Vox Sanguinis最新文献

{"title":"Increasing syphilis cases in Japan: A risk posed to blood services.","authors":"H Suzuki, N H Tsuno, K Kitsukawa, T Miyagi, K Sakamoto, K Matsubayashi, M Satake, K Muroi","doi":"10.1111/vox.70005","DOIUrl":"https://doi.org/10.1111/vox.70005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Syphilis cases surged in Japan, exceeding 10,000 in 2022, primarily through heterosexual transmission. The Japanese Red Cross Blood Services (JRCBS) screens donated blood for syphilis, disqualifying positive donors. This study explores syphilis infection among blood donors to understand its impact on blood collection and supply.</p><p><strong>Materials and methods: </strong>Data from blood donors (2015-2022) at JRCBS were analysed. Treponema pallidum (TP) antibody was tested by chemiluminescent enzyme immunoassay or chemiluminescent immunoassay. A total of 39,199,047 donations were scrutinized. Reactive samples were further tested by rapid plasma reagin (RPR).</p><p><strong>Results: </strong>The number of TP and RPR positives (referred as syphilis positives) in 2022 compared with 2015 increased by 1.7 times in blood donors and 4.9 times in the general population. High syphilis-positive rate in 2022 was mainly observed among male first-time/reactivated donors and females in their 20s and 30s. Although syphilis cases in general population declined during the Corona pandemic, no significant decrease occurred in syphilis-positive donors.</p><p><strong>Conclusion: </strong>Although the increase in syphilis positives among blood donors may be a reflection of the increase in the general population, the rate of increase was less pronounced among blood donors. Although the increase in the syphilis-positive rate may not affect blood product safety, it would have a significant impact on the number of potential blood donors in the future because the increase was more frequently observed in young donors and new donors, and currently, syphilis-positive individuals are permanently deferred from blood donation. The implementation of effective measures to prevent transmission in the general population is required.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A relational approach to understanding the factors influencing new plasma donor retention in Canada.","authors":"Morgan Seeley, Arooba Bari, Kelly Holloway","doi":"10.1111/vox.70002","DOIUrl":"https://doi.org/10.1111/vox.70002","url":null,"abstract":"<p><strong>Background and objectives: </strong>Understanding the experiences and perceptions of new plasma donors is important for developing strategies to retain them.</p><p><strong>Materials and methods: </strong>This qualitative study focuses on new donors' experiences with plasma donation, the factors that influence their interest in donating again and their thoughts about establishing a regular plasma donation routine. We conducted 48 one-on-one semi-structured interviews and used reflexive thematic analysis with a relational approach to donation to analyse these data.</p><p><strong>Results: </strong>For new plasma donors in this study, interest in returning to donate again was facilitated by relational care, where donors were cared for by attentive staff, and felt they could care for others by donating. Their interest in helping others through ongoing donation was influenced by their relationships with people who have benefited from blood products or experienced illnesses they associated with plasma-derived medicines, as well as their sense of social responsibility and community belonging. The most prevalent deterrent to donating again was the experience of feeling unwell during or after donation. The practice of relational care from staff members can mitigate the fallout of the negative experience. Retention of new donors requires flexibility to ensure that donation is easy, convenient and does not negatively impact their health and ability to care for others in their social network.</p><p><strong>Conclusion: </strong>Investigating retention decisions for new plasma donors through the lens of relational care provides insight that can help blood collection agencies develop more effective strategies for retention in non-remunerated settings.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A maximum surgical blood ordering schedule: Does it add value?","authors":"Deborah L Benzil, Moises Auron, Zaher K Otrock, Daniel Lallo, Noreen Flowers, Kenneth Cummings, NurJehan Quraishy, Deborah Tolich","doi":"10.1111/vox.13804","DOIUrl":"https://doi.org/10.1111/vox.13804","url":null,"abstract":"<p><strong>Background and objectives: </strong>Implementing and complying with a maximum surgical blood ordering schedule (MSBOS) is challenging but essential to avoid waste and reduce costs. MSBOS helps manage blood product scarcity and healthcare expenditure by avoiding unnecessary pre-transfusion testing and preparation, reducing product waste and improving clinical and operational efficiencies while maintaining patient safety.</p><p><strong>Materials and methods: </strong>A multi-hospital health system in Ohio and Florida performing more than 200,000 surgeries annually implemented MSBOS through a risk-stratified protocol and electronic medical record automation.</p><p><strong>Results: </strong>The first-year analysis included 107,149 cases in 23 surgical specialties and 18 hospitals. Compliance with MSBOS improved over time, reducing type and screen tests by 4166 and saving $223,839 in costs. No patient safety issues were identified.</p><p><strong>Conclusion: </strong>This project demonstrates that adopting MSBOS in a large health system adds value by reducing unnecessary testing and costs while maintaining patient safety.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding community perspectives for advancing inclusion of trans and gender-diverse people in blood donation in Australia.","authors":"Rachel Thorpe, Kyle Jensen, Barbara Masser, Peter Bentley, Tarin Dryden, Eleanor Forrest, Andy Kaladelfos, Travis Larcombe, Tanya Pastor, Aaron Saint-James, Shauna Wilson, Bridget Haire","doi":"10.1111/vox.70001","DOIUrl":"https://doi.org/10.1111/vox.70001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Trans and gender-diverse people who wish to donate blood face significant barriers with policies and procedures differing across countries. It remains critical to explore the experiences and perspectives of trans and gender-diverse people in different locations to understand challenges in local systems. We undertook a qualitative study focussed on procedures and processes affecting trans and gender-diverse people in Australia, and their views about needed change.</p><p><strong>Materials and methods: </strong>Stakeholders collaborated with the researchers to refine the focus of and design the research. Semi-structured interviews were conducted with 14 trans and gender-diverse people who were current, past or potential donors. The interviews comprised open-ended questions about donation experiences, knowledge of current policies and procedures and preferences for change. Interviews were analysed using thematic analysis.</p><p><strong>Results: </strong>Participants reported varied and inconsistent donation experiences. When compared with current practice, participants preferred a two-step approach to donor registration that asks for sex reported at birth followed by gender identity. However, they also expressed concern that the two-step approach could deter new donors and stressed the importance of only collecting information relevant to eligibility assessment. Participants were supportive of a gender-neutral approach to assess eligibility to donate.</p><p><strong>Conclusion: </strong>Our study highlights significant barriers and procedural inconsistencies for trans and gender-diverse individuals when (considering) donating blood. We recommend more inclusive practices including clear communication about data use, rigorous staff training on gender diversity, registration processes that respect all gender identities and adopting a gender-neutral approach to donor screening.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homozygosity for a novel A4GALT allele resulting in the rare p phenotype in an Indian blood donor.","authors":"Louise A Tilley, Vanja Karamatic Crew, Amy Tearle, Suvro Sankha Datta, Nicole M Thornton","doi":"10.1111/vox.70000","DOIUrl":"https://doi.org/10.1111/vox.70000","url":null,"abstract":"<p><strong>Background and objectives: </strong>Individuals with the rare p phenotype have red cells lacking P, P1 and P^k antigens and make clinically significant anti-PP1P^k. The phenotype arises from inactivating mutations in A4GALT, which encodes the enzyme responsible for production of P1 and P^k. We present results from serological and molecular investigations of a case of anti-PP1P^k with a novel molecular background of the p phenotype.</p><p><strong>Materials and methods: </strong>Samples from a 32-year-old Indian blood donor were investigated due to the presence of a pan-reactive alloantibody, together with samples from his sister and mother. Standard serological investigations and A4GALT sequencing were performed.</p><p><strong>Results: </strong>The donor was found to have p phenotype, and his plasma contained anti-PP1P^k. Sequencing revealed a rare homozygous missense mutation in A4GALT (c.526G>A; p.Asp176Asn; rs371893172; frequency 0.00007), representing a novel null allele. The sister was heterozygous for this allele, while surprisingly the mother did not carry the allele. Enquiries revealed the mother was not the donor's biological mother, explaining the perceived discrepant sequencing results.</p><p><strong>Conclusion: </strong>We have identified homozygosity for a novel A4GALT null allele (carrying c.526G>A, p.Asp176Asn), resulting in lack of functional 4-α-galactosyltransferase and a p phenotype, adding to the catalogue of known genetic backgrounds of this rare phenotype.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a blood proficiency testing scheme for bacterial screening of platelet components.","authors":"Marcel Prax, Lea Debes, Michael Chudy, Angela Filomena, Giulio Pisani, Simonetta Pupella, Marie Riley, Daniele Sondag-Thull, Marie-Laure Hecquet, Marie Pierre Emery, Marie Pflieger, Perrine Arnould","doi":"10.1111/vox.13803","DOIUrl":"https://doi.org/10.1111/vox.13803","url":null,"abstract":"<p><strong>Background and objectives: </strong>The European Directorate for the Quality of Medicines & HealthCare has been co-ordinating an external quality assessment programme for blood establishment (BE) laboratories since 2010. To further expand the study portfolio, a new bacterial blood proficiency testing scheme (B-PTS) for platelet components (PCs) has been developed and validated in a pilot study.</p><p><strong>Materials and methods: </strong>Sterile samples and those containing a low-count quantity of bacteria were prepared in spiking devices. Suitability of storage and shipping conditions for the samples was evaluated under different environmental conditions. Participants received the spiking devices, prepared the potentially contaminated PCs on site and tested them according to their routine screening procedures.</p><p><strong>Results: </strong>Humidity compromised the quality of the samples. Optimized storage of the samples by adding a desiccant ensured satisfactory quality. In the pilot study, 9 of the 11 participants correctly identified the positive samples as being bacterially contaminated.</p><p><strong>Conclusion: </strong>The newly developed bacterial B-PTS was successfully implemented in a pilot study. It enables an inter-laboratory comparison to determine the performance of BEs for the testing of bacterial contaminations in PCs.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Split red blood cell units contain defined extracellular K⁺ levels, which are improved by a washing procedure.","authors":"Fabiola Hoppe, Jacqueline Maier, Holger Kirsten, Martin Federbusch, Reinhard Henschler","doi":"10.1111/vox.70004","DOIUrl":"https://doi.org/10.1111/vox.70004","url":null,"abstract":"<p><strong>Background and objectives: </strong>We should control free K⁺ during massive transfusion (>80 mL/kg) of red blood cells (RBCs) in small children. To manage this, several national and international guidelines recommend using RBCs stored only up to 7 days. We tested a washing step for RBCs in saline-adenine-glucose-mannitol (SAGM) with or without irradiation to reduce supernatant K⁺ levels, improve quality and potentially extend the shelf life of stored RBCs.</p><p><strong>Materials and methods: </strong>RBCs of 240-330 mL were prepared from whole blood donations, then split into halves and stored in SAGM solution at 4 ± 2°C for 21 days. RBCs were split and washed on Days 1 and 8, and some were gamma-irradiated on Day 8. Glucose, lactate, lactate dehydrogenase (LDH), adenosine triphosphate (ATP), K⁺ and haemolysis were determined over 21 days.</p><p><strong>Results: </strong>After washing on Day 1, only glucose and lactate improved, whereas after washing on Day 8, LDH and K⁺ also improved. Irradiation resulted in accelerated K⁺ accumulation and increased haemolysis. Mean extracellular K⁺ concentrations were 21.2 ± 1.03 mM after irradiation on Day 8 versus 1.12 ± 0.05 mM after irradiation plus wash on Day 8, and 38.80 ± 2.13 mM on Day 10 after irradiation on Day 8 and 16.6 ± 0.05 mM on Day 10 after irradiation plus wash on Day 8.</p><p><strong>Conclusion: </strong>K⁺ concentrations remained <25 mM within 8 days of storage. We recommend irradiation by Day 8 at the latest for neonatal transfusion. The shelf life may be extended by another 48 h if the RBCs are also washed.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A procedure using low-cost reagents to prepare allogeneic platelet gel from standard platelet units.","authors":"Larysa Mykhailova, Javier Calvo, Anthi Gafou, Josè Antonio Garcìa Erce, Evangelia Lydaki, Maria Elena Schinocca, Dinara Samarkanova, Gabriele Scimemi, Tiziana Montemurro","doi":"10.1111/vox.70003","DOIUrl":"https://doi.org/10.1111/vox.70003","url":null,"abstract":"<p><strong>Background and objectives: </strong>Highly effective procedures for the preparation of allogeneic platelet gel (PG) use Ca-gluconate and batroxobin, an expensive commercial reagent. In this preliminary study, we explored the use of the plasmin-inhibitor, low-cost drug tranexamic acid (TXA) in place of batroxobin, based on the literature supporting TXA ability to prevent fibrinolysis and stabilize the gel formed by fibrin polymerization prompted by Ca-gluconate.</p><p><strong>Materials and methods: </strong>Eight blood centres determined PG weight and volume of non-gelled, liquid portion in 116 PG prepared in 20-mL commercial BioNest D bags. Ten-millilitre platelet aliquots from platelets in 100% plasma or in 35% plasma/65% platelet additive solution (PAS) were aseptically transferred into the D bag, followed by the injection of 3.3 mL of 10% Ca-gluconate and 0.4 mL of TXA. After 30-min incubation, PG weight and non-gelled liquid volume were determined.</p><p><strong>Results: </strong>PG weight and liquid volume at 30 min were 6.5 ± 3.4 g and 7.4 ± 3.5 mL with platelets in 100% plasma, and 3.7 ± 3.0 g and 10.2 ± 3.3 mL with PAS platelets, respectively.</p><p><strong>Conclusion: </strong>This study provides preliminary evidence supporting the use of TXA as a low-cost reagent for PG manufacturing from platelets in 100% plasma.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary determination of bacterial contamination of whole blood units in a Ghanaian blood bank: Providing evidence to improve transfusion safety.","authors":"Nana Benyin Aidoo, Sandra Ramirez-Arcos, Laurie Gillard, Daniel Edem Azumah, Angela Adatsi","doi":"10.1111/vox.13806","DOIUrl":"https://doi.org/10.1111/vox.13806","url":null,"abstract":"<p><strong>Background and objectives: </strong>Transfusion-associated bacterial sepsis poses a significant risk to patient safety. This study aimed to determine the rate of bacterial contamination of whole blood (WB) collected at the Cape Coast Teaching Hospital (CCTH) as a quality control and quality assurance activity.</p><p><strong>Materials and methods: </strong>One-hundred and three WB units collected between January and April of 2018 were screened for bacterial contamination. Bacteria isolated from positive cultures were identified and subjected to antimicrobial testing. WB recipients were followed up for clinical symptoms.</p><p><strong>Results: </strong>Of the 103 WB units tested, 33 (32%) were contaminated with bacteria. Gram-positive organisms accounted for 67% of the isolates, including coagulase-negative Staphylococcus, Staphylococcus aureus and Bacillus spp., while Gram-negative bacteria comprised 33% of the isolates, with Citrobacter freundii, Serratia marcescens, Escherichia coli and Providencia stuartii being identified. Resistance to antibiotics varied between species. No septic transfusion events were reported involving WB units tested in this study.</p><p><strong>Conclusion: </strong>The high percentage of contaminated WB units collected at the CCTH provided evidence-based data for the implementation of improved donor skin disinfection processes and the use of blood diversion pouches in 2019. These approaches allowed CCTH to comply with Ghanaian regulatory entities.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of communication interventions for promoting blood donation in low- and middle-income countries: A systematic review.","authors":"Bernard Appiah, Lucy Asamoah-Akuoko, Md Koushik Ahmed, Tara Tancred, Yvonne Dei-Adomakoh, Gursimar Singh, Cavan Reilly, Edeghonghon Olayemi, Meghan Delaney, Christopher R France, Amma Benneh-Akwasi Kuma, Alfred Edwin Yawson, Susan Telke, Michelle Asiedu-Danso, Emmanuel Nene Dei, Philip Adongo, Imelda Bates","doi":"10.1111/vox.13799","DOIUrl":"https://doi.org/10.1111/vox.13799","url":null,"abstract":"<p><strong>Background and objectives: </strong>In low- and middle-income countries (LMICs), information on the efficacy of communication interventions promoting blood donation is very scarce. The present review aimed to identify specific communication interventions and their efficacy for increasing blood donation in LMICs.</p><p><strong>Materials and methods: </strong>The databases searched were PubMed, Scopus, PsycINFO, Web of Science, CINAHL, ProQuest, AJOL and CAB Abstracts. Grey literature sources included the websites of African Society of Blood Transfusion, International Society of Blood Transfusion and World Health Organization. The outcomes of interest were donation attempt or actual blood donations.</p><p><strong>Results: </strong>A total of 16 studies including nine randomized controlled trials (RCTs) were included in the review. The communication interventions included social media and mass media, such as radio and television, as platforms for promoting blood donation, and newspaper articles or advertisements as an incentive for donor recruitment. Mobile text messages were used either alone or in combination with phone calls, and other interventions such as meetings and brochures. Only three of the 16 studies specifically targeted behavioural science theories, and none of the 16 studies used any implementation science framework. For some communication interventions, there was evidence of statistically significant increases in donations, but the quality of the studies was weak.</p><p><strong>Conclusion: </strong>The efficacy of communication interventions for promoting blood donations in LMICs remains limited due to few rigorous studies. More rigorous, theory-based studies on the use of communication interventions to increase blood donation in LMICs, especially in sub-Saharan Africa where no prior RCT were identified, are needed.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}