Vox Sanguinis最新文献

{"title":"Comparative evaluation of six large language models in transfusion medicine: Addressing language and domain-specific challenges.","authors":"Jong Kwon Lee, Sholhui Park, Sang-Hyun Hwang, Jaejoon Lee, Duck Cho, Sooin Choi","doi":"10.1111/vox.70050","DOIUrl":"https://doi.org/10.1111/vox.70050","url":null,"abstract":"<p><strong>Background and objectives: </strong>Large language models (LLMs) such as GPT-4 are increasingly utilized in clinical and educational settings; however, their validity in subspecialized domains like transfusion medicine remains insufficiently characterized. This study assessed the performance of six LLMs on transfusion-related questions from Korean national licensing examinations for medical doctors (MDs) and medical technologists (MTs).</p><p><strong>Materials and methods: </strong>A total of 23 MD and 67 MT questions (2020-2023) were extracted from publicly available sources. All items were originally written in Korean and subsequently translated into English to evaluate cross-linguistic performance. Each model received standardized multiple-choice prompts (five options), and correctness was determined by explicit answer selection. Accuracy was calculated as the proportion of correct responses, with 0.75 designated as the performance threshold. Chi-square tests were employed to analyse language-based differences.</p><p><strong>Results: </strong>GPT-4 and GPT-4o consistently surpassed the 0.75 threshold across both languages and examination types. GPT-3.5 demonstrated reasonable accuracy in English but showed a marked decline in Korean, suggesting limitations in multilingual generalization. Gemini 1.5 outperformed Gemini 1, particularly in Korean, though both exhibited variability across technical subdomains. Clova X showed inconsistent results across settings. All models demonstrated limited performance in legal and ethical scenarios.</p><p><strong>Conclusion: </strong>GPT-4 and GPT-4o exhibited robust and reliable performance across a range of transfusion medicine topics. Nonetheless, inter-model and inter-language variability highlights the need for targeted fine-tuning, particularly in the context of local regulatory and ethical frameworks, to support safe and context-appropriate implementation in clinical practice.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic high-dose granulocyte transfusions following allogeneic haematopoietic stem cell transplantation.","authors":"Yannis Hadjiyannis, Robert Bubar, Darrell J Triulzi, Joseph Kiss, Christopher C Marino, Randy M Windreich, Paul Szabolcs, Alesia Kaplan","doi":"10.1111/vox.70044","DOIUrl":"https://doi.org/10.1111/vox.70044","url":null,"abstract":"<p><strong>Background and objectives: </strong>Prophylactic granulocyte transfusions (PGTxs) are controversial. Previous studies faced numerous confounders such as achieving an adequate dose. Pre-emptive or secondary PGTx for persistent, severe pre-transplant infections has rarely been reported for patients undergoing haematopoietic stem cell transplantation (HSCT). Here, we reviewed the feasibility, safety and implementation of high-dose PGTx in high-risk patients undergoing HSCT with a history of persistent, recurrent infections.</p><p><strong>Materials and methods: </strong>We conducted a retrospective review (2018-2021) for all HSCT patients who received high-dose PGTx from donors stimulated with granulocyte colony-stimulating factor and dexamethasone at our tertiary medical centre. PGTx was carried out as secondary prophylaxis to prevent infection recurrence/progression.</p><p><strong>Results: </strong>Seven patients received PGTx during HSCT; 95% of all transfused products contained a dose ≥0.6 × 10⁹/kg. Post-transfusion absolute neutrophil count (ANC) showed an average increase of 5.5 ± 3.7 × 10⁹/L. All PGTxs were well tolerated, with no evident transfusion reactions, adverse effects or human leukocyte antigen alloimmunization. A high overall survival rate (100% at day 30), afebrile rate (85%) and absence of infections were noted.</p><p><strong>Conclusion: </strong>Optimized high-dose PGTx resulted in a measurable ANC increase and was well tolerated. Although efficacy and safety remain to be established, we highlight the ability to produce and implement optimized high-dose PGTx for high-risk patients undergoing HSCT.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses.","authors":"Xiao-Yin Zhang, Michael Murphy, Graham P Collins, Vernon J Louw, Gamuchirai Y Tadzimirwa, Satyam Arora, Nita Radhakrishnan, Carlos Gonzalez, Ryan A Metcalf, Erica Swenson, Maria A Nuñez, Edgardo Saa, Arwa Z Al-Riyami, Ali Tabatabaey, Yulia Lin, Aditya Tedjaseputra, Erica M Wood, Alexandra Pedraza, Cristina Sanz, Corentin Streel, Véronique Deneys, Amalia G Bravo, Karla Maldonado, Luiz Amorim, Thais Ferraz, Yoshihiko Tani, Naoko Goto, Fanny Delettre, Pierre Tiberghien, Jaap Jan Zwaginga, Theodora Foukaneli, Paul Kerr, Samclide Mbikayi Mutindu, Alphonse Mosolo Nganzele, Richard Schäfer, Nancy Dunbar","doi":"10.1111/vox.70014","DOIUrl":"10.1111/vox.70014","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"525-539"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study.","authors":"Nchafatso G Obonyo, Declan P Sela, Nicole White, Matthew Tunbridge, Beatrice Sim, Reema H Rachakonda, Louise E See Hoe, Gianluigi Li Bassi, Jonathon P Fanning, John-Paul Tung, Jacky Y Suen, John F Fraser","doi":"10.1111/vox.70007","DOIUrl":"10.1111/vox.70007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Randomized controlled trials have demonstrated morbidity and mortality in critically ill patients are unaffected by transfusing fresh (<7 days old) packed red blood cells (pRBCs); however, there is limited evidence regarding transfusion with pRBCs nearing expiry (35-42 days). The aim of this study was to investigate the effects of transfusing pRBCs close to the end of shelf life (≥35 days) on clinical outcomes in critically ill patients.</p><p><strong>Materials and methods: </strong>A retrospective observational analysis of data obtained from centralized electronic medical records (2007-2013), sourced from all public and licensed private hospitals in Queensland, Australia, with intensive care units. Multivariate logistic and linear regressions were used to analyse association between transfusion with pRBCs nearing expiry, and in-hospital mortality, hospital length of stay (HLOS) and rate of discharge home. Comparisons are presented as odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The study included 10,350 critically ill adult patients transfused ≥1 unit of non-irradiated pRBCs (64,594 pRBCs units transfused). Receiving at least 1-unit pRBCs ≥ 35 days old was associated with increased mortality (OR 1.21 [95% CI 1.06-1.38]; p = 0.005), decreased discharge to usual residence (OR 0.81 [95% CI 0.73-0.89]; p < 0.0001) and increased hospital LOS (estimate 2.55 [95% CI 1.60-3.49]; p < 0.0001). There was also association with increased sepsis (OR 1.27 [95% CI 1.13-1.42]; p < 0.0001) and delirium (OR 1.25 [95% CI 1.06-1.49]; p = 0.01).</p><p><strong>Conclusion: </strong>Transfusion of ≥1-unit pRBCs ≥ 35 days old was associated with higher morbidity and mortality in critically ill patients.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"481-489"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homozygosity for a novel A4GALT allele resulting in the rare p phenotype in an Indian blood donor.","authors":"Louise A Tilley, Vanja Karamatic Crew, Amy Tearle, Suvro Sankha Datta, Nicole M Thornton","doi":"10.1111/vox.70000","DOIUrl":"10.1111/vox.70000","url":null,"abstract":"<p><strong>Background and objectives: </strong>Individuals with the rare p phenotype have red cells lacking P, P1 and P^k antigens and make clinically significant anti-PP1P^k. The phenotype arises from inactivating mutations in A4GALT, which encodes the enzyme responsible for production of P1 and P^k. We present results from serological and molecular investigations of a case of anti-PP1P^k with a novel molecular background of the p phenotype.</p><p><strong>Materials and methods: </strong>Samples from a 32-year-old Indian blood donor were investigated due to the presence of a pan-reactive alloantibody, together with samples from his sister and mother. Standard serological investigations and A4GALT sequencing were performed.</p><p><strong>Results: </strong>The donor was found to have p phenotype, and his plasma contained anti-PP1P^k. Sequencing revealed a rare homozygous missense mutation in A4GALT (c.526G>A; p.Asp176Asn; rs371893172; frequency 0.00007), representing a novel null allele. The sister was heterozygous for this allele, while surprisingly the mother did not carry the allele. Enquiries revealed the mother was not the donor's biological mother, explaining the perceived discrepant sequencing results.</p><p><strong>Conclusion: </strong>We have identified homozygosity for a novel A4GALT null allele (carrying c.526G>A, p.Asp176Asn), resulting in lack of functional 4-α-galactosyltransferase and a p phenotype, adding to the catalogue of known genetic backgrounds of this rare phenotype.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"509-512"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary determination of bacterial contamination of whole blood units in a Ghanaian blood bank: Providing evidence to improve transfusion safety.","authors":"Nana Benyin Aidoo, Sandra Ramirez-Arcos, Laurie Gillard, Daniel Edem Azumah, Angela Adatsi","doi":"10.1111/vox.13806","DOIUrl":"10.1111/vox.13806","url":null,"abstract":"<p><strong>Background and objectives: </strong>Transfusion-associated bacterial sepsis poses a significant risk to patient safety. This study aimed to determine the rate of bacterial contamination of whole blood (WB) collected at the Cape Coast Teaching Hospital (CCTH) as a quality control and quality assurance activity.</p><p><strong>Materials and methods: </strong>One-hundred and three WB units collected between January and April of 2018 were screened for bacterial contamination. Bacteria isolated from positive cultures were identified and subjected to antimicrobial testing. WB recipients were followed up for clinical symptoms.</p><p><strong>Results: </strong>Of the 103 WB units tested, 33 (32%) were contaminated with bacteria. Gram-positive organisms accounted for 67% of the isolates, including coagulase-negative Staphylococcus, Staphylococcus aureus and Bacillus spp., while Gram-negative bacteria comprised 33% of the isolates, with Citrobacter freundii, Serratia marcescens, Escherichia coli and Providencia stuartii being identified. Resistance to antibiotics varied between species. No septic transfusion events were reported involving WB units tested in this study.</p><p><strong>Conclusion: </strong>The high percentage of contaminated WB units collected at the CCTH provided evidence-based data for the implementation of improved donor skin disinfection processes and the use of blood diversion pouches in 2019. These approaches allowed CCTH to comply with Ghanaian regulatory entities.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"503-508"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing syphilis cases in Japan: A risk posed to blood services.","authors":"H Suzuki, N H Tsuno, K Kitsukawa, T Miyagi, K Sakamoto, K Matsubayashi, M Satake, K Muroi","doi":"10.1111/vox.70005","DOIUrl":"10.1111/vox.70005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Syphilis cases surged in Japan, exceeding 10,000 in 2022, primarily through heterosexual transmission. The Japanese Red Cross Blood Services (JRCBS) screens donated blood for syphilis, disqualifying positive donors. This study explores syphilis infection among blood donors to understand its impact on blood collection and supply.</p><p><strong>Materials and methods: </strong>Data from blood donors (2015-2022) at JRCBS were analysed. Treponema pallidum (TP) antibody was tested by chemiluminescent enzyme immunoassay or chemiluminescent immunoassay. A total of 39,199,047 donations were scrutinized. Reactive samples were further tested by rapid plasma reagin (RPR).</p><p><strong>Results: </strong>The number of TP and RPR positives (referred as syphilis positives) in 2022 compared with 2015 increased by 1.7 times in blood donors and 4.9 times in the general population. High syphilis-positive rate in 2022 was mainly observed among male first-time/reactivated donors and females in their 20s and 30s. Although syphilis cases in general population declined during the Corona pandemic, no significant decrease occurred in syphilis-positive donors.</p><p><strong>Conclusion: </strong>Although the increase in syphilis positives among blood donors may be a reflection of the increase in the general population, the rate of increase was less pronounced among blood donors. Although the increase in the syphilis-positive rate may not affect blood product safety, it would have a significant impact on the number of potential blood donors in the future because the increase was more frequently observed in young donors and new donors, and currently, syphilis-positive individuals are permanently deferred from blood donation. The implementation of effective measures to prevent transmission in the general population is required.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"473-480"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding community perspectives for advancing inclusion of trans and gender-diverse people in blood donation in Australia.","authors":"Rachel Thorpe, Kyle Jensen, Barbara Masser, Peter Bentley, Tarin Dryden, Eleanor Forrest, Andy Kaladelfos, Travis Larcombe, Tanya Pastor, Aaron Saint-James, Shauna Wilson, Bridget Haire","doi":"10.1111/vox.70001","DOIUrl":"10.1111/vox.70001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Trans and gender-diverse people who wish to donate blood face significant barriers with policies and procedures differing across countries. It remains critical to explore the experiences and perspectives of trans and gender-diverse people in different locations to understand challenges in local systems. We undertook a qualitative study focussed on procedures and processes affecting trans and gender-diverse people in Australia, and their views about needed change.</p><p><strong>Materials and methods: </strong>Stakeholders collaborated with the researchers to refine the focus of and design the research. Semi-structured interviews were conducted with 14 trans and gender-diverse people who were current, past or potential donors. The interviews comprised open-ended questions about donation experiences, knowledge of current policies and procedures and preferences for change. Interviews were analysed using thematic analysis.</p><p><strong>Results: </strong>Participants reported varied and inconsistent donation experiences. When compared with current practice, participants preferred a two-step approach to donor registration that asks for sex reported at birth followed by gender identity. However, they also expressed concern that the two-step approach could deter new donors and stressed the importance of only collecting information relevant to eligibility assessment. Participants were supportive of a gender-neutral approach to assess eligibility to donate.</p><p><strong>Conclusion: </strong>Our study highlights significant barriers and procedural inconsistencies for trans and gender-diverse individuals when (considering) donating blood. We recommend more inclusive practices including clear communication about data use, rigorous staff training on gender diversity, registration processes that respect all gender identities and adopting a gender-neutral approach to donor screening.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"447-454"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza and COVID-19 vaccination in Canadian blood donors: A comparison across pre- and post-pandemic periods.","authors":"Sheila F O'Brien, Lori Osmond, Mindy Goldman, Steven J Drews","doi":"10.1111/vox.70006","DOIUrl":"10.1111/vox.70006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Seasonal vaccinations reduce donor illness and appointment cancellations and ensure plasma products have antibodies to vaccine-directed strains. We aimed to describe donor influenza and COVID-19 vaccination history and compare this with the general population.</p><p><strong>Materials and methods: </strong>Two online donor surveys were carried out in 2021 and 2024. Donors were asked about demographics, influenza (2019/2020, 2020/2021 and 2023/2024 seasons) and COVID-19 (ever and 2023/2024 season) vaccination and reasons for vaccination choices. General population vaccination statistics were extracted from public reports. Percentages of donors receiving vaccination were calculated with 95% confidence intervals. Multiple logistic regression models were fitted with demographics as independent variables.</p><p><strong>Results: </strong>In survey 1, 4582 (30.4% response rate) donors completed a questionnaire; in survey 2, 6376 (21% response rate). More donors under age 65 received the influenza vaccine compared with the general population under age 65 (58% vs. 30% in 2019/2020, 63% vs. 28% in 2023/2024, p < 0.0001) and aged 65+ (81% vs. 70% in 2019/2020, 90% vs. 73% in 2023/2024, p < 0.0001). Fewer donors and the general population received the COVID-19 vaccine in 2023/2024 (under 65 45% vs. 39%; 65+ 76% vs. 67%, p < 0.0001). Most said they were vaccinated to prevent infection and protect others.</p><p><strong>Conclusion: </strong>Seasonal vaccination rates are higher in older donors, consistent with public health recommendations. Blood donors are more likely to be vaccinated against seasonal influenza than the general population, but post-pandemic uptake of the COVID-19 booster vaccine was low, more similar to the general population.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"464-472"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of communication interventions for promoting blood donation in low- and middle-income countries: A systematic review.","authors":"Bernard Appiah, Lucy Asamoah-Akuoko, Md Koushik Ahmed, Tara Tancred, Yvonne Dei-Adomakoh, Gursimar Singh, Cavan Reilly, Edeghonghon Olayemi, Meghan Delaney, Christopher R France, Amma Benneh-Akwasi Kuma, Alfred Edwin Yawson, Susan Telke, Michelle Asiedu-Danso, Emmanuel Nene Dei, Philip Adongo, Imelda Bates","doi":"10.1111/vox.13799","DOIUrl":"10.1111/vox.13799","url":null,"abstract":"<p><strong>Background and objectives: </strong>In low- and middle-income countries (LMICs), information on the efficacy of communication interventions promoting blood donation is very scarce. The present review aimed to identify specific communication interventions and their efficacy for increasing blood donation in LMICs.</p><p><strong>Materials and methods: </strong>The databases searched were PubMed, Scopus, PsycINFO, Web of Science, CINAHL, ProQuest, AJOL and CAB Abstracts. Grey literature sources included the websites of African Society of Blood Transfusion, International Society of Blood Transfusion and World Health Organization. The outcomes of interest were donation attempt or actual blood donations.</p><p><strong>Results: </strong>A total of 16 studies including nine randomized controlled trials (RCTs) were included in the review. The communication interventions included social media and mass media, such as radio and television, as platforms for promoting blood donation, and newspaper articles or advertisements as an incentive for donor recruitment. Mobile text messages were used either alone or in combination with phone calls, and other interventions such as meetings and brochures. Only three of the 16 studies specifically targeted behavioural science theories, and none of the 16 studies used any implementation science framework. For some communication interventions, there was evidence of statistically significant increases in donations, but the quality of the studies was weak.</p><p><strong>Conclusion: </strong>The efficacy of communication interventions for promoting blood donations in LMICs remains limited due to few rigorous studies. More rigorous, theory-based studies on the use of communication interventions to increase blood donation in LMICs, especially in sub-Saharan Africa where no prior RCT were identified, are needed.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"432-446"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}