Vox Sanguinis最新文献

{"title":"Effects of pre-donation salt-loading on the occurrence of delayed vasovagal reactions.","authors":"Noriko Namba, Gaku Kondo, Fumihiko Ishimaru, Tatsuma Hashizume, Yoshie Yamauchi, Noriko Yano, Yoko Ikeda, Keiko Kagawa, Miwa Nakagawa, Noriko Kunii, Chiharu Kano, Kiichi Aoki, Yoshihiro Sawamura, Shigeyoshi Makino","doi":"10.1111/vox.70273","DOIUrl":"https://doi.org/10.1111/vox.70273","url":null,"abstract":"<p><strong>Background and objectives: </strong>Vasovagal reaction (VVR) is the most frequent adverse reaction in blood donation, which usually recovers soon without complications. However, syncopal VVR can result in severe injury due to a fall. Some reports have shown the possibility to prevent VVR with salt-loading prior to blood donation. This semi-randomized controlled study aims to clarify the preventive effect of salt-loading on VVR among whole blood (WB) donors.</p><p><strong>Materials and methods: </strong>During the study period, donors who donated 400 mL of WB on odd days were assigned to the salt-loading group and those who donated on even days to the control group. Participants in the salt-loading group were asked to take three tablets containing 0.3 g salt in total.</p><p><strong>Results: </strong>The incidence of VVRs occurring >20 min after needle removal (delayed VVR [dVVR]) did not significantly differ between the two groups. Secondary analysis suggested a possible dose-dependent preventive effect against dVVR (odds ratio [OR]: 0.70; 95% confidence interval [CI]: 0.52-0.94; p = 0.02). The number of delayed syncopal VVR episodes in summer was lower in the salt-loading group than in the control group (n = 1 vs. 8; OR: 0.13; p = 0.04; pre-specified α = 0.0125).</p><p><strong>Conclusion: </strong>There was no significant preventive effect of pre-donation salt-loading on VVR. Further investigations with sufficient number of participants are needed to conclude the suggested dose dependency and seasonal preventive effect on dVVRs.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International multicentre evaluation of a new anti-idiotypic anti-daratumumab for resolving pre-transfusion interferences.","authors":"Arnaud Reggiani, Sofia Lejon Crottet, Sophie Waldvogel, Charlotte Engström, Serelina Coluzzi, Antonella Matteocci, Janis R Hamilton, Levent Tufan Kumas, Karen M K de Vooght, Jill R Storry, Jennylyn Flores, Núria Nogués, Carlos Cotorruelo, Molly Rutherford, Eveline B Nilsen, Monika Pelc-Kłopotowska, Jolanta Korzeniowska, Alessandra Baffa, Inna Sareneva, Nor Hafizah Ahmad, Katarzyna Szczudlo, Athif Rahman, Laser Sanal, Lise Jørgensen, Karolina Majewska Rochowiak, Monika Salwierz, Elisaveta Grancharova, Bojana Zivkovic, Jessica Alvarez, Mareike Riedl, Achim Knappik","doi":"10.1111/vox.70269","DOIUrl":"10.1111/vox.70269","url":null,"abstract":"<p><strong>Background and objectives: </strong>Daratumumab, a therapeutic human anti-CD38 monoclonal antibody, improves multiple myeloma outcomes but interferes with pre-transfusion testing by binding CD38 on reagent red blood cells (RBCs), potentially masking clinically significant alloantibodies. This study aimed to evaluate the effectiveness of a novel high-affinity anti-idiotypic anti-daratumumab reagent in neutralizing daratumumab interference while preserving RBC alloantibody detection and ensuring compatibility with routine transfusion laboratory workflows.</p><p><strong>Materials and methods: </strong>A non-interventional, multicentre study across 28 transfusion laboratories in 15 countries evaluated a novel anti-idiotypic anti-daratumumab reagent (DaraClear). In total, 443 daratumumab-containing plasma samples and 197 RBC alloantibody-containing samples were tested. All samples were initially tested at 10% (v/v), with stepwise escalation to 20% and 30% only if neutralization was incomplete. Neutralization efficiency, antibody detection, cross-match resolution and workflow integration were assessed, alongside comparisons with dithiothreitol (DTT), papain, trypsin and DaraEx.</p><p><strong>Results: </strong>Daratumumab interference was neutralized in 99.5% of samples, with 86.2% resolved using the 10% protocol. Detection of 190/197 RBC antibodies (96.4%) was preserved, including weak/low-titre antibodies. Neutralization was superior to DTT (93.3%), papain/trypsin (84.9%) and DaraEx (68.4%; all p < 0.0001). Titration studies confirmed efficacy across various ranges of daratumumab titres. The reagent integrated seamlessly into workflows, remained stable over time and avoided RBC modification.</p><p><strong>Conclusion: </strong>Daratumumab interference was efficiently neutralized while preserving alloantibody detection. The robust performance and workflow compatibility provide a practical solution for pre-transfusion testing in daratumumab-treated patients, supporting safe and timely transfusions with reduced laboratory burden.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination and transfusion safety at the time of expanding use of live attenuated vaccines.","authors":"Pierre Tiberghien, Pierre Gallian, Virginie de La Taille, Caroline Bacquet, Syria Laperche","doi":"10.1111/vox.70272","DOIUrl":"https://doi.org/10.1111/vox.70272","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating blood donation safety for donors with sickle cell trait.","authors":"Niubel Díaz Padilla, Cornelis van der Torren, Yared Paalvast, Iris Kubbenga, Johanna Wiersum-Osselton","doi":"10.1111/vox.70271","DOIUrl":"https://doi.org/10.1111/vox.70271","url":null,"abstract":"<p><strong>Background and objectives: </strong>Finding compatible blood donors for patients from minority racial and ethnic populations can be challenging due to differences in blood group antigen frequencies with the existing donor pool. Individuals with sickle cell trait (SCTrait) are allowed to donate in some countries, but in the Netherlands, carriers are currently not permitted to donate. This study estimates the incidence of adverse events among SCTrait donors compared with non-SCTrait donors, to inform potential policy decisions.</p><p><strong>Materials and methods: </strong>A retrospective study was performed at Sanquin, including whole-blood (WB) and plasma donors, from 2012 to 2024. Adverse events related to donation were compared between SCTrait donors (identified retrospectively) and a control group of non-SCTrait donors. Donor complications included systemic events, such as vasovagal reactions (VVRs), and venipuncture-related complications.</p><p><strong>Results: </strong>A total of 259 donations from 47 SCTrait donors and 2590 donations from 1371 non-SCTrait donors were analysed. The overall rate of donor complications was low in both groups, with no differences observed between SCTrait and non-SCTrait donors. VVR rates were 2.4% versus 2.7% in WB donations and 2.2% versus 1.0% in plasma donations for SCTrait versus non-SCTrait donors, respectively (p > 0.05). Separation issues, like filter squirting in the plasma collection set, occurred in 10.0% of plasma donations from SCTrait donors versus 0.5% in non-SCTrait donors (p < 0.001).</p><p><strong>Conclusion: </strong>The low incidence of adverse events among SCTrait donors suggests that blood donation is safe in this group. However, filter-related issues do occur more frequently, and thus remain a point of concern.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing complexity in transfusion research.","authors":"S F Fustolo-Gunnink","doi":"10.1111/vox.70264","DOIUrl":"https://doi.org/10.1111/vox.70264","url":null,"abstract":"<p><p>Complexity science investigates how complex systems behave and how we interact with them. Its implementation in clinical transfusion research is limited, even though human cells, organ systems, bodies, hospitals and blood supply systems are all examples of complex systems. Complexity science can help us to better understand the systems we study using novel and existing research methods. It also highlights that there is always unpredictability in complex systems, challenging us to both accept and cope with this uncertainty. This review provides a brief introduction of complex systems, explores why many transfusion-related research questions should be viewed through the lens of complexity and discusses how we can apply this perspective to transfusion research.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intravenous immunoglobulin following plasma exchange in the management of ABO haemolytic disease of the newborn.","authors":"Yahong Hu, Jing Nie","doi":"10.1111/vox.70265","DOIUrl":"https://doi.org/10.1111/vox.70265","url":null,"abstract":"<p><strong>Background and objectives: </strong>To evaluate the efficacy of intravenous immunoglobulin (IVIG) after plasma exchange (PE) in neonates with ABO haemolytic disease of the newborn (ABO-HDN) by assessing serum biomarkers, neurodevelopment and quality of life.</p><p><strong>Materials and methods: </strong>A total of 162 neonates with ABO-HDN were randomly assigned to four groups: Control (n = 39), IVIG (n = 42), PE (n = 41) and IVIG + PE (n = 40). Serum markers, Neonatal Behavioural Neurological Assessment (NBNA), Echelle Douleur Inconfort Nouveau-Ne and Paediatric Quality of Life Inventory (PedsQL4.0) scores were evaluated.</p><p><strong>Results: </strong>The IVIG + PE group showed the most significant improvement in prealbumin (PA), total bile acid (TBA), total bilirubin (TBIL), procalcitonin (PCT), high-sensitivity C reactive protein (hs-CRP) and antibody titre levels (p < 0.05). Neurodevelopment, comfort and quality of life were significantly enhanced, with reduced jaundice duration and hospitalization time. Adverse event rates were lower in all treatment groups than in the control group (p < 0.05).</p><p><strong>Conclusion: </strong>IVIG following PE improves serum biomarkers, antibody titre levels, neurodevelopment and quality of life in ABO-HDN, supporting its clinical application.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of interactive communication interventions for motivating blood donation: A systematic review.","authors":"Louisa Boult, Tom Douglass, Madeleine Tremblett, Jack B Joyce","doi":"10.1111/vox.70263","DOIUrl":"https://doi.org/10.1111/vox.70263","url":null,"abstract":"<p><strong>Background and objectives: </strong>The global blood product shortage is a persistent problem that urgently needs addressing. Research has investigated the effects of incentives, different interventions and different modes of communication on promoting blood donation; yet, there has been no systematic review comparing interactive communication-based interventions. Identifying effective methods to recruit and retain blood donors could inform future intervention design and improve resource allocation, thereby reducing strain on blood-product supply.</p><p><strong>Materials and methods: </strong>This review brings together relevant literature found on Medline, CENTRAL, Embase and PsychINFO to address the following questions: 'What are the most effective interactive interventions for promoting blood donation?' and 'Are these different between encouraging first-time and returning blood donors?' A total of 36 studies were included in this review.</p><p><strong>Results: </strong>Overall, the quality of research on interactive communication-based interventions was poor, with several studies lacking sufficient detail to make clear conclusions. Evidence for three common interventions (phone calls, educational sessions and motivational interviews) was conflicting. Additionally, there was limited research into web-based interventions and recruitment of first-time donors.</p><p><strong>Conclusion: </strong>Reporting of communication interventions for blood donation could be improved, and our review suggests that a more heterogeneous approach to donor recruitment may be advantageous.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Comparing specificity and seroconversion sensitivity among major blood screening assays for human immunodeficiency virus and viral hepatitis'.","authors":"Ramune Sepetiene, Mohamed Ali, Guillermo Orjuela, Ted Kieffer, Ellen Ollson, Axel Stover, Jason Kang","doi":"10.1111/vox.70268","DOIUrl":"https://doi.org/10.1111/vox.70268","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing the gaps: A global snapshot.","authors":"Vera Rosa, Paul Ashford, Gopal Patidar, Barbee I Whitaker, Nicola Swarbrick, Mary Townsend, Jennifer Davies, Shruthi Narayan","doi":"10.1111/vox.70262","DOIUrl":"https://doi.org/10.1111/vox.70262","url":null,"abstract":"<p><strong>Background and objectives: </strong>Traceability of blood components ensures patient safety, allowing bidirectional tracing of donors and recipients. Records must be kept for defined intervals and stored safely to ensure data integrity. Compliance must be regularly assessed, with clear accountability and actions for deficiencies. All transfusion staff must be trained in traceability to promote safe practices. The global survey aimed to identify the current status of blood components traceability.</p><p><strong>Materials and methods: </strong>International Society of Blood Transfusion (ISBT) Working Party on Haemovigilance in collaboration with International Haemovigilance Network (IHN) and Serious Hazards of Transfusion (SHOT) conducted a global survey in traceability, built using Online Surveys by Jisc and distributed to the six World Health Organization (WHO) regions. Responses were analysed using Microsoft Excel.</p><p><strong>Results: </strong>There were 212 responses from 43 countries. In 201/212 (95%), a law or regulation for traceability was reported, and in 189/201 (94%) traceability was bidirectional. Retention periods for records were variable, with ≥30 years being the most common (117/195; 60%). The Ministry of Health (118/212; 56%) and/or regulatory bodies (189/212; 89%) were most often the responsible organizations for monitoring traceability. Training in traceability for transfusion staff was reported in 139/212 (66%). In 32/212 (17%), there was at least one recall where a donor or recipient could not be traced. Records stored in computers (28/212; 13%), hard copies (22/212; 10%) or both (132/212; 62%) were reported. Of those with legacy systems (84/160; 53%), 18 stated that these were not safely managed. A haemovigilance system or equivalent was reported in 171/212 (81%) responses. The main challenges identified were unavailability of information technology (139/212; 66%) and staffing issues (137/212; 65%).</p><p><strong>Conclusion: </strong>This survey highlights wide global variation of traceability practices and highlights critical risks requiring urgent action.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of six large language models in transfusion medicine: Addressing language and domain-specific challenges.","authors":"Jong Kwon Lee, Sholhui Park, Sang-Hyun Hwang, Jaejoon Lee, Duck Cho, Sooin Choi","doi":"10.1111/vox.70050","DOIUrl":"10.1111/vox.70050","url":null,"abstract":"<p><strong>Background and objectives: </strong>Large language models (LLMs) such as GPT-4 are increasingly utilized in clinical and educational settings; however, their validity in subspecialized domains like transfusion medicine remains insufficiently characterized. This study assessed the performance of six LLMs on transfusion-related questions from Korean national licensing examinations for medical doctors (MDs) and medical technologists (MTs).</p><p><strong>Materials and methods: </strong>A total of 23 MD and 67 MT questions (2020-2023) were extracted from publicly available sources. All items were originally written in Korean and subsequently translated into English to evaluate cross-linguistic performance. Each model received standardized multiple-choice prompts (five options), and correctness was determined by explicit answer selection. Accuracy was calculated as the proportion of correct responses, with 0.75 designated as the performance threshold. Chi-square tests were employed to analyse language-based differences.</p><p><strong>Results: </strong>GPT-4 and GPT-4o consistently surpassed the 0.75 threshold across both languages and examination types. GPT-3.5 demonstrated reasonable accuracy in English but showed a marked decline in Korean, suggesting limitations in multilingual generalization. Gemini 1.5 outperformed Gemini 1, particularly in Korean, though both exhibited variability across technical subdomains. Clova X showed inconsistent results across settings. All models demonstrated limited performance in legal and ethical scenarios.</p><p><strong>Conclusion: </strong>GPT-4 and GPT-4o exhibited robust and reliable performance across a range of transfusion medicine topics. Nonetheless, inter-model and inter-language variability highlights the need for targeted fine-tuning, particularly in the context of local regulatory and ethical frameworks, to support safe and context-appropriate implementation in clinical practice.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"496-504"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}