Vox Sanguinis最新文献_第3页

Notification of blood donors who test positive for transfusion-transmissible infections. 通知输血传播感染检测呈阳性的献血者。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1111/vox.13796

Sheila F O'Brien, Kiyuri Naicker, Lori Osmond, Kelly Holloway, Steven J Drews, Mark Bigham, Mindy Goldman

{"title":"Notification of blood donors who test positive for transfusion-transmissible infections.","authors":"Sheila F O'Brien, Kiyuri Naicker, Lori Osmond, Kelly Holloway, Steven J Drews, Mark Bigham, Mindy Goldman","doi":"10.1111/vox.13796","DOIUrl":"10.1111/vox.13796","url":null,"abstract":"Background and objectives: Despite screening procedures, a few blood donors confirm positive for transfusion-transmissible infections and are deferred. Effective notification of laboratory results is essential to ensure that donors are advised of confirmed results and to seek medical care. Here we report results from post-notification interviews of Canadian Blood Services donors.Materials and methods: Over 17 years, 2006-2022, all donors with confirmed positive results for hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus (HTLV) and syphilis were notified by registered mail of their result and advised to see a physician. In a separate communication, all donors were later invited to participate in a scripted interview asking whether they tested positive for an infection; if yes, which one, what their reaction was, whether they consulted a physician and whether public health contacted them. Frequencies of responses were calculated.Results: Of 2654 donors with confirmed positive test results, 876 (33%) participated; 90% said they were informed of a positive test result. Of these, about a quarter did not know for which infection they were positive. Most were surprised, and some were sad or disappointed. Most saw a physician after notification (77%). About two-thirds with HBV or HCV said they were contacted by public health, slightly fewer (58%) with syphilis, 27% of those with HTLV.Conclusion: Most donors recalled being notified and were aware of their positive test, but details of the infection were sometimes not understood or recalled, and not all donors consulted a physician about the infection.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"394-400"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion-dependent thalassaemia patients (FUEL trial). 两种不同方法制备的低白细胞填充红细胞的输血疗效：一项输血依赖性地中海贫血患者的随机对照试验（FUEL试验）。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-01-16 DOI: 10.1111/vox.13797

Adhikarimayum Arunkumari, Ashish Jain, Sheetal Malhotra, Hari Krishan Dhawan, Srinivasan Peyam, Sangeeta Kumari, Ratti Ram Sharma

{"title":"Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion-dependent thalassaemia patients (FUEL trial).","authors":"Adhikarimayum Arunkumari, Ashish Jain, Sheetal Malhotra, Hari Krishan Dhawan, Srinivasan Peyam, Sangeeta Kumari, Ratti Ram Sharma","doi":"10.1111/vox.13797","DOIUrl":"10.1111/vox.13797","url":null,"abstract":"Background and objectives: Great variations may be observed in the haemoglobin (Hb) content of packed red blood cell (PRBC) units prepared by different methods. This study aimed to assess the Hb increment in thalassaemia major patients transfused with leucoreduced PRBCs (LPRBCs) prepared by two different methods: (i) standard leucoreduced PRBCs (SLPRBCs) and (ii) leucoreduced PRBCs prepared by a new method where leucoreduction of whole blood is done first (NLPRBCs).Materials and methods: This prospective, randomized, controlled trial included 80 adult thalassaemia major patients who were randomized into two groups of 40 each. Group I patients received SLPRBC and those of Group II received NLPRBC transfusions for 3 months.Results: SLPRBCs had a mean (±SD) volume of 275.50 ± 17.07 mL, while it was 316.46 ± 1.42 mL for NLPRBCs (p < 0.001). The mean Hb content of SLPRBCs was 50.60 ± 5.12 g, while that of NLPRBCs was 56.98 ± 5.92 g (p < 0.001). The mean Hb increment in Group I patients was 2.11 ± 0.89 g/dL, while that of Group II patients was 2.48 ± 0.88 g/dL (p < 0.001). The mean transfusion interval for Group I patients was 20.30 ± 3.75 days, while it was 21.34 ± 5.13 days for Group II patients (p < 0.045). A significant positive correlation was observed between the Hb dose transfused and the Hb increment with both SLPRBC (ρ = 0.4, p < 0.001) and NLPRBC (ρ = 0.19, p = 0.011) transfusions.Conclusion: NLPRBCs had significantly higher Hb content than the SLPRBCs, leading to a better Hb increment post transfusion, which may potentially prolong the transfusion interval in thalassaemia major patients.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"419-427"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of immunoglobulin G homeostatic set point and recovery time in plasmapheresis donor safety monitoring: A retrospective observational cohort study. 免疫球蛋白G稳态设定值和恢复时间在血浆置换供者安全监测中的应用：一项回顾性观察队列研究。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1111/vox.13800

Janet V Warner, Michael J Drinkwater, Gerard J Chu, Shane Kelly, Jeremy S McComish

{"title":"Use of immunoglobulin G homeostatic set point and recovery time in plasmapheresis donor safety monitoring: A retrospective observational cohort study.","authors":"Janet V Warner, Michael J Drinkwater, Gerard J Chu, Shane Kelly, Jeremy S McComish","doi":"10.1111/vox.13800","DOIUrl":"10.1111/vox.13800","url":null,"abstract":"Background and objectives: Serum immunoglobulin G (IgG) and total protein are used to monitor plasmapheresis donor safety. However, there is a lack of information from large donor cohorts to determine the best use of these measurements.Materials and methods: We identified 230,144 plasmapheresis donors making their first donation between 1 July 2020 and 31 March 2024. IgG and total protein were measured prior to the first donation and then annually, following our donor safety monitoring protocol. We considered individuals who had not donated for 12 months to estimate intra-individual biological variability of IgG. We compared four models to predict which donors would develop IgG < 6 g/L.Results: The IgG reference interval for the cohort was 7.67-15.6 g/L. IgG declines 5%-11% after the age of 45 years. The intra-individual biological variability of IgG (5.2%) is small, indicating that there is homeostatic set point for individual IgG. IgG is reduced by plasmapheresis but recovers to recruitment level after 12 weeks. When plasma is donated every 2-3 weeks, mean IgG plateaus 1 g/L below recruitment concentration. IgG at recruitment is the best predictor of which donors will have IgG < 6 g/L after a year of donations. Total protein is a low-value test in this context.Conclusion: Plasmapheresis is safe and sustainable for almost every donor, at the 2-weekly frequency allowed in Australia. The donors most likely to experience unacceptably low IgG are those with very low recruitment IgG levels. These donors could be recommended 12-week intervals between donations or other donation types.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"374-382"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donors in the COVID-19 era: How did donor characteristics change in Japan? 新冠肺炎时代的捐赠者：日本的捐赠者特征发生了怎样的变化？

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1111/vox.13801

T Odajima, N H Tsuno, R Okubo, S Makino, T Miyagi, K Ikuta, K Muroi, S Kino

{"title":"Donors in the COVID-19 era: How did donor characteristics change in Japan?","authors":"T Odajima, N H Tsuno, R Okubo, S Makino, T Miyagi, K Ikuta, K Muroi, S Kino","doi":"10.1111/vox.13801","DOIUrl":"10.1111/vox.13801","url":null,"abstract":"Background and objectives: The COVID-19 pandemic caused significant disruptions to the blood service in Japan. Stay-at-home policies in schools, organizations and companies made it challenging to access potential blood donors, leading to a substantial decline in blood donation rates. This study aimed to examine the profile of blood donors during the pandemic and compare it with that in the pre-pandemic period.Materials and methods: Blood donors who contributed to the Japanese Red Cross Blood Services between April 2018 and March 2021 were evaluated based on age, gender, occupation, donation site, height, body weight (BW) and donation status (first-time [FT] or repeat). Factors influencing the return of FT donors who contributed before and during the pandemic were also explored.Results: During the initial phase of the pandemic, a significant decrease in blood donations was observed, particularly in Tokyo. Despite intermittent drops, the required blood volume was ultimately collected. Donations by both female and male repeat donors increased, although the number of male repeat donors decreased, with only female repeat donors experiencing an absolute increase. Before the pandemic, younger age, 200-mL donation, higher body mass index and fixed donation sites were significantly associated with FT donor returns. During the pandemic, higher age (for males) and 400-mL donation (for females) emerged as significant factors. With changes in donor profiles during the pandemic, there was a noticeable shift in the characteristics of FT donors who returned for a subsequent donation within the following year, particularly in terms of age and blood donation volume.Conclusion: Despite the challenges, the required blood volume was successfully collected, thanks to increased donations from repeat blood donors. Recruiting and retaining committed donors is essential for maintaining sustainable blood services, especially during crisis situations.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"383-393"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a blood proficiency testing scheme for bacterial screening of platelet components. 实施血小板成分细菌筛选血液能力测试方案。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1111/vox.13803

Marcel Prax, Lea Debes, Michael Chudy, Angela Filomena, Giulio Pisani, Simonetta Pupella, Marie Riley, Daniele Sondag-Thull, Marie-Laure Hecquet, Marie Pierre Emery, Marie Pflieger, Perrine Arnould

{"title":"Implementation of a blood proficiency testing scheme for bacterial screening of platelet components.","authors":"Marcel Prax, Lea Debes, Michael Chudy, Angela Filomena, Giulio Pisani, Simonetta Pupella, Marie Riley, Daniele Sondag-Thull, Marie-Laure Hecquet, Marie Pierre Emery, Marie Pflieger, Perrine Arnould","doi":"10.1111/vox.13803","DOIUrl":"10.1111/vox.13803","url":null,"abstract":"Background and objectives: The European Directorate for the Quality of Medicines & HealthCare has been co-ordinating an external quality assessment programme for blood establishment (BE) laboratories since 2010. To further expand the study portfolio, a new bacterial blood proficiency testing scheme (B-PTS) for platelet components (PCs) has been developed and validated in a pilot study.Materials and methods: Sterile samples and those containing a low-count quantity of bacteria were prepared in spiking devices. Suitability of storage and shipping conditions for the samples was evaluated under different environmental conditions. Participants received the spiking devices, prepared the potentially contaminated PCs on site and tested them according to their routine screening procedures.Results: Humidity compromised the quality of the samples. Optimized storage of the samples by adding a desiccant ensured satisfactory quality. In the pilot study, 9 of the 11 participants correctly identified the positive samples as being bacterially contaminated.Conclusion: The newly developed bacterial B-PTS was successfully implemented in a pilot study. It enables an inter-laboratory comparison to determine the performance of BEs for the testing of bacterial contaminations in PCs.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"401-410"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a need for an alternative source of red blood cells for clinical transfusion and will gene-edited pigs fulfil that need? 临床输血是否需要另一种红细胞来源，基因编辑的猪能否满足这一需求？

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1111/vox.13802

Asim Alam, David K C Cooper, Akihiro Maenaka

引用次数: 0

Frederic Duran-Jorda: 120th anniversary of the birth of a transfusion pioneer. 弗雷德里克·杜兰-约尔达：这位输血先驱诞辰120周年。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-04-03 DOI: 10.1111/vox.70025

Miquel Lozano, Miquel Bruguera

引用次数: 0

A maximum surgical blood ordering schedule: Does it add value? 最大手术血液订购时间表：它有价值吗？

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1111/vox.13804

Deborah L Benzil, Moises Auron, Zaher K Otrock, Daniel Lallo, Noreen Flowers, Kenneth Cummings, NurJehan Quraishy, Deborah Tolich

{"title":"A maximum surgical blood ordering schedule: Does it add value?","authors":"Deborah L Benzil, Moises Auron, Zaher K Otrock, Daniel Lallo, Noreen Flowers, Kenneth Cummings, NurJehan Quraishy, Deborah Tolich","doi":"10.1111/vox.13804","DOIUrl":"10.1111/vox.13804","url":null,"abstract":"Background and objectives: Implementing and complying with a maximum surgical blood ordering schedule (MSBOS) is challenging but essential to avoid waste and reduce costs. MSBOS helps manage blood product scarcity and healthcare expenditure by avoiding unnecessary pre-transfusion testing and preparation, reducing product waste and improving clinical and operational efficiencies while maintaining patient safety.Materials and methods: A multi-hospital health system in Ohio and Florida performing more than 200,000 surgeries annually implemented MSBOS through a risk-stratified protocol and electronic medical record automation.Results: The first-year analysis included 107,149 cases in 23 surgical specialties and 18 hospitals. Compliance with MSBOS improved over time, reducing type and screen tests by 4166 and saving $223,839 in costs. No patient safety issues were identified.Conclusion: This project demonstrates that adopting MSBOS in a large health system adds value by reducing unnecessary testing and costs while maintaining patient safety.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"411-418"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of change in transfusion practice, population mix and fertility on red blood cell alloantibody prevalence. 输血实践、人口结构和生育率的变化对红细胞异体抗体流行率的影响。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-03-27 DOI: 10.1111/vox.70022

Krishna G Badami, Sarah Hull, Charlotte Vanhecke

{"title":"Effects of change in transfusion practice, population mix and fertility on red blood cell alloantibody prevalence.","authors":"Krishna G Badami, Sarah Hull, Charlotte Vanhecke","doi":"10.1111/vox.70022","DOIUrl":"https://doi.org/10.1111/vox.70022","url":null,"abstract":"Background and objectives: Factors affecting red blood cell (RBC) alloimmunization have changed in New Zealand (NZ). We aimed to investigate whether alloimmunization prevalence had changed as a result.Materials and methods: We calculated the prevalence (%) of patients with RBC alloantibodies among those who had antibody screening/identification done in Canterbury, NZ, during three periods: 2006-2010 (P1), 2012-2016 (P2) and 2018-2022 (P3).Results: During P1, P2 and P3, respectively, females and males numbered 58,817, 30,082; 48,775, 28,383 and 56,200, 31,443. Combining the periods, the overall alloantibody prevalence in females and males was 2.4 versus 0.9, p < 0.0001, and in those ≥60 and ≤40 years, it was 1.9 versus 1.5, p < 0.0001. Prevalence declined, especially after P2. Prevalence of the five most common alloantibodies during P1, P2 and P3, respectively, was as follows: anti-E, 0.39, 0.48, 0.37; anti-D, 0.38, 0.34, 0.27; anti-K, 0.34, 0.32, 0.22; anti-Fya, 0.18, 0.19, 0.14; anti-C, 0.17, 0.16, 0.12; all alloantibodies, 2.0, 2.1, 1.5. p-values by the chi-squared test comparing prevalence (P1 vs. P2, P1 vs. P3, P2 vs. P3, respectively) were anti-E, 0.005, 0.5, 0.0006; anti-D, 0.2, <0.0001, 0.001; anti-K, 0.5, <0.0001, 0.0001; anti-Fya, 0.6, 0.04, 0.01; anti-C, 0.6, 0.006, 0.03; all alloantibodies, 0.1, <0.0001, <0.0001.Conclusion: RBC alloantibody prevalence has declined. The chief reasons for this appear to be changes in transfusion management, NZ population mix and fertility. The decline is beneficial.","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses. 在血液学恶性肿瘤患者中使用辐照血液国际论坛：反应。

IF 1.8 4区医学

Vox Sanguinis Pub Date : 2025-03-25 DOI: 10.1111/vox.70014

Xiao-Yin Zhang, Michael Murphy, Graham P Collins, Vernon J Louw, Gamuchirai Y Tadzimirwa, Satyam Arora, Nita Radhakrishnan, Carlos Gonzalez, Ryan A Metcalf, Erica Swenson, Maria A Nuñez, Edgardo Saa, Arwa Z Al-Riyami, Ali Tabatabaey, Yulia Lin, Aditya Tedjaseputra, Erica M Wood, Alexandra Pedraza, Cristina Sanz, Corentin Streel, Véronique Deneys, Amalia G Bravo, Karla Maldonado, Luiz Amorim, Thais Ferraz, Yoshihiko Tani, Naoko Goto, Fanny Delettre, Pierre Tiberghien, Jaap Jan Zwaginga, Theodora Foukaneli, Paul Kerr, Samclide Mbikayi Mutindu, Alphonse Mosolo Nganzele, Richard Schäfer, Nancy Dunbar

引用次数: 0