Vox Sanguinis最新文献

{"title":"Discordant prenatal and postnatal RhD typing caused by a novel RHD frameshift variant (c.540del; p.Leu181CysfsTer48) in Swedish individuals.","authors":"Ahlam Badri, Dan Gratschev, Tove Johansson, Agneta Wikman, Tesfai Emahazion","doi":"10.1111/vox.70351","DOIUrl":"https://doi.org/10.1111/vox.70351","url":null,"abstract":"<p><strong>Background and objectives: </strong>Non-invasive prenatal testing (NIPT) for fetal RHD genotyping is widely used to guide anti-D prophylaxis, but discrepancies between predicted fetal RhD status and postnatal serological typing can occur due to variant RHD alleles. This study aimed to confirm and characterize a suspected novel exon 4 deletion in RHD using multiple molecular methods and to assess inheritance.</p><p><strong>Materials and methods: </strong>NIPT predicted an RhD-positive fetus in an RhD-negative pregnant woman, whereas postnatal serology showed an RhD-negative phenotype. Molecular analysis of RHD was performed using the RBC-Ready Gene CDE kit (Inno-Train, Kronberg, Germany), targeted next-generation sequencing (NGS) and Sanger sequencing in the family and in an unrelated RhD-negative woman.</p><p><strong>Results: </strong>Targeted NGS identified a single-nucleotide deletion in the RHD gene (c.540del), predicted to result in a frameshift and premature termination (p.Leu181CysfsTer48). Sanger sequencing confirmed the variant in the newborn and demonstrated paternal inheritance, with the father heterozygous for the deletion. The same variant was also identified in an unrelated RhD-negative woman of Swedish origin; notably, the newborn's father was also of Swedish origin.</p><p><strong>Conclusion: </strong>This case illustrates a limitation of current NIPT approaches, which detect RHD sequences but not gene functionality. Molecular follow-up is crucial in cases of discordant RhD typing.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collection efficiency of hematopoietic cells by apheresis after mobilization in a single centre: Analysis of the last 15 years.","authors":"Paula Agritzer, Paola Charry, Glòria Carbassé, Joan Cid, John-Jairo Gallego, Elena Cahuancama, María-Queralt Salas, María Suárez-Lledó, Laura Rosiñol, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira, Miquel Lozano","doi":"10.1111/vox.70347","DOIUrl":"https://doi.org/10.1111/vox.70347","url":null,"abstract":"<p><strong>Background and objectives: </strong>Peripheral blood hematopoietic cells (CD34+) collection after mobilization by apheresis has largely replaced bone marrow harvest because of its safety and superior transplantation outcomes. This study aimed to evaluate temporal trends and factors influencing CD34+ collection efficiency (CE) by measuring counts before and after apheresis (CE1, in general considered a more accurate estimate of CE) over a 15-year period.</p><p><strong>Materials and methods: </strong>CD34+ cell mobilization was achieved using individualized drug regimens tailored to donor characteristics and underlying diagnosis. Apheresis procedures were carried out using Cobe Spectra, Spectra Optia and Amicus devices. Descriptive and analytical statistical analyses were performed using SPSS v29.0.</p><p><strong>Results: </strong>A total of 1435 collections from 1233 donors (658 males, 575 females; age 15-76 years) were analysed. Mean CD34+ CE1 increased significantly over time (p < 0.001). There was no statistically significant differences in CE1 between the six group of donors considered, but there were differences in CD34 counts before apheresis, number of total blood volume processed to reach the target number of CD34+ and the duration of collection. Male donors and individuals aged up to 39 years achieved the highest CE1. Pre-apheresis CD34+ count, leukocyte count, low mean corpuscular volume (MCV) and high platelet count inversely correlated with CE1.</p><p><strong>Conclusion: </strong>CD34+ CE1 improved significantly over the past 15 years, probably due to technological advancements. Several factors negatively influenced CE1, although some of them can be compensated for by changing the collection parameters in the apheresis platforms. The findings support optimization of apheresis protocols to reach maximum CD34+ CE1.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors.","authors":"Christina Lai Ling Lee, Li Ping Wong, Lee Lee Lai, Boon Pin Kee, Kek Heng Chua, Muhammad Amir Rasyid Ahmad Makmom, Shi Ya Chang, Mohammad Izzad Ishak, Mun Sin Chow, Haridah Alias, Kee Seong Ng, Choon Jiat Lee, Zizheng Zheng, Ting Wu, Qinjian Zhao","doi":"10.1111/vox.70336","DOIUrl":"https://doi.org/10.1111/vox.70336","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hepatitis E virus (HEV) is a recognized transfusion-transmissible pathogen with significant impact in immunocompromised recipients. Data from Southeast Asia are limited, and the epidemiology of HEV in Muslim-majority populations with low pork consumption remains poorly characterized. This study aimed to determine anti-HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) seroprevalence and associated demographic, dietary, environmental, zoonotic and knowledge-related factors among Malaysian blood donors.</p><p><strong>Materials and methods: </strong>A prospective cross-sectional study was conducted among 500 consecutive blood donors at the Universiti Malaya Medical Centre. Anti-HEV IgG and IgM were measured using enzyme-linked immunosorbent assay. A structured questionnaire assessed demographic, dietary, environmental and zoonotic exposures. Univariate and multivariable logistic regression identified predictors of anti-HEV IgG seropositivity.</p><p><strong>Results: </strong>Anti-HEV IgG seroprevalence was 2.8% (14/500), and IgM positivity was 0.6% (3/500). IgG seropositivity increased with age but showed no association with dietary exposures, including pork consumption. Knowledge of HEV was low, with a median score of 1 out of 12. Multivariable analysis identified freshwater recreational exposure (adjusted odds ratio [aOR] 20.04; p = 0.017) and direct rodent contact (aOR 13.36; p = 0.030) as factors associated with anti-HEV IgG seropositivity; however, these findings were based on small numbers of exposed individuals and should be interpreted cautiously.</p><p><strong>Conclusion: </strong>HEV seroprevalence in Malaysian blood donors was low, indicating a limited burden of previous HEV infection. The observed epidemiological profile suggests that environmental and zoonotic exposures may be associated with HEV seropositivity, although these findings require cautious interpretation. These findings provide baseline data for continued surveillance and future evaluation of transfusion-transmitted HEV risk in Malaysia.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities for vein-to-vein datasets from a blood establishment perspective: Towards a 'Pan-European Transfusion Research InfrAstructure'.","authors":"Sophie M T Wehrens, Mikko Arvas, Suzanne F Fustolo-Gunnink, Matea Vinković Vlah, Allison Waters, Christian Erikstrup, Louise Ørnskov Drechsler, Simon J Stanworth, Katja van den Hurk","doi":"10.1111/vox.70340","DOIUrl":"https://doi.org/10.1111/vox.70340","url":null,"abstract":"<p><strong>Background and objectives: </strong>The 'Pan-European Transfusion Research InfrAstructure' (PETRA) project was established to advance the use of donor, blood product and patient datasets in Europe, aiming to benefit both patient and donor health. Here, the initial PETRA objective was to describe the landscape of existing donor and blood establishment (BE) databases.</p><p><strong>Materials and methods: </strong>An online survey was circulated to the European Blood Alliance's BE-members. The survey collected information on the feasibility of accessing donor data, and challenges and possibilities for linking these datasets with information on the associated blood products and transfusion recipients, and donors' own health records.</p><p><strong>Results: </strong>Seventeen BEs across 16 countries completed the survey. The majority could, in principle, link their donor data to product data (13 BEs, 76%) and recipient data (10 BEs, 59%) for research purposes. However, capabilities were limited and in only 5 of 17 BEs was the donor to recipients' linkage an automated process. BEs reported significant challenges to achieve full vein-to-vein linkage, including legal constraints and lack of consent (11 BEs) and resources (10-14 BEs). Information technology and data issues as well as lack of knowledge and training were cited as obstacles by a minority of BEs.</p><p><strong>Conclusion: </strong>Whilst the survey results suggest considerable interest in developing linkages between blood donors, their products and recipients, many challenges remain due to a variety of obstacles. First steps in working towards a PETRA may be assistance to navigate legal frameworks as well as investing in resources and quality and harmonization of data collections.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of thrombotic complications of the arm in blood donors: Evidence from literature and national data.","authors":"Niubel Díaz Padilla, Armand Snel, Mardin Rashid, Ivan Bank, Johanna Wiersum-Osselton","doi":"10.1111/vox.70349","DOIUrl":"https://doi.org/10.1111/vox.70349","url":null,"abstract":"<p><strong>Background and objectives: </strong>Research on donor complications has focused mainly on vasovagal reactions, with less attention to local complications. Early detection of upper-extremity deep vein thrombosis (UDVT) is essential to prevent serious outcomes such as pulmonary embolism. This study assesses the association between UDVT and blood donation to facilitate identification and improve donor care.</p><p><strong>Materials and methods: </strong>A literature search was conducted using PubMed and Notify Library. Reports on therapeutic apheresis and clinical studies were excluded. Articles reporting aggregated data or individual cases of venous thrombosis, thrombophlebitis or phlebitis after donation of blood or components of blood were selected. Furthermore, donor records suggestive of arm thrombosis from December 2022 to January 2025 were extracted from our blood bank database. Donors were interviewed by telephone with a standardized questionnaire.</p><p><strong>Results: </strong>A literature search yielded 7 reports presenting 9 cases of UDVT, as well as a conference summary describing 20 cases. Arm pain and swelling were common symptoms, typically occurring within hours to days after donation. Risk factors for thrombosis were repeated sport-related arm movements, complicated phlebotomy, smoking, oral contraceptive use and genetic mutations. In our blood bank, 12 donors reported symptoms suggestive of venous thrombosis. Based on information collected in the interviews, there were three cases of UDVT, four cases of thrombophlebitis, two cases of phlebitis, one finger infection, one leg deep vein thrombosis (DVT) and one haematoma.</p><p><strong>Conclusion: </strong>UDVT is a rare complication that can occur days after donation. Prompt evaluation and referral to a general practitioner will contribute to preventing harmful consequences.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of vasovagal reactions among trans versus cisgender whole blood donors.","authors":"Antoine Lewin, Catherine Thibeault, Jessyka Deschênes, Yves Grégoire, Christian Renaud","doi":"10.1111/vox.70348","DOIUrl":"https://doi.org/10.1111/vox.70348","url":null,"abstract":"<p><strong>Background and objectives: </strong>Trans blood donors may be at higher risk of vasovagal reactions (VVRs) if their estimated blood volume is calculated without considering their sex assigned at birth. Yet no studies have addressed this research question. We assessed the rates of VVRs among trans and cisgender blood donors.</p><p><strong>Materials and methods: </strong>This was a cross-sectional study of whole blood donors in Québec, Canada (11 August 2016-25 August 2021). Trans donors were identified if they self-reported their gender transition or following an interview triggered by affirmative answers to questions on recent physician consultations and medication use. The odds of VVR were modelled using logistic regression analyses, adjusting for donor age and status.</p><p><strong>Results: </strong>Overall, 377,980 donors were included and made 1,799,509 donations: 29 were trans men (mean age ± standard deviation [SD] = 28.6 ± 9.1), 173,464 were cisgender men (mean age ± SD = 42.5 ± 16.2), 13 were trans women (mean age ± SD = 33.7 ± 9.7) and 204,474 were cisgender women (mean age ± SD = 38.7 ± 15.4). There was no statistically significant difference in the odds of VVR (any severity) between trans and cisgender men (odds ratio [OR] [95% confidence interval, CI] = 1.71 [0.88-3.32]) or between trans and cisgender women (OR [95% CI] = 1.33 [0.40-4.40]).</p><p><strong>Conclusion: </strong>In this study, the risk of VVR was similar among trans and cisgender blood donors.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why donors intend to return: Motivation, satisfaction and post-donation intention in a high-demand tertiary hospital setting in Lagos, Nigeria.","authors":"Obiageli B Okwunze, Ademola S Adewoyin, Olufemi A Oyedeji, Chika L Uche, Titilayo F Adeleke, Ayoola M Bakare, Debora Onyedikachi Ohanete, Ann A Ogbenna","doi":"10.1111/vox.70345","DOIUrl":"https://doi.org/10.1111/vox.70345","url":null,"abstract":"<p><strong>Background and objectives: </strong>Maintaining safe and adequate blood supply in low- and middle-income countries requires understanding factors influencing donor return intentions. Nigeria faces chronic blood shortages, yet evidence on determinants of return intention among blood donors in tertiary hospitals remains limited. This study assessed donor motivation, satisfaction and intention to return among blood donors at Lagos University Teaching Hospital (LUTH) and identified factors independently associated with post-donation intention.</p><p><strong>Materials and methods: </strong>A descriptive cross-sectional study was conducted among 1589 consecutive donors using a structured interviewer-administered questionnaire adapted from validated instruments. Motivation, satisfaction and intention to return were measured using Likert-scale items. Participants retrospectively reported pre-donation intention and current post-donation intention immediately after donation. Descriptive statistics, chi-square tests, McNemar's test, subgroup analyses and binary logistic regression were performed.</p><p><strong>Results: </strong>Most donors were family-replacement (70.5%) and male (91.8%), with a mean age of 30.9 years. Motivation was high (84%), driven primarily by altruism, personal choice and perceived health benefits. Satisfaction was also high (mean 4.59 ± 0.64). Intention to return increased significantly after donation (56.1%-64.2%, p < 0.001). Motivation (odds ratio [OR] = 7.32, p < 0.001) and pre-donation intention (OR = 0.014, p < 0.001) were independently associated with post-donation intention, whereas satisfaction was not significant after adjustment. Family replacement and voluntary non-remunerated donors differed significantly in motivation, satisfaction and post-donation intention.</p><p><strong>Conclusion: </strong>Blood donors at LUTH demonstrated high motivation and satisfaction. Donation experience strengthened intention to return. Differences between donor types highlight the need for donor-specific retention strategies in replacement-dominated blood systems.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in drone-based blood delivery: Comparing implementation in Rwanda and Canada.","authors":"Amaya Najma Razmi, Riya Sawhney, Pedro Kremer, Jacob Pendergrast, Juan Carlos Puyana, Meghan Delaney, Caroline Wesonga, Nakul P Raykar","doi":"10.1111/vox.70346","DOIUrl":"10.1111/vox.70346","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensated iron depletion in repeated blood donations: Stability of circulating microRNAs despite reduced ferritin stores.","authors":"Aziz Karaca, Şenol Çitli, Medeni Arpa, Kübra Sönmez","doi":"10.1111/vox.70344","DOIUrl":"https://doi.org/10.1111/vox.70344","url":null,"abstract":"<p><strong>Background and objectives: </strong>Repeated blood donations deplete 200-250 mg of iron per donation. While biochemical consequences on iron stores are well documented, the role of circulating microRNAs (miRNAs) in maintaining iron homeostasis remains poorly characterized. This study investigated whether repeated blood donation alters iron metabolism-related miRNA expression.</p><p><strong>Materials and methods: </strong>A cross-sectional study compared 42 male participants: 21 repeat donors (donating three to four times annually; mean total donations: 15) and 21 first-time donors. Plasma iron metabolism markers (ferritin, hepcidin, ferroportin, transferrin, soluble transferrin receptor 1 [sTfR1], soluble transferrin receptor 2 [sTfR2], unsaturated iron-binding capacity [UIBC]) were quantified using enzyme-linked immunosorbent assay (ELISA) and chemiluminescence methods. Expression of 13 miRNAs was analysed by quantitative reverse transcriptase polymerase chain reaction, normalized to U6 and quantified using the 2^-ΔΔCt method.</p><p><strong>Results: </strong>Repeat donors exhibited significantly lower ferritin (median: 26.8 vs. 72.2 ng/mL; p < 0.001), elevated red cell distribution width coefficient of variation (RDW-CV) (13.86% vs. 13.07%; p < 0.001) and reduced mean corpuscular haemoglobin concentration (MCHC) (33.80 vs. 34.23 g/dL; p = 0.009) while maintaining normal haemoglobin. No significant differences were observed in any miRNA after multiple-testing correction. However, miR-130a showed a marginal decrease (fold change: 0.389; p = 0.0564; Cohen's d = 0.514), while miR-200b and miR-485-3p demonstrated non-significant upward trends. Correlation analysis revealed distinct patterns between groups in iron regulatory protein relationships.</p><p><strong>Conclusion: </strong>Repeated blood donations demonstrate 'compensated iron depletion'. No significant differences were detected in the 13 selected iron-homeostasis-related miRNAs after multiple-testing correction. Within the limits of this small, male-only study evaluating a single miRNA panel, these findings indicate no detectable alteration, while underscoring the importance of ferritin monitoring; broader molecular pathways were not assessed, and given the limited statistical power, a Type II error cannot be excluded.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping syphilis surveillance: Insights into blood donation screening practices worldwide.","authors":"Michel-Andrés García-Otálora, Guillermo Orjuela-Falla, Carl P McDonald, Sandra Ramirez-Arcos","doi":"10.1111/vox.70335","DOIUrl":"https://doi.org/10.1111/vox.70335","url":null,"abstract":"<p><strong>Background and objectives: </strong>Syphilis is caused by the bacterial spirochete Treponema pallidum and can be transmitted through blood transfusion. However, there have been less than 10 documented transfusion-transmitted cases since World War II. Global data comparing population-level syphilis trends with blood donor reactivity and screening practices are limited. This study aimed to compare syphilis screening practices worldwide and to explore the value of universal donor screening.</p><p><strong>Materials and methods: </strong>A cross-sectional international survey was conducted among blood transfusion professionals. Participants reported data collected between 2018 and 2024 on syphilis prevalence, blood donor screening algorithms and reactivity rates, deferral policies and blood safety interventions. Descriptive analyses were performed by year and geographic region.</p><p><strong>Results: </strong>Thirty-nine participants from 26 countries across five continents answered the survey. Universal donor screening was reported by 35 of 36 institutions providing policy data, with treponemal assays representing the predominant screening approach. Substantial variation was observed in confirmatory testing, donor deferral criteria and donor re-entry policies. Reactivity rates varied markedly across centres and were higher among first-time donors compared to repeat donors. Institutions with higher syphilis rates generally reported higher donor reactivity. Routine leukoreduction was reported by 66.7% of institutions, while pathogen reduction technologies were routinely used by 36.1%. Most centres apply indefinite donor deferral and have not considered removing screening.</p><p><strong>Conclusion: </strong>Syphilis screening and donor management practices vary across blood services worldwide despite widespread implementation of universal screening. Local epidemiology, testing strategies and donor eligibility policies contribute to observed differences in donor reactivity and surveillance practices.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}