Vox Sanguinis最新文献

{"title":"Eligibility of blood donors with thalassaemia trait, sickle cell trait or glucose-6-phosphate-dehydrogenase deficiency in Italy: Results of a national survey and practical guidance.","authors":"Massimo La Raja, Ursula La Rocca, Gian Luca Forni, Giovanni Garozzo, Pietro Carmelo Manca, Simonetta Pupella, Luciana Teofili","doi":"10.1111/vox.70361","DOIUrl":"10.1111/vox.70361","url":null,"abstract":"<p><strong>Background and objectives: </strong>Thalassaemia trait (ThalT), glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell trait (SCT) are prevalent inherited red blood cell disorders among blood donors in Italy, particularly in southern and insular regions, and among donors of non-European origin. Despite their frequency, harmonized national guidance on eligibility of carriers for blood and apheresis donation has been lacking, resulting in heterogeneous practices across Italian transfusion centres.</p><p><strong>Materials and methods: </strong>Between 17 January and 16 February 2024, the Italian National Blood Centre distributed a structured questionnaire to 276 transfusion services across the Italian transfusion network. The survey investigated current practices in donor identification, eligibility assessment and blood component utilization for donors with ThalT, G6PD deficiency and SCT. A total of 110 responses (40% response rate) were collected and analysed.</p><p><strong>Results: </strong>ThalT donors were active in 88% of responding centres; 86 centres (78%) considered individuals with ThalT eligible for whole blood donation, 88 (80%) for plasma apheresis and 40 (36%) for platelet apheresis. G6PD-deficient donors were accepted for whole blood donation in only 19% of centres and for plasma apheresis in 44%. SCT donors were accepted for whole blood in 10% of centres and for plasma apheresis in only 17%. Significant heterogeneity in identification strategies and utilization criteria was observed across all three conditions.</p><p><strong>Conclusion: </strong>Italian practices are more restrictive than World Health Organization (WHO) and European Directorate for the Quality of Medicines and HealthCare (EDQM) recommendations. Harmonization with international guidelines and targeted haemovigilance monitoring are warranted.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased plasma collection does not automatically improve patient access to plasma-derived medicinal products.","authors":"Thierry Burnouf, Jay Epstein","doi":"10.1111/vox.70359","DOIUrl":"https://doi.org/10.1111/vox.70359","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The good donation attempt: A qualitative analysis of donor experience regardless of phlebotomy outcome.","authors":"Abigail R-A Edwards, Klara Greffin, Barbara M Masser, Rachel Thorpe","doi":"10.1111/vox.70354","DOIUrl":"https://doi.org/10.1111/vox.70354","url":null,"abstract":"<p><strong>Background and objectives: </strong>Globally, blood donation rates are declining as demand for blood products grows. Given that having a positive donation experience is key to retention, this analysis explores how aspects of service quality provided by blood collection agencies shape donation experiences.</p><p><strong>Materials and methods: </strong>To investigate donor experience, we considered both quantitative and qualitative responses provided by donors in a standard post-donation feedback survey. Responses were stratified by self-reported experience using a standard customer loyalty question and donation outcome, and analysed using iterative content analysis. Categories were identified across three coding rounds (n_total = 1800).</p><p><strong>Results: </strong>Our analysis identified seven categories shaping the blood donor experience: Accessibility, Amenities and Environment, Donor Centre Staff, Donation Process and Efficiency, Valuing Donation, Donor Care and Psychological Impact, and Physical Impact. Positive donation experiences centred on interactions with staff and convenience, while negative experiences stemmed from process management issues, perceived lack of care and experiencing pain.</p><p><strong>Conclusion: </strong>This research outlines a comprehensive framework of the elements that influence service quality in blood donation regardless of whether a donation attempt resulted in a successful collection.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous agitation induces aggregate formation in cold-stored platelets during extended storage in platelet additive solution.","authors":"Janhavi Mahajan, Pearl Lei, Christopher Roan, Matthew P Padula, Denese C Marks, Lacey Johnson","doi":"10.1111/vox.70353","DOIUrl":"https://doi.org/10.1111/vox.70353","url":null,"abstract":"<p><strong>Background and objectives: </strong>Reduced metabolic activity of cold-stored platelets (CSPs) has led to the assumption that agitation is not required during cold storage. However, guidelines from the Food and Drug Administration state that agitation is 'optional' and there is a degree of international variability described in the literature. The effect of agitation on the quality of CSPs stored in platelet additive solution (PAS) for an extended storage period has not been established.</p><p><strong>Materials and methods: </strong>Matched apheresis platelets (n = 8) in 40% plasma/60% PAS-E (SSP+) were refrigerated (2-6°C) and either non-agitated (control), continuously agitated, or periodically agitated. In vitro quality parameters were assessed at defined intervals over 21 days.</p><p><strong>Results: </strong>Agitation did not alter the metabolic properties of CSPs. The abundance of platelet glycoproteins (GPIIIa, GPIbα, GPVI) decreased, while activation markers (activated GPIIb/IIIa, fibrinogen binding, P-selectin and phosphatidylserine) increased during cold storage; however, no significant differences were observed between groups. The functional capacity of CSPs was the same regardless of agitation, with no differences in aggregation response (collagen-induced and adenosine diphosphate [ADP]-induced), or viscoelastic properties (clotting time and maximum clot strength). Platelets stored with continuous agitation developed visible aggregates; which were observed in 88% of components at Day 14, and 100% of components by Day 21. Aggregates were not observed in non-agitated or periodically agitated components.</p><p><strong>Conclusion: </strong>Continuous agitation did not improve the metabolic or functional properties of CSPs and led to the development of aggregates. These findings confirm that non-agitated storage is best practice for CSPs stored in PAS, reinforcing the operational simplicity of cold storage.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a novel high-prevalence red blood cell antigen on junctional adhesion molecule-A defines a new blood group system.","authors":"Tosti J Mankelow, Louise A Tilley, Vanja Karamatic Crew, Benjamin Jones, Marina Izak, Liora Muncher, Vered Yahalom, Nicole M Thornton","doi":"10.1111/vox.70352","DOIUrl":"https://doi.org/10.1111/vox.70352","url":null,"abstract":"<p><strong>Background and objectives: </strong>Availability of new technologies has accelerated the pace of blood group discovery, with nine of 48 known systems being discovered in the past 5 years alone, and yet uncharacterized antigens remain. This study involved investigations of samples from a female patient presenting with a moderate strength pan-reactive antibody to a high-prevalence antigen present on all red blood cells (RBCs) tested other than her own and her brother's.</p><p><strong>Materials and methods: </strong>Samples underwent extensive serological testing; however, the antibody specificity could not be assigned to any known blood group antigens. Therefore, whole exome sequencing was performed alongside antigen expression studies to identify the gene variant responsible for this rare phenotype.</p><p><strong>Results: </strong>Both individuals were found to carry a homozygous variant c.644G>A (rs755819660; gnomAD allele frequency 0.0000044) in exon 6 of the F11R gene, encoding junctional adhesion molecule-A (JAM-A). This variant encodes p.Arg215Gln located on the second extracellular immunoglobulin domain of JAM-A. Expression of JAM-A was demonstrated on all RBCs tested by flow cytometry, with cells of both the patient and her brother showing lower expression than control cells. Control (Arg215) and variant (Gln215) forms of JAM-A were expressed as both soluble Fc fusion proteins and on Chinese hamster ovary cells. In both cases, mouse monoclonal anti-JAM-A recognized both forms, whilst the patient antibody only reacted with the Arg-215-JAM-A control.</p><p><strong>Conclusion: </strong>These data demonstrate that JAM-A carries a new high-prevalence RBC antigen, lacking in the patient and her brother, thereby defining a novel blood group system encoded by F11R.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordant prenatal and postnatal RhD typing caused by a novel RHD frameshift variant (c.540del; p.Leu181CysfsTer48) in Swedish individuals.","authors":"Ahlam Badri, Dan Gratschev, Tove Johansson, Agneta Wikman, Tesfai Emahazion","doi":"10.1111/vox.70351","DOIUrl":"https://doi.org/10.1111/vox.70351","url":null,"abstract":"<p><strong>Background and objectives: </strong>Non-invasive prenatal testing (NIPT) for fetal RHD genotyping is widely used to guide anti-D prophylaxis, but discrepancies between predicted fetal RhD status and postnatal serological typing can occur due to variant RHD alleles. This study aimed to confirm and characterize a suspected novel exon 4 deletion in RHD using multiple molecular methods and to assess inheritance.</p><p><strong>Materials and methods: </strong>NIPT predicted an RhD-positive fetus in an RhD-negative pregnant woman, whereas postnatal serology showed an RhD-negative phenotype. Molecular analysis of RHD was performed using the RBC-Ready Gene CDE kit (Inno-Train, Kronberg, Germany), targeted next-generation sequencing (NGS) and Sanger sequencing in the family and in an unrelated RhD-negative woman.</p><p><strong>Results: </strong>Targeted NGS identified a single-nucleotide deletion in the RHD gene (c.540del), predicted to result in a frameshift and premature termination (p.Leu181CysfsTer48). Sanger sequencing confirmed the variant in the newborn and demonstrated paternal inheritance, with the father heterozygous for the deletion. The same variant was also identified in an unrelated RhD-negative woman of Swedish origin; notably, the newborn's father was also of Swedish origin.</p><p><strong>Conclusion: </strong>This case illustrates a limitation of current NIPT approaches, which detect RHD sequences but not gene functionality. Molecular follow-up is crucial in cases of discordant RhD typing.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collection efficiency of hematopoietic cells by apheresis after mobilization in a single centre: Analysis of the last 15 years.","authors":"Paula Agritzer, Paola Charry, Glòria Carbassé, Joan Cid, John-Jairo Gallego, Elena Cahuancama, María-Queralt Salas, María Suárez-Lledó, Laura Rosiñol, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira, Miquel Lozano","doi":"10.1111/vox.70347","DOIUrl":"https://doi.org/10.1111/vox.70347","url":null,"abstract":"<p><strong>Background and objectives: </strong>Peripheral blood hematopoietic cells (CD34+) collection after mobilization by apheresis has largely replaced bone marrow harvest because of its safety and superior transplantation outcomes. This study aimed to evaluate temporal trends and factors influencing CD34+ collection efficiency (CE) by measuring counts before and after apheresis (CE1, in general considered a more accurate estimate of CE) over a 15-year period.</p><p><strong>Materials and methods: </strong>CD34+ cell mobilization was achieved using individualized drug regimens tailored to donor characteristics and underlying diagnosis. Apheresis procedures were carried out using Cobe Spectra, Spectra Optia and Amicus devices. Descriptive and analytical statistical analyses were performed using SPSS v29.0.</p><p><strong>Results: </strong>A total of 1435 collections from 1233 donors (658 males, 575 females; age 15-76 years) were analysed. Mean CD34+ CE1 increased significantly over time (p < 0.001). There was no statistically significant differences in CE1 between the six group of donors considered, but there were differences in CD34 counts before apheresis, number of total blood volume processed to reach the target number of CD34+ and the duration of collection. Male donors and individuals aged up to 39 years achieved the highest CE1. Pre-apheresis CD34+ count, leukocyte count, low mean corpuscular volume (MCV) and high platelet count inversely correlated with CE1.</p><p><strong>Conclusion: </strong>CD34+ CE1 improved significantly over the past 15 years, probably due to technological advancements. Several factors negatively influenced CE1, although some of them can be compensated for by changing the collection parameters in the apheresis platforms. The findings support optimization of apheresis protocols to reach maximum CD34+ CE1.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors.","authors":"Christina Lai Ling Lee, Li Ping Wong, Lee Lee Lai, Boon Pin Kee, Kek Heng Chua, Muhammad Amir Rasyid Ahmad Makmom, Shi Ya Chang, Mohammad Izzad Ishak, Mun Sin Chow, Haridah Alias, Kee Seong Ng, Choon Jiat Lee, Zizheng Zheng, Ting Wu, Qinjian Zhao","doi":"10.1111/vox.70336","DOIUrl":"https://doi.org/10.1111/vox.70336","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hepatitis E virus (HEV) is a recognized transfusion-transmissible pathogen with significant impact in immunocompromised recipients. Data from Southeast Asia are limited, and the epidemiology of HEV in Muslim-majority populations with low pork consumption remains poorly characterized. This study aimed to determine anti-HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) seroprevalence and associated demographic, dietary, environmental, zoonotic and knowledge-related factors among Malaysian blood donors.</p><p><strong>Materials and methods: </strong>A prospective cross-sectional study was conducted among 500 consecutive blood donors at the Universiti Malaya Medical Centre. Anti-HEV IgG and IgM were measured using enzyme-linked immunosorbent assay. A structured questionnaire assessed demographic, dietary, environmental and zoonotic exposures. Univariate and multivariable logistic regression identified predictors of anti-HEV IgG seropositivity.</p><p><strong>Results: </strong>Anti-HEV IgG seroprevalence was 2.8% (14/500), and IgM positivity was 0.6% (3/500). IgG seropositivity increased with age but showed no association with dietary exposures, including pork consumption. Knowledge of HEV was low, with a median score of 1 out of 12. Multivariable analysis identified freshwater recreational exposure (adjusted odds ratio [aOR] 20.04; p = 0.017) and direct rodent contact (aOR 13.36; p = 0.030) as factors associated with anti-HEV IgG seropositivity; however, these findings were based on small numbers of exposed individuals and should be interpreted cautiously.</p><p><strong>Conclusion: </strong>HEV seroprevalence in Malaysian blood donors was low, indicating a limited burden of previous HEV infection. The observed epidemiological profile suggests that environmental and zoonotic exposures may be associated with HEV seropositivity, although these findings require cautious interpretation. These findings provide baseline data for continued surveillance and future evaluation of transfusion-transmitted HEV risk in Malaysia.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities for vein-to-vein datasets from a blood establishment perspective: Towards a 'Pan-European Transfusion Research InfrAstructure'.","authors":"Sophie M T Wehrens, Mikko Arvas, Suzanne F Fustolo-Gunnink, Matea Vinković Vlah, Allison Waters, Christian Erikstrup, Louise Ørnskov Drechsler, Simon J Stanworth, Katja van den Hurk","doi":"10.1111/vox.70340","DOIUrl":"https://doi.org/10.1111/vox.70340","url":null,"abstract":"<p><strong>Background and objectives: </strong>The 'Pan-European Transfusion Research InfrAstructure' (PETRA) project was established to advance the use of donor, blood product and patient datasets in Europe, aiming to benefit both patient and donor health. Here, the initial PETRA objective was to describe the landscape of existing donor and blood establishment (BE) databases.</p><p><strong>Materials and methods: </strong>An online survey was circulated to the European Blood Alliance's BE-members. The survey collected information on the feasibility of accessing donor data, and challenges and possibilities for linking these datasets with information on the associated blood products and transfusion recipients, and donors' own health records.</p><p><strong>Results: </strong>Seventeen BEs across 16 countries completed the survey. The majority could, in principle, link their donor data to product data (13 BEs, 76%) and recipient data (10 BEs, 59%) for research purposes. However, capabilities were limited and in only 5 of 17 BEs was the donor to recipients' linkage an automated process. BEs reported significant challenges to achieve full vein-to-vein linkage, including legal constraints and lack of consent (11 BEs) and resources (10-14 BEs). Information technology and data issues as well as lack of knowledge and training were cited as obstacles by a minority of BEs.</p><p><strong>Conclusion: </strong>Whilst the survey results suggest considerable interest in developing linkages between blood donors, their products and recipients, many challenges remain due to a variety of obstacles. First steps in working towards a PETRA may be assistance to navigate legal frameworks as well as investing in resources and quality and harmonization of data collections.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of thrombotic complications of the arm in blood donors: Evidence from literature and national data.","authors":"Niubel Díaz Padilla, Armand Snel, Mardin Rashid, Ivan Bank, Johanna Wiersum-Osselton","doi":"10.1111/vox.70349","DOIUrl":"https://doi.org/10.1111/vox.70349","url":null,"abstract":"<p><strong>Background and objectives: </strong>Research on donor complications has focused mainly on vasovagal reactions, with less attention to local complications. Early detection of upper-extremity deep vein thrombosis (UDVT) is essential to prevent serious outcomes such as pulmonary embolism. This study assesses the association between UDVT and blood donation to facilitate identification and improve donor care.</p><p><strong>Materials and methods: </strong>A literature search was conducted using PubMed and Notify Library. Reports on therapeutic apheresis and clinical studies were excluded. Articles reporting aggregated data or individual cases of venous thrombosis, thrombophlebitis or phlebitis after donation of blood or components of blood were selected. Furthermore, donor records suggestive of arm thrombosis from December 2022 to January 2025 were extracted from our blood bank database. Donors were interviewed by telephone with a standardized questionnaire.</p><p><strong>Results: </strong>A literature search yielded 7 reports presenting 9 cases of UDVT, as well as a conference summary describing 20 cases. Arm pain and swelling were common symptoms, typically occurring within hours to days after donation. Risk factors for thrombosis were repeated sport-related arm movements, complicated phlebotomy, smoking, oral contraceptive use and genetic mutations. In our blood bank, 12 donors reported symptoms suggestive of venous thrombosis. Based on information collected in the interviews, there were three cases of UDVT, four cases of thrombophlebitis, two cases of phlebitis, one finger infection, one leg deep vein thrombosis (DVT) and one haematoma.</p><p><strong>Conclusion: </strong>UDVT is a rare complication that can occur days after donation. Prompt evaluation and referral to a general practitioner will contribute to preventing harmful consequences.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}