Wellcome Open Research最新文献

{"title":"The chromosomal genome sequence of an acoel, <i>Convolutriloba macropyga</i> Shannon & Achatz, 2007 (Acoela: Convolutidae).","authors":"Francesca Pinton, Andreas Hejnol, Jose Victor Lopez, Nina Pruzinsky, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.27384.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.27384.1","url":null,"abstract":"<p><p>We present a genome assembly from a specimen of <i>Convolutriloba macropyga</i> (acoel; Xenacoelomorpha; Acoela; Convolutidae). The genome sequence has a total length of 1 175.98 megabases. Most of the assembly (88.04%) is scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 15.47 kilobases.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"533"},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of <i>Gardnerycteris keenani</i> (Chiroptera, Phyllostomidae, Stenodermatinae; Handley, 1960).","authors":"Nancy B Simmons, Melissa R de Waal, Meike Mai, Larry N Singh, Philge Philip, Laramie L Lindsey, Ning Zhang, Jonathan L Gray, Samuel C Talbot, Brian P O'Toole, Kirsty McCaffrey, Giulio Formenti, Linelle Abueg, Bonhwang Koo, Myrtani Pieri, Emma C Teeling, Erich D Jarvis, Sonja C Vernes","doi":"10.12688/wellcomeopenres.26494.1","DOIUrl":"10.12688/wellcomeopenres.26494.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Gardnerycteris keenani</i> (Chordata; Mammalia; Chiroptera; Phyllostomidae). The genome sequence is 2.2 Gb in span. The majority of the assembly is scaffolded into 32 chromosomal pseudomolecules, with the X and Y sex chromosomes assembled.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"527"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambling behaviour of Bradford teenagers: evidence from the Born in Bradford Age of Wonder study.","authors":"Gillian Santorelli, Jane West, John Pickavance","doi":"10.12688/wellcomeopenres.25913.2","DOIUrl":"10.12688/wellcomeopenres.25913.2","url":null,"abstract":"<p><strong>Background: </strong>Gambling among young people is a public health concern, and gambling-like mechanics in digital games (e.g., loot boxes) may increase exposure. We estimated the prevalence of traditional gambling and gambling-like online behaviours among adolescents in Bradford.</p><p><strong>Methods: </strong>Born in Bradford's Age of Wonder survey (2023-24) collected self-reported gambling behaviours from pupils in Years 8-10 (ages 12-15) across secondary schools. Invalid responses were excluded, yielding analytic samples for traditional gambling (n=7,257) and online gaming behaviours (n=7,828). Prevalence was summarised by year group, sex, and ethnicity (Pakistani British, White British, Other).</p><p><strong>Results: </strong>Of 7,254 pupils, 28.7% reported ever spending money on at least one gambling activity. Prevalence was similar for males (29.6%) and females (28.0%) and across year groups (Year 8: 30.8%; Year 9: 28.1%; Year 10: 27.1%). The most common activity was fruit/slot machines (16.7%), followed by private bets (7.9%) and playing cards for money (6.7%). Marked ethnic differences were observed: White British pupils were more likely to report ever gambling (45.8%) than Pakistani British pupils (15.8%) and pupils of other ethnicities (24.1%).Among 7,825 pupils answering online gaming questions, 55.8% had spent real money in at least one online game, 27.2% had purchased loot boxes/packs, and 3.3% had bet with in-game items. Males reported higher in-game spending than females (73.2% vs 39.8%), and White British pupils reported higher spending than Pakistani British pupils (66.8% vs 46.3%).</p><p><strong>Conclusions: </strong>Gambling and gambling-like behaviours are common among Bradford adolescents, with substantial demographic variation, particularly by ethnicity and sex. Findings support culturally sensitive, targeted public health and school-based prevention strategies addressing both traditional gambling and gambling-like online mechanisms.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnic differences in the patterns, incidence and prevalence of multiple long-term conditions: a systematic review protocol.","authors":"Irene F Bossman, Barbara I Nicholl, Srinivasa Vittal Katikireddi, Susan Browne, Valerie Wells, Catherine A O'Donnell","doi":"10.12688/wellcomeopenres.25227.2","DOIUrl":"10.12688/wellcomeopenres.25227.2","url":null,"abstract":"<p><strong>Background: </strong>Multiple long-term conditions (MLTC) or multimorbidity is increasing among populations worldwide in the last decades. Less is known about the prevalence, incidence, socio-demographic patterning and combinations of long-term conditions among different ethnic groups globally. This systematic review protocol plans to review the current literature to understand the incidence, patterns, prevalence, and impact of MLTC in different ethnic populations.</p><p><strong>Methods: </strong>This systematic review will include quantitative studies (cohort studies, cross-sectional, case-control, and baseline data from Randomised Control Trials) reporting on MLTC among adults across different ethnic groups in all settings (primary care, community or hospital). The following databases will be searched: Ovid MEDLINE, EMBASE, PsycINFO, CINAHL, ASSIA and COCHRANE CENTRAL using a combination of search terms including MLTC or multimorbidity and ethnicity. The exposure of interest is ethnicity, and included studies will report on at least one of these outcomes by ethnicity or a proxy of it: 1. prevalence and incidence of MLTC; 2. MLTC types (combinations or patterns of conditions including physical-only, mental and physical and complex multimorbidity, which is three or more (3+) chronic conditions across 3+ body system), and 3. health related outcomes (healthcare utilisation and mortality). Two reviewers will screen potential articles by titles/abstracts and full texts independently. A synthesis without meta-analysis approach to comprehensively summarise the key attributes and findings reported from each included study will be employed initially. Meta-analysis will be conducted where data allow, to estimate the risk of MLTC in minority ethnic groups vs majority ethnicity.</p><p><strong>Discussion: </strong>Some studies suggest people from ethnic minority backgrounds have a greater burden of MLTC, yet they are usually underserved in health research. Synthesising primary studies that focus on MLTC and ethnicity in this review will provide a global overview of prevalence or incidence data and their reported health outcomes among diverse ethnic populations.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"215"},"PeriodicalIF":0.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Woodland Marble, <i>Orthotaenia undulana</i> (Denis & Schiffermüller, 1775) (Lepidoptera: Tortricidae).","authors":"Liam M Crowley","doi":"10.12688/wellcomeopenres.27389.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.27389.1","url":null,"abstract":"<p><p>We present a genome assembly from an individual male <i>Orthotaenia undulana</i> (Woodland Marble; Arthropoda; Insecta; Lepidoptera; Tortricidae). The assembly contains two haplotypes with total lengths of 415.81 megabases and 414.51 megabases. Most of haplotype 1 (99.51%) is scaffolded into 28 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 16.74 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"521"},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on outcomes in people living with chronic hepatitis B (CHB)? An umbrella review protocol.","authors":"Emily Martyn, Jessica Carter, Maeve Barlow, Flora Olcott, Indrajit Ghosh, Elizabeth Waddilove, Alejandro Arenas-Pinto, Richard Gilson, Stuart Flanagan, Wd Francois Venter, Jennifer Manne-Goehler, Sally Hargreaves, Emmanouil Tsochatizis, Douglas MacDonald, Philippa C Matthews","doi":"10.12688/wellcomeopenres.26466.2","DOIUrl":"10.12688/wellcomeopenres.26466.2","url":null,"abstract":"<p><strong>Introduction: </strong>An estimated 254 million people are living with chronic hepatitis B virus (CHB) and 1.6 billion with metabolic dysfunction-associated steatotic liver disease (MASLD) worldwide. CHB remains a major global health challenge, despite a robust vaccine and suppressive antiviral treatment, and MASLD prevalence is increasing in line with a rise in cardiometabolic risk factors, such as obesity and type 2 diabetes. Thus, understanding the impact of concurrent CHB and MASLD on liver health is important to inform clinical practice and population surveillance. Current literature, including over ten systematic reviews and meta-analyses, yields conflicting evidence about the interplay between CHB and MASLD. This protocol describes a study aiming to critically appraise published systematic reviews investigating the effect of MASLD on liver outcomes in people living with CHB, identify gaps in the available data and assist scientists and clinicians in informing future research design.</p><p><strong>Methods and analysis: </strong>We will use umbrella review methodology from the Joanna Briggs Institute (JBI) to evaluate and synthesise evidence from existing systematic reviews and meta-analysis investigating liver and viral outcomes (fibrosis, cirrhosis, hepatocellular carcinoma, response to antiviral treatment, and impact on CHB biomarkers e.g. hepatitis B surface antigen, hepatitis B e-antigen and viral load) in CHB and MASLD, compared to CHB alone. We will search Ovid Medline, Ovid Embase, PubMed and Web of Science. We will assess methodological quality using the Assessing the Quality of Systematic Reviews-2 (AMSTAR-2) tool, compare study characteristics and present important results.</p><p><strong>Ethics and dissemination: </strong>No ethics approval is required as we will use only data from systematic reviews that are already published. Results will be included in a PhD thesis, submitted for consideration for presentation at international conferences and for peer review for publication in a scientific journal. We will endeavour to share results with relevant public and patient organisations. <b>Registration details</b> This umbrella review has been published on PROSPERO (ID CRD420261308282).</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"285"},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of yoga-breath linked intervention to stop smoking (Y-BLISS) in reducing the number of cigarettes smoked per day among smokers attempting to reduce or quit: Study protocol for a randomized controlled trial.","authors":"Chandra Shekar Mv, Hemant Bhargav, Bharath Holla, Jayant Mahadevan, Amit Singh, Venkata Lakshmi Narasimha, Naresh Katla, Atmakur Snigdha, Komal S, E Maheswari","doi":"10.12688/wellcomeopenres.22839.3","DOIUrl":"10.12688/wellcomeopenres.22839.3","url":null,"abstract":"<p><p>The proposed research aims to test the effects of a two-month yoga-breath linked intervention to stop smoking (Y-BLISS) as an add-on to standard treatment in tobacco use disorder (TUD; in the form of cigarette smoking) by conducting a randomized controlled study with the following primary outcome variable: number of cigarettes smoked per day. Secondary outcome variables are motivation to stop smoking, craving, dependence severity, lung capacity, and exhaled carbon-monoxide, and 7-day point-prevalence abstinence (7PPA). In this single-blinded, randomized, controlled, parallel-group superiority trial with 1:1 allocation ratio, 100 patients with TUD availing the outpatient/inpatient clinical services at a tertiary mental healthcare hospital in India will be enrolled after giving informed consent. Consecutive consenting patients will be randomly allotted to one of the two groups - yoga arm (Y-bliss arm), or desktop exercise arm (D-exercise arm). Allocation concealment will be followed, the clinicians, outcome assessors and data analysts will remain blind to subject-group allocation. A validated and standardized 12-minute yoga program (Y-BLISS) for TUD will be used as an intervention. The control group will receive an equivalent 12-minute desktop exercise module. Participants in respective arms will receive 40 online supervised sessions over 8 weeks, 5 sessions per week in the mornings as they will be asked to practice the same on an as-neededs basis whenever they feel cravings for cigarette smoking. Assessments will be done at baseline, 4th week and 8 ^th week. Data from all randomized subjects will be analyzed using intent-to-treat analysis and mixed model multivariate analysis. Dissemination Findings will be disseminated through peer-reviewed publications, conference presentations, and social media. Trial registration number The trial has been registered under Clinical Trials Registry India (CTRI) with the registration number: CTRI/2022/12/048117, date of registration: 14 ^th December 2022.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"693"},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists.","authors":"Sian Murphy, Christophe Galichet, James Baker, Luke O'Hara, Jordi L-Tremoleda, Eleni M Amaniti","doi":"10.12688/wellcomeopenres.25958.3","DOIUrl":"10.12688/wellcomeopenres.25958.3","url":null,"abstract":"<p><strong>Background: </strong>Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projects, decision-making, and collaborative research processes. Unfortunately, many ATs may feel that their professional background is insufficient or may not consistently recognise the significant scientific value of their daily activities. These perceptions can result in missed opportunities for personal and professional growth, and for advancing Refinement and Reduction initiatives within and outside their establishments.</p><p><strong>Methods: </strong>In developing the resource, our pilot study took into account commonly reported barriers to ATs engagement in scientific communication and collaboration, including perceptions of role boundaries and confidence in interactions with researchers and management. We describe the development of a practical resource designed to support ATs' self-awareness, confidence, and engagement in scientific discussions by helping them articulate their expertise clearly and effectively. The resources were evaluated during \"Tell Your Story\" workshops.</p><p><strong>Results: </strong>Feedback from the workshops was consistently positive. Participants reported increased confidence in recognising and communicating the scientific value of their work, as well as improved engagement in scientific discussions and collaboration.</p><p><strong>Conclusions: </strong>By combining an understanding of the challenges with practical tools and clear strategies, this pilot study suggests that ATs can be supported to recognise and develop their roles as knowledgeable scientific contributors and welfare advocates. This enables ATs to confidently share their expertise, advance their careers, enhance research quality and reproducibility, support the 3Rs principles, and strengthen the culture of care within a more collaborative and inclusive scientific research environment.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"243"},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to parasitic infections is associated with features and phenotypes of active convulsive epilepsy in Africa.","authors":"Nelson K Langat, Symon M Kariuki, Gathoni Kamuyu, Angelina Kakooza-Mwesige, Seth Owusu-Agyei, Kenneth Ae-Ngibise, Anne Wang'ombe, Anthony K Ngugi, Honorati Masaja, Ryan G Wagner, Charles R J C Newton","doi":"10.12688/wellcomeopenres.17049.3","DOIUrl":"10.12688/wellcomeopenres.17049.3","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy affects 70 million people worldwide, 80% of whom are in low-and-middle income countries (LMICs). Parasitic infections contribute considerably to the burden of epilepsy in LMICs, but the nature and presentation of epilepsy following these infections is not fully understood. We examined if epilepsy outcomes are associated with the exposure to parasitic infections.</p><p><strong>Methods: </strong>This was a case-comparison study nested in a cross-sectional survey of people with active convulsive epilepsy, with cases as those exposed to parasitic infections, and comparison as those unexposed. Associations of exposure to parasites with clinical and electroencephalographic features of epilepsy were done using a modified mixed effects Poisson regression model across five sites in Africa. Multiplicative and additive scale (RERI) interactions were explored to determine the effect of co-infections on epilepsy features. Population attributable fractions (PAF) were calculated to determine the proportion of severe clinical and electroencephalographic features of epilepsy attributable to parasitic infections.</p><p><strong>Results: </strong>A total of 997 participants with active convulsive epilepsy from the five African sites were analyzed, 51% of whom were males. Exposure to parasitic infections was associated with more frequent seizures in adult epilepsy (relative risk (RR) = 2.58, 95% confidence interval (95%CI): 1.71-3.89). In children, exposure to any parasite was associated with convulsive status epilepticus (RR = 4.68, (95%CI, 3.79-5.78), intellectual disabilities (RR = 2.13, 95%CI: 1.35-3.34) and neurological deficits (RR = 1.92, 95%CI: 1.42-2.61). <i>Toxoplasma gondii</i> and <i>Onchocerca volvulus</i> interacted synergistically to increase the risk of status epilepticus (RERI = 0.91, 95%CI = 0.48-1.35) in the data pooled across the sites. Exposure to parasitic infections contributed to 30% of severe features of epilepsy as shown by PAF.</p><p><strong>Conclusions: </strong>Parasitic infections may be associated with features and phenotypes of epilepsy through synergistic or antagonistic interactions, which can be different in children and adults. Interventions to control or manage infections may reduce complications and improve prognosis in people with epilepsy.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"6 ","pages":"200"},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chromosomal genome sequence of the spiny sea fan, <i>Muricea muricata</i> (Pallas, 1766) (Malacalcyonacea: Plexauridae) and its associated microbial metagenome sequences.","authors":"Carlos Prada, Jose Victor Lopez, Nicholas Jones, Nina Pruzinsky, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O'Brien","doi":"10.12688/wellcomeopenres.27232.1","DOIUrl":"10.12688/wellcomeopenres.27232.1","url":null,"abstract":"<p><p>We present a genome assembly from a <i>Muricea muricata</i> specimen (spiny sea fan; Cnidaria; Anthozoa; Malacalcyonacea; Plexauridae). The genome sequence has a total length of 453.40 megabases. Most of the assembly (98.45%) is scaffolded into 16 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 19.29 kilobases. Gene annotation of this assembly by Ensembl identified 52 164 protein-coding genes. From the metagenome data, we recovered five bins, of which three were high-quality MAGs.</p>","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"11 ","pages":"512"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}