Wellcome Open Research最新文献

{"title":"The genome sequence of Greek sea-spurrey, <i>Spergularia bocconei</i> (Scheele) Graebn. (Caryophyllaceae).","authors":"Denise Power, Maarten J M Christenhusz, Colin French, Ian Bennallick, Sahr Mian, Ilia J Leitch","doi":"10.12688/wellcomeopenres.23609.1","DOIUrl":"10.12688/wellcomeopenres.23609.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Spergularia bocconei</i> (Greek sea-spurrey; Streptophyta; Magnoliopsida; Caryophyllales; Caryophyllaceae). The genome sequence has a total length of 466.20 megabases. Most of the assembly is scaffolded into 18 chromosomal pseudomolecules suggesting the individual is an allotetraploid (2 <i>n</i> = 4 <i>x</i> = 36). The mitochondrial and plastid genome assemblies have lengths of 327.07 kilobases and 152.41 kilobases, respectively.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of Red Underwing, <i>Catocala nupta</i> Linnaeus, 1767.","authors":"Douglas Boyes, Owen T Lewis","doi":"10.12688/wellcomeopenres.23621.1","DOIUrl":"10.12688/wellcomeopenres.23621.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female specimen of <i>Catocala nupta</i> (Red Underwing; Arthropoda; Insecta; Lepidoptera; Erebidae). The genome sequence has a total length of 930.40 megabases. Most of the assembly (99.82%) is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled and is 15.57 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,889 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Dolichopus griseipennis</i> Stannius, 1831.","authors":"Mike Ashworth, James McCulloch, Liam M Crowley, C Martin Drake","doi":"10.12688/wellcomeopenres.23382.1","DOIUrl":"10.12688/wellcomeopenres.23382.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Dolichopus griseipennis</i> (Arthropoda; Insecta; Diptera; Dolichopodidae). The genome sequence has a total length of 897.50 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.12 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,532 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, aetiology, and service mapping of dementia in rural Uganda. <i>Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda).</i>","authors":"Josephine Prynn, Racheal Alinaitwe, Beatrice Kimono, Tunde Peto, Nicholas J Ashton, Claire J Steves, Joseph Mugisha, Martin Prince","doi":"10.12688/wellcomeopenres.22944.1","DOIUrl":"10.12688/wellcomeopenres.22944.1","url":null,"abstract":"<p><strong>Background: </strong>Dementia prevalence in low- and middle-income countries is increasing, yet epidemiological data from African populations remain scarce. Crucial risk factors differ in Africa from more intensively studied global areas, including a higher burden of cerebrovascular disease and HIV, but lower rates of other risk factors like physical inactivity.Understanding dementia aetiology in African settings has been limited by the expensive and invasive nature of biomarker testing. This study leverages developments in blood-based and retinal imaging biomarker technology to examine the drivers of dementia in older Ugandans.People with dementia have complex needs benefiting from multi-dimensional support. Understanding current services will allow identification of barriers and opportunities to strengthen support available to people with dementia and their families.</p><p><strong>Methods: </strong>The study is nested within the General Population Cohort run by the Medical Research Council/Uganda Virus Research Institute & London School of Hygiene and Tropical Medicine Research Unit. All adults aged 60+ (around 1400) are undergoing brief cognitive screening.In Part 1, cohort participants are selected based on screening scores to undergo detailed cognitive assessment, using methods developed by the 10/66 Dementia Research Group. Part 2 is a case control study of people with and without dementia using antecedent data, questionnaires, physical assessment, retinal imaging, and Alzheimer's blood-based biomarkers. We will also compare disability, frailty, quality of life, and social engagement in people with and without dementia.Part 3 assesses current formal support structures for people with dementia through review of publicly available literature and expert interviews.</p><p><strong>Conclusions: </strong>This is the first study in Africa using blood-based and retinal imaging biomarkers to examine pathological processes underlying dementia, and systematically map services available for people with dementia. This paves the way for effective policy strategies and further focused research regarding both dementia prevention and support for affected people and their families.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"544"},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the common sole, <i>Solea solea</i> (Linnaeus, 1758).","authors":"Enora Geslain, Filip A M Volckaert, Ann M Mc Cartney, Giulio Formenti, Alice Mouton","doi":"10.12688/wellcomeopenres.23353.1","DOIUrl":"10.12688/wellcomeopenres.23353.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual female <i>Solea solea</i> (Linnaeus, 1758) (the common sole; Chordata; Actinopteri; Pleuronectiformes; Soleidae). The genome sequence spans 643.80 megabases. Most of the assembly (97.81%) is scaffolded into 21 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 17.03 kilobases in length. Gene annotation of this assembly on Ensembl identified 21,646 protein-coding genes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a sawfly, <i>Athalia cordata</i> Serville, 1823.","authors":"Andrew Halstead, Steven Falk","doi":"10.12688/wellcomeopenres.23456.1","DOIUrl":"10.12688/wellcomeopenres.23456.1","url":null,"abstract":"<p><p>We present a genome assembly from a female specimen of <i>Athalia cordata</i> (sawfly; Arthropoda; Insecta; Hymenoptera; Athaliidae). The genome sequence has a total length of 169.00 megabases. Most of the assembly (99.98%) is scaffolded into 4 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 27.47 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a cranefly, <i>Diogma glabrata</i> (Meigen, 1818).","authors":"James McCulloch, Liam M Crowley","doi":"10.12688/wellcomeopenres.23462.1","DOIUrl":"10.12688/wellcomeopenres.23462.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Diogma glabrata</i> (cranefly; Arthropoda; Insecta; Diptera; Cylindrotomidae). The genome sequence has a total length of 1,328.70 megabases. Most of the assembly (90.7%) is scaffolded into 4 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 17.5 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Ruddy Darter, <i>Sympetrum sanguineum</i> (Müller, 1764).","authors":"Liam M Crowley, Denise C Wawman","doi":"10.12688/wellcomeopenres.23466.1","DOIUrl":"10.12688/wellcomeopenres.23466.1","url":null,"abstract":"<p><p>We present a genome assembly from a male specimen of <i>Sympetrum sanguineum</i> (Ruddy Darter; Arthropoda; Insecta; Odonata; Libellulidae). The haplotype-resolved assembly contains two haplotypes with total lengths of 1,500.53 megabases and 1,304.05 megabases. Most of haplotype 1 is scaffolded into 13 chromosomal pseudomolecules, including the X sex chromosome, while haplotype 2 is scaffolded into 12 autosomes.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PAICE project: Integrating health and health equity into UK climate change policy.","authors":"Michael Davies, Charlie Dearman, Rosemary Green, Andrew Haines, Clare Heaviside, Filiz Karakas, Sudheer Kumar Kuppili, Susan Michie, James Milner, Gemma Moore, David Osrin, Silvia Pastorino, Giorgos Petrou, Irene Pluchinotta, Charles Simpson, Phil Symonds, Catalina Turcu, Sarah Whitmee, Ke Zhou, Nici Zimmermann","doi":"10.12688/wellcomeopenres.23431.1","DOIUrl":"10.12688/wellcomeopenres.23431.1","url":null,"abstract":"<p><p>This paper announces a new initiative - the research project <i>Policy and Implementation for Climate & Health Equity</i> (PAICE), which aims to investigate the complex systemic connections between climate change action, health and health equity, for translation of evidence into policy and practice in the UK. Using transdisciplinary approaches, PAICE will: (1) co-develop a programme theory and linked monitoring and evaluation plan, (2) work with the UK Climate Change Committee (CCC) and the Greater London Authority (GLA) using system dynamics to analyse national and local policy opportunities, (3) build an integrated model of the effects of these policies on population health, health equity and greenhouse gas emissions, (4) apply the findings to the CCC monitoring framework and GLA policy development, and (5) use the programme theory to help evaluate achievement of PAICE processes and objectives. If successful, PAICE will have helped to establish a systems capability to (i) monitor whether Government plans are on track to deliver their climate targets and associated health impacts and (ii) understand how relevant policy and implementation approaches could be enhanced.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the tawny cockroach, Ectobius (Ectobius) pallidus (Olivier, 1789).","authors":"Tony Hunter","doi":"10.12688/wellcomeopenres.23463.1","DOIUrl":"10.12688/wellcomeopenres.23463.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Ectobius pallidus</i> (tawny cockroach; Arthropoda; Insecta; Blattodea; Ectobiidae). The assembly contains two haplotypes with total lengths of 2,087.55 megabases and 2,124.67 megabases, respectively. Most of haplotype 1 (98.55%) is scaffolded into 11 chromosomal pseudomolecules, while haplotype 2 is assembled to scaffold level. The mitochondrial genome has also been assembled and is 15.75 kilobases in length.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"10 ","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}