Vox Sanguinis最新文献_第2页

Factors associated with failure to disclose complete information regarding transfusion-transmissible infections among blood donors in Lahore, Pakistan. 巴基斯坦拉合尔献血者中输血传播感染的完整信息未披露的相关因素。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-23 DOI: 10.1111/vox.70035

Iqra Aroob, Muhammad Alamgir Khan, Nazish Saqlain, Tooba Fateen, Javeria Fatima, Munawar Ghous

{"title":"Factors associated with failure to disclose complete information regarding transfusion-transmissible infections among blood donors in Lahore, Pakistan.","authors":"Iqra Aroob, Muhammad Alamgir Khan, Nazish Saqlain, Tooba Fateen, Javeria Fatima, Munawar Ghous","doi":"10.1111/vox.70035","DOIUrl":"https://doi.org/10.1111/vox.70035","url":null,"abstract":"Background and objectives: This study aims to address the gap in understanding the factors associated with the non-disclosure of complete information by blood donors in Lahore, Pakistan.Materials and methods: This was a cross-sectional study, conducted from February to April 2024. The study involved interviewing transfusion-transmitted infection (TTI)-positive blood donors from three large hospitals in Lahore. A validated questionnaire was used to analyse the factors associated with non-disclosure of information by these donors.Results: A total of 25,155 blood donors were screened, of whom 1048 tested positive for TTIs. Among these, 218 participated in the study. The majority of them (92%) reported being unaware of their infection. Among those who were aware of their infection but still proceeded with blood donation, the primary reasons for the non-disclosure of infection status included a lack of seriousness, inadequate interviewing by blood bank staff and overcrowded interview areas. A significant proportion of TTI-positive donors reported uncertain sources of infection (47%), while others reported high-risk behaviours such as interaction with sex workers (34%) and blood transfusions at unauthorized clinics (7%). Future disclosure attitudes varied, with 22% preferring to keep their status confidential. Significant correlations were found between future non-disclosure and factors such as age, marital status, education, socio-economic status and number of blood donations.Conclusion: These findings emphasize the need for targeted interventions to improve donor screening and pre-donation interview protocols. The study suggests the potential use of adequate counselling and provision of appropriate interview sites to reduce non-compliant behaviour and ensure safe blood donation practices.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD36 c.1328_1331dup: A variant causing platelet CD36 deficiency and its frequency in the Chinese population. CD36 c.1328_1331dup：一种导致血小板CD36缺乏的变异及其在中国人群中的频率。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70034

Lilan Li, Guoguang Wu, Liyang Liang, Jierun Chen, Lihong Jiang, Zhoulin Zhong, Yan Zhou, Justin Wu

{"title":"CD36 c.1328_1331dup: A variant causing platelet CD36 deficiency and its frequency in the Chinese population.","authors":"Lilan Li, Guoguang Wu, Liyang Liang, Jierun Chen, Lihong Jiang, Zhoulin Zhong, Yan Zhou, Justin Wu","doi":"10.1111/vox.70034","DOIUrl":"https://doi.org/10.1111/vox.70034","url":null,"abstract":"Background and objectives: CD36 encodes glycoprotein CD36, with variants causing reduced or absent protein expression. A CD36 variant leading to platelet CD36 deficiency was identified in a Chinese male blood donor, and its molecular basis and population distribution were studied.Materials and methods: Exons 3-14 of the CD36 gene from the identified variant were analysed using Sanger sequencing. CD36 complementary DNA (cDNA) was cloned and sequenced, and a eukaryotic cell line expressing the variant CD36 cDNA transcript was established to assess its protein expression using Western blotting (WB) and flow cytometry (FCM). A genotyping assay was developed and used to type 600 random individuals from Guangxi, China, for the variant.Results: Molecular analysis identified that the subject carries a heterozygous CD36 variant, c.1328_1331dup; p.Glu445Aspfs*65, and expressed both the variant (c.1328_1331dup) and wild-type CD36 messenger RNA (mRNA) transcripts. WB and FCM confirmed that the eukaryotic cell line expressing the CD36 c.1328_1331dup variant failed to produce the CD36 protein. The incidence of the CD36 variant in Guangxi was 0.33% with an allele frequency of 0.001667.Conclusion: This study identified a CD36 variant, c.1328_1331dup; p.Glu445Aspfs*65, responsible for platelet CD36 deficiency, which is present in 0.33% of the Guangxi population.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of high mobility group box 1 (HMGB1) levels with donor's age, sex and ABO blood group in single-donor apheresis platelet concentrates. 单献血者单采血小板浓缩物中高迁移率群盒1 （HMGB1）水平与献血者年龄、性别和ABO血型的关系

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70033

Marco Heestermans, Charles-Antoine Arthaud, Amelie Prier, Marie-Ange Eyraud, Hind Hamzeh-Cognasse, Fabrice Cognasse, Anne-Claire Duchez

{"title":"Association of high mobility group box 1 (HMGB1) levels with donor's age, sex and ABO blood group in single-donor apheresis platelet concentrates.","authors":"Marco Heestermans, Charles-Antoine Arthaud, Amelie Prier, Marie-Ange Eyraud, Hind Hamzeh-Cognasse, Fabrice Cognasse, Anne-Claire Duchez","doi":"10.1111/vox.70033","DOIUrl":"https://doi.org/10.1111/vox.70033","url":null,"abstract":"Background and objectives: High mobility group box 1 (HMGB1) is a nuclear protein expressed by various cell types and recognized as a damage-associated molecular pattern (DAMP). DAMPs play a pivotal role in driving inflammatory responses. Platelet-derived HMGB1 has been associated with severe adverse reactions following platelet concentrate transfusions, underscoring its clinical relevance. This study investigated whether HMGB1 levels in single-donor apheresis platelet concentrates (SDA-PCs) are influenced by routinely documented donor characteristics, such as age, sex and ABO blood group.Materials and methods: We analysed HMGB1 levels in 190 unpaired SDA-PC units. Donor characteristics, that is, age, sex and ABO blood group were obtained from routine records and examined for associations with HMGB1 levels.Results: HMGB1 levels showed no significant correlation with donor age or ABO blood group. However, levels were modestly lower in SDA-PC units derived from female donors compared to male donors.Conclusion: These findings reveal donor-specific variability in HMGB1 levels, particularly regarding donor sex, and underscore the need to systematically document donor demographic and biological characteristics during blood donation. Such data could enhance our understanding of donor-related factors influencing transfusion outcomes.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood collection technique and processing impact the nucleosomes and complement contents of platelet products. 血液采集技术和处理影响血小板产物的核小体和补体含量。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70031

Yasmin E S de Wit, Ido J Bontekoe, Rick van Andel, Thomas R L Klei, Anja Ten Brinke, Sacha S Zeerleder

{"title":"Blood collection technique and processing impact the nucleosomes and complement contents of platelet products.","authors":"Yasmin E S de Wit, Ido J Bontekoe, Rick van Andel, Thomas R L Klei, Anja Ten Brinke, Sacha S Zeerleder","doi":"10.1111/vox.70031","DOIUrl":"https://doi.org/10.1111/vox.70031","url":null,"abstract":"Background and objectives: Platelet concentrates (PCs) available for transfusion are prepared either from whole blood donations or by platelet aphaeresis procedures. These different preparation methods may potentially affect damage-associated molecular patterns (DAMPs) and complement activation products in PC, which are associated with adverse reactions (ARs).Materials and methods: The objective of this study is to perform a comparison of platelet activation, nucleosome, mitochondrial DNA (mtDNA), haem and complement activation between differently produced leukoreduced PC. Single donor aphaeresis-PC stored in either plasma or platelet additive solution (PAS)-E and pooled buffy-coat (BC)-PC stored in PAS-E were produced in a regional setting of the Dutch Blood Establishment. For BC-PC, a pool of five BC-independent donors was used, and BC-PCs were grouped based on the time of donation (morning vs. afternoon). Directly after production, samples were collected from PC, and CD62P+ platelets, nucleosomes, mtDNA, haem and complement activation products were measured. A comparison was made between aphaeresis-PC and BC-PC.Results: Higher levels of CD62P+ platelets were observed after stimulation in aphaeresis-PC than BC-PC. The levels of nucleosomes and C4b/c were significantly increased in BC-PC compared to aphaeresis-PC. In addition, the levels of elastase-α1-antitrypsin complexes (EA) were higher in BC-PC from morning blood collections than in aphaeresis-PC or BC-PC from afternoon blood collections, which indicates increased neutrophil activation.Conclusion: Aphaeresis-PC can be better activated than BC-PC. BC-PC contains higher levels of nucleosomes and EA, most likely due to the presence of neutrophils in the BC. In addition, higher levels of complement activation products were observed in BC-PC.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality indicators for blood establishments and hospital blood banks: A report by the ISBT Quality Management Working Party. 血站和医院血库的质量指标：ISBT质量管理工作组的报告。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70036

Tomislav Vuk, Christian Seidl, Lesley Bust, Yan Qiu, Nigar Ertuğrul Örüç

{"title":"Quality indicators for blood establishments and hospital blood banks: A report by the ISBT Quality Management Working Party.","authors":"Tomislav Vuk, Christian Seidl, Lesley Bust, Yan Qiu, Nigar Ertuğrul Örüç","doi":"10.1111/vox.70036","DOIUrl":"https://doi.org/10.1111/vox.70036","url":null,"abstract":"Background and objectives: Quality monitoring is a key component of the quality management system, closely related to the concept of quality improvement. The implementation of quality indicators (QIs), as a valuable quality monitoring tool, contributes to the achievement of quality objectives.Materials and methods: During 2010, discussions about the importance and use of QIs in transfusion medicine intensified, and 3 years later, the Quality Management Working Party (QM-WP) of the International Society of Blood Transfusion (ISBT) published a set of QIs for blood establishments and hospital blood banks. QIs defined by ISBT QM-WP were further developed and revised considering data obtained from an international survey on QIs, targeted consultations with members of the ISBT QM-WP and individual expert opinions.Results: Several revisions of quality indicators proposed by ISBT QM-WP have been published. The latest version from 2023 is presented in this paper and contains data on 50 QIs. Each indicator is defined, its importance is explained and the numerator and denominator required for its calculation are defined. The indicators are divided into seven groups according to areas of activity in the transfusion chain.Conclusion: This paper underlines the importance of QIs and provides resources for their selection, implementation and monitoring.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contemporary management of haemolytic disease of the fetus and newborn. 胎儿和新生儿溶血病的当代管理。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70027

Mark D Kilby, James B Bussel, Kenneth J Moise

引用次数: 0

Feasibility of conducting a randomized controlled trial to explore the muscular influence of post-operative intravenous iron treatment for anaemia after major abdominal surgery. 开展一项随机对照试验，探讨腹部大手术后静脉铁治疗对贫血的肌肉影响的可行性。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-22 DOI: 10.1111/vox.70037

Beth MacLean, Robert U Newton, Jayne Lim, Toby Richards

{"title":"Feasibility of conducting a randomized controlled trial to explore the muscular influence of post-operative intravenous iron treatment for anaemia after major abdominal surgery.","authors":"Beth MacLean, Robert U Newton, Jayne Lim, Toby Richards","doi":"10.1111/vox.70037","DOIUrl":"https://doi.org/10.1111/vox.70037","url":null,"abstract":"Background and objectives: Iron deficiency anaemia is common in patients recovering from major surgery and is associated with poorer post-operative outcomes. We designed a randomized controlled trial treating post-operative anaemia with iron therapy to observe the influence on post-operative recovery.Materials and methods: Anaemic patients (haemoglobin [Hb] < 120 g/L for women, Hb < 130 g/L for men) recovering from major abdominal surgery at Fiona Stanley Hospital were recruited. Patients were double-blind randomized 1:1 to ferric carboxymaltose (FCM) or saline administered 4 weeks post-discharge and included in a 12-week exercise programme. Iron indices, quality of life (QoL) questionnaires and muscle function tests were conducted at 4 weeks (baseline), 8-, 12- and 16-weeks post-discharge. This pilot study primarily aimed to assess the feasibility of recruiting 20 patients per intervention arm.Trial registration: ACTRN12622001447741.Results: Of 205 eligible patients screened between 5 May 2023 and 31 August 2023, only four patients were recruited, of which one completed the study. After randomization to FCM, results obtained from the sole participant that completed the trial suggested a trend towards improvement in QoL outcomes, Hb and muscle function.Conclusion: Recruitment to a randomized controlled trial exploring the influence of iron therapy on muscle function after major abdominal surgery was not feasible.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of bleed duration and adverse donor reactions during the blood donation process. 献血过程中出血持续时间及献血者不良反应的评价。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-14 DOI: 10.1111/vox.70024

Caroline Gesu Ngunyi, Michel Noubom, Jude Eteneneng Enoh, Patrick Njukeng, Claude T Tagny, Nkenganyi Gesu, Ebaiayuknso Etambe, Nsah Bongdze-Em Lilian, Apouamoun Mouppe Amadou, Leonard Fonkeng Sama, Emmanuel Asongalem

{"title":"Evaluation of bleed duration and adverse donor reactions during the blood donation process.","authors":"Caroline Gesu Ngunyi, Michel Noubom, Jude Eteneneng Enoh, Patrick Njukeng, Claude T Tagny, Nkenganyi Gesu, Ebaiayuknso Etambe, Nsah Bongdze-Em Lilian, Apouamoun Mouppe Amadou, Leonard Fonkeng Sama, Emmanuel Asongalem","doi":"10.1111/vox.70024","DOIUrl":"https://doi.org/10.1111/vox.70024","url":null,"abstract":"Background and objectives: There are great gaps regarding the demand and supply of blood and its derivatives in the blood transfusion field, which remains a major health issue. Adverse reactions experienced in the blood donation process have been reported to be one of the demotivating factors for donors returning. This study assessed bleed duration and the occurrence of adverse donor reactions (ADRs) in a blood bank setting in Cameroon.Materials and methods: A blood bank-based experimental study was conducted over 24 months at the Bafoussam Regional Hospital, Cameroon. Signs and symptoms of ADRs were recorded from whole blood donors who bled within and above 10 min, as well as from counselled and uncounselled donors.Results: Overall, 35 of 252 (13.9%) cases presented undesirable effects from blood donation, with re-puncture-associated haematomas-occurring in 17 of 35 (5.95%)-recorded as the most common reaction. On evaluating bleed duration as a predisposing factor, 28.9% of whole blood donors with bleed duration exceeding 10 min experienced ADRs, while 10.6% of donors bled within 10 min (p = 0.0013). Whether a donor was counselled or not, it had no effect on the occurrence of ADR.Conclusion: The study identified prolonged bleeding duration as a novel predisposing factor for ADRs. Re-puncture-associated haematoma, which is an erroneous phlebotomist act, is the possible cause. The acquisition of digital vein detector devices in blood banks to curb adverse donor events, will consequently scale up blood donation and reduce the gap in the blood supply.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced liver injury due to granulocyte colony-stimulating factor in a healthy donor for allogeneic peripheral blood stem cell transplantation. 同种异体外周血干细胞移植中健康供体粒细胞集落刺激因子引起的药物性肝损伤

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-14 DOI: 10.1111/vox.70032

Kana Kato, Shuhei Kurosawa, Riki Yamakawa, Kairi Kojo, Yasutaka Sadaga, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasutaka Masuda, Hiroki Hatsusawa, Fumihiko Ouchi, Kazuki Inai, Masashi Shimabukuro, Atsushi Jinguji, Yukie Terasaki, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Yuho Najima, Masamichi Kimura, Kyoko Haraguchi, Yoshiki Okuyama, Noriko Doki

{"title":"Drug-induced liver injury due to granulocyte colony-stimulating factor in a healthy donor for allogeneic peripheral blood stem cell transplantation.","authors":"Kana Kato, Shuhei Kurosawa, Riki Yamakawa, Kairi Kojo, Yasutaka Sadaga, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasutaka Masuda, Hiroki Hatsusawa, Fumihiko Ouchi, Kazuki Inai, Masashi Shimabukuro, Atsushi Jinguji, Yukie Terasaki, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Yuho Najima, Masamichi Kimura, Kyoko Haraguchi, Yoshiki Okuyama, Noriko Doki","doi":"10.1111/vox.70032","DOIUrl":"https://doi.org/10.1111/vox.70032","url":null,"abstract":"Background and objectives: Granulocyte-colony stimulating factor (G-CSF) is commonly used for peripheral blood stem cell harvesting (PBSCH). Although its well-documented adverse effects include thrombocytopaenia and bone pain, drug-induced liver injury (DILI) is rare.Materials and methods: We present the case of a 40-year-old male donor who developed DILI 4 days after G-CSF administration for PBSCH.Results: Laboratory results indicated elevated hepatobiliary enzymes, with aspartate aminotransferase (AST) peaking at 171 U/L (×6 the upper limit of normal [ULN]) on Day 7 of G-CSF administration, alanine aminotransferase (ALT) at 244 U/L (×6 ULN) on Day 11, alkaline phosphatase (ALP) at 371 U/L (×3 ULN) on Day 5 and gamma-glutamyl transpeptidase (γ-GTP) 93 U/L (×1.5 ULN) on Day 9. The hepatobiliary dysfunction became evident after G-CSF administration had ended, despite other parameters-including white blood cell and platelet counts-remaining within acceptable ranges. DILI was confirmed by positive drug lymphocyte stimulation test results. The donor's liver function normalized within 1 month of supportive treatment, and the recipient achieved successful engraftment without G-CSF administration.Conclusion: As G-CSF allergy screening is not mandatory in current Japanese protocols, DILI due to G-CSF could present a risk during PBSCH. This case emphasizes the importance of vigilant monitoring and comprehensive risk assessment to ensure the safety of healthy donors.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies. 调查线粒体DNA的影响：对输血反应和缓解策略的见解。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1111/vox.13794

Saeede Bagheri, Fatemeh Hajiabadi, Reihaneh Vahabzadeh, Mohammad Hossein Ahmadi

{"title":"Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies.","authors":"Saeede Bagheri, Fatemeh Hajiabadi, Reihaneh Vahabzadeh, Mohammad Hossein Ahmadi","doi":"10.1111/vox.13794","DOIUrl":"10.1111/vox.13794","url":null,"abstract":"Background and objectives: Although transfusion reactions occur in less than 2% of recipients, they are currently one of the most serious concerns in blood transfusion. Damage-associated molecular patterns (DAMPs) are released from injured, stressed or dead cells, leading to inflammation and immune system activation. One of the recognized DAMPs is mitochondrial DNA (mtDNA). It is found in various blood products, including fresh frozen plasma (FFP), red blood cell units (RBCUs) and platelet concentrates (PCs), and can induce adverse reactions in recipients by stimulating the innate immune system and inflammatory cellular pathways. The aim of this study was to investigate the factors influencing the release of mtDNA in various blood products and its subsequent impact on transfusion reactions.Materials and methods: In this study, mtDNA, mitochondrial DNA, mtDNA DAMPs, extracellular mtDNA, blood products, blood components and transfusion reactions between 2009 and 2023 were searched in Google Scholar, PubMed and Scopus databases.Results: This study has demonstrated the presence of mtDNA in the extracellular milieu of various blood products, including PCs, FFP and RBCUs. Understanding the determinants of mtDNA release and its implications for transfusion safety is critical. Strategies aimed at reducing mtDNA release, such as optimizing preparation techniques and donor selection criteria, hold promise for reducing transfusion-related complications.Conclusion: By addressing these factors, healthcare providers can enhance the safety and efficacy of blood transfusion practices, ultimately improving patient outcomes.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"354-365"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0