Wellcome Open Research最新文献

{"title":"How do social norms influence the sexual and reproductive health of very young adolescents in sub-Saharan Africa? A scoping review protocol.","authors":"Fardawsa Ahmed, Owen Nyamwanza, Alice N Ladur, Jermaine Dambi, Frances Cowan, Webster Mavhu","doi":"10.12688/wellcomeopenres.23139.2","DOIUrl":"10.12688/wellcomeopenres.23139.2","url":null,"abstract":"<p><strong>Introduction: </strong>Introduction Very young adolescents (VYAs, aged 10-14 years) in sub-Saharan Africa (SSA) have the worst sexual and reproductive health (SRH) outcomes of this age group worldwide due to structural, behavioural, socioeconomic and other factors. Social and gender norms have important consequences for the SRH and wellbeing of VYAs both now and over their life course. SRH programming often focuses on older adolescents (aged 15-19 years), overlooking younger ones. This scoping review sets out to explore how social and gender norms influence VYAs' SRH in SSA, in addition to exploring interventions that have been effective, to inform a context-specific intervention.</p><p><strong>Methods: </strong>We will employ the methodology developed by Arksey and O'Malley to review the available literature. We will search online databases (PubMed/MEDLINE, CINHAL, EMBASE, PsycINFO, Cochrane Library, and African Index Medicus) for original studies published between 1 January 2000 and 31 December 2024. Further, we will perform a manual search to include relevant grey literature. The steps in the review are: 1) defining the research question, 2) identifying relevant studies, 3) selecting studies, 4) charting the data, and 5) collating, summarising, and reporting the results.</p><p><strong>Results: </strong>Results We will report findings in accordance with the guidance provided in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement. We will analyse and summarise data about study characteristics using descriptive statistics. We will use thematic analysis to analyse and summarise key themes and issues. We will triangulate quantitative and qualitative findings.</p><p><strong>Discussion: </strong>The review will map the breadth of studies focusing on social and gender norms, and SRH among VYAs, in addition to exploring interventions that have been effective. Findings will help us and others develop context-specific, bespoke interventions.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"670"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Scorched Wing moth, <i>Plagodis dolabraria</i> (Linnaeus, 1767).","authors":"Gavin R Broad, Steph Holt, Laura Sivess, Douglas Boyes","doi":"10.12688/wellcomeopenres.23761.1","DOIUrl":"10.12688/wellcomeopenres.23761.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Plagodis dolabraria</i> (Scorched Wing; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence has a total length of 939.07 megabases. Most of the assembly (99.59%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 16.97 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Dotted Footman moth, <i>Pelosia muscerda</i> (Hufnagel, 1767).","authors":"Chris Fletcher, David C Lees","doi":"10.12688/wellcomeopenres.23766.1","DOIUrl":"10.12688/wellcomeopenres.23766.1","url":null,"abstract":"<p><p>We present a genome assembly from a male <i>Pelosia muscerda</i> (Dotted Footman; Arthropoda; Insecta; Lepidoptera; Erebidae). The genome sequence has a total length of 500.49 megabases. Most of the assembly (99.98%) is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.42 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chromosomal reference genome sequence for the northern house mosquito, <i>Culex pipiens</i> form <i>pipiens</i>, Linnaeus, 1758.","authors":"Jenny C Hesson, Yuki Haba, Carolyn S McBride, Edel Sheerin, Thomas C Mathers, Michael Paulini, Damon-Lee B Pointon, James W Torrance, Cibin Sadasivan Baby, Jonathan M D Wood, Shane A McCarthy, Mara K N Lawniczak, Alex Makunin","doi":"10.12688/wellcomeopenres.23767.1","DOIUrl":"10.12688/wellcomeopenres.23767.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Culex pipiens</i> sensu stricto (the northern house mosquito; Arthropoda; Insecta; Diptera; Culicidae), from a wild population in Sweden. The genome sequence is 533 megabases in span. Most of the assembly is scaffolded into three chromosomal pseudomolecules. The complete mitochondrial genome was also assembled and is 15.6 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the click beetle, <i>Ampedus sanguinolentus sanguinolentus</i> (Schrank, 1776).","authors":"Duncan Sivell, Dmitry Telnov, Michael F Geiser, Maxwell V L Barclay","doi":"10.12688/wellcomeopenres.23712.1","DOIUrl":"10.12688/wellcomeopenres.23712.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Ampedus sanguinolentus sanguinolentus</i> (click beetle; Arthropoda; Insecta; Coleoptera; Elateridae). The assembly contains two haplotypes with total lengths of 1,574.76 megabases and 1,572.87 megabases. Most of haplotype 1 (97.13%) is scaffolded into 10 chromosomal pseudomolecules, while haplotype 2 is a scaffold-level assembly. The mitochondrial genome has also been assembled and is 15.99 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability trial of local Indonesian snack (SISTIK) enriched with chicken liver and eggshell powder as a potential food to increase micronutrient intakes among women of reproductive age.","authors":"Yenni Zuhairini, Aghnia Husnayiani Suryanto, Qorinah Estiningtyas Sakilah Adnani, Mohammad Brachim Anshari, Haidar Rizqi, Annisha Fathonah, Afini Dwi Purnamasari, Afiyah Hadiyanti Pangasih, Ayunda Jihadillah, Dina Novtyana Puspita, Dimas Erlangga Luftimas, Sofa Rahmannia, Umi Fahmida, Rosalind Gibson, Aly Diana","doi":"10.12688/wellcomeopenres.20292.2","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.20292.2","url":null,"abstract":"<p><strong>Background: </strong>Chronic micronutrient deficiencies in Indonesian women and young children contribute to poor foetal and infant growth. To address this, we formulated micronutrient-enriched crackers (MEC) incorporating nutrient-rich chicken liver, rich in iron, zinc, vitamin A, and B vitamins, along with powdered eggshells as a calcium source. Known locally as ' <i>sistik</i>,' MEC may provide a sustainable solution to improve micronutrient intakes. This study evaluated MEC acceptability among non-pregnant women of reproductive age to ensure safety and feasibility before extending future research to pregnant and lactating populations.</p><p><strong>Methods: </strong>A single-blinded, two-phase acceptability trial involved 81 non-pregnant women aged 19-35 years in Ujung Berung Sub-district, Bandung City, Indonesia. In Phase 1, participants sampled both MEC and standard wheat crackers (SWC) in a test feeding session and rated each product using a 7-point cued facial response scale, evaluating colour, smell, flavour, and texture. In Phase 2, participants were randomly assigned to receive a 14-day home supply (75 g/day) of either MEC (n=41) or SWC (n=40). Adherence was determined by weighing unconsumed products. Data were analysed using mixed linear model for liking scores and a t-test for adherence.</p><p><strong>Results: </strong>MEC received favourable ratings, with no significant differences compared to SWC in liking scores for colour (MEC 4.5±1.2 vs. SWC 5.4±0.9), smell (MEC 4.9±1.5 vs. SWC 5.6±0.9), flavour (MEC 4.9±1.4 vs. SWC 5.6±0.9), and texture (MEC 5.4±1.0 vs. SWC 5.7±0.8); p-value > 0.05. Average daily consumption over 14 days was comparable between groups (MEC: 50.8±23.0 g vs. SWC: 51.0±20.0 g; mean difference: -0.2 g; 95% CI: -6.5 to 6.1; p-value = 0.802).</p><p><strong>Conclusions: </strong>MEC demonstrates reasonable acceptability and feasibility as a daily snack, supporting its potential as a dietary intervention to improve women's micronutrient intake and reduce infant stunting, especially among those women who found it appealing.</p><p><strong>Registration: </strong>ClinicalTrials.gov ( NCT04564222, 25 ^th September 2020).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"550"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Coppice Mining Bee, <i>Andrena helvola</i> (Linnaeus, 1758).","authors":"Steven Falk, Joseph Monks","doi":"10.12688/wellcomeopenres.23746.1","DOIUrl":"10.12688/wellcomeopenres.23746.1","url":null,"abstract":"<p><p>We present a genome assembly from a female <i>Andrena helvola</i> (Coppice Mining Bee; Arthropoda; Insecta; Hymenoptera; Andrenidae). The genome sequence has a total length of 442.47 megabases. Most of the assembly (91.93%) is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.61 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"102"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the amphioxus, <i>Branchiostoma lanceolatum</i> (Pallas, 1774).","authors":"Patrick Adkins, John Bishop, Joanna Harley, Peter W H Holland","doi":"10.12688/wellcomeopenres.23671.1","DOIUrl":"10.12688/wellcomeopenres.23671.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Branchiostoma lanceolatum</i> (Amphioxus; Chordata; Leptocardii; Amphioxiformes; Branchiostomatidae). The assembly contains two haplotypes with total lengths of 468.40 megabases and 465.81 megabases, respectively. Most of haplotype 1 (99.34%) is scaffolded into 19 chromosomal pseudomolecules. Haplotype 2 is a scaffold level assembly. The mitochondrial genome has also been assembled and is 15.14 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the European mole, <i>Talpa europaea</i> Linnaeus, 1758.","authors":"Nicola Pearce, Michelle F O'Brien, Rosa Lopez Colom","doi":"10.12688/wellcomeopenres.23759.1","DOIUrl":"10.12688/wellcomeopenres.23759.1","url":null,"abstract":"<p><p>We present a genome assembly from a female <i>Talpa europaea</i> (European mole; Chordata; Mammalia; Eulipotyphla; Talpidae). The assembly contains two haplotypes with total lengths of 2,060.98 megabases and 2,056.47 megabases. Most of haplotype 1 (98.6%) is scaffolded into 17 chromosomal pseudomolecules, including the X sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled and is 16.93 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Common Sheetweb Spider <i>Linyphia triangularis</i> (Clerck, 1757).","authors":"Olga Sivell, Duncan Sivell","doi":"10.12688/wellcomeopenres.23754.1","DOIUrl":"10.12688/wellcomeopenres.23754.1","url":null,"abstract":"<p><p>We present a genome assembly from a male <i>Linyphia triangularis</i> (Common Sheetweb Spider Arthropoda; Arachnida; Araneae; Linyphiidae). The genome sequence has a total length of 1,349.10 megabases. Most of the assembly (95.36%) is scaffolded into 13 chromosomal pseudomolecules, including the X ₁ and X ₂ sex chromosomes. The mitochondrial genome has also been assembled and is 15.31 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}