Vox SanguinisPub Date : 2025-10-06DOI: 10.1111/vox.70127
Ethan Troy-Barnes, Li Shen, Sam Alimam
{"title":"Comment on McBride et al.'s 'Can medical students use artificial intelligence to learn transfusion? Evaluating ChatGPT responses to the American Society of Hematology medical student transfusion learning objectives'.","authors":"Ethan Troy-Barnes, Li Shen, Sam Alimam","doi":"10.1111/vox.70127","DOIUrl":"https://doi.org/10.1111/vox.70127","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-10-06DOI: 10.1111/vox.70126
Eileen McBride, Elaine Leung, Jason Ford
{"title":"Response to comments by Troy-Barnes et al. on 'Can medical students use artificial intelligence to learn transfusion? Evaluating ChatGPT responses to the American Society of Hematology medical student transfusion learning objectives'.","authors":"Eileen McBride, Elaine Leung, Jason Ford","doi":"10.1111/vox.70126","DOIUrl":"https://doi.org/10.1111/vox.70126","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond the human eye: Artificial intelligence revolutionizing plasma quality control.","authors":"Kriangsak Jenwitheesuk, Poonsup Sripara, Komsan Sayan, Wanut Padee, Anupong Tita, Ronnarit Boonyarat","doi":"10.1111/vox.70122","DOIUrl":"https://doi.org/10.1111/vox.70122","url":null,"abstract":"<p><strong>Background and objectives: </strong>Plasma quality control (QC) in transfusion medicine relies on subjective visual inspections, which vary depending on the technologist's experience and lighting conditions, potentially compromising safety. We developed an automated system to standardize the detection of plasma colour and turbidity abnormalities, and aimed to evaluate its accuracy and reliability in a transfusion setting.</p><p><strong>Materials and methods: </strong>At the Blood Transfusion Center, Khon Kaen University, Thailand, three experienced technologists classified 973 plasma bags. The system was trained on 789 bags (467 normal, 322 abnormal) and tested on 184 bags (145 normal, 39 abnormal) in Phase 1 and 486 bags (287 normal, 199 abnormal) in Phase 2. A sorting machine captured images under controlled lighting, and a deep learning model assessed the quality. Performance was measured using accuracy, sensitivity, specificity and precision, with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The system achieved 87.5% accuracy (95% CI: 82.7%-91.4%) in Phase 1 and 94.7% accuracy (95% CI: 92.3%-96.3%) in Phase 2, with 100% sensitivity (95% CI: 98.1%-100%) and 90.9% specificity (95% CI: 87.1%-93.7%) in Phase 2, ensuring no abnormal units were missed. Cross-validation on the training set yielded 94.8% accuracy.</p><p><strong>Conclusion: </strong>This automated QC system offers a reliable alternative to manual inspection, minimizing errors and reducing wastage (26 units vs. 29-86 with manual methods). Its high sensitivity and integration with a sorting machine support its potential to standardize plasma QC, enhancing patient safety and blood bank efficiency.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-09-24DOI: 10.1111/vox.70119
C Otín-Aparicio, N Alegre-Santos, C Cuellas-Roca, N Huguet-Otero, N Llurba-Cunillera, M Rubí-Cabrera
{"title":"Nursing staff satisfaction with the use of several transfusion safety systems at a university hospital.","authors":"C Otín-Aparicio, N Alegre-Santos, C Cuellas-Roca, N Huguet-Otero, N Llurba-Cunillera, M Rubí-Cabrera","doi":"10.1111/vox.70119","DOIUrl":"https://doi.org/10.1111/vox.70119","url":null,"abstract":"<p><strong>Background and objectives: </strong>At the Hospital Universitari Arnau de Vilanova Lleida, Spain, nursing staff utilize different transfusion safety systems (TSSs) depending on their clinical unit. These range from a basic model involving wristband-based patient identification to a more advanced system incorporating a Personal Digital Assistant (PDA), location beacon, physical barriers, specific wristbands and personal identification. This study aimed to compare nursing staff satisfaction across the various TSSs used.</p><p><strong>Materials and methods: </strong>In March 2025, nursing staff were invited to voluntarily and anonymously complete an online, self-designed questionnaire assessing their perceptions of the systems in use.</p><p><strong>Results: </strong>A total of 120 nurses participated, representing 15.6% of the total population. While overall satisfaction did not differ significantly by system type, 40.6% of respondents reported a negative perception. Users of the basic system felt less safe (65.4%) and considered it less effective at preventing errors (64.1%) than those using the complex system (87.2% and 92.8%, respectively). However, the complex system was associated with more frequent technical or usability issues (66.7%) compared with the basic system (34.6%), which contributed notably to dissatisfaction.</p><p><strong>Conclusion: </strong>Although specific factors influencing satisfaction were identified, no clear preference emerged regarding overall system satisfaction. The variability in responses may reflect the subjective nature of satisfaction. An optimal TSS would combine adaptability to staff needs, perceived safety, ease of use, intuitive visual cues, time efficiency and high reliability with minimal technical complications.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-09-23DOI: 10.1111/vox.70117
Tamar P Feldman, Mackenzie Brandon-Coatham, Jayme Kurach, Carly Olafson, Jason Acker, Michael Wellington, Bethany L Brown
{"title":"Assessing red blood cell product quality with 2,3-DPG, ATP and p50 assays: A BEST Collaborative study.","authors":"Tamar P Feldman, Mackenzie Brandon-Coatham, Jayme Kurach, Carly Olafson, Jason Acker, Michael Wellington, Bethany L Brown","doi":"10.1111/vox.70117","DOIUrl":"https://doi.org/10.1111/vox.70117","url":null,"abstract":"<p><p>To comply with regulatory guidelines, blood products undergo laboratory testing to assess red blood cell (RBC) quality during manufacturing, storage and delivery. Measurements of metabolites such as 2,3-diphosphoglycerate (2,3-DPG) have been relied upon as proxies for in vivo function, although their predictive value for clinical efficacy is not well substantiated. Following the discontinuation of the only validated commercial assay for 2,3-DPG, we reviewed existing literature and performed a retrospective analysis of datasets from two blood centres in North America to evaluate adenosine-5'-triphosphate (ATP) and p50 as alternatives. The literature did not provide sufficient evidence to support adopting p50 in place of 2,3-DPG. Although the assays are complementary, we found several exceptions in which biological and technical factors reduced the strength of correlation between 2,3-DPG and p50. ATP, another marker of RBC quality, was not well correlated either with 2,3-DPG or p50 in quality monitoring datasets or with in vivo circulation kinetics in healthy adults. Our assessment underscores the need for a replacement assay for 2,3-DPG for comprehensive characterization of novel red cell products and storage conditions.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on Ngoma et al. 'Restless legs syndrome among blood donors: A systematic review and meta-analysis'.","authors":"Nosaibah Razaqi, Rachana Mehta, Shubham Kumar, Ranjana Sah","doi":"10.1111/vox.70111","DOIUrl":"https://doi.org/10.1111/vox.70111","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-09-22DOI: 10.1111/vox.70109
Alain M Ngoma, Paulin B Mutombo, Mahmoud Mosli, Magot D Omokoko, Kenneth E Nollet, Hitoshi Ohto
{"title":"Reply to commentary on 'Restless legs syndrome among blood donors: A systematic review and meta-analysis'.","authors":"Alain M Ngoma, Paulin B Mutombo, Mahmoud Mosli, Magot D Omokoko, Kenneth E Nollet, Hitoshi Ohto","doi":"10.1111/vox.70109","DOIUrl":"https://doi.org/10.1111/vox.70109","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-09-14DOI: 10.1111/vox.70115
Jenny Erica Beckman, Niubel Díaz Padilla, Afke van der Woud, Peter van den Burg, Vĕra Novotny
{"title":"Perceptions of deferred blood donors regarding false-positive screening results for infectious diseases and European blood establishment strategies.","authors":"Jenny Erica Beckman, Niubel Díaz Padilla, Afke van der Woud, Peter van den Burg, Vĕra Novotny","doi":"10.1111/vox.70115","DOIUrl":"https://doi.org/10.1111/vox.70115","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study explores the perceptions of deferred blood donors in the Netherlands regarding the information provided upon receiving false-positive screening (FPS) deferral letters for infectious diseases. To ensure blood supply safety, rigorous screening for infectious agents is implemented by blood establishments. However, FPS results can create challenges after donor notification, leading to psychological distress.</p><p><strong>Materials and methods: </strong>The study purposively selected whole-blood donors who had received deferral letters due to two FPS results between April and October 2023. Semi-structured interviews, guided by the Health Belief Model (HBM), examined health behaviours through seven constructs. Additionally, a survey of European Blood Alliance (EBA) members was conducted to gather insights on FPS management practices. Interview transcripts were coded and modelled to illustrate relationships between the themes.</p><p><strong>Results: </strong>Ten in-depth interviews were held, revealing varied responses: some donors felt reassured by safety protocols, while the majority experienced psychological distress. Key themes included emotional reactions, contact methods, follow-up communication, engagement with Sanquin Blood Supply and altruistic motivations. The EBA survey shows varied FPS notification practices, rejection protocols, limited donor reaction studies and diverse support measures.</p><p><strong>Conclusion: </strong>Improving communication clarity, providing follow-up procedures and adopting best practices from EBA members can enhance donor experience. These efforts are essential for refining the deferral process and improving donor perceptions, ultimately benefiting the donor and the blood supply system.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vox SanguinisPub Date : 2025-09-10DOI: 10.1111/vox.70107
Helen Ryan, Mark Lambert, Sorcha Ní Loingsigh, Richard Hagan, Diarmaid O'Donghaile
{"title":"Evaluation of 6 years of fetal RHD screening in Ireland: From implementation to practice.","authors":"Helen Ryan, Mark Lambert, Sorcha Ní Loingsigh, Richard Hagan, Diarmaid O'Donghaile","doi":"10.1111/vox.70107","DOIUrl":"https://doi.org/10.1111/vox.70107","url":null,"abstract":"<p><strong>Background and objectives: </strong>The discovery of circulating fetal DNA in maternal plasma enabled non-invasive prenatal testing (NIPT) for targeted anti-D prophylaxis. In 2019, Ireland implemented an in-house test to guide this care. Here, we report 6 years of service.</p><p><strong>Materials and methods: </strong>Cell-free fetal DNA (cffDNA) was extracted from 1000-μL plasma from pregnant RhD negative women at gestation age (GA) > 11 weeks. Samples were tested in triplicate for RHD by quantitative PCR using a multiplex assay of RHD exons 7 and 10.</p><p><strong>Results: </strong>Of the 20,099 samples tested, 58.2% were predicted RhD positive and 36.9% were predicted RhD negative. Discrepancies were seen in 52 cases: 7 (0.03%) were predicted RhD negative but cord RhD positive and 45 (0.2%) were predicted RhD positive but cord RhD negative.</p><p><strong>Conclusion: </strong>This test has ensured that over 7400 women have avoided unnecessary anti-D prophylaxis. There were few discrepant results, with false negatives posing a greater clinical risk due to withheld anti-D, increasing immunization risk. Three were linked to pre-analytical errors prompting procedural changes. Due to the success of fetal RHD screening, cord blood testing has been discontinued in some countries; a practice which could be reviewed in Ireland.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}