Wellcome Open Research最新文献

{"title":"The chromosomal genome sequence of the mauve stinger jellyfish, <i>Pelagia noctiluca</i> (Forsskål, 1775) (Semaeostomeae: Pelagiidae).","authors":"Lucas Leclère, Manon Boosten, Michael N Dawson, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.27407.1","DOIUrl":"10.12688/wellcomeopenres.27407.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Pelagia noctiluca</i> (Mauve Stinger; Cnidaria; Scyphozoa; Semaeostomeae; Pelagiidae). The genome sequence has a total length of 357.08 megabases. Most of the assembly (94.91%) is scaffolded into 21 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.7 kilobases. Gene annotation of this assembly by Ensembl identified 19 573 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"552"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a muscid fly, <i>Hydrotaea militaris</i> (Meigen, 1826) (Diptera: Muscidae).","authors":"Steven Falk, Liam M Crowley","doi":"10.12688/wellcomeopenres.27391.1","DOIUrl":"10.12688/wellcomeopenres.27391.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Hydrotaea militaris</i> (Arthropoda; Insecta; Diptera; Muscidae). The assembly contains two haplotypes with total lengths of 1 703.03 megabases and 1 760.39 megabases. Most of haplotype 1 (96.2%) is scaffolded into 6 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 18.83 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"549"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Kentish Glory, <i>Endromis versicolora</i> (Linnaeus, 1758) (Lepidoptera: Endromidae).","authors":"James Hammond","doi":"10.12688/wellcomeopenres.27493.1","DOIUrl":"10.12688/wellcomeopenres.27493.1","url":null,"abstract":"<p><strong>Abstract: </strong>We present a genome assembly from an individual male <i>Endromis versicolora</i> (Kentish Glory; Arthropoda; Insecta; Lepidoptera; Endromidae). The assembly contains two haplotypes with total lengths of 391.90 megabases and 391.44 megabases. Most of haplotype 1 (99.84%) is scaffolded into 26 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.6 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p><p><strong>Species taxonomy: </strong>Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Altocrustacea; Allotriocarida; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Eumetabola; Endopterygota; Aparaglossata; Panorpida; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea; Endromidae; <i>Endromis</i>; <i>Endromis versicolora</i> (Linnaeus, 1758) (NCBI:txid119269).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"559"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Red-underwing Skipper, <i>Spialia sertorius</i> (Hoffmannsegg, 1804) (Lepidoptera: Hesperiidae).","authors":"Kay Lucek, Daniel Linke, Charlotte J Wright, Joana I Meier, Mark L Blaxter","doi":"10.12688/wellcomeopenres.24648.2","DOIUrl":"10.12688/wellcomeopenres.24648.2","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Spialia sertorius</i> (Red-underwing Skipper; Arthropoda; Insecta; Lepidoptera; Hesperiidae). The assembly contains two haplotypes with total lengths of 364.57 megabases and 323.91 megabases. Most of haplotype 1 (99.92%) is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.34 kilobases. Gene annotation of this assembly on Ensembl identified 12,823 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"390"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12552837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Shepherd's Fritillary, <i>Boloria pales</i> (Denis & Schiffermüller), 1775 (Lepidoptera: Nymphalidae).","authors":"Yannick Chittaro, Andreas Sanchez, Kay Lucek, Charlotte J Wright, Joana I Meier, Mark L Blaxter","doi":"10.12688/wellcomeopenres.24642.2","DOIUrl":"10.12688/wellcomeopenres.24642.2","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Boloria pales</i> (Shepherd's Fritillary; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The assembly contains two haplotypes with total lengths of 382.99 megabases and 364.88 megabases. Most of haplotype 1 (99.96%) is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.17 kilobases. Gene annotation of this assembly on Ensembl identified 12,117 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"442"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Southern Grizzled Skipper, <i>Pyrgus malvoides</i> (Elwes & Edwards, 1897) (Lepidoptera: Hesperiidae).","authors":"Yannick Chittaro, Kay Lucek, Charlotte J Wright, Joana I Meier, Mark L Blaxter","doi":"10.12688/wellcomeopenres.24653.2","DOIUrl":"10.12688/wellcomeopenres.24653.2","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Pyrgus malvoides</i> (Southern Grizzled Skipper; Arthropoda; Insecta; Lepidoptera; Hesperiidae). The assembly contains two haplotypes with total lengths of 746.71 megabases and 747.11 megabases. Most of haplotype 1 (99.8%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.41 kilobases. Gene annotation of this assembly on Ensembl identified 14,715 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"404"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Red Sword-grass moth, <i>Xylena vetusta</i> (Hubner, 1813) (Lepidoptera: Noctuidae).","authors":"Michael F Geiser, Inez Januszczak, Andrew Griffiths","doi":"10.12688/wellcomeopenres.27382.1","DOIUrl":"10.12688/wellcomeopenres.27382.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Xylena vetusta</i> (Red Sword-grass; Arthropoda; Insecta; Lepidoptera; Noctuidae). The assembly contains two haplotypes with total lengths of 611.09 megabases and 608.87 megabases. Most of haplotype 1 (99.67%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.42 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"545"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Small Seraphim, <i>Pterapherapteryx sexalata</i> (Retzius, 1783) (Lepidoptera: Geometridae).","authors":"Laura Sivess, Chris Fletcher, Dominic Phillips","doi":"10.12688/wellcomeopenres.27368.1","DOIUrl":"10.12688/wellcomeopenres.27368.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Pterapherapteryx sexalata</i> (Small Seraphim; Arthropoda; Insecta; Lepidoptera; Geometridae). The assembly contains two haplotypes with total lengths of 289.12 megabases and 306.72 megabases. Most of haplotype 1 (98.84%) is scaffolded into 32 chromosomal pseudomolecules, including the Z sex chromosome and the B ₁ chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.63 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"540"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melioidosis in South Asia: Scientific Advances, Regional Challenges and One Health Perspectives-An Integrated Research Synthesis from the 4th South Asian Melioidosis Congress.","authors":"Chiranjay Mukhopadhyay, Chimanjita Phukan, Saurav Jyoti Patgiri, Harpreet Kaur, Bart J Currie, David Ab Dance","doi":"10.12688/wellcomeopenres.27378.1","DOIUrl":"10.12688/wellcomeopenres.27378.1","url":null,"abstract":"<p><strong>Background: </strong>Melioidosis, caused by <i>Burkholderia pseudomallei</i>, is a severe tropical infection with diverse clinical manifestations and high mortality if untreated. Although endemic in Southeast Asia and northern Australia, its burden is increasingly recognized in South Asia, where the disease remains underdiagnosed and is frequently misclassified as tuberculosis or other infections. This review synthesizes the contemporary scientific evidence and expert consensus emerging from the 4th South Asian Melioidosis Congress held in Guwahati, Assam, India, in November 2025.</p><p><strong>Methods: </strong>We conducted an integrated narrative synthesis of the scientific content presented at the Congress, including plenary lectures, oral and poster presentations, panel discussions, and case-based deliberations. Topics encompassed epidemiology, clinical manifestations, laboratory diagnostics, genomics, treatment strategies, outbreak investigations, antimicrobial resistance, and One Health perspectives across South and Southeast Asia.</p><p><strong>Results: </strong>The Congress highlighted expanding geographic recognition of melioidosis across India and neighbouring countries, with reported cases likely representing only a small fraction of the true disease burden. Clinical discussions emphasized marked heterogeneity in presentation and strong associations with diabetes mellitus, environmental exposure, and the monsoon season. Advances in diagnostics included broader implementation of MALDI-TOF mass spectrometry, molecular assays, and rapid diagnostic tests, although significant gaps remain in laboratory capacity, surveillance, and clinical recognition. Genomic investigations demonstrated substantial strain diversity while identifying conserved virulence determinants that may support surveillance and outbreak investigations. Participants also underscored the importance of multidisciplinary collaboration, standardized diagnostic practices, and regional data sharing to improve case detection and patient outcomes.</p><p><strong>Conclusions: </strong>Melioidosis remains an underrecognized but increasingly important public health challenge in South Asia. Strengthening surveillance systems, expanding diagnostic capacity, improving clinician awareness, fostering regional laboratory networks, and adopting coordinated One Health strategies are essential to reduce morbidity and mortality. The Congress also reinforced the need for sustained advocacy toward recognition of melioidosis as a neglected tropical disease.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"535"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Copper-tipped Ermine, <i>Pseudoswammerdamia combinella</i> (Hübner, 1786) (Lepidoptera: Yponomeutidae).","authors":"Laura Sivess, Gavin R Broad, Stephanie Holt","doi":"10.12688/wellcomeopenres.27367.1","DOIUrl":"10.12688/wellcomeopenres.27367.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Pseudoswammerdamia combinella</i> (Copper-tipped Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence has a total length of 604.80 megabases. Most of the assembly (99.84%) is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled, with a length of 16.16 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"537"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}