Vox Sanguinis最新文献

{"title":"Forecasting emerging trends in transfusion medicine through complex network analysis of scholars' research.","authors":"Feng Lin, Xu He, Huifang Zhang, Yi Huang","doi":"10.1111/vox.70046","DOIUrl":"https://doi.org/10.1111/vox.70046","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to analyse and predict emerging trends in transfusion medicine using complex network analysis of high-impact global scholar rankings.</p><p><strong>Materials and methods: </strong>Network analysis was employed to uncover research trends, identify central research directions and map knowledge networks. The analytical hierarchy process was used to evaluate potential future research trajectories. The Kolmogorov-Smirnov test assessed network centrality differences, with cross-validation performed using the Association for the Advancement of Blood & Biotherapies (AABB) and the International Society of Blood Transfusion (ISBT) conference themes.</p><p><strong>Results: </strong>Clinical transfusion is the central theme, with transfusion management, evaluation and specific transfusions like platelet and plasma gaining prominence. Blood safety evolved into a standalone domain, while immunohaematology and cell therapy represent emerging trends. Innovations in blood storage, transfusion technology and omics insights are shaping future directions. Notably, despite global healthcare impacts, COVID-19 has not significantly redirected transfusion medicine research.</p><p><strong>Conclusion: </strong>The transfusion medicine landscape demonstrates stability in its core framework while increasingly focusing on emerging areas such as personalized therapies, platelet transfusion and cell-based treatments.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic high-dose granulocyte transfusions following allogeneic haematopoietic stem cell transplantation.","authors":"Yannis Hadjiyannis, Robert Bubar, Darrell J Triulzi, Joseph Kiss, Christopher C Marino, Randy M Windreich, Paul Szabolcs, Alesia Kaplan","doi":"10.1111/vox.70044","DOIUrl":"https://doi.org/10.1111/vox.70044","url":null,"abstract":"<p><strong>Background and objectives: </strong>Prophylactic granulocyte transfusions (PGTxs) are controversial. Previous studies faced numerous confounders such as achieving an adequate dose. Pre-emptive or secondary PGTx for persistent, severe pre-transplant infections has rarely been reported for patients undergoing haematopoietic stem cell transplantation (HSCT). Here, we reviewed the feasibility, safety and implementation of high-dose PGTx in high-risk patients undergoing HSCT with a history of persistent, recurrent infections.</p><p><strong>Materials and methods: </strong>We conducted a retrospective review (2018-2021) for all HSCT patients who received high-dose PGTx from donors stimulated with granulocyte colony-stimulating factor and dexamethasone at our tertiary medical centre. PGTx was carried out as secondary prophylaxis to prevent infection recurrence/progression.</p><p><strong>Results: </strong>Seven patients received PGTx during HSCT; 95% of all transfused products contained a dose ≥0.6 × 10⁹/kg. Post-transfusion absolute neutrophil count (ANC) showed an average increase of 5.5 ± 3.7 × 10⁹/L. All PGTxs were well tolerated, with no evident transfusion reactions, adverse effects or human leukocyte antigen alloimmunization. A high overall survival rate (100% at day 30), afebrile rate (85%) and absence of infections were noted.</p><p><strong>Conclusion: </strong>Optimized high-dose PGTx resulted in a measurable ANC increase and was well tolerated. Although efficacy and safety remain to be established, we highlight the ability to produce and implement optimized high-dose PGTx for high-risk patients undergoing HSCT.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion-associated graft-versus-host disease and purine analogues: What are we missing?","authors":"Chin Zhong Ng, Leigh Mosen, Christopher Corkery, Meredith Smith, Gustavo C Duarte","doi":"10.1111/vox.70047","DOIUrl":"https://doi.org/10.1111/vox.70047","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why men who have sex with men in New Zealand intend to donate or not donate blood.","authors":"Carl Webber, Koson Tony Sriamporn, Sarah L Morley, Stephen Ritchie, Brooke M Hollingshead, Susan McAllister, Patricia Priest, Mark Fisher, Peter Saxton","doi":"10.1111/vox.70043","DOIUrl":"https://doi.org/10.1111/vox.70043","url":null,"abstract":"<p><strong>Background and objectives: </strong>As blood donor deferral policies in many countries transition from blanket time-based approaches towards individualized risk-based approaches, blood services need to understand whether and why men who have sex with men (MSM) intend to donate blood. Such knowledge can help blood services develop communication strategies with a population they have historically excluded. We examined why MSM in New Zealand (NZ) intended or not to donate blood.</p><p><strong>Materials and methods: </strong>In a large and diverse NZ online human immunodeficiency virus behavioural surveillance survey (n = 3838), we asked participants: 'In your own words, please tell us why you intend to or don't intend to donate blood in the future?' We interpreted 2363 responses by MSM using reflexive thematic analysis.</p><p><strong>Results: </strong>We constructed four themes to explain why MSM intend to donate blood: (1) helping out by donating blood, (2) donor ineligibility and hesitancy, (3) considerations of individual and collective risk and (4) discrimination, exclusion, frustration and resentment. Our study showed that whether or not MSM in NZ assessed blanket deferral policies as discriminatory, many MSM in NZ were altruistically and civically motivated to donate blood. Some MSM were reluctant to donate because they were resentful or mistrustful of the New Zealand Blood Service (NZBS) or believed that donating blood was inconsistent with their indigenous values.</p><p><strong>Conclusion: </strong>Further research is required to enhance communication, improve MSM's understanding of the donation process and residual risks and accommodate the cultural values of prospective indigenous donors.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord blood freezing bag breakage at transplant centres: Low breakage rate in Japan.","authors":"Jun Ooi, Seiko Kato, Takaaki Konuma","doi":"10.1111/vox.70045","DOIUrl":"https://doi.org/10.1111/vox.70045","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is surgical smoke a relevant contamination for salvaged autologous blood? A pilot study.","authors":"Andrea Stadlbauer, Patricia Fiedler, Simon Tuemmler, Michael Gruber, Christof Schmid, Timo F Seyfried","doi":"10.1111/vox.70040","DOIUrl":"https://doi.org/10.1111/vox.70040","url":null,"abstract":"<p><strong>Background and objectives: </strong>Electrocautery-related surgical smoke removed together with the intraoperative blood collection through suction devices might be a potential hazard. The degree of contamination of the autologous blood despite cell recovery and its possible harm to the patient remain subjects of research.</p><p><strong>Materials and methods: </strong>Two types of laboratory experiments and one clinical study were conducted. Initially, toluene was added to banked erythrocytes mixed with fresh frozen plasma. This reconstituted blood was processed using the autotransfusion device XTRA, and the elimination of toluene was calculated via gas chromatography (GC). In a second experiment, slices of pigskin were cut with electrocautery while dropping reconstituted blood onto the cauterization point. The resulting smoke and the blood were sucked into a cell salvage reservoir and washed with the XTRA. Samples from the reservoir and the product were analysed by GC. The average elimination rate was calculated. In a clinical study, blood samples were collected from the reservoir of the cell saver system during cardiac surgery and analysed likewise.</p><p><strong>Results: </strong>The autotransfusion device removed 92% of toluene from the processed blood. Other unidentified contaminants showed an elimination rate above 97.9%.</p><p><strong>Conclusion: </strong>Cell salvage devices significantly reduce the amount of contaminants in wound blood. Nevertheless, despite this highly effective detoxication, the remaining contaminants may still pose a potential risk to the patient.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of conventional tube technique with automated gel microcolumn assay for antenatal antibody monitoring.","authors":"Kati Sulin, Mikko Arvas, Suvi Toivonen, Katri Haimila, Jaana Mättö, Inna Sareneva, Riina Jernman, Anna Parhamaa, Susanna Sainio","doi":"10.1111/vox.70042","DOIUrl":"https://doi.org/10.1111/vox.70042","url":null,"abstract":"<p><strong>Background and objectives: </strong>Timely identification of pregnancies at risk of severe haemolytic disease of the fetus and newborn (HDFN) requires accurate and reproducible antibody titration. This study aimed to establish a critical titre for the gel microcolumn assay (GMA) corresponding to the critical titre of ≥16 for the conventional tube technique (CTT) and to evaluate GMA's suitability for routine antenatal antibody titration.</p><p><strong>Materials and methods: </strong>Altogether, 147 antenatal plasma samples with clinically significant antibodies were studied, including eight pregnancies requiring intrauterine transfusions (IUTs). Twofold serial dilution titres with CTT were made in parallel with automated GMA. Single-dose red blood cells were used with a concentration of 3.5% for CTT and 0.8% for GMA. The critical titre for GMA was compared with CTT as the gold standard.</p><p><strong>Results: </strong>GMA titres were on average 2.88 (95% confidence interval [CI]: 2.72-3.05) dilutions higher than CTT titres. At a CTT titre of 16, the sensitivity and specificity of GMA titration were maximum (94%, 95% CI: 81-99 and 92%, 95% CI: 85-96, respectively) at a titre of 128, but one of the eight fetuses (12.5%) requiring IUTs would have been missed. At a GMA titre of ≥64, sensitivity and specificity were 100% (95% CI: 100-100) and 77% (95% CI: 68-84) respectively, but the number of pregnancies requiring clinical monitoring more than doubled (2.5×).</p><p><strong>Conclusion: </strong>A GMA titre ≥64 could be considered a safe critical value for high-risk assessment. Despite being a fully automated method benefiting the screening laboratory, the additional workload and costs caused by unnecessary monitoring at delivery hospitals were unacceptable.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing healthcare equity through patient blood management: Useful insights from a lower middle-income state.","authors":"Axel Hofmann, Irwin Gross","doi":"10.1111/vox.70039","DOIUrl":"https://doi.org/10.1111/vox.70039","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How much furosemide should be administered to prevent transfusion-associated circulatory overload? Results of a dose-finding study.","authors":"Lianne Rotin, Liying Zhang, Chantal Armali, Amie Malkin, Sophia Massin, Harley Meirovich, Daniel Roque, Samia Saeed, Shangari Vijenthira, Yulia Lin, Jacob Pendergrast","doi":"10.1111/vox.70038","DOIUrl":"https://doi.org/10.1111/vox.70038","url":null,"abstract":"<p><strong>Background and objectives: </strong>Transfusion-associated circulatory overload (TACO) is a common and life-threatening transfusion complication. Because of uncertainty regarding dosing, pre-transfusion furosemide prophylaxis is not widely endorsed. The aim of this study was to generate a furosemide dose-response curve in TACO-susceptible patients using the multiple comparisons procedure and modelling (MCP-Mod) methodology.</p><p><strong>Materials and methods: </strong>Inpatients aged ≥50 years receiving intravenous (IV) furosemide were screened for eligibility at two academic hospitals. Exclusion criteria were active bleeding, haemodynamic instability, glomerular filtration rate (GFR) < 30 mL/min/1.73 m² and diuretic therapy administered within 24 h or albumin administered within 8 h. The primary outcome measure was 6-h urine output post furosemide administration. After incorporation of age, sex, chronic diuretic use, mean arterial pressure, GFR and serum albumin as covariates of diuretic response, MCP-Mod was applied after every 50th enrolment until a weight-adjusted dose-response curve was identified with 100 mL precision.</p><p><strong>Results: </strong>One-hundred forty-nine patients were enrolled. Urine output varied widely at each furosemide dose. Because of the presence of outliers and a paucity of patients receiving higher doses, only those receiving doses up to 0.6 mg/kg (n = 132) were included. After incorporating covariates, linear-log was identified as the best fitting model. Application of this formula revealed that, depending upon patient characteristics, 10-40 mg of furosemide IV would be required to achieve a diuresis volume of 400 mL, which is sufficient to offset 1 red blood cell unit.</p><p><strong>Conclusion: </strong>We report a novel furosemide dose-response model for TACO-susceptible patients. Once validated, this model will guide furosemide dosing for a planned controlled trial evaluating furosemide for TACO prevention.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic health records reveal variations in the use of blood units by hour and medical specialty.","authors":"Esa Turkulainen, Elissa Peltola, Markus Perola, Miika Koskinen, Mikko Arvas, Minna Ilmakunnas","doi":"10.1111/vox.70016","DOIUrl":"https://doi.org/10.1111/vox.70016","url":null,"abstract":"<p><strong>Background and objectives: </strong>Efficient blood supply chain requires accurate demand estimates. Blood demand is created by clinicians making transfusion decisions based on patient status. To better understand the use of blood units, we tracked their use hourly and across a large hospital organization.</p><p><strong>Materials and methods: </strong>We analysed blood use in adult patients over 2021-2022 at HUS Helsinki University Hospital, serving a population of 1.7 million and consuming a third of blood units used in Finland. We utilized electronic health records (EHR) to map transfusions to patient demographics, diagnoses, medical specialties, treatment events, surgical procedures and laboratory values. Data were matched to transfusions of red blood cells, platelets and plasma using timestamps and treatment episodes.</p><p><strong>Results: </strong>In total, 107,331 units were transfused to 19,637 unique patients in 50,978 transfusion episodes. Most transfusions occurred in emergency settings, with 61.5% of use driven by emergency department admissions. The most common diagnoses were malignant neoplasms, anaemia and cardiovascular diseases. In total, 47.9% of transfusions were associated with a surgical procedure. Of these, 72.9% were for urgent surgery. Blood use peaked in the early evening and was lowest during morning office hours.</p><p><strong>Conclusion: </strong>The study offers a comprehensive picture of blood use in one of the largest European hospital organizations. In addition to elective use, a significant portion of blood demand is driven by urgent and emergency needs, which introduce some uncertainty in predicting blood use. Future studies should aim to understand both elective and emergency blood use to help improve demand estimates.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}