The genome sequence has a total length of 357.90 megabases. Most of the assembly (78.06%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 24.83 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"269"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis.","authors":"Jaycee Kennett, Claire Friedrich, Virginia Chiocchia, Simon E Blackwell, Toshi Furukawa, Per Carlbring, Thomy Tonia, Ava Homiar, Simonne Wright, Kelvin Opiepie, Richardson Mojica, Paulina Schenk, Susan Michie, Janna Hastings, Hossein Dehdarirad, Claire Stansfield, James Thomas, Jennifer Potts, Georgia Salanti, Andrea Cipriani","doi":"10.12688/wellcomeopenres.23278.2","DOIUrl":"10.12688/wellcomeopenres.23278.2","url":null,"abstract":"<p><strong>Background: </strong>Social anxiety is a heightened fear and discomfort in social situations. Cases of elevated distress and impaired functioning can lead to a clinical diagnosis of social anxiety disorder. Altering cognitive biases associated with social anxiety has been suggested as potentially beneficial; however, little is known about the comparative effectiveness of such interventions. The aim of this living systematic review is to examine the efficacy of cognitive bias modification for reducing social anxiety.</p><p><strong>Methods: </strong>We will search multiple electronic databases for randomised controlled trials evaluating the efficacy of cognitive bias modification for people diagnosed with social anxiety and people exposed to a social stressor. The primary outcome will be change in social anxiety related symptoms; secondary outcomes will be changes in social functioning and quality of life and adverse events. Study selection, data extraction and risk of bias assessment will be done by at least two reviewers using pre-defined tools. We will synthesise data from people with social anxiety diagnosis and those subjected to a simulated social stressor separately using random effects meta-analyses. Heterogeneity will be evaluated by investigating characteristics of included studies and we will conduct a network meta-analysis in order to compare the efficacy of subtypes of cognitive bias modification for social anxiety disorder. We will appraise the strength of the evidence for each outcome by reviewing the overall association, internal and external validity, and reporting biases. Where data allows, we will triangulate the evidence from both sources with a multidisciplinary group of experts. We will also descriptively report factors reported to mediate cognitive bias modification, The review will begin in living mode and the database search will be rerun every three months to identify potential new evidence. We will co-produce this review with members of a global lived experience advisory board. This protocol was registered on 15.10.2024 (CRD42024601380)..</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"657"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Broad Centurion soldierfly, <i>Chloromyia formosa</i> (Scopoli, 1763).","authors":"Olga Sivell, Duncan Sivell","doi":"10.12688/wellcomeopenres.24255.1","DOIUrl":"10.12688/wellcomeopenres.24255.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Chloromyia formosa</i> (Broad Centurion soldierfly; Arthropoda; Insecta; Diptera; Stratiomyidae). The genome sequence has a total length of 790.81 megabases. Most of the assembly (98.79%) is scaffolded into 7 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled, with a length of 17.69 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"266"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entomopathogenic fungi <i>Metarhizium pingshaense</i> increases susceptibility to insecticides in highly resistant malaria mosquitoes <i>Anopheles coluzzii</i>.","authors":"Doubé Lucien Lamy, Edounou Jacques Gnambani, Issiaka Sare, Souro Abel Millogo, Fatimata Aïcha Sodre, Moussa Namountougou, Mafalda Viana, Francesco Baldini, Abdoulaye Diabaté, Etienne Bilgo","doi":"10.12688/wellcomeopenres.21238.2","DOIUrl":"10.12688/wellcomeopenres.21238.2","url":null,"abstract":"<p><strong>Background: </strong><i>Metarhizium</i> spp. based mosquito control products are among the most investigated and could potentially serve as promising complements to chemical insecticides. However, limited knowledge exists on the implementation of this biocontrol tool in conjunction with primary insecticide-based strategies to achieve synergy.</p><p><strong>Methods: </strong>In laboratory bioassays, we combined 10 ⁷ conidia/ml native <i>Metarhizium pingshaense</i> strains with deltamethrin standard dose in two ways : before and after insecticide exposure. For comparison, some mosquitoes were exposed to deltamethrin or fungi alone. These combinations were tested on laboratory insecticide resistant <i>Anopheles coluzzii</i>.</p><p><strong>Results: </strong>We found that <i>Metarhizium pingshaense</i> and deltamethrin could be combined to achieve greater mortality against a highly insecticide resistance colony of <i>Anopheles coluzzii</i>. Specifically, when fungi were applied earlier than deltamethrin, mosquitoes became more sensitive to insecticide with a minimum Lethal Time to kill at least 50% of mosquito population (LT50) less than 8 days. In addition, when deltamethrin exposure was followed by <i>Metarhizium</i> infection, mosquito survival was similar to <i>Metarhizium</i> alone LT50 (LT50 ~11 days).</p><p><strong>Conclusion: </strong>These findings suggest that early mosquito infection to <i>Metarhizium pingshaense</i> followed by chemical insecticide exposure synergically increased mosquito susceptibility to the insecticide in the laboratory.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"290"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Common Goldeneye, <i>Bucephala clangula</i> (Linnaeus, 1758).","authors":"Rosa Lopez Colom, Michelle F O'Brien","doi":"10.12688/wellcomeopenres.24275.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.24275.1","url":null,"abstract":"<p><p>We present a genome assembly from a male <i>Bucephala clangula</i> (Common Goldeneye; Chordata; Aves; Anseriformes; Anatidae). The genome sequence has a total length of 1,190.92 megabases. Most of the assembly (95.05%) is scaffolded into 40 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled, with a length of 16.63 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"258"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the club-tailed millipede, <i>Cylindroiulus punctatus</i> (Leach, 1816).","authors":"Gregory D Edgecombe, Liam M Crowley, Mark G Telfer","doi":"10.12688/wellcomeopenres.24251.1","DOIUrl":"10.12688/wellcomeopenres.24251.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Cylindroiulus punctatus</i> (club-tailed millipede; Arthropoda; Diplopoda; Julida; Julidae). The genome sequence has a total length of 354.09 megabases. Most of the assembly (92.9%) is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 18.98 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"256"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The types of school attended by the ALSPAC children from1997 to 2011 (ages 5 to 19 years): A Focus on Christian Faith Schools.","authors":"Hamid Reza Tohidinik, Mark Mumme, Jean Golding","doi":"10.12688/wellcomeopenres.23025.2","DOIUrl":"10.12688/wellcomeopenres.23025.2","url":null,"abstract":"<p><p>The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal study following ~14,000 children from pregnancy through until adulthood. They were all born to women resident during pregnancy in a geographic area which comprised the city of Bristol, surrounding suburbs, rural areas, villages and towns. During their childhood almost all attended either state or private schools. The present Data Note describes the basic details of the schools attended by the cohort of children born in 1991-2, obtained by linking the names of the cohort children to the schools they attended during each school year and then anonymising the data. Details include the size of school in terms of the number of children enrolled, school sex composition, whether it is a Christian faith school (including the type of faith), whether it is fee-paying, and whether it is a boarding school. This document includes details as to how scientists can obtain the data for analysis in regard to other aspects of the children involved.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Dalmatian wall lizard, <i>Podarcis melisellensis</i> (Braun, 1877).","authors":"Nathalie Feiner, Tobias Uller, Lisa Van Linden, Joana Meier","doi":"10.12688/wellcomeopenres.24140.1","DOIUrl":"10.12688/wellcomeopenres.24140.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Podarcis melisellensis</i> (Dalmatian wall lizard; Chordata; Lepidosauria; Squamata; Lacertidae). The assembly contains two haplotypes with total lengths of 1,574.91 megabases and 1,437.04 megabases. Most of haplotype 1 (94.94%) is scaffolded into 20 chromosomal pseudomolecules, including the W and Z sex chromosomes, while most of haplotype 2 (97.63%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 18.2 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"247"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of wild privet, <i>Ligustrum vulgare</i> L.","authors":"Zoë A Goodwin, David Bell, Vladimir Krivtsov, Michelle L Hart","doi":"10.12688/wellcomeopenres.24023.1","DOIUrl":"10.12688/wellcomeopenres.24023.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Ligustrum vulgare</i> (wild privet; Streptophyta; Magnoliopsida; Lamiales; Oleaceae). The genome sequence has a total length of 1,384.00 megabases. Most of the assembly is scaffolded into 23 chromosomal pseudomolecules. The multipartite mitochondrial genome consists of two circularised molecules with lengths of 844.62 and 118.10 kilobases, and the plastid genome assembly is 161.82 kilobases long. Gene annotation of this assembly on Ensembl identified 31,482 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}