Vox Sanguinis最新文献

{"title":"Risk of vasovagal reactions among trans versus cisgender whole blood donors.","authors":"Antoine Lewin, Catherine Thibeault, Jessyka Deschênes, Yves Grégoire, Christian Renaud","doi":"10.1111/vox.70348","DOIUrl":"https://doi.org/10.1111/vox.70348","url":null,"abstract":"<p><strong>Background and objectives: </strong>Trans blood donors may be at higher risk of vasovagal reactions (VVRs) if their estimated blood volume is calculated without considering their sex assigned at birth. Yet no studies have addressed this research question. We assessed the rates of VVRs among trans and cisgender blood donors.</p><p><strong>Materials and methods: </strong>This was a cross-sectional study of whole blood donors in Québec, Canada (11 August 2016-25 August 2021). Trans donors were identified if they self-reported their gender transition or following an interview triggered by affirmative answers to questions on recent physician consultations and medication use. The odds of VVR were modelled using logistic regression analyses, adjusting for donor age and status.</p><p><strong>Results: </strong>Overall, 377,980 donors were included and made 1,799,509 donations: 29 were trans men (mean age ± standard deviation [SD] = 28.6 ± 9.1), 173,464 were cisgender men (mean age ± SD = 42.5 ± 16.2), 13 were trans women (mean age ± SD = 33.7 ± 9.7) and 204,474 were cisgender women (mean age ± SD = 38.7 ± 15.4). There was no statistically significant difference in the odds of VVR (any severity) between trans and cisgender men (odds ratio [OR] [95% confidence interval, CI] = 1.71 [0.88-3.32]) or between trans and cisgender women (OR [95% CI] = 1.33 [0.40-4.40]).</p><p><strong>Conclusion: </strong>In this study, the risk of VVR was similar among trans and cisgender blood donors.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why donors intend to return: Motivation, satisfaction and post-donation intention in a high-demand tertiary hospital setting in Lagos, Nigeria.","authors":"Obiageli B Okwunze, Ademola S Adewoyin, Olufemi A Oyedeji, Chika L Uche, Titilayo F Adeleke, Ayoola M Bakare, Debora Onyedikachi Ohanete, Ann A Ogbenna","doi":"10.1111/vox.70345","DOIUrl":"https://doi.org/10.1111/vox.70345","url":null,"abstract":"<p><strong>Background and objectives: </strong>Maintaining safe and adequate blood supply in low- and middle-income countries requires understanding factors influencing donor return intentions. Nigeria faces chronic blood shortages, yet evidence on determinants of return intention among blood donors in tertiary hospitals remains limited. This study assessed donor motivation, satisfaction and intention to return among blood donors at Lagos University Teaching Hospital (LUTH) and identified factors independently associated with post-donation intention.</p><p><strong>Materials and methods: </strong>A descriptive cross-sectional study was conducted among 1589 consecutive donors using a structured interviewer-administered questionnaire adapted from validated instruments. Motivation, satisfaction and intention to return were measured using Likert-scale items. Participants retrospectively reported pre-donation intention and current post-donation intention immediately after donation. Descriptive statistics, chi-square tests, McNemar's test, subgroup analyses and binary logistic regression were performed.</p><p><strong>Results: </strong>Most donors were family-replacement (70.5%) and male (91.8%), with a mean age of 30.9 years. Motivation was high (84%), driven primarily by altruism, personal choice and perceived health benefits. Satisfaction was also high (mean 4.59 ± 0.64). Intention to return increased significantly after donation (56.1%-64.2%, p < 0.001). Motivation (odds ratio [OR] = 7.32, p < 0.001) and pre-donation intention (OR = 0.014, p < 0.001) were independently associated with post-donation intention, whereas satisfaction was not significant after adjustment. Family replacement and voluntary non-remunerated donors differed significantly in motivation, satisfaction and post-donation intention.</p><p><strong>Conclusion: </strong>Blood donors at LUTH demonstrated high motivation and satisfaction. Donation experience strengthened intention to return. Differences between donor types highlight the need for donor-specific retention strategies in replacement-dominated blood systems.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in drone-based blood delivery: Comparing implementation in Rwanda and Canada.","authors":"Amaya Najma Razmi, Riya Sawhney, Pedro Kremer, Jacob Pendergrast, Juan Carlos Puyana, Meghan Delaney, Caroline Wesonga, Nakul P Raykar","doi":"10.1111/vox.70346","DOIUrl":"10.1111/vox.70346","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensated iron depletion in repeated blood donations: Stability of circulating microRNAs despite reduced ferritin stores.","authors":"Aziz Karaca, Şenol Çitli, Medeni Arpa, Kübra Sönmez","doi":"10.1111/vox.70344","DOIUrl":"https://doi.org/10.1111/vox.70344","url":null,"abstract":"<p><strong>Background and objectives: </strong>Repeated blood donations deplete 200-250 mg of iron per donation. While biochemical consequences on iron stores are well documented, the role of circulating microRNAs (miRNAs) in maintaining iron homeostasis remains poorly characterized. This study investigated whether repeated blood donation alters iron metabolism-related miRNA expression.</p><p><strong>Materials and methods: </strong>A cross-sectional study compared 42 male participants: 21 repeat donors (donating three to four times annually; mean total donations: 15) and 21 first-time donors. Plasma iron metabolism markers (ferritin, hepcidin, ferroportin, transferrin, soluble transferrin receptor 1 [sTfR1], soluble transferrin receptor 2 [sTfR2], unsaturated iron-binding capacity [UIBC]) were quantified using enzyme-linked immunosorbent assay (ELISA) and chemiluminescence methods. Expression of 13 miRNAs was analysed by quantitative reverse transcriptase polymerase chain reaction, normalized to U6 and quantified using the 2^-ΔΔCt method.</p><p><strong>Results: </strong>Repeat donors exhibited significantly lower ferritin (median: 26.8 vs. 72.2 ng/mL; p < 0.001), elevated red cell distribution width coefficient of variation (RDW-CV) (13.86% vs. 13.07%; p < 0.001) and reduced mean corpuscular haemoglobin concentration (MCHC) (33.80 vs. 34.23 g/dL; p = 0.009) while maintaining normal haemoglobin. No significant differences were observed in any miRNA after multiple-testing correction. However, miR-130a showed a marginal decrease (fold change: 0.389; p = 0.0564; Cohen's d = 0.514), while miR-200b and miR-485-3p demonstrated non-significant upward trends. Correlation analysis revealed distinct patterns between groups in iron regulatory protein relationships.</p><p><strong>Conclusion: </strong>Repeated blood donations demonstrate 'compensated iron depletion'. No significant differences were detected in the 13 selected iron-homeostasis-related miRNAs after multiple-testing correction. Within the limits of this small, male-only study evaluating a single miRNA panel, these findings indicate no detectable alteration, while underscoring the importance of ferritin monitoring; broader molecular pathways were not assessed, and given the limited statistical power, a Type II error cannot be excluded.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping syphilis surveillance: Insights into blood donation screening practices worldwide.","authors":"Michel-Andrés García-Otálora, Guillermo Orjuela-Falla, Carl P McDonald, Sandra Ramirez-Arcos","doi":"10.1111/vox.70335","DOIUrl":"https://doi.org/10.1111/vox.70335","url":null,"abstract":"<p><strong>Background and objectives: </strong>Syphilis is caused by the bacterial spirochete Treponema pallidum and can be transmitted through blood transfusion. However, there have been less than 10 documented transfusion-transmitted cases since World War II. Global data comparing population-level syphilis trends with blood donor reactivity and screening practices are limited. This study aimed to compare syphilis screening practices worldwide and to explore the value of universal donor screening.</p><p><strong>Materials and methods: </strong>A cross-sectional international survey was conducted among blood transfusion professionals. Participants reported data collected between 2018 and 2024 on syphilis prevalence, blood donor screening algorithms and reactivity rates, deferral policies and blood safety interventions. Descriptive analyses were performed by year and geographic region.</p><p><strong>Results: </strong>Thirty-nine participants from 26 countries across five continents answered the survey. Universal donor screening was reported by 35 of 36 institutions providing policy data, with treponemal assays representing the predominant screening approach. Substantial variation was observed in confirmatory testing, donor deferral criteria and donor re-entry policies. Reactivity rates varied markedly across centres and were higher among first-time donors compared to repeat donors. Institutions with higher syphilis rates generally reported higher donor reactivity. Routine leukoreduction was reported by 66.7% of institutions, while pathogen reduction technologies were routinely used by 36.1%. Most centres apply indefinite donor deferral and have not considered removing screening.</p><p><strong>Conclusion: </strong>Syphilis screening and donor management practices vary across blood services worldwide despite widespread implementation of universal screening. Local epidemiology, testing strategies and donor eligibility policies contribute to observed differences in donor reactivity and surveillance practices.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming thalassaemia care in India through virtual capacity building: Evolution of a national training initiative using extension for community healthcare outcomes model.","authors":"Sandeep Bhalla, Nita Radhakrishnan, Paromita Das, Mamta Manglani, Arpan Mitra, Shweta Sharma, Apoorva Karan Rai","doi":"10.1111/vox.70343","DOIUrl":"https://doi.org/10.1111/vox.70343","url":null,"abstract":"<p><strong>Background and objectives: </strong>India has one of the world's highest burdens of thalassaemia, with 10,000-15,000 births annually and a carrier prevalence of 3%-4%. Services for prevention and comprehensive care remain fragmented, especially in rural regions. To address gaps in provider knowledge and practice, Extension for Community Healthcare Outcomes (ECHO) India, in collaboration with the Post Graduate Institute of Child Health and state partners, launched a virtual tele-mentoring programme in Maharashtra, Madhya Pradesh and West Bengal.</p><p><strong>Materials and methods: </strong>We conducted a mixed-methods evaluation using a convergent parallel design. Data included pre- and post-training knowledge assessments, post-session feedback surveys and hub reflection meetings. A logical model and Moore's framework guided outcome assessment across participation, satisfaction, knowledge, competence and reported changes in practice.</p><p><strong>Results: </strong>Following a national training-of-trainers workshop in April 2023, state hubs were established and peer-reviewed modules developed. From October 2023 to March 2025, 73 ECHO sessions were conducted across the three state hubs, with curricula tailored to different participant groups (eight modules for medical officers and six for paediatricians). Paediatricians showed a mean knowledge gain of 15.8% (p < 0.001) and medical officers 11.4% (p = 0.001). Over 70% rated sessions highly relevant, and over 90% intended to apply learning. Reported behaviour changes included improved interpretation of complete blood counts, more systematic referral and promotion of antenatal screening.</p><p><strong>Conclusion: </strong>This first multicentre evaluation demonstrates that ECHO tele-mentoring strengthens thalassaemia care in India, improving provider competence and catalysing systemic and policy-level change. The model is scalable for integration into primary health systems across low- and middle-income countries.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public perspectives on potential changes to malaria deferral criteria in Canada.","authors":"Courtney Joshua, Carmen Charlton, Joelle Kasongo, Biba Tinga, Jennie Haw","doi":"10.1111/vox.70338","DOIUrl":"https://doi.org/10.1111/vox.70338","url":null,"abstract":"<p><strong>Background and objectives: </strong>As blood collection agencies (BCAs) seek to increase donor diversity, making changes to eligibility criteria to enable more people to donate is an important consideration. BCAs in Canada have a permanent deferral from whole blood and platelet donation for anyone with a history of malaria, a barrier to donation for many in African, Caribbean and Black (ACB) communities. If a malaria nucleic acid test (NAT) is implemented in donor screening, malaria-related deferral criteria could be eased. This study explored the public's views on potential changes to malaria deferral criteria.</p><p><strong>Materials and methods: </strong>A mixed-methods community-based study was conducted in Canada. This paper reports results from the qualitative component (n = 26). Topics explored in semi-structured interviews included experiences with donation, awareness and knowledge of deferral criteria, cognitive interview questions and potential responses to receiving a positive test result for malaria.</p><p><strong>Results: </strong>Participants understood blood donor screening processes as a shared responsibility of both BCAs and donors for ensuring blood safety. Participants had a literal interpretation of donor screening questions assessed, and most would feel comfortable answering the questions in a blood donation context. If malaria NAT is implemented and they were to receive a positive test result, participants shared they would respond with concern, fear and uncertainty.</p><p><strong>Conclusion: </strong>If BCAs work to implement a malaria NAT and ease deferral criteria, this must be communicated clearly and effectively to the public and donors, with particular focus on communities impacted. BCAs should work with community partners to communicate these changes.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary non-remunerated plasma collection in Denmark: Experiences from the Central Denmark Region.","authors":"Kathrine Agergård Kaspersen, Lotte Hindhede, Sabina Christensen, Cecilie Munck Bjerre, Anne Louise Pørtner, Louise Ørnskov Drechsler, Christina Mikkelsen, Erik Sørensen, Ole Birger Pedersen, Sisse Rye Ostrowski, Betina Samuelsen Sørensen, Bitten Aagaard, Mie Topholm Bruun, Bjarne Kuno Møller, Christian Erikstrup","doi":"10.1111/vox.70339","DOIUrl":"https://doi.org/10.1111/vox.70339","url":null,"abstract":"<p><strong>Background and objectives: </strong>In Denmark, increasing demand for plasma-derived medicinal products has made plasma self-sufficiency based on voluntary, non-remunerated donation a political priority. This report describes recent developments in plasma collection, with a focus on the Central Denmark Region.</p><p><strong>Materials and methods: </strong>Plasma capacity was expanded progressively over time through dedicated units, increased staffing and donor-focused initiatives in the Central Denmark Region, particularly in 2024. National and regional donation trends were described for 2016-2025. Donor characteristics and donation frequency were summarized for the Central Denmark Region. Plasma self-sufficiency was calculated assuming an immunoglobulin yield of 5 g/kg plasma.</p><p><strong>Results: </strong>From 2016 to 2025, national plasma donations increased by 167% reaching 161,438 donations in 2025, corresponding to 65% self-sufficiency. In the same period, plasma donations in the Central Denmark Region increased more than threefold to 41,268 corresponding to 70% self-sufficiency.</p><p><strong>Conclusion: </strong>Plasma collection can be substantially expanded within a voluntary, non-remunerated system. In the Central Denmark Region, dedicated infrastructure and targeted recruitment and retention were associated with a more than threefold increase in donations and 70% self-sufficiency, achieved through a single plasma centre in a region with 1.4 million inhabitants. The opening of four additional small facilities (November 2025-April 2026) supports projected full self-sufficiency within 1-2 years.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'Beyond universal mitigation: Risk-stratified approaches for preventing vasovagal reactions in blood donors'.","authors":"Radheshyam Meher, Gopal Patidar","doi":"10.1111/vox.70342","DOIUrl":"https://doi.org/10.1111/vox.70342","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo recovery and in vitro quality assessment of apheresis red blood cells stored for 42 days in non-DEHP disposable sets.","authors":"Bethany L Brown, Samatha E Mack, Emily Mason, Michael Wellington, Neeta Rugg, Susanne Marschner, Christina Gloor, Rebecca L Sedjo, Nero Evero, Joseph Rice, Jeremiah Gorman, Jack P Rhodes, Richard Cook, Caroline Alquist","doi":"10.1111/vox.70289","DOIUrl":"10.1111/vox.70289","url":null,"abstract":"<p><strong>Background and objectives: </strong>Di(2-ethylhexyl) phthalate (DEHP) has been used in blood bag manufacturing for decades, but concern about its potential toxicity has prompted regulatory efforts to eliminate it from medical devices, including blood bags. As manufacturers transition to non-DEHP materials, evaluation is required to ensure blood component quality in modified bag systems. Investigational Trima Accel disposables were developed using plasticizers approved as DEHP alternatives per the European Pharmacopoeia. Red blood cells (RBCs) were collected, and two consecutive studies evaluated in vitro quality and in vivo RBC recovery.</p><p><strong>Study design and methods: </strong>Leukoreduced RBCs (LR-RBCs) were stored in Additive Solution 3 (AS-3) at 2-6°C for 42 days. In vitro quality parameters measured on days 0, 35 and/or 42 were assessed against US Food and Drug Administration (FDA) and European Directorate for the Quality of Medicines & HealthCare (EDQM) acceptance criteria. A radiolabelling study evaluated in vivo 24-h RBC recovery using the FDA criteria.</p><p><strong>Results: </strong>Key FDA criteria were met, including haemolysis, which remained below the acceptable limit throughout 42 days of storage. All EDQM criteria were met except Day 0 haematocrit, with 8 units outside the specified range and the confidence interval (CI) lower bound at 77.6%. All FDA criteria for in vivo 24-h RBC recovery were met.</p><p><strong>Conclusion: </strong>Apheresis LR-RBCs collected with Trima Accel systems using non-DEHP disposables and stored for 42 days met key FDA and EDQM criteria, with any in vitro parameter failures considered artefactual. Products also met FDA's 24-h in vivo RBC recovery criteria, supporting their use as acceptable transfusable products.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"1173-1180"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13453911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}