Twin Research and Human Genetics最新文献

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Recollections and Reflections on the Reimer Twin Case in Canada: Interview with Dr H. Keith Sigmundson/Tribute and Twin Research Review: Remembering John L. Hopper; Nonhuman Primate Twinning/Human Interest: The Accidental Twins film; Different Looking Identical Twin Newborns. 加拿大雷默双胞胎案例的回忆与思考:专访H. Keith Sigmundson博士/致敬与双胞胎研究回顾:纪念约翰·霍珀;非人类灵长类动物双胞胎/人类利益:意外双胞胎电影;长相不同的同卵双胞胎新生儿。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-12-20 DOI: 10.1017/thg.2024.47
Nancy L Segal
{"title":"Recollections and Reflections on the Reimer Twin Case in Canada: Interview with Dr H. Keith Sigmundson/Tribute and Twin Research Review: Remembering John L. Hopper; Nonhuman Primate Twinning/Human Interest: <i>The Accidental Twins</i> film; Different Looking Identical Twin Newborns.","authors":"Nancy L Segal","doi":"10.1017/thg.2024.47","DOIUrl":"https://doi.org/10.1017/thg.2024.47","url":null,"abstract":"<p><p>Dr H. Keith Sigmundson co-authored a seminal article (with the late Dr Milton Diamond) that revealed the truth about a highly controversial twin case. Specifically, the genitals of an infant male monozygotic twin were accidentally destroyed during a medical procedure performed to alleviate his difficult urination. The child's parents were advised to physically and psychologically transform their twin son into a girl. Occasional reports about the case indicated that the plan was successful, but some members of the medical community were doubtful. An interview with Dr H. Keith Sigmundson, for the purpose of obtaining his unique perspective on this case, is presented. The interview is followed by a tribute to our late twin research colleague, Dr John L. Hopper, of Melbourne, Australia. A review of research on nonhuman primate twinning, an overview of a 2024 documentary film, <i>The Accidental Twins</i>, and a story of different looking identical twin newborns are also provided.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study. 晚育是早产和分娩的保护因素:来自遗传研究的证据。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-12-16 DOI: 10.1017/thg.2024.44
Jinghui Zou, Cheng Li, Hangyu Wu, Aijiao Xue, Lulu Yan, Yisheng Zhang
{"title":"Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study.","authors":"Jinghui Zou, Cheng Li, Hangyu Wu, Aijiao Xue, Lulu Yan, Yisheng Zhang","doi":"10.1017/thg.2024.44","DOIUrl":"https://doi.org/10.1017/thg.2024.44","url":null,"abstract":"<p><p>The objective of this study was to investigate the genetic link between the age at first birth (AFB) and the occurrence of preterm labor and delivery, utilizing Mendelian randomization (MR) data alongside genomewide association analysis (GWAS). We obtained AFB-related GWAS summary data from the European Bioinformatics Institute database and preterm labor and delivery data was sourced from the FinnGen Consortium. The study considered AFB as exposure variables, with the incidence of preterm labor and delivery serving as the outcome variable. Several MR analysis methods, such as inverse-variance weighted (IVW), MR Egger, weighted median, simple, and weighted mode were utilized. Besides MR-Egger intercepts, Cochrane's Q test evaluated heterogeneity in the MR data, while MR-PRESSO test checked for horizontal pleiotropy. To assess the association's sensitivity, A leave-one-out approach was utilized to evaluate the sensitivity of the association. The IVW analysis validated that AFB is an independent risk factor for preterm labor and delivery (<i>p</i> < .001). Horizontal pleiotropy was unlikely to bias causality (<i>p</i> > .05). The likelihood of horizontal pleiotropy affecting causality was low (<i>p</i> > .05), and there was no indication of heterogeneity among the genetic variants (<i>p</i> > .05). Ultimately, a leave-one-out analysis confirmed the stability and reliability of this correlation. Our research indicated that AFB is a protective factor for preterm labor and delivery. Further research is required to clarify the possible mechanisms.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polygenic Selection and Environmental Influence on Adult Body Height: Genetic and Living Standard Contributions Across Diverse Populations. 多基因选择和环境对成人身高的影响:遗传和生活水平在不同人群中的贡献。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-12-06 DOI: 10.1017/thg.2024.43
Davide Piffer, Emil O W Kirkegaard
{"title":"Polygenic Selection and Environmental Influence on Adult Body Height: Genetic and Living Standard Contributions Across Diverse Populations.","authors":"Davide Piffer, Emil O W Kirkegaard","doi":"10.1017/thg.2024.43","DOIUrl":"https://doi.org/10.1017/thg.2024.43","url":null,"abstract":"<p><p>We analyzed whole-genome sequencing (WGS) data from 51 populations and combined WGS and array data from 89 populations. Multiple types of polygenic scores (PGS) were employed, derived from multi-ancestry, between-family genome-wide association study (GWAS; MIX-Height), European-ancestry, between-family GWAS (EUR-Height), and European-ancestry siblings GWAS (SIB-Height). Our findings demonstrate that both genetic and environmental factors significantly influence adult body height between populations. Models that included both genetic and environmental predictors best explained population differences in adult body height, with the MIX-Height PGS and environmental factors (Human Development Index [HDI] + per capita caloric intake) achieving an <i>R</i><sup>2</sup> of .83. Our findings shed light on Deaton's 'African paradox', which noted the relatively tall stature of African populations despite poor nutrition and childhood health. Contrary to Deaton's hypotheses, we demonstrate that both genetic differences and environmental factors significantly influence body height in countries with high infant mortality rates. This suggests that the observed tall stature in African populations can be attributed, in part, to a high genetic predisposition for body height. Furthermore, tests of divergent selection based on the Q<sub>ST</sub> (i.e., standardized measure of the genetic differentiation of a quantitative trait among populations) and F<sub>ST</sub> (neutral marker loci) measures exceeded neutral expectations, reaching statistical significance (<i>p</i> < .01) with the MIX-Height PGS but not with the SIB-Height PGS. This result indicates potential selective pressures on body height-related genetic variants across populations.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-18"},"PeriodicalIF":1.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factor for Child Maltreatment at 3 Years of Age in Japanese Multiples and Singletons: A Population-Based Study. 日本多胞胎和单胞胎儿童3岁时虐待的危险因素:一项基于人群的研究。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-12-06 DOI: 10.1017/thg.2024.42
Yoshie Yokoyama, Yasue Ogata, Karri Silventoinen
{"title":"Risk Factor for Child Maltreatment at 3 Years of Age in Japanese Multiples and Singletons: A Population-Based Study.","authors":"Yoshie Yokoyama, Yasue Ogata, Karri Silventoinen","doi":"10.1017/thg.2024.42","DOIUrl":"https://doi.org/10.1017/thg.2024.42","url":null,"abstract":"<p><p>We evaluated the prevalence and risk factors for child maltreatment in multiples aged 3 years and compared them to singletons in Japanese population-based data. Records on child maltreatment and health check-ups at 3 years of age from 17,125 singletons, 488 twins and 18 triplets were collected from a Public Health Center between April 2007 and March 2011. The associations of child maltreatment with potential risk factors were analyzed using the logistic regression model. Out of all children, 76 (4.31 per 1000) children had documented maltreatment including 69 (4.03 per 1000) singletons and seven (14.31 per 1000) twins. All of the cases in twins were physical abuse (100%) and nearly half of the cases (43%) included emotional abuse. Among twins, 86% of the biological mothers were suspected. The alleged perpetrators of twins showed a significantly higher rate of maternal depression compared to those of singletons. After adjusting the results for a number of potential biological and social risk factors, twins or triplets had a higher risk for maltreatment than singletons (<i>OR</i> 3.39, 95% CI [1.17, 9.83]). Healthcare providers should be aware that a multiple birth can place considerable stress on a family leading to child maltreatment and should provide appropriate support and intervention for mothers with multiples.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Twin Births and Survival in Rural Spain: Evidence from 18th to 20th Century. 西班牙农村地区双胞胎出生和存活趋势:18 世纪至 20 世纪的证据。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-11-07 DOI: 10.1017/thg.2024.40
Francisco J Marco-Gracia
{"title":"Trends in Twin Births and Survival in Rural Spain: Evidence from 18th to 20th Century.","authors":"Francisco J Marco-Gracia","doi":"10.1017/thg.2024.40","DOIUrl":"10.1017/thg.2024.40","url":null,"abstract":"<p><p>This study examines the changes over time of the twinning rate and infant and child mortality across 17 rural villages in the province of Zaragoza (Spain) over a span of 200 years. The aim is to understand how the twinning rate evolved in conjunction with the processes of economic and social modernization, as well as the demographic transition. During the period analyzed, the twinning rate increased by 10%, rising from 1.26 per 1000 births in the second half of the 18th century to 1.38 per 1000 births in the first half of the 20th century. This rate varied due to hereditary issues, biological factors such as the mother's age and parity, and socioeconomic features like family occupation and the mother's education level. In terms of child mortality, twins historically faced a significantly higher mortality rate. However, they benefited greatly from the mortality transition, at least in absolute numbers. While nearly 60% of twins did not survive beyond 5 years of age in earlier periods, the mortality rate for twins decreased to 40% by the first half of the 20th century. The excess mortality was particularly severe for girls, driven by a widespread preference for sons, which led to higher mortality rates for girls in the first 5 years of life, especially in the earliest months. These findings help us understand the improvements in uterine and childhood survival rates for contemporary twins, which can be attributed to the socioeconomic and medical advancements of the 20th century.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chorionicity and Psychomotor Development From Infancy to Childhood: The Japan Environment and Children's Study. 绒毛膜性与婴儿期至儿童期的心理运动发育:日本环境与儿童研究
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-10-28 DOI: 10.1017/thg.2024.39
Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Satoyo Ikehara, Junji Miyazaki, Kanami Tanigawa, Takashi Kimura, Ryo Kawasaki, Hiroyasu Iso
{"title":"Chorionicity and Psychomotor Development From Infancy to Childhood: The Japan Environment and Children's Study.","authors":"Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Satoyo Ikehara, Junji Miyazaki, Kanami Tanigawa, Takashi Kimura, Ryo Kawasaki, Hiroyasu Iso","doi":"10.1017/thg.2024.39","DOIUrl":"https://doi.org/10.1017/thg.2024.39","url":null,"abstract":"<p><p>Twins lag behind singletons in their early psychomotor development, but little is known about how chorionicity affects this difference. We compared early psychomotor development in singletons, monochorionic (MC) twins and dichorionic (DC) twins. Our longitudinal data from the Japan Environment and Children's Study (JECS; see Appendix) included 98,042 singletons, 577 MC twins and 1051 DC twins representing the general Japanese population. Chorionicity was evaluated by ultrasound images and complemented by postnatal pathological examinations. Five domains of psychomotor development were evaluated at 6 time points from 6 months to 3 years of age using the Ages and Stages Questionnaires (ASQ-3). The data were analyzed using linear regression models. Twins lagged behind singletons in all areas of psychomotor development during infancy. This gap decreased over time but was still noticeable at 3 years of age. More than half of this difference was attributed to twins having lower birth weight and being born earlier in gestation. MC twins showed slightly delayed development compared to DC twins, but this difference was minor compared to the overall gap between twins and singletons. Twins delay singletons in their early psychomotor development, and this delay is not specific to MC twinning.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Predisposition of Different Social Status Indicators in Men and Women. 男性和女性不同社会地位指标的遗传倾向。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-09-09 DOI: 10.1017/thg.2024.23
Martin Fieder, Susanne Huber
{"title":"Genetic Predisposition of Different Social Status Indicators in Men and Women.","authors":"Martin Fieder, Susanne Huber","doi":"10.1017/thg.2024.23","DOIUrl":"https://doi.org/10.1017/thg.2024.23","url":null,"abstract":"<p><p>Although there is evidence that social status has a genetic basis, it is less known whether the genetic predisposition differs between men and women as well as among different status indicators and whether there are any intercorrelations among predispositions of status indicators. We therefore investigated the genetic predisposition for different indicators of social status separately for men and women, using polygenic scores obtained from the Wisconsin Longitudinal Study. We used multivariate polygenic regression of 7 different social status indicators on a total of 24 different polygenic scores. We find that in both men and women, wages and education show more associations with polygenic scores than the other status indicators. Also, the genetic predispositions for education and wages are correlated in both men and women, whereas in men more than in women, the genetic predispositions seem to cluster into wages and education on the one hand, and status indicators of position in the hierarchy, on the other hand, with being in a management position somewhere in between. These findings are consistent with an assumption of two different forms of selection pressure associated with either cognitive skill or dominance, which holds true particularly in men. We conclude that the genetic predisposition to higher social status may have changed even though the importance of the cultural trait of social status may have been very constant. Social status may thus be an example of a social trait of constant importance, but with a changing genetic predisposition.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies. 自然和医学辅助生殖双卵双胎妊娠的母体特征。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-09-06 DOI: 10.1017/thg.2024.26
Nikki Hubers, Christian M Page, Lannie Ligthart, René Pool, Jouke-Jan Hottenga, Jenny van Dongen, Cornelis B Lambalk, Jennifer R Harris, Gonneke Willemsen, Dorret I Boomsma
{"title":"Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies.","authors":"Nikki Hubers, Christian M Page, Lannie Ligthart, René Pool, Jouke-Jan Hottenga, Jenny van Dongen, Cornelis B Lambalk, Jennifer R Harris, Gonneke Willemsen, Dorret I Boomsma","doi":"10.1017/thg.2024.26","DOIUrl":"https://doi.org/10.1017/thg.2024.26","url":null,"abstract":"<p><p>Previous studies have shown that mothers of naturally conceived dizygotic (DZ) twins tend to be taller, older, and smoke more than mothers of naturally conceived monozygotic (MZ) twin and mothers of singletons. Here, we investigate whether mothers of naturally conceived DZ twins differ from mothers who conceived their DZ twins after medically assisted reproduction (MAR) in eight maternal traits related to fertility based on observational survey data. We include data from 33,648 mothers from the Netherlands Twin Register (NTR) and 1660 mothers of twins from the Norwegian Mother, Father and Child Cohort Study (MoBA). We contrast mothers of naturally conceived DZ twins with mothers of MAR DZ twins. Next, we further segment the MAR group into mothers who underwent hormonal induction of ovulation but not in vitro fertilization (IVF) and those who IVF twins, comparing them both to each other and against the mothers of naturally conceived DZ twins. Mothers of naturally conceived DZ twins smoke more often, differ in body composition, have a higher maternal age and have more offspring before the twins than mothers of MZ twins. Compared to MAR DZ twin mothers, mothers of naturally conceived DZ twins have fewer miscarriages, lower maternal age and increased height, more offspring and are more often smokers. BMI before the twin pregnancy is similar in both natural and MAR DZ twin mothers. Mothers who received hormonal induction of ovulation (OI) have a lower maternal age, fewer miscarriages, and a higher number of offspring before their twin pregnancy than twin mothers who received IVF and/or intracytoplasmic sperm injection (ICSI) treatments. Our study shows that twin mothers are a heterogenous group and the differences between twin mothers should be taken into account in epidemiological and genetic research that includes twins.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech. 基因遗传对人类语音的影响:巴西双胞胎语音的基频分析
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-08-01 Epub Date: 2024-10-02 DOI: 10.1017/thg.2024.33
Lilian C Luchesi, Julio C Cavalcanti, Tania K Lucci, Vinicius F David, Emma Otta, Patricia F Monticelli
{"title":"Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech.","authors":"Lilian C Luchesi, Julio C Cavalcanti, Tania K Lucci, Vinicius F David, Emma Otta, Patricia F Monticelli","doi":"10.1017/thg.2024.33","DOIUrl":"10.1017/thg.2024.33","url":null,"abstract":"<p><p>Voice production can be influenced by interindividual variations related to genetic, physiological, behavioral, and several environmental factors. Here we examined the effect of zygosity on speaking fundamental frequency (F0) statistical descriptors. Our aims were: (1) to determine whether the genetic similarity between monozygotic (MZ) and dizygotic (DZ) twins affects F0 characteristics, and (2) to quantify the contribution of genetic factors to these characteristics. The study involved 79 same-sex twin pairs of Brazilian Portuguese speakers, comprising 65 MZ and 14 DZ twins, aged 18 to 66 years (31.7 ± 11.6 years), with 21 male and 58 female pairs. Participants were recorded while uttering a greeting phrase and the Brazilian Portuguese version of the 'Happy Birthday to You' song. Speech segments were analyzed using Praat free software, and F0 measures were automatically extracted in both Hertz and semitone scales. Statistical descriptors, including centrality, dispersion, and extreme values of F0 were examined, and the ACE model (i.e., total genetic effects, A; shared environmental influences, C; and nonshared environmental influences, E) was employed to estimate the additive effect;ts of monozygosity. As anticipated, we observed a zygosity effect on several F0 parameters, with more similarity between MZ twins compared to DZ twins. We discuss the genetic influences on F0 parameters and the absence of a monozygosity effect in two of them. Additionally, we briefly address potential biases associated with the selected measurement scale for statistical modeling. Finally, we explore the influence of genetic factors on F0 patterns, as well as environmental, life history and linguistic factors, particularly concerning F0 variation in speech.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"215-222"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Influence on Social Support: A Twin Study. 遗传对社会支持的影响:双胞胎研究
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-08-01 Epub Date: 2024-10-02 DOI: 10.1017/thg.2024.32
Bodine M A Gonggrijp, Steve G A van de Weijer, Jenny van Dongen, Catrien C J H Bijleveld, Dorret I Boomsma
{"title":"Genetic Influence on Social Support: A Twin Study.","authors":"Bodine M A Gonggrijp, Steve G A van de Weijer, Jenny van Dongen, Catrien C J H Bijleveld, Dorret I Boomsma","doi":"10.1017/thg.2024.32","DOIUrl":"10.1017/thg.2024.32","url":null,"abstract":"<p><p>Social support is often considered an environmental factor affecting health, especially in aging populations. However, its genetic underpinnings suggest a more complex origin. This study investigates the heritability of social support through applying a threshold model on data of a large adult sample of twins (<i>N</i> = 8019) from the Netherlands Twin Register, collected between 2009 and 2011. The study employed the Duke - UNC Functional Social Support Questionnaire to assess social support quality. Our analysis revealed genetic contributions to social support, with heritability estimated at 37%, without a contribution of shared environment and no differences between men and women in heritability. The study's results underscore the complexity of social support as a trait influenced by genetic and environmental factors, challenging the notion that it is solely an environmental construct.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"193-197"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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