Vox Sanguinis最新文献

{"title":"Donors in the COVID-19 era: How did donor characteristics change in Japan?","authors":"T Odajima, N H Tsuno, R Okubo, S Makino, T Miyagi, K Ikuta, K Muroi, S Kino","doi":"10.1111/vox.13801","DOIUrl":"https://doi.org/10.1111/vox.13801","url":null,"abstract":"<p><strong>Background and objectives: </strong>The COVID-19 pandemic caused significant disruptions to the blood service in Japan. Stay-at-home policies in schools, organizations and companies made it challenging to access potential blood donors, leading to a substantial decline in blood donation rates. This study aimed to examine the profile of blood donors during the pandemic and compare it with that in the pre-pandemic period.</p><p><strong>Materials and methods: </strong>Blood donors who contributed to the Japanese Red Cross Blood Services between April 2018 and March 2021 were evaluated based on age, gender, occupation, donation site, height, body weight (BW) and donation status (first-time [FT] or repeat). Factors influencing the return of FT donors who contributed before and during the pandemic were also explored.</p><p><strong>Results: </strong>During the initial phase of the pandemic, a significant decrease in blood donations was observed, particularly in Tokyo. Despite intermittent drops, the required blood volume was ultimately collected. Donations by both female and male repeat donors increased, although the number of male repeat donors decreased, with only female repeat donors experiencing an absolute increase. Before the pandemic, younger age, 200-mL donation, higher body mass index and fixed donation sites were significantly associated with FT donor returns. During the pandemic, higher age (for males) and 400-mL donation (for females) emerged as significant factors. With changes in donor profiles during the pandemic, there was a noticeable shift in the characteristics of FT donors who returned for a subsequent donation within the following year, particularly in terms of age and blood donation volume.</p><p><strong>Conclusion: </strong>Despite the challenges, the required blood volume was successfully collected, thanks to increased donations from repeat blood donors. Recruiting and retaining committed donors is essential for maintaining sustainable blood services, especially during crisis situations.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a need for an alternative source of red blood cells for clinical transfusion and will gene-edited pigs fulfil that need?","authors":"Asim Alam, David K C Cooper, Akihiro Maenaka","doi":"10.1111/vox.13802","DOIUrl":"https://doi.org/10.1111/vox.13802","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of pregnant women for foetal neonatal alloimmune thrombocytopenia: A cost-utility analysis.","authors":"Thijs W de Vos, Ilonka Tersteeg, Enrico Lopriore, Dick Oepkes, Leendert Porcelijn, C Ellen van der Schoot, E Joanne T Verweij, Dian Winkelhorst, Masja de Haas, M Elske van den Akker-van Marle","doi":"10.1111/vox.13779","DOIUrl":"10.1111/vox.13779","url":null,"abstract":"<p><strong>Background and objectives: </strong>Foetal and neonatal alloimmune thrombocytopenia (FNAIT) results from maternal platelet-directed antibodies and can result in severe intracranial haemorrhage (ICH) in foetuses and newborns. Screening for human platelet antigen-1a (HPA-1a)-directed antibodies during pregnancy could allow timely intervention with antenatal treatment and prevent ICH. We assessed the cost effectiveness of HPA-1a typing and anti-HPA-1a-screening as part of the prenatal screening programme.</p><p><strong>Materials and methods: </strong>Different HPA-1a screening scenarios were tested in a decision analysis model and assessed for diagnostic, treatment, intervention and lifetime costs and prevention effects compared to the current situation without screening in the Netherlands. Model parameters were based on available data, literature and expert opinions. One-way sensitivity analysis and probabilistic sensitivity analysis were performed.</p><p><strong>Results: </strong>Adding screening for anti-HPA-1a antibodies to the current antenatal screening programme of the Netherlands will lead to an additional cost of €4.7 million per year and a gain of 226 quality-adjusted life years (QALYs) per year, indicating an incremental cost-effectiveness ratio (ICER) of €20,782 per QALY gained. One-way sensitivity analysis showed that the uncertainty around the incidence of ICH, lifetime costs of disabled children and the probability of having antibody quantitation >3.0 IU/mL at 20 weeks had the highest effect on the ICER.</p><p><strong>Conclusion: </strong>Antenatal anti-HPA-1a screening might be cost effective. To obtain more knowledge and thereby to improve risk stratification, a pilot screening programme is warranted.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"178-187"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a novel mini-pool intravenous immunoglobulin therapy in children with primary immunodeficiency.","authors":"Alshaimaa M Selim, Taghreed M Kamal, Madeen Adel A Abdou, Eman NasrEldin, Nada O Abdelhameed, Mariam E Abdallah, Naglaa S Osman, Maha Atwa, Magdy El-Ekiaby","doi":"10.1111/vox.13769","DOIUrl":"10.1111/vox.13769","url":null,"abstract":"<p><strong>Background and objectives: </strong>Intravenous polyvalent immunoglobulins (IVIG) for prophylaxis in patients with primary immunodeficiency disorders (PIDs) exposes them to life-threatening infections and debilitating diseases. To improve access to IVIG in lower middle-income countries, the WHO recommends a stepwise approach for the local production of purified and virus-inactivated plasma immunoglobulins by national blood transfusion services using new technologies and medical devices. One new technology relies on single-use sterile medical devices for the purification of plasma immunoglobulin G (IgG), as well as lipid-enveloped virus inactivation from mini-pools of recovered plasma separated from whole blood (mini-pool IVIG [MP-IVIG]). This study aimed to compare the safety and efficacy of MP-IVIG to standard IVIG (STD-IVIG).</p><p><strong>Materials and methods: </strong>In this prospective crossover clinical study, we investigated the safety and efficacy of MP-IVIG for STD-IVIG preparations as a replacement therapy in a cohort of 21 paediatric patients with PID.</p><p><strong>Results: </strong>Both MP-IVIG and STD-IVIG were effective in reducing the frequency of severe bacterial infections and hospital admissions in patients with PID. Mild side effects have been observed in seven patients (6.2%) with PID who received MP-IVIG and five patients (5.3%) who received STD-IVIG. No moderate or severe side effects or haemolytic transfusion reactions were reported. The mortality rates were also comparable and were not related to the study products.</p><p><strong>Conclusion: </strong>MP-IVIG presented no safety issues and was as effective as STD-IVIG in IgG replacement in patients with PID. Due to the small numbers, the results have to be addressed with caution.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"140-148"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Forum on Donor- and Recipient-triggered Lookback for Traditional Transfusion-transmitted Infections: Summary.","authors":"Ryanne Lieshout-Krikke, Veronica Hoad, Sze Sze Chua, Grace Kam, Masahiro Satake, Ikuo Hino, Susan L Stramer, Jamel A Groves, Virginie de La Taille, Syria Laperche, Anthea Cheng, Kathryn Goodison, Wai-Chiu Tsoi, Cheuk-Kwong Lee, Daniele Prati, Ilaria Pati, Steven J Drews, Mark Bigham, Georg Gratz, Christof Jungbauer, Richard Charlewood, Meredith Smith, Niamh O'Flaherty, Aoife Raftery, Salvador Oyonarte, Knut Gubbe, Juergen Luhm, Solomuzi Ngcobo, Ed Slot, Katy Davison, Su Brailsford, Nancy Dunbar","doi":"10.1111/vox.13763","DOIUrl":"10.1111/vox.13763","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"197-206"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of wrong blood in tube events at a hospital-based blood centre in a tertiary care referral hospital: A perspective from a lower middle-income country.","authors":"Aparna Krishna, Hem Chandra Pandey, Poonam Coshic, Rakesh Kumar, Romesh Jain","doi":"10.1111/vox.13767","DOIUrl":"10.1111/vox.13767","url":null,"abstract":"<p><strong>Background and objectives: </strong>Wrong blood in tube (WBIT) continues to be a preventable cause of unintended harm to the patient. The literature describing extent of the problem, its consequences and factors leading to WBIT from the perspective of lower middle-income countries (LMICs) is limited. The present study describes WBIT and its outcome in a hospital-based blood centre from an LMIC.</p><p><strong>Materials and methods: </strong>WBIT events occurring during the study period were analysed to identify the root cause. In addition, they were analysed according to discipline, department and time of sample draw. Root causes were divided and compared with standard operating procedure (SOP) for sample collection for blood requests. All WBIT events were followed and their outcomes analysed.</p><p><strong>Results: </strong>WBIT events occurred at a rate of 4.8/10,000 blood requests, with a higher rate in urgent requests (5.2/10,000 requests). The average rate of WBIT was higher in surgical disciplines compared to medical and acute care services (6.58 vs. 4.43 vs. 3/10,000 requests). The highest rate of WBIT was observed when requests were received during 8:00 PM-2:00 AM (p = 0.02). Deviations from SOP with contribution from human and organizational elements were identified as the root cause. The consequences ranged from delay in providing blood to acute haemolytic transfusion reactions.</p><p><strong>Conclusion: </strong>We found that WBITs occurred at a rate comparable to that reported from developed countries. Use of software and automation may reduce the rate of WBIT but not eliminate it completely. Strict adherence to SOPs and continuous training of phlebotomy staff would help reduce it to a minimum. Blood centres need to develop specific strategies with respect to their root causes.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"155-162"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Forum on Donor- and Recipient-triggered Lookback for Traditional Transfusion-transmitted Infections: Responses.","authors":"Ryanne Lieshout-Krikke, Veronica Hoad, Sze Sze Chua, Grace Kam, Masahiro Satake, Ikuo Hino, Susan L Stramer, Jamel A Groves, Virginie de La Taille, Syria Laperche, Anthea Cheng, Kathryn Goodison, Wai-Chiu Tsoi, Cheuk-Kwong Lee, Daniele Prati, Ilaria Pati, Steven J Drews, Mark Bigham, Georg Gratz, Christof Jungbauer, Richard Charlewood, Meredith Smith, Niamh O' Flaherty, Aoife Raftery, Salvador Oyonarte, Knut Gubbe, Juergen Luhm, Solomuzi Ngcobo, Ed Slot, Katy Davison, Su Brailsford, Nancy Dunbar","doi":"10.1111/vox.13764","DOIUrl":"10.1111/vox.13764","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"207-238"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consistent supply of global plasma for global patients.","authors":"Michelle Fransen, Toby Simon, James Knowles, Joshua Penrod","doi":"10.1111/vox.13771","DOIUrl":"10.1111/vox.13771","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"239-240"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world performance of a clinical droplet digital polymerase chain reaction assay for non-invasive foetal blood group and platelet antigen genotyping of alloimmunized pregnant women with antibodies directed against RhD, RhE, Rhc, RhC, K1, HPA-1a or HPA-5b: A 1-year experience.","authors":"Camilla Calandrini, Onno J H M Verhagen, Ahmed Tissoudali, Christa H E Homburg, Jessica Vessies, Mark Brussee, Erik H van Beers, C Ellen van der Schoot, Masja de Haas","doi":"10.1111/vox.13777","DOIUrl":"10.1111/vox.13777","url":null,"abstract":"<p><strong>Background and objectives: </strong>To test the performance of a new droplet digital polymerase chain reaction (ddPCR) non-invasive foetal blood group and platelet antigen genotyping assay in the setting of a Dutch reference laboratory for foetal blood group and platelet antigen genotyping. Our population comprised 229 consecutive alloimmunized pregnant women who presented between April 2022 and March 2023 with 250 requests for non-invasive foetal RHD, RHE, RHc, RHC, K1, HPA-1a or HPA-5b blood group and platelet antigen genotyping.</p><p><strong>Materials and methods: </strong>Samples were genotyped for blood group and platelet antigen alleles along with methylated RASSF1a (mRASSF1a) and sex-determining region of Y (SRY) and DYS14 as positive foetal controls. Negative blood group and platelet antigen results were issued only when foetal controls were positive; otherwise, such samples were classified as inconclusive.</p><p><strong>Results: </strong>The assay achieved a success rate of 98.4% (246 of 250) because one case was lost to follow-up, one case was solved with quantitative polymerase chain reaction (qPCR) and one case precluded foetal typing due to RHD variant mothers. Only 10 cases needed a second sample and one case a third for a valid final result. We identified 116 maternal-foetal blood group and platelet antigen incompatibilities.</p><p><strong>Conclusion: </strong>Clinical non-invasive foetal blood group and platelet antigen typing of alloimmunized pregnant women via ddPCR is successful and represents an improvement over qPCR because of the addition of a foetal control and because ddPCR circumvents potential interference from maternal cell-free DNA (cfDNA) background for foetal HPA-1 and K1.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"170-177"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Has the switch to sexual risk behaviour screening impacted deferrals for pre- and post-exposure prophylaxis therapy for human immunodeficiency virus?","authors":"Mindy Goldman, Samra Uzicanin, Sheila F O'Brien","doi":"10.1111/vox.13773","DOIUrl":"10.1111/vox.13773","url":null,"abstract":"<p><strong>Background and objectives: </strong>Canadian Blood Services defers donors during and for 4 months after oral pre-exposure or post-exposure prophylaxis (PrEP/PEP) for human immunodeficiency virus (HIV) because of concerns about altered viral kinetics. We assessed the impact of the switch from a time-based deferral for men who have sex with men (MSM) to sexual risk behaviour criteria on PrEP/PEP deferrals.</p><p><strong>Materials and methods: </strong>Data on PrEP/PEP deferral codes were extracted from our National Epidemiology Database for the 22 months before (Period 1) and after (Period 2) the criteria change.</p><p><strong>Results: </strong>PEP deferrals remained stable (2.3 vs. 1.7 per 100,000 donations in Periods 1 and 2, p = 0.2892), about 45% and 33%, respectively, of these donors who reported a recent needle stick injury. PrEP deferrals increased from 5.9 to 12.4 per 100,000 (p = 0.0001); approximately 30% of donors in both periods had other HIV risk factor deferrals. Donors deferred for PrEP use alone were more likely to be male, first-time users and younger than other donors.</p><p><strong>Conclusion: </strong>The switch to sexual risk behaviour led to a small increase in deferrals for PrEP. We may not be measuring the full impact of deferral criteria because potential donors may self-defer and PrEP use is increasing.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"193-196"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}