Vox Sanguinis最新文献

{"title":"From technical assistance to systematic construction: The evolution and effectiveness of the China-Association of Southeast Asian Nations blood safety cooperation model under the belt and road initiative.","authors":"Changshan Su, Bin Li, Baoren He, Shilin Li, Yujia Li, Chanthala Souksakhone, Limin Chen","doi":"10.1111/vox.70393","DOIUrl":"https://doi.org/10.1111/vox.70393","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of human platelet lysate production: Results of an International Survey of the ISBT Working Party on Cellular Therapies.","authors":"Sandra Laner-Plamberger, Michaela Oeller, Thierry Burnouf, Reinhard Henschler, Katharina Schallmoser","doi":"10.1111/vox.70392","DOIUrl":"https://doi.org/10.1111/vox.70392","url":null,"abstract":"<p><strong>Background and objectives: </strong>Global demand is rising for human platelet lysate (HPL) in the manufacture of cell-based medicinal products, but platelet resources are scarce. As protocols for the production process and quality testing are heterogeneous, the Working Party on Cellular Therapies of the International Society of Blood Transfusion (ISBT) has recently conducted a survey to obtain information from blood establishments worldwide.</p><p><strong>Materials and methods: </strong>The survey was created at limesurvey.net and consisted of 29 questions on the use of platelet concentrates (PCs) for HPL production to determine the status, conditions, standardization efforts, area of application, and potential difficulties. The link was sent to all ISBT members, and data were analyzed descriptively.</p><p><strong>Results: </strong>Of 78 participating centers, 12 routinely produce HPL according to in-house protocols, mainly by pooling expired PCs, whereas quality control testing is established in 10 institutions. HPL is used for basic research (n = 7) and for the manufacture of cell-based medicinal products (n = 7).</p><p><strong>Conclusion: </strong>HPL manufacture is still heterogeneous and limited to a few blood centers worldwide. Prospective collaborations between these institutions may contribute to the efforts for international harmonization and consistent regulation of HPL applications.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and age-specific daily and seasonal rhythms in haemoglobin and ferritin among Dutch blood donors.","authors":"Sophie Michelle Tisia Wehrens, Amber Meulenbeld, Mart Pothast, Femmeke Prinsze, Katja van den Hurk","doi":"10.1111/vox.70386","DOIUrl":"https://doi.org/10.1111/vox.70386","url":null,"abstract":"<p><strong>Background and objectives: </strong>Intra-individual haemoglobin (Hb) and ferritin variation is often overlooked in clinical practice, yet may be relevant where levels are around the cut-offs. We characterised Hb and ferritin fluctuations across the year and day in Dutch blood donors.</p><p><strong>Materials and methods: </strong>We included 337,218 capillary Hb (cHb) and 171,542 serum ferritin measurements routinely collected between 8:00 AM and 9:00 PM in new blood donors aged 18-65 years. Cosinor rhythms with 24-h and 12-month periods were fitted for males and females separately. Donor groups were stratified into <45 and ≥45 years of age as a proxy for the onset of menopause and age-related changes in circadian physiology.</p><p><strong>Results: </strong>cHb levels showed a 24-h rhythm, peaking around 10:30 AM. The daily amplitude was larger for males (0.122 mmol/L) than females (0.093 mmol/L), but females ≥45 years had a larger amplitude (0.106 mmol/L) than those <45. The cHb peak time occurred earlier in donors ≥45 (around 9:40 AM) than those <45 (around 10:40 AM). cHb levels were higher in winter than in summer. The yearly amplitude was larger in males (0.036 mmol/L) than in females (0.020 mmol/L). Ferritin levels also peaked in winter with similar amplitude in males and females.</p><p><strong>Conclusion: </strong>The cosinor behaviour of cHb levels during the day may indicate contribution of circadian physiology. An earlier cHb peak time in older donors agrees with the known association between 'morningness' and older age. These results support the interpretation of cHb and ferritin measurements in clinical practice and may fuel further research into underlying mechanisms.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-buffy-coat platelet concentrates: Evaluation of a Welsh blood supply chain contingency strategy with wider opportunities for European practice.","authors":"Michael Cahillane, Nicola Pearce, Christine Saunders, Chloe George","doi":"10.1111/vox.70387","DOIUrl":"https://doi.org/10.1111/vox.70387","url":null,"abstract":"<p><strong>Background and objectives: </strong>Platelet concentrates (PC) are essential for haemostatic support in clinical care. The Welsh Blood Service (WBS) previously showed through data modelling that three-buffy-coat-derived PC (3BC-PC) could meet UK contingency and European Directorate for the Quality of Medicines & HealthCare (EDQM) Council of Europe specifications. This study aimed to validate the real-world manufacture of 3BC-PC, assessing quality and compliance against UK and European regulatory standards.</p><p><strong>Materials and methods: </strong>Three ABO-compatible BCs were pooled with platelet additive solution-E (PAS-E) and processed per standard WBS protocols. Sixteen 3BC-PC were manufactured and stored at 20-24°C with agitation for 7 days. Samples were tested on Days 1, 2, 6 and 8 for platelet yield, recovery and specification compliance. Functional and quality assessments included platelet activation (CD62P, Annexin V, soluble CD62P), biochemistry (pH, glucose, lactate), light transmission aggregometry (adenosine diphosphate [ADP], thrombin receptor activator peptide-6 [TRAP-6]) and thromboelastography (TEG) (R, K, α-angle, maximum amplitude [MA]).</p><p><strong>Results: </strong>Mean platelet yield was 247 ± 26 × 10⁹/unit following Day 2 bacteriology sampling. All 3BC-PC met UK contingency (≥150 × 10⁹/unit) and EDQM routine (≥200 × 10⁹/unit) specifications throughout storage, although UK routine compliance (≥240 × 10⁹/unit) declined to 62.5% following Day 2 bacteriology sampling. Biochemical, activation and functional changes reflected expected platelet storage lesions, while TEG showed preserved global haemostatic function.</p><p><strong>Conclusion: </strong>Practical validation supports the feasibility of 3BC-PC as a contingency component. Quality metrics aligned with UK and European specifications, suggesting operational and clinical viability. These findings bridge prior modelling with practical manufacture and support both UK contingency and routine European adoption while identifying future optimisation considerations for potential routine UK use.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the military blood donor pool through non-donor recruitment.","authors":"Michael Carrillo, Kandie Ibarra, Ariel Pestanas, Ryan Comes, Mary Ann Spott, Chih Huang, Matthew Hanson, Jennifer Bein, Andrew Hall","doi":"10.1111/vox.70390","DOIUrl":"https://doi.org/10.1111/vox.70390","url":null,"abstract":"<p><strong>Background and objectives: </strong>The United States Armed Services Blood Program (ASBP) oversees blood collection for the US Department of War but faces recurring shortages. Donor motivations have been examined; the barriers and incentives affecting military non-donors have not.</p><p><strong>Materials and methods: </strong>A survey was conducted of 390 US military-affiliated non-donors served by two Air Force base donor centers. Participants rated 15 barriers and 13 incentives on 5-point Likert scales and gave open-text responses. Cronbach's alpha, principal component analysis, and analysis of variance assessed reliability, structure, and demographic differences; open text was coded with a multi-label codebook.</p><p><strong>Results: </strong>Barriers grouped into access/information, fear/low priority, and readiness/eligibility factors. Highest rated barriers were preferring other ways to contribute (mean 2.95), low priority (2.88), eligibility concerns (2.88), and lack of notification (2.85). Fear of needles (2.39) and distrust (2.11) rated the lowest. Incentives grouped into tangible/time-based rewards, informational appeals, and recognition. Additional leave (4.22) and gift cards (3.86) rated the highest. Reliability was high (α = 0.86-0.89). Barriers and responsiveness to tangible rewards declined with years of service and age and were higher among enlisted personnel (η² = 0.01-0.10); informational appeals showed no demographic differences. Sixty-four percent were likely to donate. Sixteen percent of open-text responses described being turned away because the respondent's blood type was not being collected.</p><p><strong>Conclusion: </strong>Military non-donors are disengaged and uninformed rather than fearful. Time-based incentives, eligibility clarity, drive notification, and a pathway for non-group-O volunteers are practical strategies to expand the ASBP donor pool.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune platelet transfusion refractoriness associated with anti-CD36 alloimmunisation in a Brazilian patient with platelet CD36 deficiency.","authors":"Rayane Dayse Alves Conserva, Luiz Frederico Bezerra Honorato Junior, Ana Paula Hitomi Yokoyama, Thiago Henrique Costa, Luis Henrique Cardoso Fedeli, Ana Cynira Franco Marret, Eduardo Perez Bastos, Fabio Pires de Souza Santos, Luana Nobrega Costa, Livia Chiosini de Nadai, Carolina Bonet-Bub, Jose Mauro Kutner","doi":"10.1111/vox.70385","DOIUrl":"https://doi.org/10.1111/vox.70385","url":null,"abstract":"<p><strong>Background and objectives: </strong>Immune platelet transfusion refractoriness (PTR) is usually mediated by anti-HLA class I antibodies; immunisation against CD36 (platelet glycoprotein IV [GPIV]) is relatively rare. Platelet CD36 deficiency shows marked ethnic variability and is seldom reported in admixed Latin American populations. We describe the diagnostic and transfusional challenges of anti-CD36 alloimmunisation in a Brazilian patient.</p><p><strong>Materials and methods: </strong>A 48-year-old Brazilian woman with a myeloid/lymphoid neoplasm with fibroblast growth factor receptor 1 (FGFR1) rearrangement developed severe PTR. Platelet antibodies were assessed by a Luminex-based Pak-Lx assay, CD36 expression by flow cytometry and CD36 genotyping by Sanger sequencing.</p><p><strong>Results: </strong>Platelet counts remained <5 × 10⁹/L with absent corrected count increment and recurrent mucocutaneous bleeding. Platelet antibody testing showed isolated anti-GPIV/CD36 reactivity (median fluorescence intensity [MFI] 4388); no additional HLA class I or human platelet antigen (HPA) antibodies were detected. No CD36 expression was detected on the patient's platelets by flow cytometry, and CD36 gene sequencing identified two heterozygous variants (c.975T>G and c.1079T>G) known to be associated with CD36 deficiency. Crossmatches remained incompatible with all available platelet units, including from an HLA-identical brother, reflecting the scarcity of CD36-negative platelet donors. The patient died of disease progression.</p><p><strong>Conclusion: </strong>Anti-CD36 alloimmunisation should be considered in severe PTR with negative HLA antibody screening, particularly in heavily transfused patients from admixed populations. To our knowledge, this is the first Brazilian case of anti-CD36 alloimmunisation causing severe PTR; platelet CD36 deficiency has previously been reported in a Brazilian woman with anti-CD36 antibodies in the context of pregnancy, underscoring the importance of considering this antibody specificity in persistent PTR despite negative HLA and HPA antibody screening.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of lymphocyte subsets in regular blood donors.","authors":"Xiaoyan Yu, Lijuan Liu, Yaru Li, Qian Zhou","doi":"10.1111/vox.70384","DOIUrl":"https://doi.org/10.1111/vox.70384","url":null,"abstract":"<p><strong>Background and objectives: </strong>To assess the effects of long-term regular leukocyte-reduced platelet (PLT) apheresis on lymphocyte subsets in volunteer donors.</p><p><strong>Materials and methods: </strong>We enrolled 178 participants, including Amicus-using donors (Group A, n = 55), Trima-using donors (Group T, n = 64), and first-time donor controls (n = 59). Apheresis donors completed ≥8 PLT collections within 1 year on one fixed separator. Lymphocyte-subset measurements were performed on pre-donation screening samples.</p><p><strong>Results: </strong>After age/sex adjustment, both apheresis groups exhibited significantly lower absolute counts and percentages of natural killer (NK) cells versus controls (p < 0.05), while CD3⁺, CD4⁺, CD8⁺ T cells, and B lymphocytes were similar among groups. Several T-cell markers showed nominal downward trends with higher lifetime donations (raw p < 0.05), yet no associations persisted after correcting for false discovery rate (FDR). Neither lifetime nor 1-year donation counts correlated with lymphocyte or routine hematological parameters; overall lymphocyte-subset profiles did not differ between Group A and Group T. Subgroup analysis revealed reduced NK cell counts only in the high-donation stratum (≥100 donations) of Group A and the low-donation stratum (<40 donations) of Group T.</p><p><strong>Conclusion: </strong>Long-term leukocyte-reduced PLT apheresis is associated with decreased circulating NK cells. Multiple-testing correction provided no evidence for progressive lymphocyte decline with cumulative donations. One-year donation frequency had no impact on lymphocyte subsets. With plasma rinseback activated for all Trima procedures, lymphocyte profiles were comparable between devices. Routine hematological parameters remained stable in long-term apheresis donors.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of the Japanese Red Cross Blood Center in Ishikawa Prefecture to the 2024 Noto Peninsula earthquake.","authors":"Satoshi Yasumura, Kosuke Wakamori, Shinji Nakao","doi":"10.1111/vox.70100","DOIUrl":"10.1111/vox.70100","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"1494-1496"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood bank preparedness for hurricanes and flooding: A Florida Blood Center's experiences and perspectives.","authors":"Rita A Reik, Marlene Pagan, Diane Whitelock","doi":"10.1111/vox.70310","DOIUrl":"10.1111/vox.70310","url":null,"abstract":"<p><p>Hurricanes and flooding pose serious challenges to the stability of the blood supply, particularly in vulnerable regions such as Florida. We aimed to describe and evaluate the preparedness, response and recovery strategies of a large blood centre over the past decade, with a focus on Hurricane Irma (2017). Drawing on the centre's Business Continuity Plan, after-event reports and disaster response data, we examined how operations were disrupted and how the blood supply was maintained under extreme conditions. Combined, these storms resulted in tens of millions of dollars in losses through cancelled blood drives, damage to facilities, interruptions in operations and widespread breakdowns in communications, logistics and supply chains. At the same time, emergency coordination with hospitals, community partners and public agencies helped sustain blood availability when it was most needed. The experience with Hurricane Irma illustrates the complexity of maintaining resilience during large-scale disasters and highlights both the strengths and the vulnerabilities of existing preparedness measures. Over the decade, lessons learned from these events have been integrated into the centre's planning, leading to continuous improvements and a more robust framework for future emergencies. Yet critical gaps remain that will require new resources, stronger interorganizational networks, expanded research and ongoing data analysis to close. As climate change intensifies the frequency and severity of hurricanes, the urgency of addressing these vulnerabilities grows. Strengthening preparedness and resilience will be essential to safeguard the blood supply against the storms yet to come.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"1545-1552"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interorganizational task force for disasters affecting US blood supply.","authors":"Glenn Ramsey, Frank Berry","doi":"10.1111/vox.70166","DOIUrl":"10.1111/vox.70166","url":null,"abstract":"<p><strong>Background and objectives: </strong>The US Interorganizational Task Force for Domestic Disasters and Acts of Terrorism (Interorganizational Disaster Task Force [IDTF]) is coordinated by the Association for the Advancement of Blood & Biotherapies (AABB). The IDTF was founded in 2001 in response to the 9/11 attack and is part of the US Department of Homeland Security's National Response Framework for disaster responses. We sought to set out the objectives, methods and activities of the IDTF.</p><p><strong>Materials and methods: </strong>We reviewed the organization and history of the IDTF and representative disaster responses coordinated by the IDTF.</p><p><strong>Results: </strong>The IDTF is composed of representatives from five civilian and military blood organizations, five key healthcare organizations and liaisons from the US Department of Health and Human Services (HHS) and two HHS agencies. The IDTF promotes disaster preparation by blood centres and transfusion services and communicates weekly with its federal partners on the disaster readiness of the US blood supply. During disasters, which often interrupt regional donor operations, the IDTF helps in guiding national blood collection efforts, provides data-based messages to HHS and the public on blood donation needs and coordinates inter-regional blood transport and blood-supply infrastructure support. The IDTF has been activated for large-scale weather events, Zika and COVID-19 epidemics, cyberattacks and an earthquake (Haiti).</p><p><strong>Conclusion: </strong>Because the US blood supply is not under a centralized authority, the IDTF is a unique and critical forum for collaborative private-public sector partnership to overcome disaster-related challenges to blood availability.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"1565-1571"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}