Vox Sanguinis最新文献

{"title":"Contemporary patient blood management in abnormally invasive placenta at a tertiary centre, with a focus on the role of the transfusion practitioner.","authors":"Ethan Troy-Barnes, Melat Rone, Madeleine Daly, Lia Estrada, Sharron Ramirez, Lubna Awas, Chris Steward, Sofhia Akhtar, Zeynab Jeewa, Patrick O'Brien, Sam Alimam","doi":"10.1111/vox.70063","DOIUrl":"10.1111/vox.70063","url":null,"abstract":"<p><strong>Background and objectives: </strong>Abnormally invasive placenta (AIP) refers to a rare (<0.2% of live births) spectrum of obstetric disorders characterized by dysfunctional placental implantation, associated with major obstetric haemorrhage at delivery. There is limited evidence regarding effective patient blood management (PBM) strategies peripartum. In this study, we describe the clinical characteristics and outcomes of AIP at our centre over a 5-year period, with a particular focus on PBM.</p><p><strong>Materials and methods: </strong>We carried out a retrospective review of the electronic medical records for all (34) women with AIP who underwent delivery between January 2019 and November 2023.</p><p><strong>Results: </strong>At delivery, the median age was 37 years (range 25-52) and the median gestational age was 36 weeks (range 29-39). All deliveries were by caesarean section and coordinated through a multidisciplinary approach with direct input from a transfusion practitioner (TP) during delivery. The median estimated blood loss was 4.7 L (range 0.7-14). Thirty-two (94%) patients received packed red blood cells (median 6 units, range 0-23). Red cell salvage (RCS) was performed in 29 (85%). There were no maternal or neonatal deaths. Seventeen (50%) patients underwent hysterectomy and 17 (50%) required intensive therapy unit admission. There was no maternal red cell alloimmunization or acute transfusion reactions.</p><p><strong>Conclusion: </strong>Our data reinforce the importance of effective PBM strategies for AIP by demonstrating favourable survival outcomes with a hysterectomy rate of 50% using a multidisciplinary approach with direct involvement by a TP and utilizing RCS.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"913-920"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratified blood donation volumes: Lessons from Japan and India on mitigating vasovagal reactions in older female donors.","authors":"Rajat Bansal, Pandeep Kaur, Amit Kumar Chatterjee, Tarun Dhawan, Ritvik Viniak, Shubhra Sinha","doi":"10.1111/vox.70073","DOIUrl":"10.1111/vox.70073","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"950-951"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Abstract\".","authors":"","doi":"10.1111/vox.70097","DOIUrl":"10.1111/vox.70097","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"952"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of haemovigilance reports reveals 12.5% of acute haemolytic transfusion reactions are attributed to antibodies to low-incidence antigens.","authors":"Holly Elizabeth Perry, William Nicholas Charles Perry","doi":"10.1111/vox.70068","DOIUrl":"10.1111/vox.70068","url":null,"abstract":"<p><strong>Background and objectives: </strong>Many transfusion centres no longer perform an antiglobulin crossmatch on patients without clinically significant red cell alloantibodies, but instead use an abbreviated crossmatch. This policy brings many benefits but has an acknowledged risk of haemolytic transfusion reactions (HTRs). Historical estimates of reactions caused by undetected antibodies to low-incidence antigens (LIAs) were in the region of 1 reaction per 500,000 red cell transfusions. This meta-analysis of haemovigilance reports compares historical estimates with recorded events.</p><p><strong>Materials and methods: </strong>This study analysed 255 acute HTR (AHTR) and 385 delayed HTR (DHTR) published in haemovigilance reports from four countries between 2006 and 2022.</p><p><strong>Results: </strong>The rate of HTRs (acute + delayed) per 100,000 red cells issued/transfused varied from 0.75 to 4.46 by country. The majority of antibodies (59.6%) causing AHTRs were uncharacterized. Antibodies to LIAs accounted for 12.5% (n = 32) of AHTRs, and of these, 59.4% (n = 19) were identified as anti-Wr^a (DI3 in the Diego system). Of note was one fatal reaction likely attributable to anti-Wr^a. Antibodies to LIAs accounted for only 1.6% of DHTRs, where antibodies from other blood group systems were responsible, notably in the Rh and Kidd systems.</p><p><strong>Conclusion: </strong>The risk of HTRs caused by undetected antibodies to LIAs calculated in this study is in the region of 1 reaction per 1 million red cell transfusions.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"928-934"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for incident human immunodeficiency virus infection in South African blood donors.","authors":"Avril Swarts, Karin van den Berg, Marion Vermeulen, Ute Jentsch, Darryl Creel, Ronel Swanevelder, Jennifer J Hemingway-Foday, Edward L Murphy, Brian Custer","doi":"10.1111/vox.70071","DOIUrl":"10.1111/vox.70071","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recruiting blood donors among a population with a high human immunodeficiency virus (HIV) burden requires detailed information on HIV risks. We studied demographic and behavioural risk factors for incident HIV infection among blood donors in South Africa.</p><p><strong>Materials and methods: </strong>We conducted a case-control study. Incident HIV was defined as HIV antibody negative and RNA positive, or concordant serology and RNA positive with a limiting antigen avidity assay optical density of <1.5. Cases were matched to infection-negative controls (ratio 1:3) on race, age and geography. Risk factors in the 6 months before donation were ascertained by audio computer-assisted self-interview. Data were fitted using separate multivariable logistic regression models for males and females.</p><p><strong>Results: </strong>From April 2014 to March 2017, we enrolled 323 people with incident HIV and 877 controls. Among women, incident HIV was associated with sex with a person living with HIV (PLWH) or unknown HIV status, multiple male sex partners, never or occasional condom use, anal preparation before sex, first-time donor status and referral to donation by a healthcare worker. Among men, incident HIV was associated with being aged 31-40 years, sex with a PLWH or unknown HIV status, multiple sex partners, more than four lifetime male sex partners, gay/bisexual identity, marriage or stable partnership, lower education, penetrative injury, occasional condom use and first-time or lapsed donor status. Some novel or indirect risks for incident HIV were also observed.</p><p><strong>Conclusion: </strong>We confirmed the known sexual behaviours asked on the donor screening questionnaire. The findings highlight ongoing challenges in donor disclosure during selection and the importance of donor education.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"892-903"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Thomas et al. 'Management strategies and clinical outcomes of obstetric patients who decline allogeneic blood transfusion'.","authors":"Rui Terada, Yuko Mishima","doi":"10.1111/vox.70110","DOIUrl":"https://doi.org/10.1111/vox.70110","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-enhanced digital microscopy for personalized assessment of red blood cell storage lesions.","authors":"Jiang Deng, Hailong Zhuo, Chaojie Wang, Ning Zhao, Liping Lv, Ping Ma, Tao Wu, Qun Luo, Ke Zhang, Yanyu Zhang","doi":"10.1111/vox.70103","DOIUrl":"https://doi.org/10.1111/vox.70103","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aims to develop a novel platform combining machine learning and microscope images for personalized assessment of red blood cell (RBC) storage lesions. RBCs undergo storage lesions, which adversely affect transfusion outcomes. Currently, there is no individualized assessment method for RBC aging applicable in clinical practice.</p><p><strong>Materials and methods: </strong>Blood smears and cytospin preparations from stored donor RBCs were digitized using whole-slide scanning. Predictive models were developed and validated using classical machine learning, deep learning and ensemble learning techniques. These models were tested against various datasets and validated with flow cytometry. The training dataset comprised 550,870 images, the internal testing set included 192,562 images and the external testing set contained 350,793 images. Models such as k-nearest neighbour, support vector machine, extra trees, DenseNet-121, InceptionV3 and ResNet101 were employed, with ensemble learning leveraging InceptionV3 for enhanced performance.</p><p><strong>Results: </strong>Classical machine learning models showed modest performance, whereas deep learning models (DenseNet-121, InceptionV3, ResNet101) significantly outperformed them, achieving accuracy rates up to 0.86 on the internal testing set and 0.83 on the external testing set. The RBC morphology ensemble learning model (RBC-MELM) further enhanced predictive capabilities, particularly in the blood smear and cytospin datasets. Comparative analyses with flow cytometry indicated that while flow cytometry detected accelerated aging under certain conditions, our machine learning approaches more effectively identified RBCs exhibiting accelerated aging.</p><p><strong>Conclusion: </strong>The proposed method utilizing machine learning techniques and microscopic blood smear analysis provides a rapid, accurate and stable approach for the personalized assessment of RBC storage lesions.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis.","authors":"Sunil Golia, Aseem Kumar Tiwari, Samruddhi Pawar, Leo M G van de Watering","doi":"10.1111/vox.70102","DOIUrl":"https://doi.org/10.1111/vox.70102","url":null,"abstract":"<p><strong>Background and objectives: </strong>Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National sero-epidemiology data on major transfusion-transmitted infections (TTI) in blood donors are lacking in India. This review aimed to estimate the prevalence of TTI in India, examine zonal variations, assess donor demographics and testing methodologies and analyse prevalence trends to further provide recommendations for blood safety.</p><p><strong>Materials and methods: </strong>A systematic search of all original articles published in India from January 2019 to January 2024 in MEDLINE, SCOPUS, CINAHL and Google Scholar databases was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Data regarding donor demographics, zonal distribution and TTI prevalence were retrieved from the studies after methodological evaluation. Meta-analysis was performed by the binary random-effects model. The risk of bias and publication bias were assessed utilizing RStudio.</p><p><strong>Results: </strong>The analysis included 41 studies with 1,860,594 blood donors. The pooled prevalence rates for HIV, HBV, HCV, syphilis and malaria among Indian blood donors were 0.12%, 0.91%, 0.28%, 0.14% and 0.01%, respectively. Males, replacement donors and first-time donors had a higher prevalence compared to females, voluntary donors and repeat donors, respectively. HIV (0.18%) and HCV (0.83%) were most prevalent in the North-east, HBV (1.57%) in the Central, syphilis (0.48%) in the North and malaria (0.04%) in the East zone.</p><p><strong>Conclusion: </strong>This review highlighted the influence of donor demographics and testing methodologies on TTI prevalence, emphasizing zonal disparities, with findings laying the groundwork for policy development and future research to improve blood supply reliability.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced O₂ availability in platelet concentrates stored for neonatal transfusion is independent of agitation: Evidence from direct oximetry and Fickian diffusion modelling.","authors":"Dean Pym, Oleg Grinberg, Amanda J Davies, Jessica O Williams, Christine Saunders, Chloë E George, Philip E James","doi":"10.1111/vox.70101","DOIUrl":"https://doi.org/10.1111/vox.70101","url":null,"abstract":"<p><strong>Background and objectives: </strong>Platelet transfusions are essential for mitigating the bleeding risk of neonatal patients with thrombocytopenia. As neonatal patients have a small blood volume, adult therapeutic dose platelet units are split into reduced-volume storage containers to maximize the use of the donated product and reduce donor exposure. The shelf-life of platelets stored in reduced-volume containers, however, is limited to 5 days. Agitation in platelet concentrate (PC) storage is thought to promote gaseous exchange by maintaining a gradient of O₂ across the bag film; however, recent studies have shown that agitation-induced shear promotes the progressive decline of platelet quality over storage.</p><p><strong>Materials and methods: </strong>Electron paramagnetic resonance oximetry and Fickian diffusion modelling of O₂ were used to investigate the differences in O₂ availability, by assessing the O₂ concentration, oxygen consumption rate (OCR), influx of O₂, total PC OCR and O₂ distribution in PCs stored under routine conditions in neonatal (Macopharma, VQE605B) versus adult (Haemonetics, ATSBC1ESE) PC storage containers. The influence of agitation on neonatal PC storage was evaluated.</p><p><strong>Results: </strong>Results indicate neonatal PCs experience significantly higher O₂ availability compared to adult PCs and can withstand greater insult to their ambient O₂ concentration. Adjusting the agitation frequency of neonatal PCs stored from 20 to 400 rpm had no detrimental effect on O₂ availability, compared to storage at 60 rpm.</p><p><strong>Conclusion: </strong>Neonatal PCs can maintain higher O₂ availability and tolerate reduced agitation without compromising oxygenation; therefore, reduced agitation strategies may be a feasible option to minimize shear during storage without compromising O₂ availability.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of plasma donation frequency on total serum protein, immunoglobulin G and donor safety: A non-inferiority randomized controlled trial.","authors":"Morten Haugen, Lise Sofie Haug Nissen-Meyer, Tor A Strand, Karin Magnussen","doi":"10.1111/vox.70105","DOIUrl":"https://doi.org/10.1111/vox.70105","url":null,"abstract":"<p><strong>Background and objectives: </strong>The safety of varying plasma donation frequencies remains unclear. This non-inferiority randomized controlled trial investigated the effect of plasma donation frequency on total serum protein (TSP), immunoglobulin G (IgG) concentrations, additional biomarkers, adverse events (AEs) and psychological distress.</p><p><strong>Materials and methods: </strong>In this trial, 120 male donors were randomized into three groups: high-frequency plasma donors (HFPDs, three times every 2 weeks), regular-frequency plasma donors (RFPDs, once every 2 weeks) and a control group (whole blood donation every 3 months). Blood samples were collected biweekly from baseline until the last donation in Week 16 and 4 weeks after the last donation.</p><p><strong>Results: </strong>HFPDs completed median (range) 21.5 (1-24), RFPDs 8 (1-8) and controls 2 (1-2) donations. HFPDs had lower concentrations of TSP and IgG compared to controls, with a mean difference (95% confidence interval [CI]) of -5.5 g/L (-7.4, -3.6) and -2.8 g/L (-3.8, -1.8), respectively. Within-group analysis revealed significant reductions, which increased with the frequency of donations, in TSP, IgG, IgG subclasses, immunoglobulin M (IgM), immunoglobulin A (IgA), ferritin and haemoglobin. Many of the biomarkers required more than 4 weeks to return to baseline levels. Only mild AEs were reported, and plasma donation frequency had no effect on psychological distress.</p><p><strong>Conclusion: </strong>High- and regular-frequency plasmapheresis substantially reduces concentrations of TSP, IgG and other biomarkers, with greater reductions at higher donation frequencies. Further research is needed to assess the long-term health implications of frequent plasma donation.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}