Vox Sanguinis最新文献

{"title":"Role of instant messaging applications in Indian blood banking.","authors":"Satyam Arora, Kriti Batni, Seema Dua, Anupa Pokhrel","doi":"10.1111/vox.70010","DOIUrl":"https://doi.org/10.1111/vox.70010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Instant messaging applications (IMAs) have revolutionized the means of communication. Like various disciplines in medicine, transfusion medicine and blood banking have also utilized these applications for connecting with donors for recruitment, routine blood centre work and clinical consulting. We aim to study the pattern of usage of IMAs by the Indian blood bank community.</p><p><strong>Materials and methods: </strong>This was a descriptive cross-sectional survey (27 questions) of doctors and technicians working in the blood centres. The target was to collect at least 100 responses from blood bank staff. The survey was open from 28 March 2024 to 28 May 2024.</p><p><strong>Results: </strong>One hundred and thirty-nine out of 575 individuals dealing with blood banking responded to the survey (24% response rate). The responders were mainly doctors (85.6%), young professionals (<40 years; 53.2%) and males (53.9%). WhatsApp® on smartphones seems to be one of the most preferred ways (~95% responders) of IMAs among the Indian blood bank community. IMAs were mainly used to communicate with the blood centre staff (83%) as well as clinical counter colleagues (68.5%). More than 50% of our responders were members of more than five chat groups dealing with blood bank. IMAs were also used to disseminate knowledge, such as sharing recent guidelines (81%) and research articles (69%).</p><p><strong>Conclusion: </strong>Our study demonstrates that the blood bank community has embraced the internet-based IMA (mainly WhatsApp) and uses it mainly on their mobile devices.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence chatbots in transfusion medicine: A cross-sectional study.","authors":"Prateek Srivastava, Ashish Tewari, Arwa Z Al-Riyami","doi":"10.1111/vox.70009","DOIUrl":"https://doi.org/10.1111/vox.70009","url":null,"abstract":"<p><strong>Background and objectives: </strong>The recent rise of artificial intelligence (AI) chatbots has attracted many users worldwide. However, expert evaluation is essential before relying on them for transfusion medicine (TM)-related information. This study aims to evaluate the performance of AI chatbots for accuracy, correctness, completeness and safety.</p><p><strong>Materials and methods: </strong>Six AI chatbots (ChatGPT 4, ChatGPT 4-o, Gemini Advanced, Copilot, Anthropic Claude 3.5 Sonnet, Meta AI) were tested using TM-related prompts at two time points, 30 days apart. Their responses were assessed by four TM experts. Evaluators' scores underwent inter-rater reliability testing. Responses from Day 30 were compared with those from Day 1 to evaluate consistency and potential evolution over time.</p><p><strong>Results: </strong>All six chatbots exhibited some level of inconsistency and varying degrees of evolution in their responses over 30 days. None provided entirely correct, complete or safe answers to all questions. Among the chatbots tested, ChatGPT 4-o and Anthropic Claude 3.5 Sonnet demonstrated the highest accuracy and consistency, while Microsoft Copilot and Google Gemini Advanced showed the greatest evolution in their responses. As a limitation, the 30-day period may be too short for a precise assessment of chatbot evolution.</p><p><strong>Conclusion: </strong>At the time of the conduct of this study, none of the AI chatbots provided fully reliable, complete or safe responses to all TM-related prompts. However, ChatGPT 4-o and Anthropic Claude 3.5 Sonnet show the highest promise for future integration into TM practices. Given their variability and ongoing development, AI chatbots should not yet be relied upon as authoritative sources in TM without expert validation.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study.","authors":"Nchafatso G Obonyo, Declan P Sela, Nicole White, Matthew Tunbridge, Beatrice Sim, Reema H Rachakonda, Louise E See Hoe, Gianluigi Li Bassi, Jonathon P Fanning, John-Paul Tung, Jacky Y Suen, John F Fraser","doi":"10.1111/vox.70007","DOIUrl":"https://doi.org/10.1111/vox.70007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Randomized controlled trials have demonstrated morbidity and mortality in critically ill patients are unaffected by transfusing fresh (<7 days old) packed red blood cells (pRBCs); however, there is limited evidence regarding transfusion with pRBCs nearing expiry (35-42 days). The aim of this study was to investigate the effects of transfusing pRBCs close to the end of shelf life (≥35 days) on clinical outcomes in critically ill patients.</p><p><strong>Materials and methods: </strong>A retrospective observational analysis of data obtained from centralized electronic medical records (2007-2013), sourced from all public and licensed private hospitals in Queensland, Australia, with intensive care units. Multivariate logistic and linear regressions were used to analyse association between transfusion with pRBCs nearing expiry, and in-hospital mortality, hospital length of stay (HLOS) and rate of discharge home. Comparisons are presented as odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The study included 10,350 critically ill adult patients transfused ≥1 unit of non-irradiated pRBCs (64,594 pRBCs units transfused). Receiving at least 1-unit pRBCs ≥ 35 days old was associated with increased mortality (OR 1.21 [95% CI 1.06-1.38]; p = 0.005), decreased discharge to usual residence (OR 0.81 [95% CI 0.73-0.89]; p < 0.0001) and increased hospital LOS (estimate 2.55 [95% CI 1.60-3.49]; p < 0.0001). There was also association with increased sepsis (OR 1.27 [95% CI 1.13-1.42]; p < 0.0001) and delirium (OR 1.25 [95% CI 1.06-1.49]; p = 0.01).</p><p><strong>Conclusion: </strong>Transfusion of ≥1-unit pRBCs ≥ 35 days old was associated with higher morbidity and mortality in critically ill patients.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty-eight-hour cold-stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures.","authors":"Amy L Kiskaddon, Jennifer Andrews, Cassandra D Josephson, Michael T Kuntz, Dominique Tran, Jennifer Jones, Vyas Kartha, Nhue L Do","doi":"10.1111/vox.13786","DOIUrl":"10.1111/vox.13786","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cold-stored whole blood (CS-WB) in paediatric cardiac surgery is making a resurgence, given its identified benefits compared to conventional blood component therapy (CT).</p><p><strong>Study design and methods: </strong>A single-centre retrospective study was conducted from January 2018 to October 2018 by including children <18 years of age undergoing cardiac surgery requiring cardiopulmonary bypass. ABO-compatible CS-WB from non-directed random donors was leukoreduced with platelet-sparing filters and compared with CT.</p><p><strong>Results: </strong>Fifty-seven patients (30, 53% CS-WB; 27, 47% CT) were studied. Patient demographics were similar, although CT patients were cooled to a lower intra-operative temperature. Blood product requirements 24 h post operation were less in the CS-WB group (11.1 vs. 26.7 mL/kg, p = 0.048). Twelve (40%) patients in the CS-WB cohort had more than one donor exposure versus 25 (93%) in the CT group (p < 0.001). CT patients compared to CS-WB patients had a greater decrease in pre-operative versus 48-h post-operative haemoglobin, platelets and prothrombin time. Patients who received CT compared to CS-WB had a trend towards higher median (interquartile range [IQR]) chest-tube output (mL/kg/h) in the first 4 h post cardiac intensive care unit (ICU) admission (2.1 [0.8, 3] vs. 1.6 [0.8, 2.2], p = 0.197). There was no difference in antifibrinolytic use, length of stay, sepsis, acute kidney injury or wound infection. Survival to discharge was similar.</p><p><strong>Conclusion: </strong>CS-WB in paediatric cardiac surgery may reduce donor exposure and improve haemostatic balance. Future multi-centre prospective studies are needed to validate these findings and identify patients who would benefit from CS-WB in paediatric cardiac surgery.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"293-300"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging with young professionals in transfusion medicine: Insights from a needs assessment survey targeting an international cohort.","authors":"Eunike C McGowan, Antoine Lewin, Jian Ou-Yang, Saikat Mandal, Nour Almozain, Abiy Belay Ambaye, Jannison Karlly Cavalcante Ribeiro, Lilian Antwi Boateng, Carla Luana Dinardo, Praiseldy Langi Sasongko","doi":"10.1111/vox.13783","DOIUrl":"10.1111/vox.13783","url":null,"abstract":"<p><strong>Background and objectives: </strong>Professionals who work or study in transfusion medicine under 40 years of age are considered young professionals (YPs) by the International Society of Blood Transfusion (ISBT). While the ISBT provides opportunities for YPs, their needs have to be assessed to customize initiatives in a way that could potentially improve their engagement. This survey aimed to assess the needs of YPs in transfusion medicine and understand their perspectives on future ISBT initiatives.</p><p><strong>Materials and methods: </strong>Between January and February 2023, a 28-question online survey was accessible through a generalized link across the ISBT network. Skip-logic responses from 352 YPs, including 151 ISBT members and 201 non-members, were analysed. Each question varied in the number of responders and, consequently, the number of responses.</p><p><strong>Results: </strong>Firstly, the most important needs of YPs from the survey were educational opportunities and training programmes, with 70% of respondents indicating for educational content in specific fields of transfusion. Secondly, Transfusion Today published by the ISBT (46.9%) ranked the highest in engagement, while ISBT Academy and Academy funding ranked the lowest (12.8%). ISBT members reported attending ISBT activities or using ISBT resources more often than non-members, although this was not statistically significant. The primary barrier preventing both non-members and ISBT members from engaging in ISBT activities was a lack of awareness.</p><p><strong>Conclusion: </strong>Raising awareness on a regular basis, a customized communication style (e.g., by a representative or different languages) and activities for non-members may be key to improving YP engagement and expanding the ISBT network.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"320-325"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a simplified platelet cryopreservation method: An in vitro investigation of reducing the DMSO concentration to allow administration without its pre-transfusion removal.","authors":"Lacey Johnson, Pearl Lei, Christopher Roan, Denese C Marks","doi":"10.1111/vox.13789","DOIUrl":"10.1111/vox.13789","url":null,"abstract":"<p><strong>Background and objectives: </strong>The most widely used method of platelet cryopreservation requires the addition of 5%-6% dimethylsulphoxide (DMSO), followed by its pre-freeze removal via centrifugation, to minimize toxicity. However, this adds complexity to the pre-freeze and post-thaw processing. Accordingly, the aim of this study was to simplify platelet cryopreservation by reducing the DMSO concentration and omitting the requirement for pre-transfusion removal.</p><p><strong>Materials and methods: </strong>Apheresis platelets were cryopreserved at -80°C according to standard blood-banking methods using 5.5% DMSO, with centrifugation, pre-freeze removal of DMSO and reconstitution in plasma following thawing (standard). In parallel, doses of DMSO (0%, 1.5%, 3%, 5.5%) were tested without centrifugation and reconstitution (no-wash). In vitro platelet quality was assessed by flow cytometry, aggregation, viscoelastic testing (thromboelastography [TEG]) and clot retraction.</p><p><strong>Results: </strong>Many in vitro platelet quality parameters showed DMSO dose dependency using the no-wash protocol (recovery, annexin-V, TEG maximum amplitude [MA]). Platelets frozen using the no-wash method with 3% DMSO showed a higher abundance of GPIbα (3% DMSO no-wash median fluorescence intensity [MFI]: 228 ± 16; standard MFI: 184 ± 16; p = 0.0016) and less degranulation (reduced P-selectin-positive platelets and concentration of supernatant P-selectin) than platelets frozen using the standard method. All functional properties measured were comparable to those of platelets frozen using the standard method.</p><p><strong>Conclusion: </strong>This study shows that improvements in cryopreserved platelet quality parameters can be obtained by removing the centrifugation processes (standard vs. 5.5% DMSO no-wash). A reduction in DMSO to 3% supports quality parameters, and if shown to be clinically acceptable, this cryopreservation method could improve platelet accessibility, as it is simpler and cheaper than the standard method.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":"120 3","pages":"284-292"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Forum on Genotyping of Blood Antigens in Donors: Responses.","authors":"Jennie Haw, Kelly Holloway, Gwen Clarke, Galit Eliyahu Nuni, Liora Muncher, James Daly, Jacqui Martin, Klaus Rieneck, Morten H Dziegiel, Cinzia Paccapelo, Luisa Ronzoni, Diarmaid O'Donghaile, Helen Ryan, Celina Montemayor Garcia, Cheuk-Kwong Lee, Wai-Chiu Tsoi, Hironori Kobayashi, Hiroyuki Igarashi, Tuulia Palukka, Katri Haimila, Nuria Nogues, Cecilia Gonzalez-Santesteban, Aaron J Gottschalk, Åsa Hellberg, Martin L Olsson, Thierry Peyrard, Ute Jentsch, Ai Leen Ang, Chew Yen Phang, Lorna Wall, Dhana Gounder, Nancy Dunbar","doi":"10.1111/vox.13791","DOIUrl":"10.1111/vox.13791","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"333-348"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing reagents and techniques for identifying RhCE variants in routine serological testing.","authors":"Tatiane Aparecida de Paula Vendrame, Carine Prisco Arnoni, Giovana Faria Devides, Nayara Moraes Silva, Afonso José Pereira Cortez, Flavia Roche Moreira Latini, Lilian Castilho","doi":"10.1111/vox.13792","DOIUrl":"10.1111/vox.13792","url":null,"abstract":"<p><strong>Background and objectives: </strong>Identifying RhCE variants is essential to prevent alloimmunization and manage complex cases. Unfortunately, these variants are often only detected after antibody formation, as they may go unnoticed in serological tests. This study aimed to assess monoclonal antisera using various methodologies to define the reactivity patterns of some variants by variable expression of RhCE antigens.</p><p><strong>Materials and methods: </strong>Samples were chosen based on atypical reactivity on routine RhCE typing of donors, screening of Afro-descendant donors using tube testing and patient samples with antibodies against their own antigens. All 53 samples were tested using tube, gel and microplate tests with five antisera. Antigen expression was assessed by flow cytometry, and RhCE variants were molecularly classified.</p><p><strong>Results: </strong>Tube test screening of African descent donors proved more effective in identifying a broad range of weak or partial antigens, particularly when using anti-e composed of MS-21, MS-16, MS63 clones and anti-c from the MS8011531019 clone. Automated instrument phenotyping successfully identified samples with RHCE*ceJAL allele, while most other variants were detected as positive (4+), similar to gel test, which intensified most reactions. When comparing methods and antisera for detecting variant e antigens, tube test identified a higher percentage of weak samples (63%-77%) compared with microplate (35%) and gel tests (14%).</p><p><strong>Conclusion: </strong>The results highlight the critical role of tube test in serological routines and the need to select clones capable of identifying RhCE variants. Detecting reduced RhCE antigen expression during routine serological testing can guide further molecular investigations and help prevent Rh alloimmunization.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"301-309"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removing upper age restrictions for returning donors and increasing the new donor upper age: Novel adverse event findings using a comprehensive donor vigilance system in Australia.","authors":"Joanna Speedy, Gabrielle Josling, Veronica C Hoad","doi":"10.1111/vox.13776","DOIUrl":"10.1111/vox.13776","url":null,"abstract":"<p><strong>Background and objectives: </strong>In July 2019, Australia removed the upper age limit for returning donors (previously 80 years) and increased the upper age for new donors from 70 to 75 years. This study assessed the safety of our new policy for our newly eligible upper age donors (NEUADs).</p><p><strong>Materials and methods: </strong>For the period, 14 July 2019 to 30 June 2023, the relative risk (RR) of individual adverse events in NEUADs was compared with younger cohorts.</p><p><strong>Results: </strong>There were 4529 NEUADs who made 8000 donations. The overall rates of vasovagal reactions (VVRs) were significantly lower in the NEUAD cohort. However, compared with younger donors; returning NEUADs had a significantly higher rate of loss of consciousness (RR 2.62; 95% confidence interval [CI]: 1.41-4.86) and new NEUADs had a significantly higher rate of offsite VVRs (RR 1.60; 95% CI: 1.08-2.37). Both new and returning NEUADs had significantly higher rates of VVR requiring outside medical care (RR 2.48; 95% CI: 1.28-4.79 and RR 4.45; 95% CI: 2.00-9.91 respectively).</p><p><strong>Conclusion: </strong>Our findings support historical findings that overall VVR rates decline with age but suggest a higher risk of more serious VVRs.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"315-319"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless legs syndrome among blood donors: A systematic review and meta-analysis.","authors":"Alain M Ngoma, Paulin B Mutombo, Mahmoud Mosli, Magot D Omokoko, Kenneth E Nollet, Hitoshi Ohto","doi":"10.1111/vox.13780","DOIUrl":"10.1111/vox.13780","url":null,"abstract":"<p><strong>Background and objectives: </strong>Restless legs syndrome (RLS), with adverse health outcomes, has been linked to blood donation, but evidence published thus far has not been rigorously analysed. This systematic review aggregates existing evidence on RLS among blood donors and identifies associated factors worthy of further investigation.</p><p><strong>Materials and methods: </strong>MEDLINE and EMBASE were searched for articles published through 16 December 2023. Eleven studies from eight countries were selected from 142 publications. The pooled prevalence of RLS was calculated using a random-effects model, with heterogeneity assessed by the Cochran Q and I² statistics. Meta-regression and sensitivity analyses explored sources of heterogeneity and the robustness of findings.</p><p><strong>Results: </strong>Eleven studies, involving 20,255 blood donors, were included. The pooled prevalence of RLS among blood donors was 10.30% (95% confidence interval [CI]: 5.54%-16.30%), which was significantly higher than in the general adult population (3.0%, 95% CI: 1.4%-3.8%). Meta-regression identified the year of study and geographical region as significant sources of heterogeneity. From the five studies that used logistic regression analyses, female sex and older age stand out as associated factors. No publication bias was detected, and sensitivity analysis confirmed the robustness of results.</p><p><strong>Conclusion: </strong>Our findings suggest a high burden of RLS among blood donors, underscoring the need for further research with standardized criteria, appropriate design and analytical methodologies to better understand the impact of RLS on individual donors and the global blood supply.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"246-255"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}