The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort.

Q1 Medicine

Wellcome Open Research Pub Date : 2025-05-16 eCollection Date: 2024-01-01 DOI:10.12688/wellcomeopenres.20992.2

Gillian Santorelli, Dan Lewer, Krishnarajah Nirantharakumar, Siang Ing Lee, Katherine Phillips, Rosemary R C McEachan, John Wright

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引用次数: 0

Abstract

Background: Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants.

Methods: 21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity.

Results: The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]).

Conclusions/discussion: This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.

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生命过程中常见健康状况的出现：来自布拉德福德出生家庭队列的证据。

背景：出生在布拉德福德（BiB）是一项与常规健康记录相关的家庭队列研究。我们计算了常见健康状况的比率，并探讨了欧洲白人和南亚参与者之间的差异。方法：从电子病历中提取诊断代码和处方记录，对21种疾病进行鉴定。我们计算了招募前2年的患病率，并计算了从招募到2021年底（或审查）的每1000人年的发病率。年龄校正Cox比例风险模型按种族估计风险比（HR）。结果：样本包括9784名母亲，52%为南亚血统，48%为欧洲白人。常见精神疾病和湿疹的患病率和发病率最高。南亚女性14种疾病的发病率较高，包括糖尿病（HR 3.94 [95% CI 3.15, 4.94]）、慢性肝病（HR 2.98[2.29, 3.88]）和甲状腺疾病（HR 1.87[1.50, 2.33]），但癌症（HR 0.51[0.38, 0.68]）、其他常见精神健康障碍（HR 0.56[0.45, 0.71]和CI 0.69[0.64, 0.74]）和其他神经肌肉疾病（HR 0.63[0.49, 0.82]）的发病率较低。结论/讨论：这项研究揭示了欧洲白人和南亚妇女在几种非传染性健康状况的发生方面存在显著差异。在南亚妇女中观察到的几种疾病的发病率较高，与关于糖尿病等疾病风险增加的既定知识相一致，可能反映了社会、文化、生活方式、环境和遗传决定因素的复杂相互作用。这些发现强调需要采取文化敏感和有针对性的公共卫生干预措施，旨在解决个人和系统层面可改变的风险因素，以减轻长期健康状况的负担并减少现有的健康不平等。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wellcome Open Research Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.50

自引率

0.00%

发文量

426

审稿时长

1 weeks

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