Sunil Golia, Aseem Kumar Tiwari, Samruddhi Pawar, Leo M G van de Watering
{"title":"印度献血者中输血传播感染的血清患病率：一项系统回顾和荟萃分析。","authors":"Sunil Golia, Aseem Kumar Tiwari, Samruddhi Pawar, Leo M G van de Watering","doi":"10.1111/vox.70102","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National sero-epidemiology data on major transfusion-transmitted infections (TTI) in blood donors are lacking in India. This review aimed to estimate the prevalence of TTI in India, examine zonal variations, assess donor demographics and testing methodologies and analyse prevalence trends to further provide recommendations for blood safety.</p><p><strong>Materials and methods: </strong>A systematic search of all original articles published in India from January 2019 to January 2024 in MEDLINE, SCOPUS, CINAHL and Google Scholar databases was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Data regarding donor demographics, zonal distribution and TTI prevalence were retrieved from the studies after methodological evaluation. Meta-analysis was performed by the binary random-effects model. The risk of bias and publication bias were assessed utilizing RStudio.</p><p><strong>Results: </strong>The analysis included 41 studies with 1,860,594 blood donors. The pooled prevalence rates for HIV, HBV, HCV, syphilis and malaria among Indian blood donors were 0.12%, 0.91%, 0.28%, 0.14% and 0.01%, respectively. Males, replacement donors and first-time donors had a higher prevalence compared to females, voluntary donors and repeat donors, respectively. HIV (0.18%) and HCV (0.83%) were most prevalent in the North-east, HBV (1.57%) in the Central, syphilis (0.48%) in the North and malaria (0.04%) in the East zone.</p><p><strong>Conclusion: </strong>This review highlighted the influence of donor demographics and testing methodologies on TTI prevalence, emphasizing zonal disparities, with findings laying the groundwork for policy development and future research to improve blood supply reliability.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis.\",\"authors\":\"Sunil Golia, Aseem Kumar Tiwari, Samruddhi Pawar, Leo M G van de Watering\",\"doi\":\"10.1111/vox.70102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National sero-epidemiology data on major transfusion-transmitted infections (TTI) in blood donors are lacking in India. This review aimed to estimate the prevalence of TTI in India, examine zonal variations, assess donor demographics and testing methodologies and analyse prevalence trends to further provide recommendations for blood safety.</p><p><strong>Materials and methods: </strong>A systematic search of all original articles published in India from January 2019 to January 2024 in MEDLINE, SCOPUS, CINAHL and Google Scholar databases was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Data regarding donor demographics, zonal distribution and TTI prevalence were retrieved from the studies after methodological evaluation. Meta-analysis was performed by the binary random-effects model. The risk of bias and publication bias were assessed utilizing RStudio.</p><p><strong>Results: </strong>The analysis included 41 studies with 1,860,594 blood donors. The pooled prevalence rates for HIV, HBV, HCV, syphilis and malaria among Indian blood donors were 0.12%, 0.91%, 0.28%, 0.14% and 0.01%, respectively. Males, replacement donors and first-time donors had a higher prevalence compared to females, voluntary donors and repeat donors, respectively. HIV (0.18%) and HCV (0.83%) were most prevalent in the North-east, HBV (1.57%) in the Central, syphilis (0.48%) in the North and malaria (0.04%) in the East zone.</p><p><strong>Conclusion: </strong>This review highlighted the influence of donor demographics and testing methodologies on TTI prevalence, emphasizing zonal disparities, with findings laying the groundwork for policy development and future research to improve blood supply reliability.</p>\",\"PeriodicalId\":23631,\"journal\":{\"name\":\"Vox Sanguinis\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vox Sanguinis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/vox.70102\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vox Sanguinis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/vox.70102","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis.
Background and objectives: Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National sero-epidemiology data on major transfusion-transmitted infections (TTI) in blood donors are lacking in India. This review aimed to estimate the prevalence of TTI in India, examine zonal variations, assess donor demographics and testing methodologies and analyse prevalence trends to further provide recommendations for blood safety.
Materials and methods: A systematic search of all original articles published in India from January 2019 to January 2024 in MEDLINE, SCOPUS, CINAHL and Google Scholar databases was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Data regarding donor demographics, zonal distribution and TTI prevalence were retrieved from the studies after methodological evaluation. Meta-analysis was performed by the binary random-effects model. The risk of bias and publication bias were assessed utilizing RStudio.
Results: The analysis included 41 studies with 1,860,594 blood donors. The pooled prevalence rates for HIV, HBV, HCV, syphilis and malaria among Indian blood donors were 0.12%, 0.91%, 0.28%, 0.14% and 0.01%, respectively. Males, replacement donors and first-time donors had a higher prevalence compared to females, voluntary donors and repeat donors, respectively. HIV (0.18%) and HCV (0.83%) were most prevalent in the North-east, HBV (1.57%) in the Central, syphilis (0.48%) in the North and malaria (0.04%) in the East zone.
Conclusion: This review highlighted the influence of donor demographics and testing methodologies on TTI prevalence, emphasizing zonal disparities, with findings laying the groundwork for policy development and future research to improve blood supply reliability.
期刊介绍：
Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections:
1) Transfusion - Transmitted Disease and its Prevention:
Identification and epidemiology of infectious agents transmissible by blood;
Bacterial contamination of blood components;
Donor recruitment and selection methods;
Pathogen inactivation.
2) Blood Component Collection and Production:
Blood collection methods and devices (including apheresis);
Plasma fractionation techniques and plasma derivatives;
Preparation of labile blood components;
Inventory management;
Hematopoietic progenitor cell collection and storage;
Collection and storage of tissues;
Quality management and good manufacturing practice;
Automation and information technology.
3) Transfusion Medicine and New Therapies:
Transfusion thresholds and audits;
Haemovigilance;
Clinical trials regarding appropriate haemotherapy;
Non-infectious adverse affects of transfusion;
Therapeutic apheresis;
Support of transplant patients;
Gene therapy and immunotherapy.
4) Immunohaematology and Immunogenetics:
Autoimmunity in haematology;
Alloimmunity of blood;
Pre-transfusion testing;
Immunodiagnostics;
Immunobiology;
Complement in immunohaematology;
Blood typing reagents;
Genetic markers of blood cells and serum proteins: polymorphisms and function;
Genetic markers and disease;
Parentage testing and forensic immunohaematology.
5) Cellular Therapy:
Cell-based therapies;
Stem cell sources;
Stem cell processing and storage;
Stem cell products;
Stem cell plasticity;
Regenerative medicine with cells;
Cellular immunotherapy;
Molecular therapy;
Gene therapy.
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