Vox Sanguinis最新文献

{"title":"Comparative analysis of serological reactivity in genetically confirmed Rh variants within a recipient population.","authors":"Maïlis Lauwers, Philippe Akiki, Samy Bensaid, Saad Bakrim, Mélanie Monfort, Hanane El Kenz","doi":"10.1111/vox.70285","DOIUrl":"https://doi.org/10.1111/vox.70285","url":null,"abstract":"<p><strong>Background and objectives: </strong>Detecting Rh variants in transfusion recipients is essential to prevent alloimmunization. This study compared the serological reactivity of various monoclonal antibodies using two techniques (gel column agglutination and microplate technology at room temperature) in relation to genetically confirmed Rh variants.</p><p><strong>Materials and methods: </strong>Over an 18-month period, all EDTA blood samples referred to the molecular laboratory were analysed. RHD and RHCE genotyping was performed, and samples carrying at least one variant allele underwent serological testing. Statistical analysis was performed using the McNemar test (p < 0.05).</p><p><strong>Results: </strong>Among 610 samples, 118 (19%) carried at least one Rh variant. The most frequent alleles were RHCE*CeRN (n = 39) and RHD*weak D type 1 (n = 14). Weak RhD (types 1 and 3) and partial RhD from RHD*DAR were serologically weakened (<4+) with both methods. Homozygosity for RHCE*CeRN was suggested by serological weakening of RH5 with both methods, whereas heterozygosity was indicated by serological weakening of RH2 with microplate only. Other variants with a few samples (RH1 of RHD*weak D type 2 and 5, RH2 of RHD*RHD-CE (4-7)-D, RH3 of RHCE*cEIV, RH4 of RHCE*ceJAL and RH5 of RHCE*ceMO.01 and RHCE*ceAR) showed weak serological intensities but lacked statistical confirmation. Finally, 39% of Rh variants were not detected as serologically weakened by both serological methods.</p><p><strong>Conclusion: </strong>Phenotyping remains the first-line screening tool. Weak serological intensities help guide molecular investigations. However, detection of Rh variants using serology alone is highly variable. Combining different clones and techniques improves sensitivity.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing candidate blood donors' deferral, retention and blood safety in Tanzania: A prospective cross-sectional study.","authors":"Jorien Laermans, Michiel Jennes, Hans Scheers, Nathalie Bergs, Ambre Parisse, Sigrid De Lepeleire, Florine Fisette, Emmy De Buck","doi":"10.1111/vox.70286","DOIUrl":"https://doi.org/10.1111/vox.70286","url":null,"abstract":"<p><strong>Background and objectives: </strong>Several Tanzanian regions fall short of annual whole blood donation targets. Understanding what motivates first-time and repeat donors, and whether certain recruitment and retention strategies may affect blood safety, is essential to improving retention and ensuring a safe blood supply. This study aimed to identify variables associated with pre-donation deferral, donor retention and transfusion-transmitted infection (TTI) prevalence in Tanzanian (candidate) blood donors.</p><p><strong>Materials and methods: </strong>Between February and April 2023, 1471 (candidate) donors were surveyed at 43 mobile blood collections across 5 Tanzanian regions to collect data on socio-demographics, motivations, incentives received after donation and recruitment methods used. Multivariable logistic regression modelling was performed on a dataset of 675 participants to identify predictors of pre-donation deferral, retention and TTI rates.</p><p><strong>Results: </strong>Pre-donation deferral was more likely among females, first-time donors, those recruited via multiple methods and those attending collections at public places (all p < 0.05). Donor retention was positively associated with increasing age, having received an incentive and donating at Nyarugusu refugee camp (all p < 0.05). Donors mainly motivated by receiving test results had significantly higher TTI rates than those wanting to save lives. TTI rates were lower in those donating at schools/universities and Nyarugusu compared to public places.</p><p><strong>Conclusion: </strong>This study revealed multiple important predictors of pre-donation deferral, retention and TTI rates in Tanzanian (candidate) blood donors. Further research is needed to identify the most effective donor recruitment and retention strategies and to assess the value of targeting specific populations for a more stable blood supply in Tanzania.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the cryopreservation period on the CD34+ cell viability of cryopreserved cord blood units.","authors":"Hye Ryun Lee, Eun Youn Roh, Namhee Kim, Hyunwoong Park, Jong Hyun Yoon, Sue Shin","doi":"10.1111/vox.70281","DOIUrl":"https://doi.org/10.1111/vox.70281","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cord blood (CB) is an important source for haematopoietic stem cell transplantation because of its long-term cryopreservation. However, concerns remain regarding the potential decline in CB quality with prolonged cryopreservation. This study aimed to evaluate the post-thaw viability of CD45+ and CD34+ cells in CB units and to investigate how their viabilities change over prolonged cryopreservation.</p><p><strong>Materials and methods: </strong>We enrolled 726 CB units that underwent pre-transplantation examination from May 2006 through June 2023. Post-thaw viabilities of CD45+ and CD34+ cells were analysed in relation to cryopreservation period and across 4-year cryopreservation groups.</p><p><strong>Results: </strong>The mean post-thaw viabilities were 60.5% for CD45+ cells and 91.2% for CD34+ cells. CD45+ cell viability showed a positive correlation with the cryopreservation period (r = 0.304, p < 0.001); however, no consistent trend was observed among the cryopreservation period groups. In contrast, CD34+ cell viability showed a significant negative correlation with the cryopreservation period (r = - 0.306, p <0.001) and decreased, with units cryopreserved for 1-4 years and 5-8 years having significantly higher viabilities than those cryopreserved for 9-12 years and 13-16 years.</p><p><strong>Conclusion: </strong>Our findings demonstrate that the post-thaw viabilities of CD45+ and CD34+ cells in cryopreserved CB units exceed internationally accepted standards, with CD34+ cell viability showing a tendency to decline with prolonged cryopreservation. These results underscore the importance of securing an adequate CD34+ cell dose at the time of cryopreservation to maintain the long-term quality and clinical utility of CB units.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of D variants in Brazilian blood donors and their association with RhCE and Duffy phenotypes.","authors":"Thamy C S Silva, Marcia R Dezan, Sidneia Costa, Beatriz C Girardo, Bruno R Cruz, Karen Ziza, Dante M Langhi, José O Bordin, Lilian Castilho, Carla L Dinardo","doi":"10.1111/vox.70283","DOIUrl":"https://doi.org/10.1111/vox.70283","url":null,"abstract":"<p><strong>Background and objectives: </strong>Serological classification of RhD-negative and weak D is often insufficient in admixed populations, where diverse RHD variants have clinical implications. In Brazil's highly admixed population, RhD interpretation and donor-recipient matching are particularly challenging. We used Duffy phenotyping to support ancestry inference and contextualize Rh variants. Understanding RHD alleles and their associations with RhCE and Duffy is essential for transfusion safety. Here, we characterize RHD variants in Brazilian donors and relate them to RhCE and Duffy phenotypes across regions.</p><p><strong>Materials and methods: </strong>We analysed 321 blood donor samples with either weak D expression (n = 295) or a D-negative phenotype with C and/or E antigen positivity (n = 26). RhD, RhCE and Duffy phenotyping was performed, followed by RHD, RHCE and FY genotyping using multiplex polymerase chain reaction with sequence-specific primers (PCR, PCR-SSP) and real-time PCR. Samples unresolved by targeted assays underwent sequencing.</p><p><strong>Results: </strong>Among weak D donors, 88% carried known RHD variants, with weak D types 1, 2 and 3 accounting for 67% of cases. Partial D alleles such as DAR, DAU4 and weak partial 11 were identified, particularly among donors with Fy(a-b-) and Fy(a+b-) phenotypes, often associated with RHCE*733G. In the D-negative group, 50% of samples harboured non-functional or hybrid RHD alleles, including RHD*03N.01/RHD*08N.01 and RHD*08N.01/RHD*01N.01, linked to the r's haplotype and RHCE*ceS allele.</p><p><strong>Conclusion: </strong>This study reveals the wide spectrum of RHD variants in an admixed population and underscores the importance of integrating molecular genotyping and phenotype associations to improve transfusion safety and guide Rh immunoprophylaxis.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between NT-proBNP and false-positive Coombs test in patients with heart failure and elevated NT-proBNP.","authors":"Ana Lamilla Álvarez, María Asunción Cámara Rodenas, Sofía Russo Botero, Pau Aracil Boigues, Cristina Játiva Sáez, Elena Vidal Rico, Elena Santos Cañamares, Alma Rangel Algaba, Sebastian Ortiz-Zuluaga, Josefa Esperanza Marco Buades, Lorenzo Fácila Rubio, José Pérez-Silvestre, María de la Encarnación López-Pavía","doi":"10.1111/vox.70284","DOIUrl":"https://doi.org/10.1111/vox.70284","url":null,"abstract":"<p><strong>Background and objectives: </strong>The human antiglobulin test or Coombs' test is a key tool in the diagnosis and classification of haemolytic anaemia and could present as falsely positive. A retrospective study has described that B-type natriuretic peptide (NT-proBNP), a biomarker used for heart failure (HF), could be an additional cause of false positives in the Coombs test.</p><p><strong>Materials and methods: </strong>A prospective, observational, single-centre study was conducted in adult patients diagnosed with HF between October 2024 and March 2025 at a tertiary hospital. The Coombs' test was considered as false positive in cases in which the specificity of the test included immunoglobulin G (IgG), the subsequent elution yielded a negative result, and blood haemolysis parameters were within normal ranges.</p><p><strong>Results: </strong>Thirty-six patients were included, of whom nine (25%) had a false-positive Coombs test. These patients had significantly higher levels of NT-proBNP (10,825 pg/mL [2587-35,000] vs. 3314 pg/mL [278-11,856], p = 0.0076) and lower glomerular filtration rate (35.3 mL/min/1.73 m² [23.6-46.3] vs. 63.3 mL/min/1.73 m² [21.9-90.0], p = 0.0055) compared to patients with a negative Coombs test. No statistically significant associations were found with drugs used concomitantly for HF.</p><p><strong>Conclusion: </strong>The results suggest that elevated NT-proBNP could also be a cause of false positives in the Coombs test.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An automatic consult reply system for therapeutic plasma exchange using retrieval-augmented generation.","authors":"Jong Kwon Lee, Sooin Choi, Sholhui Park, Qute Choi, Sang-Hyun Hwang, Duck Cho","doi":"10.1111/vox.70280","DOIUrl":"https://doi.org/10.1111/vox.70280","url":null,"abstract":"<p><strong>Background and objectives: </strong>Large language models (LLMs) show promise for clinical decision support but remain vulnerable to factual errors. Retrieval-augmented generation (RAG) mitigates this limitation by grounding outputs in authoritative domain knowledge. Therapeutic plasma exchange (TPE) requires consistent, guideline-driven decisions based on the 2023 American Society for Apheresis (ASFA) recommendations. This study aimed to evaluate whether an RAG-based framework could improve accuracy, reliability and standardization of decision support for TPE, compared to conventional LLMs.</p><p><strong>Materials and methods: </strong>We built a hybrid RAG pipeline combining BAAI/bge-base-en-v1.5 embeddings with Chroma and BM25, coupled with structured prompts that encode ASFA categories and grades, Health Insurance Review and Assessment (HIRA) service criteria, and plasma volume computation rules. Thirty de-identified real-world consultation cases were converted into standardized queries. Across six RAG and three non-RAG generative pre-trained transformer (GPT)-series model configurations, each case was answered five times (1,350 outputs). Performance was assessed by item-level accuracy for six elements (diagnosis, ASFA category, grade, insurance applicability, plasma volume, and replacement fluid) and reproducibility on 14 disease-name prompts. Response time and output length were also analyzed.</p><p><strong>Results: </strong>RAG configurations consistently outperformed non-RAG baselines across items, with the largest gains in plasma-volume calculation and ASFA classification. Reproducibility was markedly higher with RAG across repeated runs. Among all configurations, RAG GPT-4.1-mini showed the most balanced and superior performance, delivering high accuracy with low latency.</p><p><strong>Conclusion: </strong>A guideline-grounded RAG approach substantially enhances the accuracy, stability and standardization of TPE consultation compared with conventional LLMs. This RAG-TPE framework demonstrates the feasibility of reliable, clinically oriented decision support in transfusion medicine, warranting further evaluation in prospective clinical workflows.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staff satisfaction with the use of bedside electronic transfusion checks at three hospitals in London.","authors":"Florence Oyekan, Montasir Ahmed, Catherine Booth, Louise Bowles, Ollie Djurdjevic, Yan Feng, Kirsty Hancock, Suzanne Makki, Helinor McAleese, Josephine McCullagh, Khin Mon, Michael F Murphy, Simon J Stanworth, Nathan Proudlove, Laura Green","doi":"10.1111/vox.70282","DOIUrl":"https://doi.org/10.1111/vox.70282","url":null,"abstract":"<p><strong>Background and objectives: </strong>Bedside transfusion errors, especially positive patient identification (PPID), are a risk to patient safety. Bedside electronic transfusion checks (BETC), using barcode-enabled personal digital assistants (PDAs), are recommended to improve safety and efficiency. This study assessed staff satisfaction with BETC versus manual transfusion checks in three large London hospitals. The surveys aimed to compare clinical staff satisfaction with BETC versus the manual system.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was conducted immediately after training and 6 months after routine BETC use. The initial (21 questions) and follow-up (15 questions) surveys assessed usability, accuracy, workflow efficiency and patient care impact. Responses were collected via Microsoft Forms and analysed using descriptive statistics and logistic regression, adjusting for job role, experience and hospitals.</p><p><strong>Results: </strong>A total of 2085 staff completed the initial survey (55% response) and 514 the follow-up (13%), predominantly nurses (75%). For group and screen (G&S) labelling, ratings of 'ease of use' and 'accuracy' improved significantly between surveys, while perceived impact on reducing mislabelling remained consistently high (96.2% vs. 94.7%). Compared with manual checks, BETC was rated significantly by clinicians for ease of use (89% → 94%) and accuracy (89% → 95%; both p < 0.001). Improvements were also observed for the time saved by clinical staff (75% → 89%), patient care (77% → 89%), fewer nurses required (79% → 91%) and traceability (80% → 87%), all statistically significant (p < 0.001).</p><p><strong>Conclusion: </strong>BETC was associated with significantly greater clinical staff satisfaction than manual transfusion checks, providing large-scale evidence for their adoption to enhance transfusion safety, efficiency and staff experience.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet transfusion efficacy in pregnant women with thrombocytopenia: A retrospective study.","authors":"Shaoheng Chen, Huimin Deng, Xiao Wang, Lan Hu, Meiting Li, Huiying Qiu, Ming Yan, Yanlin Du, Yuanshan Lu, Zhicheng Wang, Rong Xia","doi":"10.1111/vox.70196","DOIUrl":"https://doi.org/10.1111/vox.70196","url":null,"abstract":"<p><strong>Background and objectives: </strong>Platelet transfusion plays an irreplaceable role in the treatment of thrombocytopenia during pregnancy. We examined the effect of prophylactic platelet transfusions in the prenatal period through retrospective analysis of 106 women with 192 platelet transfusions between 2016 and 2023.</p><p><strong>Study design and methods: </strong>Univariate and multivariable analyses determined the independent risk factors for suboptimal platelet concentrate (PC) transfusion response (corrected count increment [CCI] <7 at 18-24 h after platelet transfusion) and platelet transfusion refractoriness (PTR) (at least two consecutive ABO-matched PC transfusions with a CCI < 7).</p><p><strong>Results: </strong>Suboptimal platelet transfusion response occurred in 117 of the 192 (60.9%) transfusion episodes, which was independently associated with previous allogeneic PC transfusion and severe thrombocytopenia (<50 × 10⁹/L); 55.4% of transfusion episodes with suboptimal response were found in those women with previous allogeneic PC transfusion and severe thrombocytopenia. In addition, 25 of the 106 (23.6%) women developed PTR, which was independently associated with advanced maternal age (>35 years), previous PC transfusion, low gestational age (<37 weeks), severe thrombocytopenia and immune thrombocytopenia (ITP). Furthermore, women with PTR had longer hospital stays, a greater rate of intensive care unit (ICU) transfer and a slower platelet recovery until 42 days postpartum.</p><p><strong>Conclusion: </strong>Prophylactic platelet transfusions are often associated with poor efficacy in pregnant women with thrombocytopenia. The findings will contribute to further research on the potential mechanism of PTR to optimize transfusion practices.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life, death and rapid diagnostic tests in the world's blood deserts.","authors":"Avery A Thompson, Samir C Seshadri, Cindy Makanga, Riya Sawhney, Edward Mutebi, Nick Mogaka, Tecla Chelagat, Linda S Barnes, Nakul Raykar","doi":"10.1111/vox.70279","DOIUrl":"https://doi.org/10.1111/vox.70279","url":null,"abstract":"<p><strong>Background and objectives: </strong>Millions of people globally reside in 'blood deserts', where systemic barriers prevent timely access to safe blood components. Lodwar County Referral Hospital (LCRH) in Turkana County, Kenya, is a district hospital lacking on-site testing capacity for transfusion-transmissible infection (TTI) screening, resulting in critical transfusion delays. We present three cases in which validated rapid diagnostic tests (RDTs) could have facilitated point-of-care donor screening and transfusion in life-threatening situations.</p><p><strong>Patients and methods: </strong>We present three cases of critically ill patients-two teenagers and an elderly woman-who presented to LCRH over the course of a single week.</p><p><strong>Results: </strong>Each patient required emergent transfusions but experienced fatal delays along various points in the transfusion continuum due to the inability to rapidly screen available donor or banked blood for TTIs.</p><p><strong>Conclusion: </strong>These cases illustrate how delays in TTI screening can directly contribute to preventable mortality, even when blood is otherwise available. They highlight the urgent need for standardized, contextually appropriate emergency transfusion protocols that formally incorporate RDT use. Our experience suggests that such protocols may reduce transfusion delays, improve access to lifesaving blood and serve as a scalable model for improving blood access in rural and remote 'blood deserts' around the world.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional survey of the barriers and enablers to preventing iatrogenic anaemia in inpatients with haematological malignancies: The CONSERVE study.","authors":"Courtney Black, Nicole C Gavin, Theodora Ogle, Samantha Keogh","doi":"10.1111/vox.70270","DOIUrl":"https://doi.org/10.1111/vox.70270","url":null,"abstract":"<p><strong>Background and objectives: </strong>Patients with haematological malignancies are at high risk of anaemia due to disease and treatment factors, making patient blood management (PBM) strategies critical. We aimed to identify the barriers and enablers to implementing the principles of PBM to conserve patients' own blood and reduce the risk of iatrogenic anaemia in inpatients receiving treatment for haematological malignancies.</p><p><strong>Materials and methods: </strong>A cross-sectional study of inpatient clinicians was conducted using a survey. Acute care clinicians (nursing and medical) from two wards that treat haematological malignancies at one hospital were invited to complete an online survey between December 2024 and January 2025. The 31 questions (answered on a 5-point Likert scale) were designed to assess awareness, enablers and barriers related to PBM. The survey was conceptually aligned to the 14 domains of the Theoretical Domains Framework and the six domains of the Capability, Opportunity, Motivation-Behaviour Model. Responses were condensed into barrier, neutral and enabler categories, and proportions were calculated.</p><p><strong>Results: </strong>The questionnaire was completed by 80 participants (52% response rate), 82% being nurses. Barriers were found in five domains, namely reinforcement, knowledge, behavioural regulation, training and goals. Enablers were found in 10 domains: beliefs about consequences, intentions, role and identity, emotion, skills, environment, social influence, beliefs about capabilities, memory and equipment.</p><p><strong>Conclusion: </strong>This study highlights the barriers and enablers to implementing PBM strategies into inpatient haematology practice. Future implementation studies should address these enablers to assist in overcoming the barriers of implementing PBM strategies in this vulnerable patient cohort.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}