Vox Sanguinis最新文献

{"title":"Role of instant messaging applications in Indian blood banking.","authors":"Satyam Arora, Kriti Batni, Seema Dua, Anupa Pokhrel","doi":"10.1111/vox.70010","DOIUrl":"10.1111/vox.70010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Instant messaging applications (IMAs) have revolutionized the means of communication. Like various disciplines in medicine, transfusion medicine and blood banking have also utilized these applications for connecting with donors for recruitment, routine blood centre work and clinical consulting. We aim to study the pattern of usage of IMAs by the Indian blood bank community.</p><p><strong>Materials and methods: </strong>This was a descriptive cross-sectional survey (27 questions) of doctors and technicians working in the blood centres. The target was to collect at least 100 responses from blood bank staff. The survey was open from 28 March 2024 to 28 May 2024.</p><p><strong>Results: </strong>One hundred and thirty-nine out of 575 individuals dealing with blood banking responded to the survey (24% response rate). The responders were mainly doctors (85.6%), young professionals (<40 years; 53.2%) and males (53.9%). WhatsApp® on smartphones seems to be one of the most preferred ways (~95% responders) of IMAs among the Indian blood bank community. IMAs were mainly used to communicate with the blood centre staff (83%) as well as clinical counter colleagues (68.5%). More than 50% of our responders were members of more than five chat groups dealing with blood bank. IMAs were also used to disseminate knowledge, such as sharing recent guidelines (81%) and research articles (69%).</p><p><strong>Conclusion: </strong>Our study demonstrates that the blood bank community has embraced the internet-based IMA (mainly WhatsApp) and uses it mainly on their mobile devices.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"630-634"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma exchange in Susac syndrome: Unlocking treatment for a rare disease.","authors":"Yamac Akgun","doi":"10.1111/vox.70017","DOIUrl":"10.1111/vox.70017","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"557-559"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of change in transfusion practice, population mix and fertility on red blood cell alloantibody prevalence.","authors":"Krishna G Badami, Sarah Hull, Charlotte Vanhecke","doi":"10.1111/vox.70022","DOIUrl":"10.1111/vox.70022","url":null,"abstract":"<p><strong>Background and objectives: </strong>Factors affecting red blood cell (RBC) alloimmunization have changed in New Zealand (NZ). We aimed to investigate whether alloimmunization prevalence had changed as a result.</p><p><strong>Materials and methods: </strong>We calculated the prevalence (%) of patients with RBC alloantibodies among those who had antibody screening/identification done in Canterbury, NZ, during three periods: 2006-2010 (P1), 2012-2016 (P2) and 2018-2022 (P3).</p><p><strong>Results: </strong>During P1, P2 and P3, respectively, females and males numbered 58,817, 30,082; 48,775, 28,383 and 56,200, 31,443. Combining the periods, the overall alloantibody prevalence in females and males was 2.4 versus 0.9, p < 0.0001, and in those ≥60 and ≤40 years, it was 1.9 versus 1.5, p < 0.0001. Prevalence declined, especially after P2. Prevalence of the five most common alloantibodies during P1, P2 and P3, respectively, was as follows: anti-E, 0.39, 0.48, 0.37; anti-D, 0.38, 0.34, 0.27; anti-K, 0.34, 0.32, 0.22; anti-Fya, 0.18, 0.19, 0.14; anti-C, 0.17, 0.16, 0.12; all alloantibodies, 2.0, 2.1, 1.5. p-values by the chi-squared test comparing prevalence (P1 vs. P2, P1 vs. P3, P2 vs. P3, respectively) were anti-E, 0.005, 0.5, 0.0006; anti-D, 0.2, <0.0001, 0.001; anti-K, 0.5, <0.0001, 0.0001; anti-Fya, 0.6, 0.04, 0.01; anti-C, 0.6, 0.006, 0.03; all alloantibodies, 0.1, <0.0001, <0.0001.</p><p><strong>Conclusion: </strong>RBC alloantibody prevalence has declined. The chief reasons for this appear to be changes in transfusion management, NZ population mix and fertility. The decline is beneficial.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"615-624"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of CD177 (human neutrophil antigen 2) polymorphisms using nanopore sequencing.","authors":"Kirstine Kløve-Mogensen, Thure Mors Haunstrup, Anne-Louise Fjordside Bilde, Rudi Steffensen","doi":"10.1111/vox.70020","DOIUrl":"10.1111/vox.70020","url":null,"abstract":"<p><strong>Background and objectives: </strong>Human neutrophil antigen 2 (HNA-2), encoded by the CD177 gene, is considered one of the most important neutrophil antigens in human medicine, but molecular testing of CD177 is complicated and therefore not a standard procedure for investigating CD177 expression. CD177 expression can vary from 0% to 100%, and to date, the molecular basis for altered or non-expressed genes has not been determined. Reliance on phenotyping and crossmatching to investigate these neutropenic clinical cases is inconvenient for patients and demands substantial resources within the laboratory. The purpose of this study was therefore to test a new molecular testing approach based on long-read nanopore sequencing.</p><p><strong>Materials and methods: </strong>DNA from 44 Danish blood donors with different levels of CD177 expression, 22 of whom were found to be CD177 null, was selected as test samples. All the DNA was sequenced for the first eight exons and the beginning of exon 9 of CD177.</p><p><strong>Results: </strong>All incidences of CD177 null cases could be associated with the known variant c.787A>T;p.K263X (rs20182172), and a correlation was observed between c.787A>T heterozygosity and a reduced expression of CD177, which is consistent with previously published findings. The c.1291G>A;p.G431R (rs78718189) variant was found to be linked to the atypical expression of CD177. The nanopore assay revealed a total of 14 variants in 7 exons in the 44 tested samples.</p><p><strong>Conclusion: </strong>On the basis of these observations, we conclude that long-read nanopore sequencing can be a reliable tool for the routine laboratory molecular testing of CD177.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"605-614"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of deferrals for variant Creutzfeldt-Jakob disease risk: Impact on new and previously deferred donors.","authors":"Mindy Goldman, David McKee, Shane Smith, Sheila F O'Brien","doi":"10.1111/vox.70021","DOIUrl":"10.1111/vox.70021","url":null,"abstract":"<p><strong>Background and objectives: </strong>Concern over variant Creutzfeldt-Jakob disease (vCJD) led to the deferral of donors who had resided in the United Kingdom since January 1980. This deferral was implemented in 1999 and subsequently modified to include other countries. Some deferrals were removed in February 2022; deferrals for the United Kingdom, Ireland and France were removed on 22 November 2023. In this study, we describe efforts made to encourage donation from newly eligible people and the resulting donation gain.</p><p><strong>Materials and methods: </strong>Actions targeted individual donors deferred after 1 January 2012. Marketing included website, social media and general advertising. Staff asked first-time donors if the criteria change had motivated their donation. Deferred and returning donor data were determined from our donor database.</p><p><strong>Results: </strong>In the 12 months post-implementation, 12.8% of first-time donors surveyed were newly eligible (n = 8667) and 7.8% of vCJD risk deferred donors returned (n = 5159). Eighty-five percent of deferrals occurred pre-2017; the return rate was 6.5% in this group. The highest return rate (24%) occurred in donors deferred after 2020.</p><p><strong>Conclusion: </strong>Removal of the vCJD deferrals had a major positive impact. The greatest gain was in new donors who had previously self-deferred. Despite intensive efforts, only one-quarter of recently deferred donors returned.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"635-638"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing iron depletion in regular platelet apheresis donors: A comparison of reticulocyte haemoglobin and serum ferritin.","authors":"Parintorn Nakdee, Thanatphak Warindpong, Sutasinee Virat, Parichart Permpikul, Janejira Kittivorapart","doi":"10.1111/vox.70023","DOIUrl":"10.1111/vox.70023","url":null,"abstract":"<p><strong>Background and objectives: </strong>Frequent platelet apheresis donations can lead to iron depletion. Serum ferritin is traditionally measured to assess iron status in donors. Reticulocyte haemoglobin (RET-He) has emerged as a rapid, convenient and cost-effective alternative. This study aimed to determine the prevalence of iron depletion among regular platelet apheresis donors and to evaluate the sensitivity and specificity of RET-He compared to serum ferritin in diagnosing iron depletion.</p><p><strong>Materials and methods: </strong>This cross-sectional study involved 100 healthy, regular platelet apheresis donors aged 18-60 years who donated at least once a month. RET-He, serum ferritin and complete blood count results were analysed. The sensitivity and specificity of RET-He were calculated against serum ferritin.</p><p><strong>Results: </strong>Of the 100 donors, 13.00% (13 out of 100 donors) had serum ferritin levels <15 ng/mL, indicating iron depletion. RET-He showed a sensitivity of 76.92% (95% confidence interval [95% CI]: 46.19%-94.96%) and specificity of 44.83% (95% CI: 34.15%-55.87%) in detecting iron depletion. Significant differences in RET-He levels, donation frequency, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell count and red cell distribution width were detected between the iron-depleted and non-iron-depleted groups (p = 0.045, 0.032, 0.053, 0.026, 0.069 and 0.027, respectively).</p><p><strong>Conclusion: </strong>Frequent platelet donations increase the risk of iron depletion; therefore, iron supplementation is recommended for regular donors. While RET-He testing is convenient, cost effective and fast, it cannot replace serum ferritin testing because of insufficient sensitivity and specificity.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"560-565"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators of and barriers to blood donation among voluntary non-remunerated blood donors in sub-Saharan Africa: A scoping review.","authors":"Austrida Gondwe, Effie Chipeta, Mina C Hosseinipour, Bridon Mbaya, Adamson S Muula, Victor Mwapasa, Patani Mhango, Princess Kaira, Tiyamike Nthani, Sydney Puerto-Meredith, Natasha Nsamala, Emmanuel Singogo","doi":"10.1111/vox.70013","DOIUrl":"10.1111/vox.70013","url":null,"abstract":"<p><strong>Background and objectives: </strong>In many countries, including Africa, the widespread gap between national blood requirements and actual blood supplies contributes to unnecessary deaths. This scoping review explores common facilitators and barriers to blood donation in sub-Saharan Africa (SSA) and strategies that are used to increase and maintain repeat blood donation.</p><p><strong>Materials and methods: </strong>We conducted a scoping review of facilitators and barriers to blood donation in SSA. We searched PubMed, Ovid MEDLINE, Ovid EMBASE and COCHRANE to identify relevant papers. Of the 2225 articles screened by title, abstract and papers published after 2010, 37 were included in the final full-text screening. Article quality for inclusion was assessed on the basis of a predefined eligibility and inclusion checklist. We analysed all papers that reported barriers and facilitators to blood donation in Africa.</p><p><strong>Results: </strong>The review included 11 studies. The common facilitators for blood donation reported were altruism, the opportunity for disease testing, friendly recruitment strategies and future easy access to blood at hospitals when needed. We identified the following barriers: lack of knowledge, awareness of blood donation and place of donation, fear, ineffective incentives, bad service experiences and religious and cultural beliefs.</p><p><strong>Conclusion: </strong>Findings of this review can be used to propose better strategies for improving blood donation in SSA. Strategies that encourage blood donation can be leveraged and implemented, while those that discourage blood donation can be adapted to better achieve an adequate supply.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"546-556"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing healthcare equity through patient blood management: Useful insights from a lower middle-income state.","authors":"Axel Hofmann, Irwin Gross","doi":"10.1111/vox.70039","DOIUrl":"10.1111/vox.70039","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"544-545"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet transfusion stated practices among neonatal and paediatric veno-arterial extracorporeal membrane oxygenation providers: A survey.","authors":"Trupti Ingle, Brian Simms, Jesse Bain, Melania M Bembea, Jill M Cholette, Madhuradhar Chegondi, Eva Cheung, Robert Niebler, Caroline Ozment, Matthew Paden, Ofer Schiller, Marianne E Nellis, Oliver Karam","doi":"10.1111/vox.70018","DOIUrl":"10.1111/vox.70018","url":null,"abstract":"<p><strong>Background and objectives: </strong>Extracorporeal membrane oxygenation (ECMO) provides cardiopulmonary support to over 4000 neonates and children annually worldwide. Although potentially lifesaving, ECMO carries bleeding and thromboembolic risks, often managed with platelet transfusions to maintain specific thresholds. Platelet transfusions themselves carry many risks. This survey aimed to describe stated prophylactic platelet transfusion practices among paediatric veno-arterial (VA)-ECMO providers and identify factors influencing transfusion decisions.</p><p><strong>Materials and methods: </strong>This is a cross-sectional electronic survey of paediatric ECMO providers from 10 centres evaluating platelet transfusion thresholds based on six patient scenarios (non-bleeding, minimally bleeding and resolved bleeding in neonates and children). Descriptive statistics were used for analysis.</p><p><strong>Results: </strong>The survey response rate was 56% (114 of 204). Paediatric intensivists comprised 66% of respondents. The median pre-transfusion platelet count varied across VA-ECMO scenarios, with a threshold of 50 × 10⁹/L (interquartile range [IQR] 45-75) for non-bleeding children and 70 × 10⁹/L (IQR 50-85) for non-bleeding neonates. The threshold for minimally bleeding children, minimally bleeding neonates and resolved bleeding in children was 75 × 10⁹/L (IQR 50-100). The threshold for resolved bleeding in neonates was 80 × 10⁹/L (IQR 50-100). There was significant heterogeneity between and within sites (p < 0.001). Uncertainty about the level of evidence was high (59%), with clinical judgement being the most influential factor in transfusion decisions (85%).</p><p><strong>Conclusion: </strong>Prophylactic platelet transfusion practices in paediatric ECMO vary widely, highlighting uncertainty and the need for clinical trials to improve patient outcomes.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"597-604"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful implementation of a patient blood management programme in a lower middle-income state.","authors":"Denise Menezes Brunetta, Luany Elvira Mesquita Carvalho, Nathália Martins Beserra, Claudianne Maia de Farias Lima, Claudia Mota Leite Barbosa Monteiro, Lara Facundo de Alencar Araripe, Fernanda Luna Neri Benevides, Maria Isaaquielle Andrade de Oliveira, Anastácia Maria Viana Silva, Suzanna Araújo Tavares Barbosa, Eliane Ribeiro da Costa Oliveira, Davi Alves Cavalcante, Franklin Jose Candido Santos, Luciana Maria de Barros Carlos","doi":"10.1111/vox.13772","DOIUrl":"10.1111/vox.13772","url":null,"abstract":"<p><strong>Background and objectives: </strong>Transfusions are common, but their use is decreasing in some countries as a result of increased risk awareness and the implementation of patient blood management (PBM), an evidence-based approach to optimize patient outcomes. This study aimed to detail the implementation of PBM in a Brazilian state and its impact on transfusion rates and associated costs.</p><p><strong>Materials and methods: </strong>The PBM implementation involved several strategies: medical education, haematology consultation services, provision of intravenous iron and other medications, establishment of PBM and perioperative anaemia clinics, cell salvage and acute normovolaemic haemodilution, anaemia reference laboratories and rotational thromboelastometry. The program's implementation was assessed through quality indicators and cost analysis.</p><p><strong>Results: </strong>Since 2016, there have been reductions in transfusion rates, mainly in red blood cell (RBC) transfusion. Quality indicators showed an increase in single-RBC transfusions from 53% in December 2015 to 85.9% in June 2024 and a decrease in transfusions for patients with Hb ≥7 g/dL from 5.9% in March 2021 to 2.7% in May 2024. The PBM programme led to an estimated annual cost saving of R$2.63 million (US $487,000), if considered RBC direct costs, and from R$9.69 million to R$16.145 million (US $1.79-$2.99 million) in activity-based costs, considering only the reduction in RBC transfusions.</p><p><strong>Conclusion: </strong>The PBM programme in Ceará successfully reduced transfusion rates and associated costs through a multidisciplinary approach, medical education and government support. This model demonstrates the potential for significant healthcare improvements and cost savings and can serve as a benchmark for other regions and countries, especially in low- and middle-income settings.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"574-583"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}