Wellcome Open Research最新文献

{"title":"The genome sequence of the Blind Ringlet, <i>Erebia pharte</i> (Hubner, 1803-1804) (Lepidoptera: Nymphalidae).","authors":"Kay Lucek, Irena Klečková, Charlotte J Wright, Joana I Meier, Mark L Blaxter","doi":"10.12688/wellcomeopenres.27705.1","DOIUrl":"10.12688/wellcomeopenres.27705.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Erebia pharte</i> (Blind Ringlet; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The genome sequence has a total length of 616.83 megabases. Most of the assembly (98.95%) is scaffolded into 20 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled, with a length of 15.21 kilobases. Gene annotation of this assembly by Ensembl identified 15,135 protein-coding genes. This work is part of Project Psyche, a collaborative programme generating genomes for European butterflies and moths.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"592"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a gelechiid moth, <i>Acompsia subpunctella</i> Svensson, 1966 (Lepidoptera: Gelechiidae).","authors":"Marko Mutanen, Mikko Vallinmäki, Niina Kiljunen, Charlotte J Wright, Joana I Meier, Mark L Blaxter","doi":"10.12688/wellcomeopenres.27694.1","DOIUrl":"10.12688/wellcomeopenres.27694.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Acompsia subpunctella</i> (gelechiid moth; Arthropoda; Insecta; Lepidoptera; Gelechiidae). The assembly contains two haplotypes with total lengths of 475.14 megabases and 473.16 megabases. Most of the haplotype 1 assembly (99.91%) was scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.46 kilobases. This work is part of Project Psyche, a collaborative programme generating genomes for European butterflies and moths.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"581"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Umbilicaria deusta</i> (L. Baumg., 1790) (Umbilicariales: Umbilicariaceae).","authors":"Rebecca Yahr, Nathan A M Chrismas","doi":"10.12688/wellcomeopenres.27481.1","DOIUrl":"10.12688/wellcomeopenres.27481.1","url":null,"abstract":"<p><p>We present a genome assembly of <i>Umbilicaria deusta</i> (Peppered Rock Tripe; Ascomycota; Lecanoromycetes; Umbilicariales; Umbilicariaceae). The genome sequence has a total length of 40.76 megabases. Most of the assembly (95.36%) is scaffolded into 24 chromosomal pseudomolecules. The mitochondrial genome has been assembled, with a length of 100.51 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"573"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Dermanura phaeotis</i> (Chiroptera, Phyllostomidae, Stenodermatinae; Miller, 1902).","authors":"Melissa R de Waal, Nancy B Simmons, Brian P O'Toole, Ning Zhang, Jonathan L Gray, Erick Duarte, Linelle Abueg, Samuel C Talbot, Kirsty McCaffrey, Bonhwang Koo, Giulio Formenti, Meike Mai, Myrtani Pieri, Erich D Jarvis, Emma C Teeling, Sonja C Vernes","doi":"10.12688/wellcomeopenres.27248.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.27248.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Dermanura phaeotis</i> (Chordata; Mammalia; Chiroptera; Phyllostomidae). The genome sequence is 2.2 Gb in span. The majority of the assembly is scaffolded into 30 chromosomal pseudomolecules, with the X and Y sex chromosomes assembled.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"571"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chromosomal genome sequence of the giant green anemone, <i>Anthopleura xanthogrammica</i> (Brandt, 1835) (Actiniaria: Actiniidae).","authors":"Samuel Bedgood, Michael N Dawson, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.27544.1","DOIUrl":"10.12688/wellcomeopenres.27544.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Anthopleura xanthogrammica</i> (giant green anemone; Cnidaria; Anthozoa; Actiniaria; Actiniidae). The genome sequence has a total length of 290.04 megabases. Most of the assembly (97.36%) is scaffolded into 19 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 20.04 kilobases. Gene annotation of this assembly by Ensembl identified 25,034 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"566"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Aesculus hippocastanum</i> L., 1753 (Sapindales: Sapindaceae).","authors":"Markus Ruhsam, Peter M Hollingsworth","doi":"10.12688/wellcomeopenres.27204.1","DOIUrl":"10.12688/wellcomeopenres.27204.1","url":null,"abstract":"<p><p>We present a genome assembly of <i>Aesculus hippocastanum</i> (Horse-chestnut tree; Streptophyta; Magnoliopsida; Sapindales; Sapindaceae). The assembly consists of two haplotypes with total lengths of 513.59 megabases and 506.90 megabases. Most of haplotype 1 (98.22%) is scaffolded into 20 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial sequence has a length of 507.21 kilobases and the plastid genome assembly has a length of 156.08 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"563"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIVE MIND - Establishing diagnostic criteria for HIV associated acquired epidermodysplasia verruciformis: an international Delphi study.","authors":"Sophie H Kelly, Stephen L Walker, Nicola Willis, Rashida A Ferrand, L Claire Fuller, Eneyi Kpokiri, Vimbainashe Karimatsenga, Sinéad M Langan","doi":"10.12688/wellcomeopenres.26218.3","DOIUrl":"10.12688/wellcomeopenres.26218.3","url":null,"abstract":"<p><strong>Background: </strong>Acquired epidermodysplasia verruciformis (aEV) is a skin condition caused by increased vulnerability to cutaneous human papillomaviruses. aEV disproportionately affects people who acquire HIV perinatally. There are no accepted diagnostic criteria for aEV. The lack of routine diagnosis has limited research into this condition. There are no community prevalence estimates, no evidence-based treatments and no cohort studies to understand the risk of skin malignancy. Most people with perinatally-acquired HIV, live in low-resource settings without access to specialist skin doctors or skin biopsies. There is therefore a need to develop diagnostic criteria that can be used by non-specialists and are applicable in low-resource settings.</p><p><strong>Aim: </strong>This Delphi study aims reach consensus on screening and diagnostic criteria for HIV-associated aEV which are applicable in both high and low resource settings.</p><p><strong>Methods: </strong>Modified Delphi methodology will be used to achieve expert consensus. A panel of 20-30 experts with at least 5 years' experience in HIV or dermatology and experience with aEV will be asked to complete a series of surveys. Firstly, they will contribute all possible features of aEV. They will then rate these features in terms of importance. This will be used to guide the creation of draft diagnostic criteria. Panellists will rate their agreement with each criterion and adoption of the criteria as a whole. This will continue until consensus is reached. Consensus is defined a priori as when more than >60% of the panel either agree or strongly agree with each criterion and ≥ 80% of the panel with the adoption of criteria as a whole.</p><p><strong>Expected outcomes: </strong>A screening tool to identify people with possible aEV who warrant further examination.A set of diagnostic criteria that can be applied in real world settings to diagnose aEV.</p><p><strong>Ethical approval: </strong>This study has been approved by the LSHTM Research Ethics Committee (Reference: 33189.).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"276"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot take on a cool topic: is there really a need for a systemic master mediator of metabolic suppression in mouse daily torpor?","authors":"Mike Ambler, Anthony Pickering, Steven Swoap","doi":"10.12688/wellcomeopenres.27516.1","DOIUrl":"10.12688/wellcomeopenres.27516.1","url":null,"abstract":"<p><p>We argue in this perspective that daily torpor in the mouse, induced by a lack of caloric intake and a relatively cool environment, does not require a dedicated \"master mediator\" for systemic metabolic rate (MR) suppression. Instead, a set of centrally mediated changes, most notably: cessation of physical activity; dramatically reduced thermogenesis, along with a lowering of the defended minimum body temperature (Tb); and, reduced cardiovascular work, together drive the substantial drop in metabolic rate at the initiation of daily torpor in the mouse. That is, rather than invoking a global, organism-wide suppression of metabolism across all tissues, we argue that MR reduction during mouse daily torpor is selective and physiologically organized, targeting a small number of energetically dominant organ systems. Once Tb has declined in response to the initial physiological adaptations, temperature-dependent effects on biochemical reaction rates can account for much of the further reduction in whole-animal MR during the torpid state, resulting in an ultimate fall in MR of 75-80% in daily torpor of the mouse. This framework also aligns torpor with the normal ultradian rhythm of sleep-associated reductions in MR and Tb, differing mainly in the much deeper nadir reached.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"561"},"PeriodicalIF":0.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chromosomal genome sequence of a staghorn coral, <i>Acropora</i> cf.  <i>manni</i> (Scleractinia: Acroporidae).","authors":"David J Combosch, Andrew H Baird, David R Burdick, Hector Torrado, Dareon Rios, Sebastian Metz, Michael Sweet, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.27174.1","DOIUrl":"10.12688/wellcomeopenres.27174.1","url":null,"abstract":"<p><p>We present a genome assembly from a colony sample of <i>Acropora cf. manni</i> (staghorn coral; Cnidaria; Anthozoa; Scleractinia; Acroporidae). The assembly contains two haplotypes with total lengths of 459.26 megabases and 489.30 megabases. Most of haplotype 1 (94.39%) is scaffolded into 14 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 18.48 kilobases. Metagenome binning recovered one bacterial bin from the phylum Chlamydiota.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"551"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Orange Ripple Bryozoan, <i>Schizoporella japonica</i> Ortmann, 1890 (Cheilostomatida: Schizoporellidae).","authors":"John Bishop","doi":"10.12688/wellcomeopenres.27394.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.27394.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Schizoporella japonica</i> (Orange Ripple Bryozoan; Bryozoa; Gymnolaemata; Cheilostomatida; Schizoporellidae). The genome sequence has a total length of 255.53 megabases. Most of the assembly (99.03%) is scaffolded into 19 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 18.45 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"556"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}