Wellcome Open Research最新文献

{"title":"Update to: Study Pre-protocol for \"BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study\".","authors":"Thomas C Williams, Steve Cunningham, Simon B Drysdale, Helen Groves, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Robin Marlow, Abigail Maxwell-Hodkinson, Chengetai D Mpamhanga, Shaun O'Hagan, Ian Sinha, Olivia V Swann, Thomas Waterfield, Damian Roland","doi":"10.12688/wellcomeopenres.16778.3","DOIUrl":"10.12688/wellcomeopenres.16778.3","url":null,"abstract":"<p><strong>Background: </strong>In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.</p><p><strong>Study question: </strong>We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.</p><p><strong>Methods and likely impact: </strong>We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"6 ","pages":"120"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378404.2/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9080703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Orange-tipped sea squirt, <i>Corella eumyota</i> Traustedt, 1882.","authors":"John Bishop, Christine Wood, Robert J Mrowicki, Joanna Harley","doi":"10.12688/wellcomeopenres.21141.2","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21141.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual specimen of <i>Corella eumyota</i> (the Orange-tipped sea squirt; Chordata; Ascidiacea; Phlebobranchia; Corellidae). The genome sequence is 129.3 megabases in span. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 14.53 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"146"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the common green Tenthredo, <i>Tenthredo mesomela</i> Linnaeus, 1758.","authors":"Steven Falk, Andrew Green, Gavin R Broad","doi":"10.12688/wellcomeopenres.18992.2","DOIUrl":"10.12688/wellcomeopenres.18992.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Tenthredo mesomela</i> (the common green Tenthredo; Arthropoda; Insecta; Hymenoptera; Tenthredinidae). The genome sequence is 392.8 megabases in span. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 15.6 kilobases in length. Gene annotation of this assembly on Ensembl has identified 11,086 protein coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"8 ","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Satin Lutestring moth, <i>Tetheella fluctuosa</i> (Hübner, 1803).","authors":"Tom Prescott","doi":"10.12688/wellcomeopenres.23076.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23076.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Tetheella fluctuosa</i> (the Satin Lutestring moth; Arthropoda; Insecta; Lepidoptera; Drepanidae). The genome sequence has a total length of 369.10 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.41 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,318 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"576"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Currant Clearwing moth, <i>Synanthedon tipuliformis</i> (Clerck, 1759).","authors":"Douglas Boyes, Peter W H Holland","doi":"10.12688/wellcomeopenres.19647.2","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.19647.2","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Synanthedon tipuliformis</i> (the Currant Clearwing; Arthropoda; Insecta; Lepidoptera; Sesiidae). The genome sequence is 295.8 megabases in span. Most of the assembly (99.98%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 27.05 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,878 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"8 ","pages":"300"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11499843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of infection care terms among outpatients and carers in a public health facility: a cross-sectional survey.","authors":"Ebruphiyo Ruth Useh, Bongeka Mfeketo, Okuhle Mbengo, Innocent Karangwa, Timothy Pennel, Adam Boutall, Salome Maswime, Linda Pohl, Esmita Charani, Marc Mendelson, Oluchi Mbamalu","doi":"10.12688/wellcomeopenres.20162.2","DOIUrl":"10.12688/wellcomeopenres.20162.2","url":null,"abstract":"<p><strong>Background: </strong>As healthcare recipients and individuals affected by antimicrobial resistance (AMR), patients and their carers can be engaged in infection prevention and control (IPC) and antimicrobial stewardship (AMS) initiatives to manage AMR. To effectively participate in these initiatives, patients and carers need to understand general terms used in infection care. We explored awareness of commonly used infection-related terms among patients and carers in the surgical out-patient of a tertiary academic hospital.</p><p><strong>Methods: </strong>Self-administered paper survey distributed among out-patients from August to September 2022. Categorical variables were analysed using Chi squared test. Significance was set as p-value of < 0.05. Content analysis identified terms commonly used by patients when talking about infections.</p><p><strong>Results: </strong>Overall, 896 out of 1,269 respondents (response rate 70.6%), with a 1:3 male to female ratio were included. Most respondents were patients (75%), with a minimum of high school education (91.2%) and a surgical history (60.3%). <i>Surgical wound infection</i> was the most familiar term to participants. While many respondents had not heard of Methicillin-resistant Staphylococcus aureus ( <i>MRSA</i>) (92.3%, n=754) or <i>antimicrobial resistance</i> (92.8%, n=755), significantly more were aware of the descriptions provided for these terms (13.7% and 33.0%, respectively; p<0.001). Participants considered <i>antibiotic resistance</i> to be a condition in which the body rejects, resists, or does not respond to antibiotics.</p><p><strong>Conclusions: </strong>Findings show dissonance between patients' awareness of and healthcare workers' use of infection-care terms, highlighting the need for relatable and accessible terms in infection-care engagement initiatives. More than half of respondents acknowledged that patient engagement responsibility is everyone's, underscoring the need for contextually fit and relevant communication strategies to advance patient engagement and infection awareness.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"8 ","pages":"574"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the white-tailed eagle, <i>Haliaeetus albicilla</i> (Linnaeus, 1758).","authors":"Snæbjörn Pálsson, Kristinn Haukur Skarphéðinsson, Julia Heintz, Pernilla Quarfordt, Ann-Sofi Strand, Ignas Bunikis, Olga Vinnere Pettersson","doi":"10.12688/wellcomeopenres.23089.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.23089.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Haliaeetus albicilla</i> (the white-tailed eagle; Chordata; Aves; Accipitriformes; Accipitridae). The genome sequence has a total length of 1,320.30 megabases. Most of the assembly is scaffolded into 34 chromosomal pseudomolecules, including the Z and W sex chromosomes. Gene annotation of this assembly on Ensembl identified 17,501 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"575"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in gestational age at live birth in Scotland from 2005 to 2019: a population-based study.","authors":"Emily Moore, Sonya Scott, Jeeva John, Clara Calvert, Rachael Wood, Sarah J Stock","doi":"10.12688/wellcomeopenres.20916.2","DOIUrl":"10.12688/wellcomeopenres.20916.2","url":null,"abstract":"<p><strong>Background: </strong>Gestation at birth is associated with short and long-term outcomes. This study used high quality, national, administrative data to examine trends in gestation at birth in Scotland.</p><p><strong>Methods: </strong>This observational study used maternity hospital discharge records for 2005 to 2019 to determine trends in the percentage of live births that were preterm (<37 weeks gestation), term (37-41 weeks), and post-term (≥42 weeks), overall and by maternal age and deprivation category. Preterm births were further examined by category of preterm birth (moderate to late [32-36 weeks]; very [28-31 weeks]; extremely [<28 weeks] preterm), and onset of labour (spontaneous; provider-initiated). Singleton and multiple births were examined separately. Aggregate logistic regression was used to estimate the annual change in the odds of a birth being in a specified gestational category.</p><p><strong>Results: </strong>The percentage of singleton births in Scotland that were preterm decreased from 2005 (6.5%, 3,361/51,665) to 2010 (5.8%, 3268/56344), then increased to 2019 (7.2%, 3,408/47,507). The percentage of singleton births that were spontaneous moderate to late, very, and extremely preterm all increased between 2010 and 2019. The percentage of singleton births that were provider-initiated moderate to late preterm also increased between 2010 and 2019, however provider-initiated very or extremely preterm birth decreased. The percentage of singleton births that were preterm increased over time across all maternal age and deprivation categories, with increases greatest in groups at highest baseline risk. The percentage of singleton births that were post-term increased from 2005 to 2009, then decreased to 2019.</p><p><strong>Conclusions: </strong>There has been an increase in spontaneous preterm birth from 2010 to 2019, which is not fully explained by changes in maternal age or deprivation. Further research to examine the contribution of other, preventable, risk factors is warranted. Trends in provider-initiated preterm birth, and post-term birth, are likely to reflect changing clinical practice.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"254"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11530745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the common alder, <i>Alnus glutinosa</i> (L.) Gaertn. (Betulaceae).","authors":"Maarten J M Christenhusz, Zoë Goodwin, David G Bell, Claudia A Martin","doi":"10.12688/wellcomeopenres.23137.1","DOIUrl":"10.12688/wellcomeopenres.23137.1","url":null,"abstract":"<p><p>We present a genome assembly of a diploid specimen of <i>Alnus glutinosa</i> (the common alder; Streptophyta; Magnoliopsida; Fagales; Betulaceae). The genome sequence has a total length of 456.80 megabases. Most of the assembly is scaffolded into 14 chromosomal pseudomolecules. The mitochondrial genome assemblies have lengths of 505.23 and 155.85 kilobases and the plastid genome is 160.82 kilobases long. Gene annotation of this assembly on Ensembl identified 23,728 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"570"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the giant tachinid fly, <i>Tachina grossa</i> (Linnaeus, 1758).","authors":"","doi":"10.12688/wellcomeopenres.23102.1","DOIUrl":"10.12688/wellcomeopenres.23102.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Tachina grossa</i> (the giant tachinid fly; Arthropoda; Insecta; Diptera; Tachinidae). The genome sequence spans 936.90 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 19.82 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,428 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"571"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}