Wellcome Open Research最新文献

{"title":"The genome sequence of the common awl robberfly, <i>Neoitamus cyanurus</i> (Loew, 1849).","authors":"Liam M Crowley, Ruth Y Akinmusola","doi":"10.12688/wellcomeopenres.22253.2","DOIUrl":"10.12688/wellcomeopenres.22253.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Neoitamus cyanurus</i> (the common awl robberfly; Arthropoda; Insecta; Diptera; Asilidae). The genome sequence has a total length of 365.5 megabases. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.63 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,046 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"289"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Atlantic mackerel, <i>Scomber scombrus</i> Linnaeus, 1758.","authors":"Mitchell Brennan, Kimberly Bird, Birthe Zancker, Vengamanaidu Modepali, Patrick Adkins","doi":"10.12688/wellcomeopenres.23186.1","DOIUrl":"10.12688/wellcomeopenres.23186.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual <i>Scomber scombrus</i> (the Atlantic mackerel; Chordata; Actinopteri; Scombriformes; Scombridae). The genome sequence has a total length of 764.10 megabases. Most of the assembly is scaffolded into 24 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.56 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"610"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Inga</i> <i>oerstediana</i> Benth.","authors":"Rowan J Schley, R Toby Pennington, Alex D Twyford, Kyle G Dexter, Catherine Kidner, Todd P Michael","doi":"10.12688/wellcomeopenres.23146.1","DOIUrl":"10.12688/wellcomeopenres.23146.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual of <i>Inga oerstediana</i> (Streptophyta; Magnoliopsida; Fabales; Fabaceae). The genome sequence has a total length of 970.60 megabases. Most of the assembly is scaffolded into 13 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 1,166.81 and 175.18 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 33,334 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"607"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the acorn piercer, <i>Pammene fasciana</i> (Linnaeus, 1761).","authors":"Douglas Boyes, Thomas Lewin","doi":"10.12688/wellcomeopenres.18114.2","DOIUrl":"10.12688/wellcomeopenres.18114.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Pammene fasciana</i> (acorn piercer; Arthropoda; Insecta; Lepidoptera; Tortricidae). The genome sequence is 564 megabases in span. Most of the assembly (99.94%) is scaffolded into 28 chromosomal pseudomolecules with the Z sex chromosome assembled. The complete mitochondrial genome was also assembled and is 16.4 kilobases in length. Gene annotation of this assembly on Ensembl identified 21,224 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"7 ","pages":"258"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the planthopper, <i>Conomelus anceps</i> (Germar, 1821).","authors":"Stephen Moran, Andy Griffiths, Liam M Crowley","doi":"10.12688/wellcomeopenres.23104.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23104.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Conomelus anceps</i> (planthopper; Arthropoda; Insecta; Hemiptera; Delphacidae). The genome sequence has a total length of 957.80 megabases. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 21.98 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"605"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil.","authors":"Enny S Paixao, Thiago Cerqueira-Silva, Pilar T V Florentino, Orlagh Carroll, Nuria Sanchez Clemente, Deborah A Lawlor, Rita de Cássia Ribeiro Silva, Laura Cunha Rodrigues, Liam Smeeth, Mauricio L Barreto","doi":"10.12688/wellcomeopenres.22430.2","DOIUrl":"10.12688/wellcomeopenres.22430.2","url":null,"abstract":"<p><strong>Background: </strong>In utero exposure to infections might set the stage for a chain of events leading to a wide spectrum of long-term health outcomes observed in children and adolescents. This proposal aims to investigate whether syphilis, zika, dengue and chikungunya during pregnancy can increase the risk of the offspring developing a non-infectious chronic condition during childhood and adolescence.</p><p><strong>Objectives: </strong>1) Estimate the risk of non-infectious chronic conditions associated to syphilis, zika, dengue and chikungunya during pregnancy and when appropriate, explore if the risk varies by timing during pregnancy when the infection is acquired (first, second or third trimester) and severity (such as severe or mild dengue); 2) Investigate whether in uterus exposure to maternal infection affects the growth pattern of children and adolescents; 3) Examine the extent to which the relationship between maternal infection and non-infectious chronic outcomes are mediated by intrauterine growth restriction and preterm birth.</p><p><strong>Methods: </strong>We will compare health outcomes and growth trajectories of children and adolescents born to mothers with and without specific infections during pregnancy using conventional multivariable regression in the whole study population, in a within sibship design, using the subgroup of offspring with at least one sibling who is not exposed to the infection, and negative control outcome. Then we will decompose the direct and mediated effects (by preterm birth and small for gestational age) of maternal infection on chronic disorders.</p><p><strong>Results and conclusions: </strong>The results from this study will advance our understanding of the relationship between infections during pregnancy and chronic disorders, with widespread implications enabling targeting of critical points along the path from in utero exposure to outcomes to avoid or mitigate illness and disability over the life course.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"320"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the harlequin ladybird, <i>Harmonia axyridis</i> (Pallas, 1773).","authors":"Douglas Boyes, Liam M Crowley","doi":"10.12688/wellcomeopenres.17349.2","DOIUrl":"10.12688/wellcomeopenres.17349.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Harmonia axyridis</i> (the harlequin ladybird; Arthropoda; Insecta; Coleoptera; Coccinellidae). The genome sequence is 426 megabases in span. The majority (99.98%) of the assembly is scaffolded into 8 chromosomal pseudomolecules, with the X sex chromosome assembled.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"6 ","pages":"300"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of fat-hen, <i>Chenopodium album</i> L.","authors":"Sahr Mian, Maarten J M Christenhusz","doi":"10.12688/wellcomeopenres.23015.1","DOIUrl":"10.12688/wellcomeopenres.23015.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual <i>Chenopodium album</i> (fat-hen; Streptophyta; Magnoliopsida; Caryophyllales; Chenopodiaceae). The genome sequence has a total length of 1,593.80 megabases. Most of the assembly (99.61%) is scaffolded into 27 chromosomal pseudomolecules suggesting the individual is an allohexaploid (2 <i>n</i> = 6 <i>x</i> = 54). The mitochondrial and plastid genome assemblies have lengths of 312.95 kilobases and 152.06 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 50,077 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"508"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurturing a positive research culture within your laboratory.","authors":"Adrian Liston, Denise C Fitzgerald","doi":"10.12688/wellcomeopenres.22492.1","DOIUrl":"10.12688/wellcomeopenres.22492.1","url":null,"abstract":"<p><p>As a Principal Investigator leading a research team, creating a positive research culture for your team members is one of the best long-term investments you can make, for your research programme, for the sector and for society. A positive research environment is one where team members are empowered, recognised, have a clear career developmental pathway, can contribute to impactful and reproducible research and, ideally, propagate these effects. While these virtues can arise organically from a team built around kindness and integrity, they are also values that should be deliberately embedded within your lab. Here we provide advice on how to create a culture of integrity and a culture of belonging for your team members. We focus on thoughtful consideration of your key lab values, and the use of structure, language and your personal actions to make these values explicit. A holistic approach to integrating positive culture throughout every facet of your research team creates a system that can be self-sustaining in scientific integrity and more resilient to negative challenges. Starting on the pathway to self-improvement as a manager, recognising that this requires often uncomfortable self-reflection, provides both personal and professional reward.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"341"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Golden-tabbed robberfly, <i>Eutolmus rufibarbis</i> (Meigen, 1820).","authors":"Will J Nash, Andrew Halstead","doi":"10.12688/wellcomeopenres.23162.1","DOIUrl":"10.12688/wellcomeopenres.23162.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female Golden-tabbed robberfly, <i>Eutolmus rufibarbis</i> (Arthropoda; Insecta; Diptera; Asilidae). The genome sequence has a total length of 285.90 megabases. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.22 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"593"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}