Ultrasound in Obstetrics & Gynecology最新文献

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Time to reconcile the dichotomy of the cardiovascular-placental axis.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 DOI: 10.1002/uog.29207
P I Cavoretto, N R Nayak, A O Odibo
{"title":"Time to reconcile the dichotomy of the cardiovascular-placental axis.","authors":"P I Cavoretto, N R Nayak, A O Odibo","doi":"10.1002/uog.29207","DOIUrl":"https://doi.org/10.1002/uog.29207","url":null,"abstract":"","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":"65 4","pages":"401-403"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between abnormal umbilical vein flow and birth-weight percentile in low-risk term pregnancies: secondary analysis of multicenter prospective study.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1002/uog.29192
R Ramirez Zegarra, B Valentini, I F Carbone, L Angeli, F Gigli, C Di Ilio, O Barba, O Cassardo, E Ferrazzi, T Ghi
{"title":"Correlation between abnormal umbilical vein flow and birth-weight percentile in low-risk term pregnancies: secondary analysis of multicenter prospective study.","authors":"R Ramirez Zegarra, B Valentini, I F Carbone, L Angeli, F Gigli, C Di Ilio, O Barba, O Cassardo, E Ferrazzi, T Ghi","doi":"10.1002/uog.29192","DOIUrl":"10.1002/uog.29192","url":null,"abstract":"","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"507-508"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Routine 36-week scan: diagnosis of fetal abnormalities.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-03-25 DOI: 10.1002/uog.29218
A Syngelaki, R Mitsigiorgi, J Goadsby, K Hamed, R Akolekar, K H Nicolaides
{"title":"Routine 36-week scan: diagnosis of fetal abnormalities.","authors":"A Syngelaki, R Mitsigiorgi, J Goadsby, K Hamed, R Akolekar, K H Nicolaides","doi":"10.1002/uog.29218","DOIUrl":"10.1002/uog.29218","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate further the incidence and types of fetal abnormality identified at a routine 36-week ultrasound examination, which had not been diagnosed in previous scans at 20 weeks and 12 weeks' gestation, and to report the fetal abnormalities that are diagnosed only postnatally.</p><p><strong>Methods: </strong>This was a prospective study of 104 151 women with a singleton pregnancy attending for a routine ultrasound examination at 35 + 0 to 36 + 6 weeks' gestation. In each case, a detailed examination was carried out for the diagnosis of fetal abnormality. All women had undergone a previous ultrasound examination at 19 + 0 to 23 + 6 weeks and 95 801 (92.0%) women also had a scan at 11 + 0 to 14 + 1 weeks. We excluded pregnancies with known aneuploidy. Fetal abnormalities were classified according to the affected major organ system, and the type and incidence of new abnormalities were determined.</p><p><strong>Results: </strong>There were four main findings of this study. First, in the study population, abnormality was identified in 2552 (2.5%) fetuses/neonates. Second, at the 36-week scan, abnormality was detected in 2144 (2.1%) fetuses and the most common abnormalities first detected at the 36-week scan were ventricular septal defect, unilateral or bilateral hydronephrosis, unilateral empty renal fossa (with or without pelvic kidney), unilateral or bilateral duplex kidney and mild ventriculomegaly. Third, 1341 (62.5%) of the fetuses with abnormality detected at the 36-week scan had been diagnosed previously during the first or second trimester and therefore, the incidence of abnormality detected for the first time in the third trimester was 0.77% (803/104 151). The most common abnormalities that were diagnosed exclusively for the first time during the third-trimester scan were ovarian cyst, achondroplasia, microcephaly, vein of Galen malformation and hematocolpos. Fourth, the incidence of abnormality detected for the first time postnatally was 0.39% (408/104 151). The most common abnormalities detected for the first time postnatally were polydactyly, oligodactyly or syndactyly, hypospadias/epispadias, mild talipes treated with physiotherapy, ventricular septal defect and isolated cleft palate. The most common abnormalities diagnosed exclusively for the first time postnatally were isolated cleft palate, anal atresia, atrial septal defect and esophageal atresia with fistula.</p><p><strong>Conclusion: </strong>A high proportion of fetal abnormalities are detected for the first time during a routine 36-week scan. Such diagnosis and subsequent management, including the selection of timing and place for delivery and postnatal investigation, could potentially improve postnatal outcome. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.</p>","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"427-435"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twin pregnancy in woman with T-shaped uterus from CUME study.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1002/uog.29196
A Ludwin, M Loboda, L Zaborowska, W P Martins, I Ludwin
{"title":"Twin pregnancy in woman with T-shaped uterus from CUME study.","authors":"A Ludwin, M Loboda, L Zaborowska, W P Martins, I Ludwin","doi":"10.1002/uog.29196","DOIUrl":"10.1002/uog.29196","url":null,"abstract":"","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"508-510"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of first-trimester ultrasound screening strategy for fetal congenital heart disease.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1002/uog.29186
S Yang, G Qin, G He, M Liang, Y Liang, S Luo, Z Yang, Y Pang, F Long, Y Tang
{"title":"Evaluation of first-trimester ultrasound screening strategy for fetal congenital heart disease.","authors":"S Yang, G Qin, G He, M Liang, Y Liang, S Luo, Z Yang, Y Pang, F Long, Y Tang","doi":"10.1002/uog.29186","DOIUrl":"10.1002/uog.29186","url":null,"abstract":"<p><strong>Objective: </strong>To assess the performance of a standardized first-trimester ultrasound screening strategy for fetal congenital heart disease (CHD).</p><p><strong>Methods: </strong>This was a large retrospective study involving 74 839 consecutive mixed-risk pregnancies (77 396 fetuses). Routine ultrasound scans at 11 + 0 to 13 + 6 weeks' gestation were performed in a single center from January 2015 to June 2023. All fetuses were examined using a predefined standardized ultrasound scanning strategy with adjustment of imaging parameters, which included assessment of the fetal heart. The ultrasound results (e.g. extracardiac congenital malformations), ultrasound markers (e.g. nuchal translucency thickening, reversed a-wave in the ductus venosus and tricuspid regurgitation), follow-up, genetic tests and diagnostic results were recorded and analyzed.</p><p><strong>Results: </strong>In total, there were 831 cases of CHD, with an incidence of 1.07% (831/77 396). In the first-trimester scan, 590 fetuses were diagnosed with CHD, but four were confirmed as normal in later examinations. In addition, 245 cases were missed. The detection rate was 70.52%, with a sensitivity, specificity, false-positive rate and false-negative rate of 70.52%, 99.99%, 0.01% and 29.48%, respectively. In fetuses with negative ultrasound markers and no extracardiac malformations, the detection rate of CHD was 45.79% (185/404). There were 281 cases that underwent karyotyping and chromosomal microarray (245 fetuses) or whole-exome sequencing (36 fetuses). In total, 38.79% (109/281) had a positive genetic test result. There were 273/831 CHD cases associated with extracardiac malformations. The abnormal image patterns and abnormal features of each view in the scanning strategy were summarized.</p><p><strong>Conclusions: </strong>Ultrasound screening for fetal CHD in the first trimester of pregnancy enables earlier prenatal diagnosis and consultation. The standardized ultrasound screening strategy used in this study had a high detection rate for fetal CHD in the first trimester. Our proposed fetal heart screening strategy shows promising effectiveness for early diagnosis of CHD and we recommend its use. It is important to note, however, that first-trimester ultrasound screening for fetal CHD should not replace fetal echocardiography in the second trimester. © 2025 International Society of Ultrasound in Obstetrics and Gynecology.</p>","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"478-486"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-frequency ultrasound: promising tool for intraoperative ex-vivo assessment of lymph nodes.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1002/uog.29211
M Ciancia, F Moro, E Teodorico, M Pavone, D Querleu, G Garganese, A Fagotti, G Scambia, A C Testa
{"title":"High-frequency ultrasound: promising tool for intraoperative ex-vivo assessment of lymph nodes.","authors":"M Ciancia, F Moro, E Teodorico, M Pavone, D Querleu, G Garganese, A Fagotti, G Scambia, A C Testa","doi":"10.1002/uog.29211","DOIUrl":"10.1002/uog.29211","url":null,"abstract":"","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"503-505"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1002/uog.29183
D Fischerova, F Planchamp, J L Alcázar, P Dundr, E Epstein, A Felix, F Frühauf, G Garganese, I Salvesen Haldorsen, D Jurkovic, R Kocian, D Lengyel, F Mascilini, A Stepanyan, M Stukan, S Timmerman, T Vanassche, Z Yuan Ng, U Scovazzi
{"title":"ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.","authors":"D Fischerova, F Planchamp, J L Alcázar, P Dundr, E Epstein, A Felix, F Frühauf, G Garganese, I Salvesen Haldorsen, D Jurkovic, R Kocian, D Lengyel, F Mascilini, A Stepanyan, M Stukan, S Timmerman, T Vanassche, Z Yuan Ng, U Scovazzi","doi":"10.1002/uog.29183","DOIUrl":"10.1002/uog.29183","url":null,"abstract":"<p><p>The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) with the European Society of Gynaecological Oncology (ESGO) jointly developed clinically relevant and evidence-based statements on performing ultrasound-guided biopsies in gynecological oncology. The objective of this Consensus Statement is to assist clinicians, including gynecological sonographers, gynecological oncologists and radiologists, to achieve the best standards of practice in ultrasound-guided biopsy procedures. ISUOG/ESGO nominated a multidisciplinary international group of 16 experts who have demonstrated leadership in the use of ultrasound-guided biopsy in the clinical management of patients with gynecological cancer. In addition, two early-career gynecological fellows were nominated to participate from the European Network of Young Gynae Oncologists (ENYGO) within ESGO and from ISUOG. The group also included a patient representative from the European Network of Gynaecological Cancer Advocacy Groups. The document is divided into six sections: (1) general recommendations; (2) image-guided biopsy (imaging guidance, sampling methods); (3) indications and contraindications; (4) technique; (5) reporting; and (6) training and quality assurance. To ensure that the statements are evidence-based, the current literature was reviewed and critically appraised. Preliminary statements were drafted based on this review of the literature. During a conference call, the whole group discussed each preliminary statement, and a first round of voting was carried out. The group achieved consensus on all 46 preliminary statements without the need for revision. These ISUOG/ESGO statements on ultrasound-guided biopsy in gynecological oncology, together with a summary of the evidence supporting each statement, are presented herein. This Consensus Statement is supplemented by detailed narrated videoclips presenting different approaches and indications for ultrasound-guided biopsy, a patient leaflet, and an extended version which includes a detailed review of the evidence. © 2025 The Authors. Published by John Wiley & Sons Ltd on behalf of The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and by Elsevier Inc. on behalf of the European Society of Gynaecological Oncology and the International Gynecologic Cancer Society.</p>","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"517-535"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrosalpinx treatment before in-vitro fertilization: systematic review and network meta-analysis. 体外受精前肾积水治疗的系统回顾和网络荟萃分析。
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1002/uog.27697
F Pérez-Milán, M Caballero-Campo, M Carrera-Roig, E Moratalla-Bartolomé, J A Domínguez-Arroyo, J L Alcázar-Zambrano, L Alonso-Pacheco, J A Carugno
{"title":"Hydrosalpinx treatment before in-vitro fertilization: systematic review and network meta-analysis.","authors":"F Pérez-Milán, M Caballero-Campo, M Carrera-Roig, E Moratalla-Bartolomé, J A Domínguez-Arroyo, J L Alcázar-Zambrano, L Alonso-Pacheco, J A Carugno","doi":"10.1002/uog.27697","DOIUrl":"10.1002/uog.27697","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the safety and effectiveness of different methods, both ablative and non-ablative, to treat hydrosalpinx in infertile patients before in-vitro fertilization embryo transfer (IVF-ET) via a systematic review and network meta-analysis (NMA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A structured literature search was conducted in common citation databases. Eligibility criteria included peer-reviewed randomized controlled trials (RCTs) or cohort studies comparing the effectiveness and/or safety of different hydrosalpinx treatments, including salpingectomy, laparoscopic proximal tubal occlusion (LTO), insertion of an intratubal device (ITD), ultrasound-guided aspiration, sclerotherapy and expectant management. Primary outcomes were live birth, ongoing pregnancy and clinical pregnancy. Miscarriage, ectopic pregnancy and procedural complications were considered as secondary outcomes. The main NMA included only RCTs, while observational studies were included in a secondary aggregate NMA. Pooled effects were summarized as odds ratios (ORs) with 95% CI for direct and indirect comparisons, derived from random-effects models. Imprecision of NMA estimates was assessed by comparison of their 95% CIs with predefined thresholds for effect size considered to represent clinical relevance (OR &lt; 0.9 or &gt;1.1). Heterogeneity for NMA findings was estimated using the variance of the distribution of the underlying treatment effects (τ&lt;sup&gt;2&lt;/sup&gt;), expressed as a 95% prediction interval. Surface under the cumulative ranking curve (SUCRA) was used to predict relative treatment rankings for each outcome.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The main analysis included nine RCTs, while an additional 17 observational studies were incorporated into the aggregate analysis. The NMA of RCTs revealed no significant differences in live birth rate between hydrosalpinx treatment methods, with LTO achieving the highest SUCRA value (0.9). Salpingectomy and ultrasound-guided aspiration significantly increased the ongoing pregnancy rate compared with no treatment (OR, 4.35 (95% CI, 1.70-11.14) and 2.80 (95% CI, 1.03-7.58), respectively), with salpingectomy having the highest SUCRA value (0.9). Clinical pregnancy rate was significantly higher following salpingectomy (OR, 2.24 (95% CI, 1.30-3.86)) and LTO (OR, 2.55 (95% CI, 1.20-5.51)) compared with no treatment, despite some heterogeneity; LTO had the highest SUCRA value (0.8). NMA showed no significant differences in secondary outcomes between treatments. Aggregate NMA indicated that sclerotherapy significantly increased the live birth rate compared with no treatment. Higher ongoing pregnancy rate was observed in patients treated with salpingectomy, ultrasound-guided aspiration and LTO compared to untreated patients, with salpingectomy having the highest SUCRA value (0.9). Except for ITD insertion, all interventions increased the clinical pregnancy rate compared with no treatment. LTO had a greater effect on cl","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"414-426"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal biometry reference ranges derived from prospective twin population and evaluation of adverse perinatal outcome.
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1002/uog.29190
P Dicker, S Daly, R M Conroy, F M McAuliffe, M P Geary, J J Morrison, S S Carroll, F D Malone, F M Breathnach
{"title":"Fetal biometry reference ranges derived from prospective twin population and evaluation of adverse perinatal outcome.","authors":"P Dicker, S Daly, R M Conroy, F M McAuliffe, M P Geary, J J Morrison, S S Carroll, F D Malone, F M Breathnach","doi":"10.1002/uog.29190","DOIUrl":"10.1002/uog.29190","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Ultrasound-derived estimates of fetal size play an integral role in the prenatal management of twin pregnancy. These biometric measurements are conventionally plotted against singleton standards. We sought to establish fetal growth references for abdominal circumference, head circumference, biparietal diameter, femur diaphysis length and estimated fetal weight (EFW) in twin pregnancy. We also aimed to determine whether the performance of a twin fetal growth reference was superior to a singleton reference in the prediction of adverse perinatal outcome in twin pregnancies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a retrospective analysis of data collected prospectively in the Evaluation of Sonographic Predictors of Restricted growth in Twins (ESPRiT) study, which was conducted at eight academic perinatal centers in Ireland, all with tertiary neonatal intensive care facilities. Only diamniotic twin pregnancies with two live fetuses were eligible for inclusion. Exclusion criteria were monoamnionicity, congenital abnormality, twin-to-twin transfusion syndrome or previable fetal demise (&lt; 24 weeks' gestation). Using serial ultrasound observations, we applied fractional polynomial multilevel models to derive an equation for fetal centile determination. We compared these centiles with published singleton and twin fetal references, with particular focus on the Fetal Medicine Foundation (FMF) references. Using the last ultrasound examinations before delivery, we determined associations between biometric measures and a composite measure of adverse perinatal outcome (intraventricular hemorrhage, periventricular leukomalacia, hypoxic ischemic encephalopathy, necrotizing enterocolitis, bronchopulmonary dysplasia, sepsis or perinatal death), neonatal intensive care unit admission, preterm delivery (&lt; 34 weeks) and birth-weight discordance ≥ 25%, based on the varied prevalence of these outcomes. We compared our results with the singleton and twin FMF reference ranges and the twin reference of the Southwest Thames Obstetric Research Collaborative (STORK) study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among the 948 twin pairs that met the inclusion criteria, 776 (81.9%) dichorionic and 172 (18.1%) monochorionic twin pairs completed the prospective 2-weekly ultrasound surveillance program. Fetal biometric measurements were obtained in 15 274 ultrasound assessments (12 279 in dichorionic and 2995 in monochorionic twin pairs) from serial ultrasound assessments. The median number of ultrasound assessments per pregnancy was 8 (interquartile range, 7-9). Growth trajectories in this cohort were consistent with the FMF and STORK published twin cohorts and notably less consistent with the FMF singleton standard. Compared with the FMF singleton standards, the 50&lt;sup&gt;th&lt;/sup&gt; centiles for twins were greater early in pregnancy and lower later in pregnancy for all biometric measures, in both dichorionic and monochorionic twin pregnancies. This crossover","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"436-446"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased nuchal translucency thickness and normal chromosomal microarray: Danish nationwide cohort study. 颈部透明层厚度增加和染色体微阵列正常:丹麦全国性队列研究。
IF 6.1 1区 医学
Ultrasound in Obstetrics & Gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1002/uog.29198
K Gadsbøll, N Brix, P Sandager, O B Petersen, A P Souka, K H Nicolaides, I Vogel
{"title":"Increased nuchal translucency thickness and normal chromosomal microarray: Danish nationwide cohort study.","authors":"K Gadsbøll, N Brix, P Sandager, O B Petersen, A P Souka, K H Nicolaides, I Vogel","doi":"10.1002/uog.29198","DOIUrl":"10.1002/uog.29198","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To assess the outcome of pregnancies with increased fetal nuchal translucency (NT) thickness and a normal result from chromosomal microarray (CMA) vs conventional karyotyping.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a Danish nationwide registry-based cohort study of all singleton pregnancies seen for combined first-trimester screening between 2008 and 2018. Data on NT thickness and pregnancy outcome were retrieved from the Danish Fetal Medicine Database, whereas data on cytogenetic and molecular karyotypes were retrieved from the Danish Cytogenetic Central Register. Pregnancies were stratified according to NT thickness, and we computed the prevalence of chromosomal aberration, termination of pregnancy (due to non-genetic abnormal findings aside from increased NT), pregnancy loss, major congenital malformation and unaffected live birth (live birth ≥ 24 weeks' gestation with no chromosomal aberration or major congenital malformation diagnosed). The prevalence of the different outcomes was further estimated for pregnancies with increased NT (≥ 3.5 mm) and a normal CMA result. Finally, to assess the impact of CMA compared with conventional karyotyping for increased NT, we compared the prevalence of chromosomal aberrations and each pregnancy outcome between the periods 2008-2012 and 2014-2018 (during which &lt; 3% and &gt; 60%, respectively, of pregnancies with increased NT were examined using CMA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We identified 557 896 pregnancies with a NT measurement for which outcome data were registered. Fetal NT was ≥ 3.5 mm in 3717 (0.7%) pregnancies, of which 3368 (91%) underwent genetic examination. The prevalence of chromosomal aberrations increased significantly with increasing NT thickness, from 21% in pregnancies with NT of 3.5-4.4 mm to 69% in pregnancies with NT ≥ 6.5 mm. Trisomies 21, 18 and 13 accounted for the majority of chromosomal aberrations diagnosed in all subgroups of increased NT (range, 61-87%). In pregnancies with increased NT and a normal CMA result, the prevalence of unaffected live birth decreased significantly from 87% for NT of 3.5-4.4 mm to 29% for NT ≥ 6.5 mm. Increased uptake of CMA during 2014-2018 compared with 2008-2012 slightly increased the detection of submicroscopic aberrations. However, a normal CMA result, compared with a normal result from conventional karyotyping, did not substantially improve the prognosis in pregnancies with increased NT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our study reaffirms the association between increased NT and chromosomal aberrations. Although CMA improves diagnostic resolution in pregnancies with increased NT, a normal test result does not substantially impact the prevalence of unaffected live births. This highlights the ongoing need for accurate clinical guidance and continued research, especially as whole-genome sequencing is increasingly adopted in prenatal care. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by","PeriodicalId":23454,"journal":{"name":"Ultrasound in Obstetrics & Gynecology","volume":" ","pages":"462-469"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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